Journal of Bone Metabolism最新文献_第5页

Association between Fat Mass and Obesity-Related Transcript Polymorphisms and Osteoporosis Phenotypes. 脂肪量和肥胖相关转录本多态性与骨质疏松症表型之间的关系

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.48

Krisel De Dios, Ngoc Huynh, Thach S Tran, Jacqueline R Center, Tuan V Nguyen

{"title":"Association between Fat Mass and Obesity-Related Transcript Polymorphisms and Osteoporosis Phenotypes.","authors":"Krisel De Dios, Ngoc Huynh, Thach S Tran, Jacqueline R Center, Tuan V Nguyen","doi":"10.11005/jbm.2024.31.1.48","DOIUrl":"10.11005/jbm.2024.31.1.48","url":null,"abstract":"Background: Common variants in the fat mass and obesity-related transcript (FTO) gene are related to body mass index and obesity, suggesting its potential association with bone mineral density (BMD) and fracture risk. This study sought to define the association between FTO gene variants and the following phenotypes: (1) BMD; (2) bone loss; and (3) fracture risk.Methods: This analysis was based on the Dubbo Osteoporosis Epidemiology Study that included 1,277 postmenopausal women aged ≥60 years living in Dubbo, Australia. BMD at the femoral neck and lumbar spine was measured biennially by dual energy X-ray absorptiometry (GE Lunar). Fractures were radiologically ascertained. Six single nucleotide polymorphisms (SNPs; rs1421085, rs1558902, rs1121980, rs17817449, rs9939609, and rs9930506) of the FTO gene were genotyped using TaqMan assay.Results: Women homozygous for the minor allele (GG) of rs9930506 had a significantly higher risk of hip fracture (adjusted hazard ratio, 1.93; 95% confidence interval, 1.15-3.23) than those homozygous for the major allele (AA) after adjusting for potential confounding effects. Similar associations were also observed for the minor allele of rs1121980. However, there was no significant association between the FTO SNPs and BMD or the rate of bone loss.Conclusions: Common variations in the FTO gene are associated with a hip fracture risk in women, and the association is not mediated through BMD or bone loss.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"48-55"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Clinical and Radiological Outcomes after Vertebroplasty and Balloon Kyphoplasty in the Treatment of Osteoporotic Vertebral Compression Fractures. 椎体成形术和球囊椎体成形术治疗骨质疏松性椎体压缩骨折的临床和放射学疗效比较。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.56

Sung-Hyun Yoon, Hee-Gon Park, Dae-Hee Lee, Dong-Uk Lee

{"title":"Comparison of Clinical and Radiological Outcomes after Vertebroplasty and Balloon Kyphoplasty in the Treatment of Osteoporotic Vertebral Compression Fractures.","authors":"Sung-Hyun Yoon, Hee-Gon Park, Dae-Hee Lee, Dong-Uk Lee","doi":"10.11005/jbm.2024.31.1.56","DOIUrl":"10.11005/jbm.2024.31.1.56","url":null,"abstract":"Background: Vertebroplasty (VP) and balloon kyphoplasty (KP) are effective means with which to improve pain and function in osteoporotic vertebral compression fractures. However, the risk of complications after these procedures is poorly understood, with concerns regarding adjacent vertebral fractures. This study retrospectively investigated the clinical and radiological outcomes of these procedures.Methods: A total of 115 patients who experienced their first vertebral fracture were treated with VP (N=63) or KP (N=52) at the Dankook University Hospital between January 2013 and December 2022. The clinical outcomes were evaluated using the visual analog scale (VAS) preoperative and at 1-year follow-up. Radiological comparisons were performed for kyphosis correction, vertebral height restoration, and postoperative cement leakage.Results: KP was more effective than VP, especially for vertebral body height restoration and kyphotic angle reduction (P<0.05). However, the incidence of cement leakage, new adjacent vertebral fractures, and improvement in pain assessed by VAS did not differ statistically between the 2 groups (P>0.05).Conclusions: Considering that KP was performed on fractures with severe deformity, no differences were observed in the clinical outcomes and incidence of adjacent vertebral fractures compared Considering that KP was performed for fractures with severe deformity, there was no difference in clinical outcomes and incidence of adjacent vertebral fractures compared to VP. Improvements in radiological measurements were demonstrated. Therefore, KP may be a good treatment option for pain relief and long-term prognosis in patients with high-compressive-rate vertebral fractures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"56-62"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women. 日本成年男性和女性前臂骨矿物质密度与人体测量之间的横向和纵向关系

