Journal of biomedical materials research最新文献_第3页

Corrosion testing of stents: a novel fixture to hold entire device in deployed form and finish. 支架的腐蚀测试:一种新颖的夹具，以保持整个设备的部署形式和完成。

Journal of biomedical materials research Pub Date : 1999-01-01 DOI: 10.1002/(sici)1097-4636(1999)48:6<829::aid-jbm10>3.0.co;2-#

R Venugopalan

引用次数: 31

Fatigue behavior of calcium phosphate coatings with different stability under dry and wet conditions. 干湿条件下不同稳定性磷酸钙涂层的疲劳行为。

Journal of biomedical materials research Pub Date : 1999-01-01 DOI: 10.1002/(sici)1097-4636(1999)48:5<741::aid-jbm21>3.0.co;2-#

J A Clemens, J G Wolke, C P Klein, K de Groot

{"title":"Fatigue behavior of calcium phosphate coatings with different stability under dry and wet conditions.","authors":"J A Clemens, J G Wolke, C P Klein, K de Groot","doi":"10.1002/(sici)1097-4636(1999)48:5<741::aid-jbm21>3.0.co;2-#","DOIUrl":"https://doi.org/10.1002/(sici)1097-4636(1999)48:5<741::aid-jbm21>3.0.co;2-#","url":null,"abstract":"To obtain stable plasma sprayed calcium phosphate coatings, coatings with a high crystallinity and low solubility were developed. However, stability of ceramic coatings is also influenced by their fatigue resistance. Recently, fatigue failure was proposed to explain coating detachment from implants under loaded conditions. Therefore, plasma-sprayed calcium phosphate coatings with different crystallinity were investigated in vitro for fatigue failure. An amorphous and a crystalline hydroxylapatite coating (AHA and CHA) and a highly crystalline fluorapatite coating (FA) were subjected to cyclic load tests, both in dry conditions and in simulated body fluid (SBF). The results in SBF revealed that the crystalline CHA and FA coating detached completely at the highest stressed middle section of the bar. The FA coating delaminated earlier than the CHA coating. The amorphous AHA coating showed only partial coating loss at the completion of the test. Tests in dry conditions did not reveal any change in the coatings tested. These results suggest a relation between crystallinity of apatite coatings and their failure due to fatigue: high crystallinity coatings demonstrate earlier and more complete fatigue failure than the amorphous apatite coatings. It can be concluded that coating stability is not determined solely by static dissolution, but by fatigue failure as well.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"48 5","pages":"741-8"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(sici)1097-4636(1999)48:5<741::aid-jbm21>3.0.co;2-#","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21353620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Real-time dissolution measurement of sized and unsized calcium phosphate glass fibers. 施胶和未施胶磷酸钙玻璃纤维的实时溶解测定。

Journal of biomedical materials research Pub Date : 1999-01-01 DOI: 10.1002/(sici)1097-4636(1999)48:6<833::aid-jbm11>3.0.co;2-#

