Journal of Bone and Mineral Metabolism最新文献

{"title":"Causal association between gut microbiota and osteonecrosis in European populations: a two-sample Mendelian randomization analysis.","authors":"Haiqing Li, Zhen Yang, Mingfeng Li, Huiqin Yang, Dejiu Liu, Yuke Bi, Xuejun Dai, Xin Chen, Lirong Miao, Fang Yang, Zhuoyuan Chen","doi":"10.1007/s00774-026-01704-4","DOIUrl":"10.1007/s00774-026-01704-4","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies have linked gut microbiota composition to osteonecrosis, but the causal relationship remains unclear. Clarifying this relationship is clinically important because osteonecrosis currently lacks early biomarkers and etiology-targeted therapies; if causal, the gut microbiome would offer a readily modifiable intervention target.</p><p><strong>Methods: </strong>We conducted a two-sample Mendelian randomization analysis to explore this relationship. Exposure data were sourced from the MiBioGen consortium (N = 18,340), while outcome data on osteonecrosis were obtained from FinnGen (N = 392,580). The Inverse Variance Weighted method was used as the primary analytical approach, supplemented by comprehensive sensitivity analyses to assess the robustness of our findings.</p><p><strong>Results: </strong>Our analysis screened 196 microbial taxa and identified seven taxa associated with osteonecrosis risk in European populations. Protective effects were noted for the genus Odoribacter (OR = 0.579; P = 0.027) and family Alcaligenaceae (OR = 0.703; P = 0.049). Conversely, increased risk was linked to the genus Eubacterium fissicatena group (OR = 1.272; P = 0.046), genus Bifidobacterium (OR = 1.372; P = 0.038), order Bifidobacteriales (OR = 1.412; P = 0.023), family Bifidobacteriaceae (OR = 1.412; P = 0.023) and phylum Actinobacteria (OR = 1.750; P = 0.001). Sensitivity analyses confirmed the robustness of these findings, with no evidence of pleiotropy or heterogeneity.</p><p><strong>Conclusion: </strong>This study establishes a causal link between gut microbiota composition and osteonecrosis, suggesting that gut microbiota may be a modifiable factor in its pathogenesis. Further research is needed to elucidate underlying mechanisms and evaluate microbiota-targeted interventions for prevention and treatment.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"406-417"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between femoral localized cortical thickening (\"beaking\" or \"flaring\") and bisphosphonate duration in glucocorticoid-induced osteoporosis.","authors":"Yudai Yano, Sachiko Kawasaki, Takaaki Kosugi, Takahiro Mui, Hiroyuki Tamaki, Hikari Tasaki, Masatoshi Nishimoto, Kaori Tanabe, Masahiro Eriguchi, Ken-Ichi Samejima, Yoshinobu Uchihara, Masakazu Okamoto, Yasuhiro Akai, Kazuhiko Tsuruya, Kenji Kawamura","doi":"10.1007/s00774-025-01689-6","DOIUrl":"10.1007/s00774-025-01689-6","url":null,"abstract":"<p><strong>Introduction: </strong>Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary osteoporosis, and bisphosphonates (BPs) are widely used for treatment. Localized cortical thickening (LCT, \"beaking\" or \"flaring\") is a characteristic radiographic finding and a potential precursor of atypical femoral fracture, a known complication of long-term BP use. The incidence of LCT and its association with BP duration in GIOP remain unclear.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, 86 outpatients with GIOP (mean age, 60.6 years; 62.8% women) were included. Femoral radiographs were evaluated for LCT, cortical thickness index (CTI; diaphyseal/subtrochanteric), and lateral bowing angle (LBA). Patients were stratified by BP duration (≥2 or ≥4 years), and 1:1 propensity score matching was used to evaluate the association with LCT. Associations of BP duration with CTI and LBA were analyzed using linear mixed-effects models; correlations with bone turnover markers (BTMs) and bone mineral density (BMD) were also examined.</p><p><strong>Results: </strong>LCT was observed in 11 (12.8%) patients, including 10 undergoing BP therapy. Patients with LCT had a significantly longer duration of BP use (median: 8.0 years vs. 1.2 years, p <0.01). After matching, BP use for ≥4 years was significantly associated with LCT (odds ratio=11.29, p=0.01), whereas that for ≥2 years was not. Diaphyseal CTI significantly increased with BP duration; no associations were found with subtrochanteric CTI, LBA, BTMs, or BMD.</p><p><strong>Conclusion: </strong>In GIOP, prolonged BP use, especially for ≥4 years, was associated with LCT and greater diaphyseal cortical thickness. Radiographic assessment is essential in patients with GIOP and long-term BP use.