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.21

Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone

{"title":"Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women.","authors":"Masahiro Ishizawa, Kazuya Fujihara, Junko Yachida, Izumi Ikeda, Takaaki Sato, Takaho Yamada, Ayako Kobayashi, Shiro Tanaka, Yoshimi Nakagawa, Takashi Matsuzaka, Hitoshi Shimano, Minoru Tashiro, Satoru Kodama, Kiminori Kato, Hirohito Sone","doi":"10.11005/jbm.2024.31.1.21","DOIUrl":"10.11005/jbm.2024.31.1.21","url":null,"abstract":"Background: No consensus exists regarding which anthropometric measurements are related to bone mineral density (BMD), and this relationship may vary according to sex and age. A large Japanese cohort was analyzed to provide an understanding of the relationship between BMD and anthropometry while adjusting for known confounding factors.Methods: Our cohort included 10,827 participants who underwent multiple medical checkups including distal forearm BMD scans. Participants were stratified into four groups according to age (≥50 years or <50 years) and sex. The BMD values were adjusted for confounding factors, after which single and partial correlation analyses were performed. The prevalence of osteopenia was plotted for each weight index (weight or body mass index [BMI]) class.Results: Cross-sectional studies revealed that weight was more favorably correlated than BMI in the older group (R=0.278 and 0.212 in men and R=0.304 and 0.220 in women, respectively), whereas weight and BMI were weakly correlated in the younger age groups. The prevalence of osteopenia exhibited a negative linear relationship with weight among older women ≥50 years of age, and an accelerated increase was observed with decreasing weight in older men weighing <50 kg and younger women weighing <60 kg. When weight was replaced with BMI, the prevalence was low in most subgroups classified by weight.Conclusions: Weight, rather than BMI, was the most important indicator of osteopenia but it might not be predictive of future bone loss.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"21-30"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality Rate and Outcomes of Omicron Variant Positive Patients with Osteoporotic Fractures: A Retrospective Study. 骨质疏松性骨折患者的死亡率和预后：一项回顾性研究

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.40

Hoe Jeong Chung, Bum Seok Lee, Hoon-Sang Sohn

{"title":"Mortality Rate and Outcomes of Omicron Variant Positive Patients with Osteoporotic Fractures: A Retrospective Study.","authors":"Hoe Jeong Chung, Bum Seok Lee, Hoon-Sang Sohn","doi":"10.11005/jbm.2024.31.1.40","DOIUrl":"10.11005/jbm.2024.31.1.40","url":null,"abstract":"Background: During the lockdown period associated with the coronavirus disease 2019 (COVID-19) pandemic, increased mortality rates among patients with COVID-19 have been reported. This study aimed to analyze the mortality rate of osteoporotic hip fractures in patients who were COVID-19-positive after the lockdown during the Omicron period.Methods: A retrospective study was performed with 194 patients who were aged 70 years or more and diagnosed with osteoporotic hip fracture. The patients were divided into two groups according to their COVID-19 diagnoses. Surgery was performed within 10 days of diagnosis. Age, sex, past medical history, time until surgery, postoperative complications, and the primary outcome of mortality rate at 30 and 90 days were analyzed.Results: Among the 194 patients, 13 and 181 were in the COVID-19-positive and negative group, respectively. The total, 30-day, and 90-day mortality rates in the control and COVID-positive group were 11% and 0% (P=0.368), 1.7% and 0% (P=1.000), and 5.0% and 0% (P=1.000), respectively. No significant differences were observed in age, sex, history, time to surgery, postoperative complications, or postoperative mortality. In 1:1 propensity score matching, the time to surgery was 5.34 days in patients who were COVID-19-positive, and 3.00 days in patients who were COVID-19 negative, with no statistical significance (P=0.09). Age, sex, medical history, postoperative complications, and postoperative mortality were not significantly different between the groups.Conclusions: Regardless of the COVID-19 diagnosis, surgical treatment without delay is believed to result in positive outcomes in older patients with osteoporotic hip fractures, as no significant differences in mortality rate and respiratory complications were observed between patients who were COVID-19-positive and those who were COVID-19 negative.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of COVID-19 on the Incidence of Fragility Fracture in South Korea. COVID-19 对韩国脆性骨折发病率的影响。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.31

Seungjin Baek, Ye-Jee Kim, Beom-Jun Kim, Namki Hong

{"title":"Impact of COVID-19 on the Incidence of Fragility Fracture in South Korea.","authors":"Seungjin Baek, Ye-Jee Kim, Beom-Jun Kim, Namki Hong","doi":"10.11005/jbm.2024.31.1.31","DOIUrl":"10.11005/jbm.2024.31.1.31","url":null,"abstract":"Background: The coronavirus disease 2019 (COVID-19) pandemic and the consequent social distancing period are thought to have influenced the incidence of osteoporotic fracture in various ways, but the exact changes have not yet been well elucidated. The purpose of this study was to investigate the impact of the COVID-19 pandemic on the incidence of osteoporotic fracture using a nationwide cohort.Methods: The monthly incidence rates of vertebral; hip; and non-vertebral, non-hip fractures were collected from a nationwide database of the Korean National Health Insurance Review and Assessment from July 2016 to June 2021. Segmented regression models were used to assess the change in levels and trends in the monthly incidence of osteoporotic fractures.Results: There was a step decrease in the incidence of vertebral fractures for both males (6.181 per 100,000, P=0.002) and females (19.299 per 100,000, P=0.006). However, there was a negative trend in the incidence of hip fracture among both males (-0.023 per 100,000 per month, P=0.023) and females (-0.032 per 100,000 per month, P=0.019). No impact of COVID-19-related social distancing was noted.Conclusions: In conclusion, during the early days of the COVID-19 pandemic, vertebral fracture incidence considerably decreased with the implementation of social distancing measures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"31-39"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis. 韩国女性骨质疏松症患者对骨质疏松症的看法。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.63