J D Rinehart, T D Taylor, Y Tian, R A Latour

{"title":"Real-time dissolution measurement of sized and unsized calcium phosphate glass fibers.","authors":"J D Rinehart, T D Taylor, Y Tian, R A Latour","doi":"10.1002/(sici)1097-4636(1999)48:6<833::aid-jbm11>3.0.co;2-#","DOIUrl":"https://doi.org/10.1002/(sici)1097-4636(1999)48:6<833::aid-jbm11>3.0.co;2-#","url":null,"abstract":"The objective of this study was to develop an efficient \"real time\" measurement system able to directly measure, with microgram resolution, the dissolution rate of absorbable glass fibers, and utilize the system to evaluate the effectiveness of silane-based sizing as a means to delay the fiber dissolution process. The absorbable glass fiber used was calcium phosphate (CaP), with tetramethoxysilane selected as the sizing agent. E-glass fiber was used as a relatively nondegrading control. Both the unsized-CaP and sized-CaP degraded linearly at both the 37 degrees C and 60 degrees C test temperature levels used. No significant decrease in weight-loss rate was recorded when the CaP fiber tows were pretreated, using conventional application methods, with the tetramethoxysilane sizing for either temperature condition. The unsized-CaP and sized-CaP weight loss rates were each significantly higher at 60 than at 37 degrees C (both p < 0.02), as expected from dissolution kinetics. In terms of actual weight loss rate measured using our system for phosphate glass fiber, the unsized-CaP fiber we studied dissolved at a rate of 10.90 x 10(-09) and 41.20 x 10(-09) g/min-cm(2) at 37 degrees C and 60 degrees C, respectively. Considering performance validation of the developed system, the slope of the weight loss vs. time plot for the tested E-glass fiber was not significantly different compared to a slope equal to zero for both test temperatures.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"48 6","pages":"833-40"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(sici)1097-4636(1999)48:6<833::aid-jbm11>3.0.co;2-#","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21417170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

In vitro elution of vancomycin from biodegradable beads. 万古霉素在生物可降解微球中的体外洗脱。

Journal of biomedical materials research Pub Date : 1999-01-01 DOI: 10.1002/(sici)1097-4636(1999)48:5<613::aid-jbm4>3.0.co;2-#

S J Liu, S W Ueng, E C Chan, S S Lin, C H Tsai, F C Wei, C H Shih

{"title":"In vitro elution of vancomycin from biodegradable beads.","authors":"S J Liu, S W Ueng, E C Chan, S S Lin, C H Tsai, F C Wei, C H Shih","doi":"10.1002/(sici)1097-4636(1999)48:5<613::aid-jbm4>3.0.co;2-#","DOIUrl":"https://doi.org/10.1002/(sici)1097-4636(1999)48:5<613::aid-jbm4>3.0.co;2-#","url":null,"abstract":"The current antibiotics delivery system for orthopedic infection treatment uses polymethylmethacrylate (PMMA) beads as a drug release. However the nonbiodegradable nature of the PMMA necessitates a second operation to remove the beads. This article explores the alternative of using biodegradable polymers as antibiotic beads for a long-term drug release. The effect of different processing factors on the release rate of the beads was investigated. To manufacture an antibiotic bead, polylactide-polyglycolide copolymers were mixed with vancomycin. The mixture was compressed and sintered at 55 degrees C to form beads of different sizes. An elution method was employed to characterize the release rate of antibiotic over a 35-day period at 37 degrees C. Biodegradable beads released high concentrations of antibiotic (well above the breakpoint sensitivity concentration) in vitro for the period of time needed to treat bone infection; i.e., 4-6 weeks. A bacterial inhibition test was carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 6.5-10 mm, which is equivalent to 12.5-100% of relative activity. By changing the processing parameters, we were able to control the release rate of the beads. This provides advantages of meeting the specific antibiotics requirement for patients with various surgical infections.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"48 5","pages":"613-20"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(sici)1097-4636(1999)48:5<613::aid-jbm4>3.0.co;2-#","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21353835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Adhesion of different bacterial strains to low-temperature plasma-treated sutures. 不同细菌菌株对低温等离子处理缝合线的粘附。

Journal of biomedical materials research Pub Date : 1998-09-05 DOI: 10.1002/(sici)1097-4636(19980905)41:3<349::aid-jbm2>3.3.co;2-z

