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Sensitivity and prognostic significance of circulating tumor DNA (ctDNA) in stage I to III malignant melanoma. 循环肿瘤DNA （ctDNA）在I ~ III期恶性黑色素瘤中的敏感性及预后意义。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-05-09 DOI: 10.1007/s00432-026-06478-w
Ann-Sophie Bohne, Marilena Heber, Franziska Axt, Nikolas von Bubnoff, Katharina Kähler
{"title":"Sensitivity and prognostic significance of circulating tumor DNA (ctDNA) in stage I to III malignant melanoma.","authors":"Ann-Sophie Bohne, Marilena Heber, Franziska Axt, Nikolas von Bubnoff, Katharina Kähler","doi":"10.1007/s00432-026-06478-w","DOIUrl":"https://doi.org/10.1007/s00432-026-06478-w","url":null,"abstract":"<p><strong>Background: </strong>Risk stratification to guide adjuvant treatment in early stages of melanoma becomes increasingly important. This study investigated circulating tumor (ct)DNA in early melanoma stages to predict disease progression in real-world settings in German melanoma patients.</p><p><strong>Methods: </strong>In this retrospective, single-center study, 61 patients with melanoma stages I-III with known disease-progression following primary diagnosis were included. Patients were requested to have baseline serum samples ≤ 4 weeks after diagnosis and ≥ 12 weeks preceding disease progression. In ctDNA isolated from 185 serum samples matching inclusion criteria, BRAF V600E/K, NRAS Q61K/L/R and TERT promoter mutations were quantified and correlated with serum levels of S100 and LDH.</p><p><strong>Results: </strong>Mutated ctDNA was detected in ≥ 1sample in 43 of 53 patients (81.13%). CtDNA was more sensitive in the prediction of melanoma relapse than established biomarker S100, LDH (p < 0.001) and both LDH/S100 (p < 0.001). Highest mean ctDNA was measured during shift of stage III to stage IV disease (24.25 cps/µL) and shift within stage III (12.42 cps/µL). The detection of ctDNA at any time point trended towards shorter overall survival.</p><p><strong>Conclusion: </strong>Our study demonstrates the superiority of ctDNA harboring melanoma specific mutations over LDH and S100 in identifying patients at risk for recurrence in early melanoma stages in a single center cohort of melanoma patients. Future prospective trials are warranted to confirm this.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Investigating the oncogenic potential of MTHFD2 in oral squamous cell carcinoma. 更正：研究MTHFD2在口腔鳞状细胞癌中的致癌潜力。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-05-07 DOI: 10.1007/s00432-026-06486-w
Jiusong Han, Wei Wang, Simin Li, Juan Wang
{"title":"Correction: Investigating the oncogenic potential of MTHFD2 in oral squamous cell carcinoma.","authors":"Jiusong Han, Wei Wang, Simin Li, Juan Wang","doi":"10.1007/s00432-026-06486-w","DOIUrl":"10.1007/s00432-026-06486-w","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13153337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and clinical significance of cytochrome b561 in endometrial cancer. 细胞色素b561在子宫内膜癌中的表达及临床意义。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-05-04 DOI: 10.1007/s00432-026-06483-z
Hao Lei, Hongyuan Liao, Zheng An, Xueyue Li, Xiude Li, Jing Hu, Xiaofeng Zhou
{"title":"Expression and clinical significance of cytochrome b561 in endometrial cancer.","authors":"Hao Lei, Hongyuan Liao, Zheng An, Xueyue Li, Xiude Li, Jing Hu, Xiaofeng Zhou","doi":"10.1007/s00432-026-06483-z","DOIUrl":"https://doi.org/10.1007/s00432-026-06483-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression level of cytochrome b561 (CYB561) in endometrial carcinoma tissues and analyze its relationship with clinicopathological characteristics and patient prognosis.</p><p><strong>Methods: </strong>Bioinformatic analysis was performed to assess CYB561 mRNA expression and its correlation with prognosis in endometrial cancer. Immunohistochemical staining was used to detect CYB561 protein expression in 195 endometrial carcinoma tissues and 40 adjacent normal endometrial tissues. The associations between CYB561 expression and clinicopathological parameters, as well as its impact on overall survival (OS) and disease-free survival (DFS), were analyzed.</p><p><strong>Results: </strong>CYB561 expression was significantly higher in endometrial carcinoma tissues compared to adjacent normal tissues (P < 0.001). Low CYB561 expression was significantly associated with advanced FIGO stage (P < 0.05). Moreover, patients with low CYB561 expression exhibited significantly poorer overall survival (OS) and disease-free survival (DFS) (log-rank P < 0.001 for both).</p><p><strong>Conclusion: </strong>CYB561 is up-regulated in endometrial carcinoma, and its high expression is associated with a more favorable prognosis, suggesting its potential role as a prognostic biomarker for endometrial cancer.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13139544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Active surveillance for CIN2: biomarkers show promise, but real-world implementation faces unresolved barriers-a comment on Frayle et al. 主动监测CIN2：生物标志物显示出希望，但现实世界的实施面临未解决的障碍——对Frayle等人的评论。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-05-02 DOI: 10.1007/s00432-026-06484-y
Shiqiong Zhou, Qinghua Ke
