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Advances in NKT cell Immunotherapy for Glioblastoma. NKT细胞免疫治疗胶质母细胞瘤的研究进展。
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 Epub Date: 2018-06-18 DOI: 10.4172/1948-5956.1000533
Kalyani Pyaram, Viveka Nand Yadav
{"title":"Advances in NKT cell Immunotherapy for Glioblastoma.","authors":"Kalyani Pyaram,&nbsp;Viveka Nand Yadav","doi":"10.4172/1948-5956.1000533","DOIUrl":"https://doi.org/10.4172/1948-5956.1000533","url":null,"abstract":"<p><p>Type I or invariant natural killer T cells belong to a unique lineage of innate T cells, which express markers of both T lymphocytes and NK cells, namely T cell receptor (TCR) and NK1.1 (CD161C), respectively. Thus, apart from direct killing of target cells like NK cells, and they also produce a myriad of cytokines which modulate the adaptive immune responses. Unlike traditional T cells which carry a conventional αβ TCR, NKT cells express semi-invariant TCR - Vα14-Jα18, coupled with Vβ8, Vβ7 and Vβ2 in mice. In humans, the invariant TCR is composed of Vα24-Jα18, coupled with Vβ11.</p>","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/1948-5956.1000533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36429903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effects of a 6-week Hike on Physical Activity Levels, Psycholog ical Wellbeing and Quality of Life in Breast Cancer Survivors 6周徒步旅行对乳腺癌幸存者身体活动水平、心理健康和生活质量的影响
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000538
F. Baumann, O. Bieck, M. Strunk, N. Reimer, E. Zopf, W. Bloch, S. Han
{"title":"Effects of a 6-week Hike on Physical Activity Levels, Psycholog ical Wellbeing and Quality of Life in Breast Cancer Survivors","authors":"F. Baumann, O. Bieck, M. Strunk, N. Reimer, E. Zopf, W. Bloch, S. Han","doi":"10.4172/1948-5956.1000538","DOIUrl":"https://doi.org/10.4172/1948-5956.1000538","url":null,"abstract":"","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"21 1","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73051598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNAs as a Potential Target for Cancer Therapy MicroRNAs作为癌症治疗的潜在靶点
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000535
A. Mekuria, Abraham Degaga Abdi, K. M. Mishore
{"title":"MicroRNAs as a Potential Target for Cancer Therapy","authors":"A. Mekuria, Abraham Degaga Abdi, K. M. Mishore","doi":"10.4172/1948-5956.1000535","DOIUrl":"https://doi.org/10.4172/1948-5956.1000535","url":null,"abstract":"MicroRNAs (miRNAs) are evolutionary conserved small non-coding RNAs that negatively regulate gene expression by several mechanisms. Deregulation in expression of miRNAs has been reported in the pathogenesis of cancer. Accordingly, studies identified down regulation in the expression of miRNAs having tumor suppressor role and up-regulation in the expression of oncogenic miRNAs in different types of cancer. In response to these observations currently there are ongoing efforts to develop safe and effective miRNA-based therapeutics in the hope of fighting against cancer. This paper aimed at reviewing the role of miRNAs in tumorigenesis, and strategies for therapeutic targeting of miRNAs in cancer.","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"1 1","pages":"152-161"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74464101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Impact of a Screening Program in the Diagnosis, Surgical Treatm ent and Management of Breast Cancer 筛查项目对乳腺癌诊断、手术治疗和管理的影响
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000537
I. Lete, M. Aguiar, Arguine Andonegui, Nagore Zeberio, M. Cuadra, J. Mendizabal, J. Gorostiaga
{"title":"Impact of a Screening Program in the Diagnosis, Surgical Treatm ent and Management of Breast Cancer","authors":"I. Lete, M. Aguiar, Arguine Andonegui, Nagore Zeberio, M. Cuadra, J. Mendizabal, J. Gorostiaga","doi":"10.4172/1948-5956.1000537","DOIUrl":"https://doi.org/10.4172/1948-5956.1000537","url":null,"abstract":"Introduction: The effects of early detection on treatment need to be evaluated. The objective of this study was to assess the impact of the Basque breast cancer early detection program (BCEDP) on breast cancer surgery in our hospital. Materials and Methods: A retrospective study was conducted of women who underwent surgery for breast cancer between 1 January 2015 and 31 December 2016. Participants were classified into: Group A, those referred from the screening program after routine mammography; or group B, those referred from primary care