A Yousefi Rad, H Ayhan, E Pişkin

{"title":"Adhesion of different bacterial strains to low-temperature plasma-treated sutures.","authors":"A Yousefi Rad, H Ayhan, E Pişkin","doi":"10.1002/(sici)1097-4636(19980905)41:3<349::aid-jbm2>3.3.co;2-z","DOIUrl":"https://doi.org/10.1002/(sici)1097-4636(19980905)41:3<349::aid-jbm2>3.3.co;2-z","url":null,"abstract":"In this study, five different bacteria with their different strains were isolated and characterized. Contact angles were measured by a captive-bubble technique. Surface-free energies were calculated from the contact angles. Hydrophobicities also were evaluated by rho-xylene adhesion. The zeta potentials and surface charges of the bacteria were obtained. The contact angles of the gram-positive bacteria and gram-negative bacteria were within the range of 48 degrees-69 degrees and 43.5 degrees-55 degrees, respectively, while corresponding surface-free energies were in the limits of 45.4-51.6 erg/cm-2 and 51.7-61.8 erg/cm-2, respectively. The rho-xylene adhesions were parallel to hydrophobicities defined by contact angles, and 32.2-80.3% and 2.3-36.6% for the gram-positive bacteria and gram-negative bacteria, respectively. The zeta potentials for these bacteria were from -650.2 to +17.5 mV and from -159.6 to -6.0 mV, respectively. Most of the bacteria were negatively charged, except the CNS-2 and CPS-1 strains. In the second part of the study, attachment of these bacteria to Vicryl sutures and their DMAEMA and AAc plasma-treated forms were investigated. Hydrophobic bacteria attached more to hydrophobic Vicryl sutures. Both plasma treatments caused significant drops in bacterial attachment in most cases. Effects of AAc plasma treatment were more pronounced.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"41 3","pages":"349-58"},"PeriodicalIF":0.0,"publicationDate":"1998-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20577326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of modification of oxide layer on NiTi stent corrosion resistance. 氧化层改性对NiTi支架耐蚀性的影响。

Journal of biomedical materials research Pub Date : 1998-01-01 DOI: 10.1002/(sici)1097-4636(199824)43:4<433::aid-jbm11>3.0.co;2-#

C Trépanier, M Tabrizian, L H Yahia, L Bilodeau, D L Piron

{"title":"Effect of modification of oxide layer on NiTi stent corrosion resistance.","authors":"C Trépanier, M Tabrizian, L H Yahia, L Bilodeau, D L Piron","doi":"10.1002/(sici)1097-4636(199824)43:4<433::aid-jbm11>3.0.co;2-#","DOIUrl":"https://doi.org/10.1002/(sici)1097-4636(199824)43:4<433::aid-jbm11>3.0.co;2-#","url":null,"abstract":"Because of its good radiopacity, superelasticity, and shape memory properties, nickel-titanium (NiTi) is a potential material for fabrication of stents because these properties can facilitate their implantation and precise positioning. However, in vitro studies of NiTi alloys report the dependence of alloy biocompatibility and corrosion behavior on surface conditions. Surface oxidation seems to be very promising for improving the corrosion resistance and biocompatibility of NiTi. In this work, we studied the effect on corrosion resistance and surface characteristics of electropolishing, heat treatment, and nitric acid passivation of NiTi stents. Characterization techniques such as potentiodynamic polarization tests, scanning electron microscopy, Auger electron spectroscopy, and X-ray photoelectron spectroscopy were used to relate corrosion behavior to surface characteristics and surface treatments. Results show that all of these surface treatments improve the corrosion resistance of the alloy. This improvement is attributed to the plastically deformed native oxide layer removal and replacement by a newly grown, more uniform one. The uniformity of the oxide layer, rather than its thickness and composition, seems to be the predominant factor to explain the corrosion resistance improvement.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"43 4","pages":"433-40"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20764262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 293

Ultrastructural features of the bone response to a plasma-sprayed hydroxyapatite coating in sheep. 羊骨对等离子喷涂羟基磷灰石涂层反应的超微结构特征。