{"title":"Active surveillance for CIN2: biomarkers show promise, but real-world implementation faces unresolved barriers-a comment on Frayle et al.","authors":"Shiqiong Zhou, Qinghua Ke","doi":"10.1007/s00432-026-06484-y","DOIUrl":"10.1007/s00432-026-06484-y","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiotherapy combined with immunotherapy for esophageal cancer: current status and challenge. 食管癌放疗联合免疫治疗的现状与挑战。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-05-02 DOI: 10.1007/s00432-026-06480-2
Yuqing Wang, Junjie Gu, Xinchen Sun
{"title":"Radiotherapy combined with immunotherapy for esophageal cancer: current status and challenge.","authors":"Yuqing Wang, Junjie Gu, Xinchen Sun","doi":"10.1007/s00432-026-06480-2","DOIUrl":"10.1007/s00432-026-06480-2","url":null,"abstract":"<p><p>With the advent of the immunotherapy era, the combination of radiotherapy and immunotherapy has become a critical strategy to enhance patient outcomes. In addition to its direct cytotoxicity, radiotherapy modulates the immune response within the tumor and its surrounding microenvironment by stimulating the body's anti-tumor immune response. This interplay provides the rationale for combining radiotherapy with immunotherapy. This review will summarize the immunomodulatory mechanisms of radiation therapy, evaluate the clinical efficacy and safety of combining radiotherapy with immunotherapy, and outline its current applications, challenges, and future potential. In the future, the combination of radiotherapy and immunotherapy holds immense potential in esophageal cancer treatment. Through additional prospective clinical trials exploring optimal combinations, timing, and biomarkers, we can further refine treatment strategies and enhance patient survival.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 5","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HDHD5 promotes triple-negative breast cancer growth and drives EMT-associated phenotypes via regulating S100A4. HDHD5通过调节S100A4促进三阴性乳腺癌的生长并驱动emt相关表型。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-04-29 DOI: 10.1007/s00432-026-06477-x
Jia-Yang Cai, Yin-Ling Zhang, Fang-Lin Zhang, Qian Zhao, Meng-Ke Ma, Zhi-Min Shao
{"title":"HDHD5 promotes triple-negative breast cancer growth and drives EMT-associated phenotypes via regulating S100A4.","authors":"Jia-Yang Cai, Yin-Ling Zhang, Fang-Lin Zhang, Qian Zhao, Meng-Ke Ma, Zhi-Min Shao","doi":"10.1007/s00432-026-06477-x","DOIUrl":"10.1007/s00432-026-06477-x","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General health versus tumor stage: determinants of survival in Merkel cell carcinoma assessed by sentinel lymph node biopsy. 总体健康状况与肿瘤分期：通过前哨淋巴结活检评估默克尔细胞癌存活的决定因素
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-04-28 DOI: 10.1007/s00432-026-06485-x
Thilo Gambichler, Ekaterina Heinzer, Nessr Abu Rached, Hans-Joachim Schulze, Kirsten Noah, Silke C Hofmann, Ulrich Wesselmann, Ralf Gutzmer, Stefanie Boms, Laura Susok, Sera S Weyer-Fahlbusch, Alexander Kreuter, Julia Hyun, Valentina L Müller, Rosanna Auer, Jürgen C Becker
{"title":"General health versus tumor stage: determinants of survival in Merkel cell carcinoma assessed by sentinel lymph node biopsy.","authors":"Thilo Gambichler, Ekaterina Heinzer, Nessr Abu Rached, Hans-Joachim Schulze, Kirsten Noah, Silke C Hofmann, Ulrich Wesselmann, Ralf Gutzmer, Stefanie Boms, Laura Susok, Sera S Weyer-Fahlbusch, Alexander Kreuter, Julia Hyun, Valentina L Müller, Rosanna Auer, Jürgen C Becker","doi":"10.1007/s00432-026-06485-x","DOIUrl":"10.1007/s00432-026-06485-x","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial-myoepithelial carcinoma of the lung: a case report and literature review. 肺上皮-肌上皮癌1例报告并文献复习。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-04-27 DOI: 10.1007/s00432-026-06467-z
Hui Duan, Ming-Yu Xie, Li-Hong Chen, Bo-Tao Luo, Yan Qi
{"title":"Epithelial-myoepithelial carcinoma of the lung: a case report and literature review.","authors":"Hui Duan, Ming-Yu Xie, Li-Hong Chen, Bo-Tao Luo, Yan Qi","doi":"10.1007/s00432-026-06467-z","DOIUrl":"https://doi.org/10.1007/s00432-026-06467-z","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge mapping and bibliometric insights of scientific research on targeted protein degradation in oncology. 肿瘤学中靶向蛋白质降解科学研究的知识图谱和文献计量学见解。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-04-27 DOI: 10.1007/s00432-026-06482-0
Moutaz W Sweileh
{"title":"Knowledge mapping and bibliometric insights of scientific research on targeted protein degradation in oncology.","authors":"Moutaz W Sweileh","doi":"10.1007/s00432-026-06482-0","DOIUrl":"https://doi.org/10.1007/s00432-026-06482-0","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Investigating the role of the Pon1-rs854560 (L55M) SNP in colorectal Cancer susceptibility. 更正：研究Pon1-rs854560 (L55M) SNP在结直肠癌易感性中的作用。
IF 2.8 3区 医学
Journal of Cancer Research and Clinical Oncology Pub Date : 2026-04-25 DOI: 10.1007/s00432-026-06479-9
Xi Wei, Rong Qin, Liang Yin, Muhammad Asad Iqbal, Zakari Shaibu, Guorui Li, Ting Wu
{"title":"Correction: Investigating the role of the Pon1-rs854560 (L55M) SNP in colorectal Cancer susceptibility.","authors":"Xi Wei, Rong Qin, Liang Yin, Muhammad Asad Iqbal, Zakari Shaibu, Guorui Li, Ting Wu","doi":"10.1007/s00432-026-06479-9","DOIUrl":"https://doi.org/10.1007/s00432-026-06479-9","url":null,"abstract":"","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"152 4","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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