Journal of Blood Medicine最新文献

{"title":"Genotyping Approach to Predict Co^a and Co^b Antigens in Thai Blood Donor Populations.","authors":"Oytip Nathalang,&nbsp;Kamonchanok Asisathaporn,&nbsp;Kamphon Intharanut,&nbsp;Wanlapa Chaibangyang,&nbsp;Nipapan Leetrakool,&nbsp;Supattra Mitundee,&nbsp;Sasitorn Bejrachandra","doi":"10.2147/JBM.S398720","DOIUrl":"https://doi.org/10.2147/JBM.S398720","url":null,"abstract":"<p><strong>Purpose: </strong>Co^a and Co^b antigens of the Colton (CO) blood group system are implicated in acute and delayed hemolytic transfusion reactions (HTRs). Owing to the inadequate supply of specific antiserum, data on CO phenotypes remain limited. This study aimed to develop genotyping methods to predict Co^a and Co^b antigens and to estimate transfusion-induced alloimmunization risks in three Thai blood donor populations.</p><p><strong>Materials and methods: </strong>The study included 2451 blood samples from unrelated healthy Thai blood donors obtained from central, northern, and southern Thailand. DNA sequencing was used to determine the <i>CO*A</i> and <i>CO*B</i> alleles. In-house PCR with sequence-specific primers (PCR-SSP) and high-resolution melting curve (HRM) assays were performed and genotyping results were compared using DNA sequencing. <i>CO*A</i> and <i>CO*B</i> allele frequencies among Thais were determined using PCR-SSP and their frequencies were compared with other populations. The risks of Co^a and Co^b transfusion-induced alloimmunization among Thai donor populations were calculated.</p><p><strong>Results: </strong>The validated genotyping results by PCR-SSP and HRM assays agreed with DNA sequencing. The <i>CO*A</i>/<i>CO*A</i> was the most common (100.0, 100.0, and 99.3%), followed by <i>CO*A</i>/<i>CO*B</i> (0.0, 0.0, and 0.7%) among central, northern and southern Thais. Homozygous <i>CO*B</i>/<i>CO*B</i> was not found. The <i>CO*A</i> and <i>CO*B</i> allele frequencies among central Thais significantly differed compared among southern Thais (<i>p</i> < 0.01) but not among northern Thais. Those allele frequencies among Thais were similar to those of Taiwanese, Chinese and Malay-Malaysian populations but not to South Asian, Southeast Asian, Korean, Japanese, Filipino, French Basque, and Maltese populations (<i>p</i> < 0.01). A higher risk of anti-Co^b production rather than anti-Co^a production was particularly noted in the southern Thai population.</p><p><strong>Conclusion: </strong>This study constitutes the first to determine <i>CO*A</i> and <i>CO*B</i> genotypes using PCR-SSP and HRM assays among Thais and this finding would be beneficial in predicting alloimmunization risk and providing safe transfusions among Thais.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"133-140"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/fa/jbm-14-133.PMC9942508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Blood Donation Practice Among Health Care Providers of Public Hospitals in Bahir Dar City, North West Ethiopia: A Case Control Study.","authors":"Belto Tebabal,&nbsp;Tadele Fentabil Anagaw,&nbsp;Ayinengida Adamu,&nbsp;Desta Debalkie Atnafu","doi":"10.2147/JBM.S423013","DOIUrl":"https://doi.org/10.2147/JBM.S423013","url":null,"abstract":"<p><strong>Background: </strong>Blood donation is a technique in which blood is collected from a healthy individual for transfusion to someone else. WHO estimates that it is necessary to donate blood to 2% to 3% of the country's population to meet blood needs. However, blood donation remains challenging in developing countries.</p><p><strong>Objective: </strong>This study aimed to identify factors influencing blood donation practices among healthcare providers in public hospitals in Bahir Dar City.</p><p><strong>Methods: </strong>This institution-based unmatched case-control study was conducted in Bahir Dar City Public Hospitals from May 01 to May 25, 2022. Total sample size was 491 (123 cases and 368 controls) and then the study subject was selected by using simple random sampling technic and collect data through self-administered questionnaire. Bi-variable and multi-variable binary logistic regression analyses were used to determine the association between dependent and independent variables. Finally, the results are presented in charts and tables, and the AOR and CI are reported. Statistical significance was set at P < 0.05.