or other gynecological clinics within our health region. Results: In the study period, 630 women were diagnosed with and treated for breast cancer. Their mean age was 60.2 years (standard deviation 5.4). Out of these, 220 (35%) referred from the BCEDP formed group A, the other 410 women (65%) forming group B. Invasive cancer was diagnosed in 185 women in group A (84%) and in 370 (90.2%) in group B (p=0.02). Regarding treatment, mastectomies were carried out in 47 women (21.4%) in Group A and 225 (54.9%) in group B (p<0.001); axillary lymphadenectomies were performed in 31 women (14.1%) in Group A and 83 (20.2%) in Group B, (p=0.02); and adjuvant chemotherapy was given in 66 women (30%) in Group A and 148 (36.1%) in Group B (p<0.001). Conclusion: In our setting, breast cancer patients referred through the BCEDP have earlier stage cancer, can be expected to benefit from less radical surgery, have lower proportion of axillary lymph node involvement and require less adjuvant chemotherapy.","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"23 1","pages":"152-155"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84556715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current and Future Developments of PARP Inhibitors in the Treat ment of Breast and Ovarian Cancer PARP抑制剂治疗乳腺癌和卵巢癌的现状和未来发展
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000542
Dieuwke Luijten, M. Vreeswijk, Ingrid Boere, J. Kroep
{"title":"Current and Future Developments of PARP Inhibitors in the Treat ment of Breast and Ovarian Cancer","authors":"Dieuwke Luijten, M. Vreeswijk, Ingrid Boere, J. Kroep","doi":"10.4172/1948-5956.1000542","DOIUrl":"https://doi.org/10.4172/1948-5956.1000542","url":null,"abstract":"The use of Poly ADP-ribose polymerase (PARP) inhibitors has recently been expanded. PARP inhibitors were initially only registered for patients with BRCA mutated high-grade serous epithelial ovarian, including primary peritoneal and fallopian tube cancer (EOC). Currently, PARP inhibitors are also registered for patients with recurrent EOC who are in a complete or partial response to platinum-based chemotherapy, irrespective of their BRCA status. Current findings indicate that patients with BRCA mutations and/or a BRCA like tumour defined by a BRCAness profile, benefit the most. Combination therapies of PARP inhibitors with immunotherapy and/or angiogenesis inhibitors are fast evolving and studied from first line therapy to recurrent disease. This review summarizes the current findings, obstacles and future developments of PARP inhibitor with a focus on female cancer.","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"11 1 1","pages":"178-189"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79672918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA Expression of Cytochrome P450 and its Clinical Impact in Breast Cancer Patients 细胞色素P450在乳腺癌患者中的RNA表达及其临床意义
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000557
Kanakaiah Thota, K. Prasad, M. Rao
{"title":"RNA Expression of Cytochrome P450 and its Clinical Impact in Breast Cancer Patients","authors":"Kanakaiah Thota, K. Prasad, M. Rao","doi":"10.4172/1948-5956.1000557","DOIUrl":"https://doi.org/10.4172/1948-5956.1000557","url":null,"abstract":"Objectives: The expression pattern of cytochrome P450 genes (CYPs) affected by tumorigenesis may have an important role in the progression of cancer and in the metabolism of anticancer drugs. The aim of the present study was to determine the mRNA expression pattern of two cytochrome P450 genes (CYP3A4, and CYP3A5) in breast cancer patients. Methods: Tumor samples were collected from 38 patients recently diagnosed with breast cancer along with corresponding non-malignant tissues. Quantitative polymerase chain reaction (qPCR) was used to quantify the levels of gene expression in all the samples. The association between CYPs expression and clinico-pathological parameters was also analyzed. Results: In the present study, our results showed that CYP3A5 gene expression was not significantly associated with breast cancer (p=0.14). Significant differences in CYP3A4 mRNA expression were observed between tumor tissue and the corresponding normal tissue (p<0.003). There was no statistical difference between CYP3A4 and CYP3A5 expression and clinical and pathological features. Conclusion: CYP3A4 expression has a potential role as a breast cancer prognosis marker. We conclude that increased expression levels of the examined CYP3A4 may promote breast cancer progression and also may associate with resistance to drug treatment by inactivation of anticancer drugs. Moreover, one potential therapeutic approach may be to block CYP3A4 function.","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81192141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor Immunology: Uncovering Relationship Between Cancer and Immune System 肿瘤免疫学:揭示肿瘤与免疫系统的关系
