Z. Yu, S. Blaak, C. Prins, Z. Chang, C. Lancée, J. Bosch, N. de Jong, G. Meijer, M. Pertijs
{"title":"A 9-channel low-power receiver ASIC for 3D transesophageal echocardiography","authors":"Z. Yu, S. Blaak, C. Prins, Z. Chang, C. Lancée, J. Bosch, N. de Jong, G. Meijer, M. Pertijs","doi":"10.1109/ULTSYM.2012.0516","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0516","url":null,"abstract":"This paper presents a 9-channel low-power receiver ASIC dedicated to a matrix piezoelectric ultrasound transducer for 3D Trans-Esophageal Echocardiography (TEE). It consists of 9 low-noise amplifiers (LNAs), 9 time-gain-compensation (TGC) amplifiers and a 9:1 micro-beamformer. A prototype ASIC has been implemented in 0.35 μm CMOS technology, with a core area of 0.98 mm × 1.7 mm. It is operated at a 3.3 V supply and consumes only 0.5 mW per channel. The measured channel-to-channel mismatch is within ±1 dB. Acoustic measurements proved the micro-beamforming function of the ASIC when processing real ultrasound signals from a 3 × 3 transducer array. These promising results show that this design, after layout optimization, is suitable to be scaled up to accommodate a full matrix transducer.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128779627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chih-Ming Lin, Yung-Yu Chen, V. Felmetsger, D. Senesky, A. Pisano
{"title":"Dispersion characteristics of high-order lamb wave modes in an AlN/3C-SiC layered plate","authors":"Chih-Ming Lin, Yung-Yu Chen, V. Felmetsger, D. Senesky, A. Pisano","doi":"10.1109/ULTSYM.2012.0132","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0132","url":null,"abstract":"A new propagation layered media composed of a piezoelectric thin film and a substrate plate is studied in this work. The displacement profiles, phase velocities, and electromechanical coupling coefficients of Lamb wave modes are theoretically investigated for the c-axis oriented AlN films on cubic silicon carbide (3C-SiC) plates. Due to the different material properties of the AlN and 3C-SiC layers, the displacement profiles of Lamb wave modes are not simply antisymmetric or symmetric with respect to the neutral axis. According to the displacement profiles, the plate acoustic wave modes in the layered plate are classified as quasi-Lamb wave modes. Some high-order quasi-Lamb wave modes in the layered plate have larger electromechanical couplings than the corresponding Lamb wave modes in an AlN thin plate. In addition, the third quasi-symmetric (QS3) Lamb wave mode exhibits a low motional impedance (Rm) of 91 ohm and a high quality factor (Q) up to 5510 at a frequency (fs) of 2.92 GHz, resulting in the highest fs·Q product, 1.61×1013 Hz, among suspended piezoelectric thin film resonators reported to date.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128294190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Song, M. Urban, A. Manduca, Heng Zhao, J. Greenleaf, Shigao Chen
{"title":"Comb-push Ultrasound Shear Elastography (CUSE): A novel and fast technique for shear elasticity imaging","authors":"P. Song, M. Urban, A. Manduca, Heng Zhao, J. Greenleaf, Shigao Chen","doi":"10.1109/ULTSYM.2012.0462","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0462","url":null,"abstract":"Multiple push-detect acquisitions are typically required in current acoustic radiation force based shear wave elasticity imaging methods to reconstruct a full FOV elasticity map, which can result in potential motion artifacts and difficulties in studying tissue dynamic mechanical properties. Comb-push Ultrasound Shear Elastography (CUSE) is a novel and fast shear elasticity imaging technique which utilizes the comb-push to produce a complex shear wave field with shear waves propagating through all imaging pixels so that a full FOV shear elasticity map can be reconstructed with only one rapid data acquisition (less than 25 ms). Three versions of CUSE are presented in this paper: Unfocused CUSE (U-CUSE), Focused CUSE (F-CUSE), and Marching CUSE (M-CUSE). Homogeneous and inclusion phantom experiments showed that all CUSE methods produced accurate and smooth shear elasticity maps with excellent contrast between the inclusion and background. Comparable elasticity maps to Supersonic Shear Imaging (SSI) could be obtained using CUSE, with low MI and heating. Finally, the feasibility of using CUSE in clinical studies was demonstrated by promising results from preliminary in vivo case studies on human biceps muscle, thyroid, breast and liver.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129047124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vander Teixeira Prado, Ricardo Tokio Higuti, C. Kitano, Ó. Martínez-Graullera, Julio Cezar Adamowski