</p><p><strong>Results: </strong>Fear of anemia (adjusted odds ratio (AOR): 0.02; 95% CI 0.007-0.078), lack of opportunity (AOR: 0.42; 95% CI 0.22-0.83), lack of time (AOR: 0.03; 95% CI, 0.005-0.199), profession (AOR: 0.15; 95% CI, 0.05-0.42), aware of free medical checkup (AOR: 31.79; 95% CI 13.13-76.94), willingness to donate blood (AOR: 5.09; 95% CI 2.25-11.50), blood group type (AOR: 5.67; 95% CI 1.42-22.68), and higher work experience (AOR: 7.99; 95% CI 2.59-24.67) were found to be significantly associated with blood donation practice.</p><p><strong>Conclusion: </strong>This study revealed that multiple factors influenced the practice of blood donation among healthcare providers. Therefore, access to blood donation areas and emphasizing the importance of donor blood donation are important for facilitating blood donation.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"487-498"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/5a/jbm-14-487.PMC10479530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10236730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombin Deficiency and Thrombosis: A Wide Clinical Scenario Reported in a Single Institution.","authors":"Ana Marco-Rico,&nbsp;Pascual Marco-Vera","doi":"10.2147/JBM.S416355","DOIUrl":"https://doi.org/10.2147/JBM.S416355","url":null,"abstract":"<p><p>Congenital antithrombin (AT) deficiency represents the form of thrombophilia with the highest thrombotic risk. It is characterized by a heterogeneous clinical presentation, depending mostly on the family history of thrombosis and type of genetic mutation. Inherited AT deficiency promotes idiopathic thrombosis at an early age (even in the pediatric population) and at atypical sites. Therefore, a positive family background necessitates ruling out this high-risk thrombophilia at a young age. Studying first-degree relatives, even if they are asymptomatic, is essential to establish thromboprophylaxis and a proper therapeutic approach in case of thrombosis. Patients with congenital AT deficiency require indefinite anticoagulation owing to the high thrombotic recurrence rate. Here, we present four unrelated cases reported in our institution who were diagnosed with hereditary AT deficiency, with a contrasting clinical evolution.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"499-506"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/b3/jbm-14-499.PMC10478923.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10236731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Gene Rearrangement by Multiplex PCR in De Novo Acute Myeloid Leukemia in Adult Iraqi Patients.","authors":"Ali AlJabban,&nbsp;Jaffar Alalsaidissa","doi":"10.2147/JBM.S416825","DOIUrl":"https://doi.org/10.2147/JBM.S416825","url":null,"abstract":"<p><strong>Introduction: </strong>Gene rearrangements of acute myeloid leukemia (AML) play a significant role in categorizing patients and provide valuable information about prognosis and treatment choices. However, in Iraq, the prevalence and prognostic significance of gene rearrangements in AML have not been previously examined.</p><p><strong>Methods: </strong>This study utilized a multiplex reverse transcription real-time PCR (RT-qPCR) system to identify gene rearrangements in a group of 115 adult patients from Iraq who had been diagnosed with De Novo AML. The diagnosis of AML was confirmed through blood film and flow cytometry. The ethical committee of the College of Medicine at the University of Baghdad provided approval for this research study.</p><p><strong>Results: </strong>In this study, 66.1% of the patients diagnosed with acute myeloid leukemia (AML) exhibited distinct genetic abnormalities. Among these abnormalities, the most frequent was the rearrangement involving the KMT2A gene, observed in 19.9% of the patients. The risk stratification analysis revealed that 40% of the patients were classified as having a favorable risk, 4.3% as intermediate risk, and 25.2% as adverse risk. A subtype of AML known as core-binding factor (CBF) AML was identified in 21.7% of the cases, with 84% of these patients achieving complete remission. The NPM-RARA gene rearrangement, found in 43% of acute promyelocytic leukemia (APL) cases, was associated with a 71% complete remission rate. Among patients with KMT2A rearrangement, which accounted for 19.9% of all AML cases, the MLL-AF10 rearrangement was the most common, although only one patient with KMT2A rearrangement achieved complete remission. Furthermore, the analysis of demographic data revealed a significant association between increased risk and advanced age, presence of comorbidities, and FAB classification (M0 subtype).</p><p><strong>Conclusion: </strong>The prevalence of genetic rearrangements in Iraqi De Novo AML patients is higher than the global trend, highlighting the importance of genetic characterization in risk assessment and treatment decisions.