Journal of Babol University of Medical Sciences最新文献_第2页

Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures 橙皮素对戊四唑致痫动物模型的抗惊厥作用

Journal of Babol University of Medical Sciences Pub Date : 2018-11-10 DOI: 10.18869/ACADPUB.JBUMS.20.11.2

S. Baradaran, M. Ghasemi-Kasman, A. Ebrahimpour, Ahmadian, M. Pouramir

{"title":"Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures","authors":"S. Baradaran, M. Ghasemi-Kasman, A. Ebrahimpour, Ahmadian, M. Pouramir","doi":"10.18869/ACADPUB.JBUMS.20.11.2","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.11.2","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Hesperetin as the main flavonoid in citrus possesses various pharmacological properties including antioxidant and anti-inflammatory effects. In this study, the effects of hesperetin on seizures behavior and its function on total antioxidant capacity and lipid peroxidation has been investigated in pentylenetetrazol (PTZ)-induced seizures model. METHODS: In this experimental study, thirty-five NMRI mice were divided into five experimental groups (n=7) as control, saline and hesperetin at doses of 10, 20 or 50 mg/kg. Animals received orally the related interventions for 7 days. On day 7, 30 minutes after oral gavage, convulsion was induced by single intraperitoneal (i.p.) injection of PTZ at dose of 60 mg/kg. After recording of convulsion behaviors including latency to myoclonic jerks, latency and duration of generalized tonic-clonic seizures, time to death, measuring of Ferric Reducing Antioxidant Power (FRAP) and Thiobarbituric acid reactive substances (TBARS) was carried out in hippocampus tissues. FINDINGS: Pretreatment with hesperetin at dose of 50 mg/kg significantly increased the latency of myoclonic jerks (hesperetin 50: 22±3.35 s, p=0.032) and generalized tonic-clonic seizures (hesperetin 10: 1±21.48 s, p=0.0003, hesperetin 20: 35.2±83.6 s, 0.001, hesperetin 50: 34.5±2.30 s, p=0.004). The use of hespertin at dose of 10 mg/kg significantly reduced TBARS values compared to saline (p<0.003) and doses of 20 and 50 mg/kg hespertin (p<0.0001). Any significant difference in FRAP levels was not observed between different experimental groups. CONCLUSION: The results of study indicate that hesperetin might be effective as supplementary treatment in epilepsy disorder.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"8 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2018-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83057091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case Report of Primary Angiitis of the Central Nervous System 原发性中枢神经系统血管炎1例报告

Journal of Babol University of Medical Sciences Pub Date : 2018-11-10 DOI: 10.18869/ACADPUB.JBUMS.20.11.1

Am Soleimani joniyani, P. Saadat

引用次数: 0

Comparison of the Sedative Effect and Recovery Time of Dexmedetomidine and Fentanyl during Elective Colonoscopy 选择性结肠镜检查中右美托咪定与芬太尼镇静效果及恢复时间的比较

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.14

Shima Rajaei, P. Amri, S. H. Hamidi, J. Shokri, M. Hamidian, K. Hajian

引用次数: 0

ترکیبات شیمیایی، خواص آنتی اکسیدانی و ضد میکروبی اسانس گیاه مرزنجوش بخارایی (Origanum vulgar ssp. gracile) در محیط آزمایشگاهی

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.36

فایق مولودی, محمد علیزاده خالدآبادی, رزاق محمودی, محمود رضازادآبادی

引用次数: 0

An Evaluation of the Effect of Polycaprolactone/Gelatin (Pcl/Gt) Nanofiber Scaffold on the Therapeutic Function of Hematopoietic Stem Cells 聚己内酯/明胶纳米纤维支架对造血干细胞治疗功能的影响