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000568
Y. H. A. Montenegro, A. D. Ramos, G. C. L. Silva
{"title":"Tumor Immunology: Uncovering Relationship Between Cancer and Immune System","authors":"Y. H. A. Montenegro, A. D. Ramos, G. C. L. Silva","doi":"10.4172/1948-5956.1000568","DOIUrl":"https://doi.org/10.4172/1948-5956.1000568","url":null,"abstract":"Yorran Hardman Araújo Montenegro1*, Anderson dos Santos Ramos2 and Geilza Carla de Lima Silva3 1Department of Biological Sciences at the State University of Paraíba, Laboratory of Genetics and Molecular Biology (LGBM), Brazil 2Department of Cellular and Molecular Biology, Federal University of Paraíba, Laboratory of Molecular Biology Applied to Health, Brazil 3Department of Applied Biology to Health, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Brazil","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81331171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cetuximab Induced Aseptic Meningitis: A Rare Side Effect 西妥昔单抗诱发无菌性脑膜炎:一种罕见的副作用
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000546
S. Kaur, H. Khatun, Abhishek Kumar, M. Ellis, D. Mehta, G. Guron
{"title":"Cetuximab Induced Aseptic Meningitis: A Rare Side Effect","authors":"S. Kaur, H. Khatun, Abhishek Kumar, M. Ellis, D. Mehta, G. Guron","doi":"10.4172/1948-5956.1000546","DOIUrl":"https://doi.org/10.4172/1948-5956.1000546","url":null,"abstract":"A 65-year-old African American female was diagnosed with laryngeal cancer (T1N2M0) in August 2015. She received platinum-based chemotherapy initially. After an initial remission patient had a systemic recurrence which was treated with Cetuximab. The patient presented to ER six hours after receiving the first dose of cetuximab with high grade fever and signs of meningeal irritation. CSF analysis showed neutrophil predominant pleocytosis with negative gram stain and culture. It was concluded that the patient had cetuximab induced aseptic meningitis. The patient was re-challenged with lower dose of cetuximab which was tolerated well. Cetuximab induced aseptic meningitis is a rare side effect reported in handful of cases.","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"11 1","pages":"211-213"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84990557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
EGFR Primary T790M and L858R Double Mutation Confers Clinical Benefit to Erlotinib and Resistance to Osimertinib in One Lung Adenocarcinoma Patient: A Case Report 1例肺腺癌患者EGFR原发性T790M和L858R双突变对厄洛替尼和奥西替尼耐药有临床益处
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000569
Xiao-ying Zhao
{"title":"EGFR Primary T790M and L858R Double Mutation Confers Clinical Benefit to Erlotinib and Resistance to Osimertinib in One Lung Adenocarcinoma Patient: A Case Report","authors":"Xiao-ying Zhao","doi":"10.4172/1948-5956.1000569","DOIUrl":"https://doi.org/10.4172/1948-5956.1000569","url":null,"abstract":"","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91076666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Assessment of Minimal Residual Disease by Flow Cytometry in Acute Myeloid Leukaemia and its Correlation with Treatment Outcome 流式细胞术评估急性髓系白血病微小残留病变及其与治疗结果的相关性
Journal of Cancer Science & Therapy Pub Date : 2018-01-01 DOI: 10.4172/1948-5956.1000545
Elsalakawy Wa, Abdelbary Hm, Youssef, Abdelmohsen Ea
{"title":"Assessment of Minimal Residual Disease by Flow Cytometry in Acute Myeloid Leukaemia and its Correlation with Treatment Outcome","authors":"Elsalakawy Wa, Abdelbary Hm, Youssef, Abdelmohsen Ea","doi":"10.4172/1948-5956.1000545","DOIUrl":"https://doi.org/10.4172/1948-5956.1000545","url":null,"abstract":"Copyright: © 2018 Elsalakawy WA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Assessment of Minimal Residual Disease by Flow Cytometry in Acute Myeloid Leukaemia and its Correlation with Treatment Outcome","PeriodicalId":15170,"journal":{"name":"Journal of Cancer Science & Therapy","volume":"42 1","pages":"205-210"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73881794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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