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"445-453"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/26/jbm-14-445.PMC10426445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet Selectin Levels in Patients with Cerebral Venous Sinus Thrombosis: Preliminary Findings.","authors":"Eswi Zenobia,&nbsp;Nushrotul Lailiyya,&nbsp;Sofiati Dian,&nbsp;Cep Juli,&nbsp;Asep Nugraha Hermawan,&nbsp;Lisda Amalia","doi":"10.2147/JBM.S405975","DOIUrl":"https://doi.org/10.2147/JBM.S405975","url":null,"abstract":"<p><strong>Background: </strong>Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease with an estimated annual incidence of 3-4 cases per 1 million population with an 8% mortality rate caused by hypercoagulable conditions and hyper aggregation and also Platelet Selectin (P-Selectin) as one of coagulation biomarker for both of them. This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung.</p><p><strong>Objective: </strong>This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung.</p><p><strong>Methods: </strong>This is a descriptive observational study on patients ≥18 years old diagnosed with CVST at the Neurology outpatient polyclinic of RSUP Dr. Hasan Sadikin Bandung for March-May 2022. All samples that meet the inclusion criteria will be included as research subjects.</p><p><strong>Results: </strong>There were 55 research subjects with a median age of 48 (range 22-69 years), the majority were women (80%), the most complaints were headaches (92.7%), the majority onset was chronic (96.4%) with a length of treatment ≥12 months (61.8%). P-selectin levels were found to increase in the group of subjects with subacute onset (mean 5.20 ± 2.977), infectious etiology (mean 5.26 ± 3.561), duration of treatment <3 Months (mean 3.79 ± 3.065), history of hyper aggregation (mean 3.89±2.805), hypercoagulation (mean 3.50±2.719), increased D-dimer (mean 3.93±2.710), normal fibrinogen (mean 3.38±2.693), and in the group with multiple affected sinuses (mean 6.08±2.681).</p><p><strong>Conclusion: </strong>P-selectin could be a diagnostic marker for hyper aggregation and hypercoagulable state in patients with CVST, but it still needs further research to prove it.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"359-365"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/22/jbm-14-359.PMC10239894.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9645615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Workup of Transfusion Reactions Reveals Passive Co-Reporting of Handling Errors.","authors":"Elisabeth Nitsche,&nbsp;Jan Dreßler,&nbsp;Reinhard Henschler","doi":"10.2147/JBM.S411188","DOIUrl":"https://doi.org/10.2147/JBM.S411188","url":null,"abstract":"<p><strong>Introduction: </strong>Reporting of transfusion reactions is good practice and required by many guidelines. Errors in the transfusion chain can also lead to severe patient reactions and depend on active error reporting. We aimed to characterize transfusion incidents and asked whether workup of transfusion reactions may also contribute to revealing logistical errors.</p><p><strong>Methods: </strong>Transfusion medical records from 2011 to 2019 at our tertiary medical centre, as well as forensic autopsy reports, digitized sections, and court records from 1990 to 2019 were analysed. A total of 230,845 components were transfused between 2011 and 2019 at our own institution.</p><p><strong>Results: </strong>Overall, 322 transfusion incidents were reported. Of these, 279 were from our own institution, corresponding to a frequency of 0.12% of all transfusions. The distribution of reaction types is consistent with the literature, with allergic reactions (55.9%), febrile-non-hemolytic reactions (FNHTR, 24.2%), hemolytic reactions (3.4%) and other types at smaller frequencies (<3%). Twenty-nine (10.4%) of the 279 reports revealed logistical errors, including hemoglobin above guideline threshold (4.3%), incorrect or non-performed bedside tests (3.2%), inadequate patient identification (2.5%), laboratory and issuing errors, missed product checks or failure to follow recommendations (1.1% each). Eight of 29 (27.5%) of the logistical errors were detected by serendipity during workup of incident reports. In addition, 8/932 autopsy cases under code A14 (medical treatment errors) were found to be transfusion-associated (0.9%).</p><p><strong>Conclusion: </strong>Systematic workup of transfusion incidents can identify previously undetected errors in the transfusion chain. Passive reporting of errors through the recording of side effects may serve as a tool to assess more closely assess the frequency and quality of handling errors in real life, and thus serve to improve patient safety.