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.7

F. Zaffari, E. Moghanloo, M. Sadeghi, M. Khafaei, M. Bakhtiyari, S. Teimourian

{"title":"An Evaluation of the Effect of Polycaprolactone/Gelatin (Pcl/Gt) Nanofiber Scaffold on the Therapeutic Function of Hematopoietic Stem Cells","authors":"F. Zaffari, E. Moghanloo, M. Sadeghi, M. Khafaei, M. Bakhtiyari, S. Teimourian","doi":"10.18869/ACADPUB.JBUMS.20.10.7","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.10.7","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Hematopoietic stem cells are one of the new therapeutic options for treating skin ulcers. Recently, a new perspective has been developed to better utilize stem cells using nanofiber scaffolds. The present study was conducted to investigate the effect of polycaprolactone/gelatin (PCL/GT) nanofiber scaffold on the therapeutic function of hematopoietic stem cells. METHODS: In this experimental study, 15 male BALB / c mice were divided into three groups of five, including the control group, the group receiving stem cells in the wound site (cell group) and the group receiving cell + PCL nanofiber scaffold. PCL/GT nanofiber scaffold was prepared by electrotherapy. After hematoxylin and eosin staining, the parameters of epidermal repair and hair follicle formation in the wound site were evaluated by fluorescence microscope and Image J and SPSS programs. FINDINGS: On day 28 after transplantation, the highest and lowest epidermal thicknesses were observed in the cell + scaffold group and control group, which were 10.5±0.3 and 27.3±0.9 μm, respectively, which was significant (p<0.05). Moreover, the highest and lowest number of hair follicles were observed in the cell + scaffold group and control group, respectively; 5.2±0.2 and 4.2±0.3. The difference between the two groups was significant (p<0.01) CONCLUSION: Polycaprolactone / gelatin (PCL/GT) nanofiber scaffold significantly increases the therapeutic function of hematopoietic stem cells in the wound site.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"22 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2018-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81985966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of Zinc Oxide Nanoparticles Using Eucalyptus Mellidora Leaf Extract and Evaluation of its Antimicrobial Effects 桉树叶提取物绿色合成氧化锌纳米颗粒及其抗菌效果评价

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.28

Behnam Rafiee, S. Ghani, Davoud Sadeghi, M. Ahsani

引用次数: 3

Abolhassan Ahmad bin Mohammad Tabari Taranji; The famous Iranian Physician

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.71

S. Golshani

引用次数: 0

An Evaluation of the Effect of Deprivation of Maternal Care on LTP Induction in Neurons of Hippocampal CA1 Region in Morphine-Dependent Rats 剥夺母性照顾对吗啡依赖大鼠海马CA1区神经元LTP诱导的影响

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.21

Fatemeh Aghighi, Mojgan Mohammadifar, M. Salami, G. Hamidi, S. A. Talaei

{"title":"An Evaluation of the Effect of Deprivation of Maternal Care on LTP Induction in Neurons of Hippocampal CA1 Region in Morphine-Dependent Rats","authors":"Fatemeh Aghighi, Mojgan Mohammadifar, M. Salami, G. Hamidi, S. A. Talaei","doi":"10.18869/ACADPUB.JBUMS.20.10.21","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.10.21","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Deprivation of maternal care as a stressor causes disruption in cognitive and neurochemical activities of the brain. The aim of this study was to evaluation the effect of deprivation of maternal care on LTP induction in neurons of hippocampal CA1 region in morphine-dependent rats. METHODS: This experimental study was conducted among 40 45-day-old male rats in control group, morphinedependent group, and 3 groups of rats that were deprived of treatment for one, two and three weeks after birth for 3 hours daily. Except for the control group, the rest of the groups received 10 mg/kg body weight morphine sulfate subcutaneously every 12 hours for 10 days. On the eleventh day, the symptoms of deprivation syndrome were investigated by the Gellert-Holtzman method, and on the following day, the synaptic plasticity of neurons in CA1 region was studied. FINDINGS: The Gellert-Holtzman score in the morphine-dependent group was 14.98±4.16 and increased to 31.79±5.12 in the group that was deprived of maternal treatment for 3 weeks (p<0.001). Although morphine dependence did not affect basic responses of CA1 region neurons and LTP induction, deprivation of maternal care reduced the range of basic responses from 1.01±0.04 in the morphine-dependent group to 0.68±0.09 mV in the group that was deprived of maternal care for 3 weeks (p<0.001) and prevented LTP induction (p<0.001) in a time-dependent manner. CONCLUSION: The results of the study showed that deprivation of maternal care undermines the postsynaptic potential of the hippocampal CA1 region following morphine administration and disrupts the synaptic plasticity of the neurons in this region.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"22 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2018-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90947188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlation of Tissue Eosinophils with Prognosis in Head and Neck Cutaneous Squamous Cell Carcinomas 组织嗜酸性粒细胞与头颈部皮肤鳞状细胞癌预后的关系