{"title":"Technique to combine images produced by different propagation modes of guided waves for damage detection and contrast improvement in plate-like structures","authors":"Vander Teixeira Prado, Ricardo Tokio Higuti, C. Kitano, Ó. Martínez-Graullera, Julio Cezar Adamowski","doi":"10.1109/ULTSYM.2012.0360","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0360","url":null,"abstract":"This paper describes an image compounding technique based on the use of different apodization functions, the evaluation of the signals phases and information from the interaction of different propagation modes of Lamb waves with defects for enhanced damage detection, resolution and contrast. A 16 elements linear array is attached to a 1 mm thickness isotropic aluminum plate with artificial defects. The array can excite the fundamental A0 and S0 modes at the frequencies of 100 kHz and 360 kHz, respectively. For each mode two synthetic aperture (SA) images with uniform and Blackman apodization and one image of Coherence Factor Map (CFM) are obtained. The specific interaction between each propagation mode and the defects and the characteristics of acoustic radiation patterns due to different apodization functions result in images with different resolution and contrast. From the phase information one of the SA images is selected at each pixel to compound the final image. The SA images are multiplied by the CFM image to improve contrast and for the dispersive A0 mode it is used a technique for dispersion compensation. There is a contrast improvement of 47.5 dB, reducing the dead zone and improving resolution and damage detection.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129149933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Renaud, J. Bosch, N. de Jong, A. V. D. van der Steen, V. Shamdasani, R. Entrekin
{"title":"Counter-propagation interaction for contrast-enhanced ultrasound imaging","authors":"G. Renaud, J. Bosch, N. de Jong, A. V. D. van der Steen, V. Shamdasani, R. Entrekin","doi":"10.1109/ULTSYM.2012.0169","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0169","url":null,"abstract":"Most techniques for contrast-enhanced ultrasound imaging such as phase inversion and amplitude modulation require linear propagation to detect nonlinear scattering of contrast agent microbubbles. Waveform distortion due to nonlinear propagation impairs the ability to distinguish contrast agent microbubbles from tissue. This leads to erroneous detection of contrast agent behind any vessel or blood pool containing contrast agent. These artifacts can significantly impair the accuracy of medical diagnoses. Unlike biological tissue, lipid-coated gas microbubbles used as contrast agent allow the interaction of two ultrasound waves propagating in opposite directions (counter-propagation). We describe a strategy to detect microbubbles based on counter-propagation interaction that is free from nonlinear propagation artifacts. The new method was implemented in an ultrasound scanner (Philips iU22 and L9-3 probe) and tested in vitro in a tissue-mimicking phantom containing a cavity filled with a 1:1000 dilution of BR14 contrast agent (Bracco). It is compared to the default contrast mode of the scanner employing amplitude modulation as a technique to detect contrast agent microbubbles. A low acoustic pressure (110 kPa peak pressure) as used in vivo for carotid imaging is employed in our in vitro study. Whereas amplitude modulation produces a pseudo-enhancement behind the cavity in the contrast image, the pulse sequence exploiting counterpropagating wave interaction is free from artifacts due nonlinear propagation in contrast agent.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"2593 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128814135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Guidi, R. Mori, J. Viti, N. de Jong, P. Tortoli
{"title":"Implementation of arbitrary contrast imaging strategies on an US Open Platform","authors":"F. Guidi, R. Mori, J. Viti, N. de Jong, P. Tortoli","doi":"10.1109/ULTSYM.2012.0170","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0170","url":null,"abstract":"Comparing the performance of different contrast imaging techniques can be difficult and somewhat confusing, since the tests were typically made using different in vitro setups, contrast agents, ultrasound transducers and systems. In this study, we report on the implementation of arbitrary contrast-pulse-sequences (CPS) in the ULA-OP open ultrasound system. Combined with a home-made phantom, a convenient and consistent evaluation of the main parameters characterizing various techniques is obtained. Several experiments were performed exciting BR14 microbubbles at a dilution between 1/200 and 1/800, with an average MI = 0.1, through 10 different excitation schemes including power modulation, chirp reversal and their combination. Chirp Amplitude Modulation (CAM) and Chirp Reversal Amplitude Modulation (CRAM) showed the best performance with an average CTR of 34 dB.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122754456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heng Zhao, C. Amador, M. Urban, P. Song, J. Greenleaf, Shigao Chen
{"title":"Shear wave speed measurement using repeated short push pulses","authors":"Heng Zhao, C. Amador, M. Urban, P. Song, J. Greenleaf, Shigao Chen","doi":"10.1109/ULTSYM.2012.0465","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0465","url":null,"abstract":"Measurement of shear wave propagation speed in tissues has clinical significance of indicating tissue stiffness and health state. Shear waves are usually produced by a high voltage, long duration ultrasound push beam. Many ultrasound scanners cannot produce such push beams due to power droop of the transmit circuitry. We propose using repeated short push pulses instead to generate shear waves. The waveform of such shear wave is separated into a push and a release shear wave as the collective push duration increases. Shear wave magnitudes and speeds in phantoms produced by different numbers and repetition intervals of short pulses were studied and the speeds were compared with 1D transient elastography results. The method was further validated using in vivo biceps measurements from a healthy volunteer. Results show accurate shear wave speed can be measured from shear waves produced by multiple short push pulses. Such short Doppler-like pulses could be used by conventional and low-end ultrasound scanners to do shear wave measurement.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132617377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sorace, Joseph A. Knowles, C. Heath, E. Rosenthal, K. Hoyt