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"435-443"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/6e/jbm-14-435.PMC10422960.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Ferritin Levels and Other Associated Parameters with Diabetes Mellitus in Adult Patients Suffering from Beta Thalassemia Major.","authors":"Ahmed Saleh Ibrahim,&nbsp;Azza Hasan Abd El-Fatah,&nbsp;Ayman Fathy Abd El-Halim,&nbsp;Farid Fawzy Mohamed","doi":"10.2147/JBM.S390666","DOIUrl":"https://doi.org/10.2147/JBM.S390666","url":null,"abstract":"<p><strong>Background: </strong>Although beta thalassemia major (BTM) patients are properly treated with blood transfusions in accompany with iron chelation therapy, they suffer from complications, such as diabetes mellitus (DM).</p><p><strong>Purpose: </strong>The purpose was to detect the critical serum ferritin level and other parameters correlated with DM among adult BTM patients. Also, it was to study whether each of these parameters is associated with a certain period of age.</p><p><strong>Patients and methods: </strong>This study included 200 adult BTM patients. A cross-sectional study was carried out. Patients clinical and laboratory variables, such as ferritin levels, and fasting blood glucose (FBS) were extracted from medical records at Zagazig University Hospital, Egypt. Liver and cardiac iron contents were assessed using MRI T2* methods. Statistical analysis was performed using IBM SPSS V26.0 software package.</p><p><strong>Results: </strong>The overall frequency of DM over the total sample equals 6.5%. There were no impaired fasting glucose (IFG) in the medical records. Statistical significance between serum ferritin and DM was (P = 0.014). The serum ferritin 2500 ng/mL with age group (27-<32) years-old were risk factors. The distributions of DM according to BMI were (3.5%) of class overweight. Significant association between DM and BMI was (r = 0.357, P < 0.001). Liver MRI T2* has significant correlation with serum ferritin, but cardiac MRI T2* was poorly correlated. Association between liver and cardiac MRI T2* was not found.</p><p><strong>Conclusion: </strong>Age group (27-<32) years-old and ferritin >2500 ng/mL should be properly treated immediately. The serum ferritin and BMI of class \"overweight\" were risk factors for DM. Factors such as diet should be followed. Serum ferritin can be used for estimating liver iron content for economic factors. But cardiac MRI T2* must be performed for evaluating cardiac iron accurately.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"67-81"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/20/jbm-14-67.PMC9921443.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10721760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Transfusion Complications and Associated Factors Among Blood-Transfused Adult Patients at Debre Markos Comprehensive Specialized Hospital, Ethiopia: A Cross Sectional Study.","authors":"Yalew Muche,&nbsp;Yemataw Gelaw,&nbsp;Aytenew Atnaf,&nbsp;Zegeye Getaneh","doi":"10.2147/JBM.S412002","DOIUrl":"https://doi.org/10.2147/JBM.S412002","url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion is the infusion of whole blood or its components into the veins of the patient to improve tissue oxygenation and maintain hemostasis. Besides its clinical use, it can pose a risk of transfusion complications with different factors.</p><p><strong>Purpose: </strong>The aim of this study was to assess blood transfusion complications, and associated factors among transfused adult patients at Debre Markos Comprehensive Specialized Hospital, North West Ethiopia, 2022.</p><p><strong>Materials and methods: </strong>An institution-based cross-sectional study design was conducted on a total of 182 patients from March 20 to June 15, 2022. Patients were enrolled in the study using consecutive sampling method. The socio-demographic and clinical data were collected using a structured questionnaire and data extraction sheet, respectively. About 3 ml of anti-coagulated blood and 30 ml of urine samples were collected to assess transfusion complications. CBC and Coombs test were performed from blood and urinalysis from urine, respectively. Chi-square, Fisher's exact test, and binary logistic regression were done using SPSS version 25. P-values less than 0.05 are declared as statistically significant.</p><p><strong>Results: </strong>An acute transfusion reaction (ATR) was encountered in 12 (6.6%) patients. It was 4.13, 7.78 and 3.96 times more likely to occur among patients with a previous history of transfusion, abortion, and transfused blood stored for more than 20 days compared to their counterparts, respectively. In addition, the odds of developing ATR increase by 2.07 as the number of transfused blood units increases by 1 unit.