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.45

J. Halimi, S. Siadati, H. Abbaszadeh, H. Gholinia, S. Nafarzadeh

{"title":"Correlation of Tissue Eosinophils with Prognosis in Head and Neck Cutaneous Squamous Cell Carcinomas","authors":"J. Halimi, S. Siadati, H. Abbaszadeh, H. Gholinia, S. Nafarzadeh","doi":"10.18869/ACADPUB.JBUMS.20.10.45","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.10.45","url":null,"abstract":"BACKGROUND AND OBJECTIVE: The skin squamous cell carcinoma (CSCC) is the second most common skin cancer. The correlation between severe tissue eosinophilia with optimal and undesirable prognosis, or even an ineffectiveness effect was related. The aim of the present study was to investigate the correlation between tissue eosinophilia and prognosis in patients with head and neck squamous cell carcinoma. METHODS: In this cross-sectional study, 33 patients with squamous cell carcinoma of the pathology department of Shahid Beheshti hospital of University of Babol University of Medical Sciences (age, sex, tumor site) were collected and histopathologic in the vascular and nervous invasions was studied. Numbers of eosinophils (eos.) were counted in 15 successive fields at invasive fronts of HNCSCCs (area of 15 fields=1.2mm) at×400 magnification with optical microscope. The correlation between the mean number of eosinophils per Mm2 and the severity of eosinophilia (mild and severe) and clinical-histopathologic factors was analyzed. FINDINGS: Mean eos/mm was 99.1913±104.39897. Overall survival rate, disease-specific survival rate and diseasefree survival rate were %72.72, %61.53% and %84.84, respectively. There was inverse significant correlation between disease-free survival with eos/mm (p=0.043). There were no significant correlation between other clinicalhistopathologic factors with mean eos/ mm.There were inverse significant correlations between 5-year overall survival rate and 5-year disease-free survival rate with severity of tissue eosinophilia (p=0.02 and 0.013 respectively).There were not significant correlations between 5-year disease-specific survival and other factors with severity of tissue eosinophilia. CONCLUSION: There was inverse correlation between severity of tissue eosinophilia with survival.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"23 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2018-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74961873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inhibitory Effect of Carvacrol on the Expression of Candida albicans Hyphae-Specific Gene (HWP1) 香芹酚对白色念珠菌菌丝特异性基因HWP1表达的抑制作用

Journal of Babol University of Medical Sciences Pub Date : 2018-10-10 DOI: 10.18869/ACADPUB.JBUMS.20.10.63

A. Khodavandi, F. Alizadeh, S. Zadeh

{"title":"Inhibitory Effect of Carvacrol on the Expression of Candida albicans Hyphae-Specific Gene (HWP1)","authors":"A. Khodavandi, F. Alizadeh, S. Zadeh","doi":"10.18869/ACADPUB.JBUMS.20.10.63","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.10.63","url":null,"abstract":"J Babol Univ Med Sci; 20(10); Oct 2018; PP: 63-71 Received: Apr 4 2018, Revised: Sep 5 2018, Accepted: Sep 8 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Candida albicans infection is a problem of growing clinical importance, particularly in immunocompromised populations. This study aimed to investigate the inhibitory effect of carvacrol on the hyphae formation and expression of C. albicans HWP1. METHODS: This cross-sectional study was done over a 6-month period in 2016-2017. Vaginal, mouth and skin surface swabs were obtained from immunocompromised patients. Colonizing clinical isolates of C. albicans were identified and drug susceptible isolates detected using WHONET software. The susceptibility test for carvacrol (range 6.25–300 μg/ml) were carried out with a broth microdilution according to the CLSI guidelines against drug susceptible C. albicans. The time kill assay of carvacrol (range 2 × MIC to 1⁄4 × MIC) was determined. Hyphae inhibition was evaluated by light microscopy. We determined the expression levels of HWP1 implicated in hyphae formation of C. albicans ATCC 14053 cells by quantitative RT-PCR. FINDINGS: Ten colonizing clinical isolates of drug susceptible C. albicans were identified. Carvacrol was inhibited the growth of all drugs susceptible isolates of C. albicans (MIC range, 25-200 μg/ml). Time kill curve assay demonstrated that carvacrol could significantly inhibit the growth of C. albicans (p≤0.05). Carvacrol efficiently prevented hyphae formation in drug susceptible C. albicans. The expression levels of HWP1 gene were down-regulated by 1.82and 1.62fold at concentrations of 2 × MIC and 1×MIC of carvacrol, respectively. CONCLUSION: These results suggest that carvacrol could provide an improved and safe clinical approach in treating Candida infections by prevention of hyphae formation.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"91 1","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2018-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75720497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1