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"354-362"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How postmenopausal osteoporosis influences epidemiology and clinical features of CRPS-1.","authors":"Massimo Varenna, Raffaele Di Taranto, Francesco Orsini, Andrea Amati, Chiara Crotti, Francesca Zucchi","doi":"10.1007/s00774-026-01701-7","DOIUrl":"10.1007/s00774-026-01701-7","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between Osteoporosis (OP) and Complex Regional Pain Syndrome type 1 (CRPS-1), in the hypothesis that OP can influence the epidemiological and clinical features of CRPS-1.</p><p><strong>Materials and methods: </strong>From March 2013 to May 2024, consecutive patients newly diagnosed with CRPS-1 were recruited. Demographic and clinical variables were collected in a standardised fashion. Univariate analyses and multivariate linear regression models were used to investigate the sample.</p><p><strong>Results: </strong>We enrolled 425 patients, mostly females (70.1%), more than half (52.2%) with a fracture as the inciting event. A previous OP diagnosis was found in 113 patients (26.6%). Variables significantly associated with OP were female gender, hand localisation, fracture as the inciting event, and a more severe CRPS-1. A fracture in patients with OP seems to trigger CRPS-1 mainly in women in the first decade after menopause, while in males and in older women a weaker association was observed. Multivariate analysis showed a correlation between OP and a more severe CRPS-1 (p = 0.014).</p><p><strong>Conclusion: </strong>A higher incidence of OP was observed more frequently in women with CRPS-1 in the first decade after menopause. This result could be driven by the proinflammatory cytokines increase observed in the early menopause, inducing both a faster systemic bone loss and an \"inflammatory milieu\" acting as a predisposing factor for CRPS-1 onset and a more severe disease.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"396-405"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of sequential therapy using anti-resorptive agents after administering once-weekly teriparatide or twice-weekly teriparatide.","authors":"Hidehiro Matsumoto, Manabu Tsukamoto, Nobukazu Okimoto, Satoshi Ikeda, Masahiro Tanaka, Mitsugu Takahashi, Yoshiaki Ikejiri, Fumihiro Oha, Satoshi Mizuno, Keiichi Shigenobu, Akinori Sakai, Junichi Takada","doi":"10.1007/s00774-026-01690-7","DOIUrl":"10.1007/s00774-026-01690-7","url":null,"abstract":"<p><strong>Introduction: </strong>Studies launched in Japan on once-weekly teriparatide (1/W-TPTD) and twice-weekly teriparatide (2/W-TPTD) are limited. Therefore, we examined the effects of sequential therapy using anti-resorptive agents after administering 1/W-TPTD and 2/W-TPTD using dual-energy X-ray absorptiometry (DXA) and DXA-based 3D modeling.</p><p><strong>Materials and methods: </strong>This was a multicenter retrospective study following a phase 3 clinical trial called the TWICE study. Two-year follow-up data were collected after administering 1/W-TPTD or 2/W-TPTD for 1 year (follow-up after the phase 3 clinical trial).</p><p><strong>Results: </strong>20 subjects in the group of pre-treatments with 1/W-TPTD followed by sequential administration of bisphosphonate or denosumab (1/W-TPTD [BP/denosumab]), and 22 in the group 2/W-TPTD (BP/denosumab) were included in the analysis of changes in the BMD by post-treatment. In the 1/W-TPTD (BP/denosumab) group, a significant increase in L2-4 BMD was observed. In the 2/W-TPTD (BP/denosumab) group, a significant increase in total hip, neck, and L2-4 BMD values was observed. Analysis by 3D-SHAPER revealed that both the 1/W-TPTD (BP/denosumab) and 2/W-TPTD (BP/denosumab) groups demonstrated significant increases in cortical sBMD and vBMD 2 years after the initiation of post-treatment.</p><p><strong>Conclusion: </strong>In subjects who received 1/W-TPTD and 2/W-TPTD for about 1 year followed by sequential administration of BP or denosumab, significant improvements in BMD were continuously observed. Furthermore, significant improvements in cortical sBMD and vBMD were also demonstrated by analysis using 3D-SHAPER. Both 1/W-TPTD and 2/W-TPTD were effective in the treatment of osteoporosis by using anti-resorptive agents for sequential administration.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"363-374"},"PeriodicalIF":2.