</p><p><strong>Conclusion: </strong>The incidence of acute transfusion reactions was high. During transfusion, clinicians should closely monitor patients who had history of transfusion, abortion, transfused old blood and more than 1 unit.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"389-398"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/4f/jbm-14-389.PMC10259606.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Venous Sinus Thrombosis induced By Hypercoagulation in Patient With Systemic Lupus Erythematosus: A Case Report and Literature Review.","authors":"Lisda Amalia","doi":"10.2147/JBM.S387075","DOIUrl":"https://doi.org/10.2147/JBM.S387075","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic lupus erythematous (SLE) are autoimmune diseases and cerebral venous sinus thrombosis (CVST) is coincidence regarding hypercoagulable condition of both diseases. The presence of both diseases in the same patient is rare, which suggests a relative incompatibility between these diseases.</p><p><strong>Case presentation: </strong>I report a female case with Systemic Lupus Erythematosus history, aged 27 years, with blurred vision, diplopia, severe headache, numbness and progressive right hemiparesis in 2 weeks. There was narrowing caliber at left transversus and right sigmoid sinus in magnetic resonance venography. She showed improvement in vision, numbness, headache and motor strength in right extremities after receiving pulse dose of corticosteroid for three days.</p><p><strong>Conclusion: </strong>The distinction between SLE and CVST is a diagnostic challenge for the neurologist, and the presence of both diseases should be considered in patients with clinical neurologic manifestations who present with typical systemic manifestations of SLE and CVST. Neurogenic inflammation can induce disorders of the blood vessel wall (endothelium) that cause hypercoagulability and changes in acute vascular conditions can occur consisting of intraluminal platelet aggregation, thrombosis and also can cause total cerebral thrombotic venous or venular occlusion in SLE patients.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"1-6"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/06/jbm-14-1.PMC9840394.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Moringa oleifera</i> Leaf Powder on Hematological Profile of Male Wistar Rats.","authors":"Titing Nurhayati,&nbsp;Muhammad Irfan Fathoni,&nbsp;Siti Nur Fatimah,&nbsp;Vita Murniati Tarawan,&nbsp;Hanna Goenawan,&nbsp;Resti Gradia Dwiwina","doi":"10.2147/JBM.S407884","DOIUrl":"https://doi.org/10.2147/JBM.S407884","url":null,"abstract":"<p><strong>Background: </strong>Indonesia is a country with high biodiversity of more than 20,000 plant species, and 35% of them are identified as having health benefits. <i>Moringa oleifera</i> is one plant that almost all of its parts have been used as nutritional supplements and traditional medicines. Moringa leaves contain nutrients, antioxidants, and bioactive substances that have anti-inflammatory, wound healing, and anti-anemia properties.</p><p><strong>Purpose: </strong>This study aimed to investigate the hematological effect of Moringa leaf powder in male Wistar rats under normal conditions.</p><p><strong>Methods: </strong>Twenty-four male Wistar rats strain (<i>Rattus norvegicus</i>) 9-10 weeks old and 250-275 grams were divided into four groups (n=6), normal as a control group and three other groups were given Moringa leaf powder at doses 200, 400, and 800 mg/kgBW during 12 weeks. Blood samples at week 12 were administered to determine blood count.</p><p><strong>Results: </strong>The results of this study showed differences between the various doses of Moringa leaf powder for each hematological profile. These differences were more significant for MCH parameters that indicated a decrease in the D800 group compared with the control group.</p><p><strong>Conclusion: </strong>In conclusion, this study revealed that the consumption of Moringa leaf powder for 12 weeks did not have a significant change in the hematological profile, except for the MCH value that revealed a modification.</p>","PeriodicalId":15166,"journal":{"name":"Journal of Blood Medicine","volume":"14 ","pages":"477-485"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/44/jbm-14-477.PMC10460593.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10111410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}