Journal of biomedical materials research Pub Date : 1997-09-05

J Hemmerlé, A Onçag, S Ertürk

{"title":"Ultrastructural features of the bone response to a plasma-sprayed hydroxyapatite coating in sheep.","authors":"J Hemmerlé, A Onçag, S Ertürk","doi":"","DOIUrl":"","url":null,"abstract":"The intentions of this study were to characterize the macroscopic, microscopic, and structural aspects of a plasma-sprayed implant and to thoroughly investigate bone tissue response after its implantation in sheep. Therefore, we used scanning electron microscopy, transmission electron microscopy (TEM), high-resolution TEM, X-ray diffraction, and energy-dispersive X-ray analyses. Assessment of the biomaterial prior to implantation showed a coating with irregular outlines and varying thickness, mainly consisting of hydroxyapatite (HA) covering a rough metallic implant core. Six months after insertion of the HA-coated Ti-6A1-4V implant, neither mechanical failure of the coating-substrate interface nor a significant loss of coating thickness was evident. However, an occasional lack of HA coating and phagocytosis of HA particles were noted. More generally, the implant was surrounded by well-mineralized bone investing the smallest cavities of the plasma-sprayed layer. Newly formed microcrystals with size, shape, and structure similar to those of bone apatite crystals were growing directly at the coating surface. These results suggest that the bone-bonding behavior of the considered grooved implant should provide satisfactory osseointegration and be suitable for fixed prostheses.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"36 3","pages":"418-25"},"PeriodicalIF":0.0,"publicationDate":"1997-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20202095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TiO2-polymer composites for biomedical applications. 生物医学应用的二氧化钛聚合物复合材料。

Journal of biomedical materials research Pub Date : 1997-04-01

J Peña, M Vallet-Regí, J San Román

引用次数: 0

New radiopaque polyHEMA-based hydrogel particles. 新型不透射线多聚血红蛋白基水凝胶颗粒。

Journal of biomedical materials research Pub Date : 1997-02-01

D Horák, M Metalová, F Rypácek

引用次数: 0

In vitro cell response to differences in poly-L-lactide crystallinity. 体外细胞对聚l -丙交酯结晶度差异的响应。

Journal of biomedical materials research Pub Date : 1996-05-01

A Park, L G Cima

{"title":"In vitro cell response to differences in poly-L-lactide crystallinity.","authors":"A Park, L G Cima","doi":"","DOIUrl":"","url":null,"abstract":"Many different processing techniques are currently being used to produce tissue regeneration devices from polyesters in the polylactide/polyglycolide family. While it is generally well recognized that processing techniques influence bulk mechanical and degradation properties of these materials, the effects on surface properties are relatively less well studied. We thus investigated the effects of processing conditions that are known to change bulk properties, but not composition, on the surface properties of poly-L-lactide (PLLA). Specifically, we investigated the role of bulk crystallinity of PLLA substrates on several physiochemical aspects of the surface and on the attachment, morphology, and differentiated function of cultured primary hepatocytes and growth of 3T3 fibroblasts. We fabricated smooth, clear PLLA films of 13-37% crystallinity. Glancing angle X-ray diffraction indicated that low crystallinity films lacked order in the first 50 A of the surface while relatively high crystallinity films had detectable order in this range. In other aspects, the surfaces of all PLLA substrates appeared identical with XPS, SEM, and advancing contact angle analysis, but contact angle hysteresis was slightly greater for more crystalline films. Although the physicochemical properties of the surfaces appeared almost identical, we observed differences in cell behavior on less crystalline versus more crystalline films. Hepatocytes formed spheroids on all PLLA substrates, but spheroid formation was faster (24-48 H) on crystalline substrates. quantitative image analysis was used to assess the average cell area as a function of time in culture, and our data confirm previous reports that retention of differentiated function is inversely related to cell spreading where function was assessed by P-450 enzyme activity. In addition, the growth rate of 3T3 fibroblasts was lower on crystalline substrates than on amorphous substrates. An important conclusion from this work is that processing techniques that lead to seemingly inconsequential changes in bulk and surface properties of these polymers may influence biological response.","PeriodicalId":15159,"journal":{"name":"Journal of biomedical materials research","volume":"31 1","pages":"117-30"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19704540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0