The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia.

IF 2.1 Q3 HEMATOLOGY

Journal of Blood Medicine Pub Date : 2023-10-27 eCollection Date: 2023-01-01 DOI:10.2147/JBM.S425667

Delita Prihatni, Frany Charisma Budianto, Basti Andriyoko, Suryarini Trisa

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引用次数: 0

Abstract

Introduction: sP-selectin is a glycoprotein located in α granules of platelet and endothelial's Weibel Palade body, as expression to platelet activation and endothelial cell stimulation by SARS-CoV-2 binding with ACE2 receptor. Consumptive thrombocytopenia is also related to platelet activation. Elevation of sP-selectin and thrombocytopenia are related to COVID-19 complication and often correlated with severity of COVID-19.

Purpose: Assess the correlation between sP-selectin and platelet in COVID-19 patients at intensive care and non-intensive care.

Patients and methods: The study population was hospitalized COVID-19 patients confirmed by Real-Time PCR that underwent platelet examination within 48 hours upon admission, divided into intensive care and non-intensive care group. sP-selectin examination using ELISA methods. Platelet cell count and sP-selectin divided based on normal reference range.

Results: The subjects consist of 24 were in intensive care, 25 were in non-intensive care group. A 66.7% of subject in intensive care group has an elevation in sP-selection (>44.0 ng/mL). Thrombocytopenia was significantly correlated with intensive group (r =-0.32, p<0.05). The combination of platelet count <150.000/mm³ and sP-selectin >44.0ng/mL was not correlated with the intensive and non-intensive group. Platelet and sP-selectin were not correlated with each other.

Conclusion: Thrombocytopenia is able to induce the expression of sP-selectin.

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印度尼西亚西爪哇岛转诊医院新冠肺炎患者血清选择素与血小板计数的相关性。

引言：sP-选择素是一种位于血小板和内皮细胞Weibel Palade体的α颗粒中的糖蛋白，表达为严重急性呼吸系统综合征冠状病毒2型与ACE2受体结合对血小板活化和内皮细胞刺激。消耗性血小板减少症也与血小板活化有关。sP-选择素升高和血小板减少与新冠肺炎并发症相关，通常与COVID-19的严重程度相关。目的：评估重症监护和非重症监护新冠肺炎患者的sP-选择蛋白与血小板之间的相关性。患者和方法：研究人群为入院后48小时内经实时PCR确诊的新冠肺炎患者，分为重症监护组和非重症监护组。用ELISA方法检测sP-选择素。根据正常参考范围划分血小板计数和sP-选择素。结果：受试者24人在重症监护组，25人在非重症监护组。重症监护组中66.7%的受试者sP选择升高（>44.0 ng/mL）。血小板减少与强化组显著相关（r=-0.32，p3和sP-选择素>44.0ng/mL与强化组和非强化组无相关性。

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来源期刊

Journal of Blood Medicine HEMATOLOGY-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine (blood components, stem cell transplantation, apheresis, gene based therapeutics), Blood collection, Donor issues, Transmittable diseases, and Blood banking logistics, Immunohematology, Artificial and alternative blood based therapeutics, Hematology including disorders/pathology related to leukocytes/immunology, red cells, platelets and hemostasis, Biotechnology/nanotechnology of blood related medicine, Legal aspects of blood medicine, Historical perspectives. Original research, short reports, reviews, case reports and commentaries are invited.