{"title":"Ultrasound therapy amplifies chemotherapeutic effectiveness in head and neck cancer","authors":"A. Sorace, Joseph A. Knowles, C. Heath, E. Rosenthal, K. Hoyt","doi":"10.1109/ULTSYM.2012.0107","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0107","url":null,"abstract":"Microbubble (MB) mediated ultrasound (US) therapy is a novel technique to non-invasively enhance cancer treatment by increasing cell membrane permeability and vascular extravasation. The objective of this experiment is to determine if MB-mediated US therapy can improve cancer therapy, specifically cisplatin or cetuximab, in head and neck cancer. In vitro experiments included combination chemotherapy and MB-mediated US therapy on head and neck cancer cell line, SCC-5, and dose curve responses to therapy. In vivo experimentation included a four week study of MB-mediated US therapy compared to current standard therapy of drug alone. Monitoring of tumor response to therapy included caliper measurements, diffusion-weighted magnetic resonance (DW-MR) imaging, and immunohistologic analysis. Anti-tumor effects increased by over 50% when combining MB-mediated US therapy with cetuximab and cisplatin (P = 0.01, P = 0.02). MBmediated US therapy was seen to produce as additive effect by increasing localized delivery of drug in head and neck cancer. This technique shows potential for improved localized therapy in cancer.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129328574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polarization inverted (0001) / (000-1) ScAIN film resonators operating in second overtone mode","authors":"Masashi Suzuki, T. Yanagitani, H. Odagawa","doi":"10.1109/ULTSYM.2012.0482","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0482","url":null,"abstract":"Polarization-inverted multilayered structure can excite high overtone mode resonance. Resonant frequency of high order mode resonator is higher than that of 1st mode resonator even though entire film thickness is same. The film thickness of high order mode resonator is thicker in same operating frequency. Therefore, high order mode resonator is expected to have high power handling capability. Polarization are controlled by bottom surface properties in epitaxial films, but polarization inverted multilayer structure can not be fabricated. We obtained polarization inversion in ScAlN film by Al target sputtering with small amount of Al2O3 ingot. Thickness extensional mode electromechanical coupling coefficient kt of the ScAlN film was estimated to be 0.21. Two layered polarization inverted ScAlN film resonator was prepared in this deposition process. Suppression of 1st mode resonance and excitation of 2nd overtone mode resonance were observed.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130147565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of microbubble size distribution on postexcitation thresholds for single ultrasound contrast agent using double passive cavitation detection","authors":"M. Gauthier, D. King, W. O’Brien","doi":"10.1109/ULTSYM.2012.0103","DOIUrl":"https://doi.org/10.1109/ULTSYM.2012.0103","url":null,"abstract":"A recent study has shown that double passive cavitation detection (DPCD) is a valid method for determining cavitation characteristics including collapse thresholds of isolated microbubbles based on the detection of postexcitation signal (PES) occurring 1 to 5 μs after the principle excitation of the bubble. The hypothesis is that PES is associated with the collapse of a free gas bubble released from the ultrasound contrast agent (UCA) after the rupture of its shell. It has been shown that responses of UCAs depend on several parameters such as the shell and gas core as well as the size of the microbubble. However, a detailed study of the influence of size distribution only on single microbubble collapse thresholds is still not available. The aim of this study was to determine whether there was a significant correlation between microbubble size distribution and collapse thresholds. Experiments were performed using serum albumin and dextrose microbubbles. Four size distributions were obtained and we determined microbubble collapse thresholds for each distribution using the DPCD method (3 cycle tone bursts at the central frequency of 4.6 MHz). Statistical analysis was based on comparing the means of collapse threshold for the four size distributions using an analysis of variance. The microbubble collapse threshold was found to be significantly (p<;0.05) correlated to the microbubble size distribution: the DPCD experiments demonstrated that, in the configuration of the experiments, PES thresholds were higher for microbubbles exhibiting smaller size distribution.","PeriodicalId":150948,"journal":{"name":"2012 IEEE International Ultrasonics Symposium","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129022218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}