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Comment on \"Bone fragility and atypical femoral fractures in SLE-role of disease activity, infection, and treatment\".","authors":"Hiroe Sato, Naoki Kondo, Tomoya Watarai, Eriko Hasegawa, Ayako Wakamatsu, Yukiko Nozawa, Daisuke Kobayashi, Takeshi Kuroda, Suguru Yamamoto","doi":"10.1007/s00774-026-01719-x","DOIUrl":"https://doi.org/10.1007/s00774-026-01719-x","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on \"Assessing deep learning model performance in osteoporosis screening with lumbar spine radiographs\".","authors":"Artit Boonrod, Arunnit Boonrod","doi":"10.1007/s00774-026-01726-y","DOIUrl":"https://doi.org/10.1007/s00774-026-01726-y","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Assessing deep learning model performance in osteoporosis screening with lumbar spine radiographs\".","authors":"Dhananjay Kumar Mishra, Koyel Roy, Tarun Madan Kanade","doi":"10.1007/s00774-026-01725-z","DOIUrl":"10.1007/s00774-026-01725-z","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Bone fragility and atypical femoral fractures in SLE: role of disease activity, infection, and treatment\".","authors":"Manish Juneja, Harshawardhan Ramteke, Rakhshanda Khan","doi":"10.1007/s00774-026-01718-y","DOIUrl":"10.1007/s00774-026-01718-y","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging skeletal stem cell diversity and human skeletal modeling.","authors":"Shoichiro Tani","doi":"10.1007/s00774-025-01686-9","DOIUrl":"10.1007/s00774-025-01686-9","url":null,"abstract":"<p><strong>Background: </strong>Skeletal stem cells (SSCs) underlie skeletal development, homeostasis, regeneration, and aging, yet their identities and functions are highly heterogeneous across anatomical sites and life stages. Mouse genetic studies have identified multiple SSC populations-each residing in distinct niches such as the growth plate, periosteum, and bone marrow-and revealed their dynamic regulation across developmental, homeostatic, regenerative, and aging contexts. However, translating these insights to humans remains challenging due to species differences and limited access to physiological human skeletal tissues. This review synthesizes current understanding of SSC diversity and how distinct compartments contribute to skeletal formation and maintenance throughout life. It also summarizes emerging human skeletal modeling strategies, including pluripotent stem cell differentiation, bioengineered in vitro systems, and in vivo transplantation, evaluating their ability to reconstruct skeletal components and SSC-bearing niches. Although recent models reproduce partial structures such as perichondrium-like layers or bone marrow-like microenvironments, most remain compartment-specific and lack integrated, stage-aware architectures that recapitulate physiological SSC behavior and skeletal functions in vivo. We propose an SSC-centric framework that incorporates spatiotemporal diversity, multi-compartment integration, physiological cues, and cross-validation with human tissues, providing predictive and translational platforms for skeletal biology, disease modeling, and regenerative medicine.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"172-185"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimmune interactions in arthritis: linking pain sensitisation and inflammation.","authors":"Tammie Tao Min Sow, Tetsuo Hasegawa","doi":"10.1007/s00774-025-01678-9","DOIUrl":"10.1007/s00774-025-01678-9","url":null,"abstract":"<p><p>Arthritis represents a group of chronic joint diseases characterised by persistent inflammation, pain, and progressive tissue damage. Despite advances in therapeutic management, many patients experience incomplete symptom relief, highlighting the need to better understand the underlying mechanisms that sustain inflammation and pain. Emerging evidence indicates that neuroimmune interactions within the joint microenvironment play a central role in the pathogenesis of arthritis. The synovium, a thin membrane that lines the joint cavity, is the primary site of pathology in arthritis and serves as a dynamic interface integrating immune, vascular, and neural components. Under physiological conditions, tissue-resident macrophages, fibroblasts, and sensory nerve fibres maintain joint homeostasis. However, during arthritis, the synovium undergoes extensive remodelling, including hyperplasia, angiogenesis, and nerve fibre sprouting, which together amplify inflammatory and nociceptive signalling. Distinct macrophage subsets within the synovium exhibit specialised roles in mediating inflammation and communicating with neurons. Macrophage-derived cytokines such as IL-1β, IL-6, and TNF-α can directly sensitise nociceptors, whilst chemokines like CCL2 engage neuronal receptors to enhance excitability. Conversely, activated sensory neurons release neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P (SP), which can modulate immune cell behaviour. Sympathetic signalling further contributes to immune modulation and correlates with disease severity. Together, these studies reveal that arthritis progression and chronic pain are shaped by reciprocal signalling between the nervous and immune systems. Understanding these complex pathways offers new perspectives for therapeutic intervention, suggesting that targeting neuroimmune crosstalk could provide dual benefits-reducing inflammation whilst alleviating chronic pain in arthritic disease.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":"213-220"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}