Kyung-Hag Lee, Guhyun Lee, Taehyun Lee, Dong-Won Byun, Yong-Chan Ha

{"title":"Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis.","authors":"Kyung-Hag Lee, Guhyun Lee, Taehyun Lee, Dong-Won Byun, Yong-Chan Ha","doi":"10.11005/jbm.2024.31.1.63","DOIUrl":"10.11005/jbm.2024.31.1.63","url":null,"abstract":"Background: Patient perception is a key element in improving compliance with medications for osteoporosis. This study evaluated the awareness, perception, sources of information, and knowledge of osteoporosis among Korean women with osteoporosis.Methods: A questionnaire survey was conducted from July 22, 2021 to 13 August 2021. Patients who were followed up in endocrinology (Endo), orthopedic surgery (OS), and gynecology (GY) were recruited (N=40, 40, and 20 in each group). Patients were allocated according to their age, as follows: 15, 15, and 10 patients in their 60s, 70s, and 80s for Endo and OS, and 10 and 10 patients in their 60s and 70s for GY. The questionnaire was composed of the following topics: patient journey to the hospital, drug-related issues, communication with medical doctors, patient knowledge, and sources of information about osteoporosis.Results: The results of medical check-ups were the most common reason for patient visits to the hospital for an initial diagnosis of osteoporosis (61%). A knowledge gap regarding mortality, refracture, and drug-induced osteoporosis was observed. Doctors were the most preferred and trustful source of information, while health-related TV shows were the second most common source of information. Patients with OS reported lower perceived severity and higher drug discontinuation, along with a higher proportion of fractures, as the initial reasons for hospital visits for osteoporosis.Conclusions: Variations in perceptions according to the issue and group were identified. These should be considered during patient consultations to improve compliance with osteoporosis treatment.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study. 改善骨质疏松症治疗依从性的针对性辅导：C-STOP研究的单臂变异。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.13

Carrie Ye, Finlay A McAlister, Debbie Bellerose, Meng Lin

{"title":"Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study.","authors":"Carrie Ye, Finlay A McAlister, Debbie Bellerose, Meng Lin","doi":"10.11005/jbm.2024.31.1.13","DOIUrl":"10.11005/jbm.2024.31.1.13","url":null,"abstract":"Background: In this pre-planned variation of the Comparing Strategies Targeting Osteoporosis to Prevent Fractures After an Upper Extremity Fracture (C-STOP) trial, we investigated whether adherence-specific coaching by the case manager (CM) further improved the adherence and persistence rates compared to those seen in the C-STOP trial.Methods: We conducted a prospective observational cohort study of community-dwelling adults 50 years or older who suffered an upper-extremity fracture and were not previously treated with osteoporosis medications, to assess whether a well-trained CM can partner with patients to improve adherence to and persistence with oral bisphosphonate intake. The primary outcome was adherence (taking > 80% of prescribed doses) to oral bisphosphonate intake at 12 months after study enrollment. Secondary outcomes included primary adherence to and 12-month persistence with oral bisphosphonate and calcium and vitamin D supplement intake at 12 months.Results: The study cohort consisted of 84 participants, of which 30 were prescribed an oral bisphosphonate. Twenty-two (73.3%) started treatment within 3 months. The adherence rate at 12 months was 77.3%. The persistence rate at 12 months was 95.5%. Of those not prescribed an oral bisphosphonate, 62.8% were taking supplemental calcium and 93.0% were taking supplemental vitamin D at 12 months. Depression was a significant predictor of 12-month non-adherence (adjusted odds ratio, 9.8; 95% confidence interval, 1.2-81.5).Conclusions: Adherence-specific coaching by a CM did not further improve the level of medication adherence achieved in the original C-STOP study. Importantly, these results can inform adherence in future intervention studies.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications. 肌肉疏松症是老龄化的行动能力表型：临床意义。

Journal of Bone Metabolism Pub Date : 2024-02-01 Epub Date: 2024-02-29 DOI: 10.11005/jbm.2024.31.1.1

Sunghwan Ji, Hee-Won Jung, Ji Yeon Baek, Il-Young Jang, Eunju Lee

{"title":"Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications.","authors":"Sunghwan Ji, Hee-Won Jung, Ji Yeon Baek, Il-Young Jang, Eunju Lee","doi":"10.11005/jbm.2024.31.1.1","DOIUrl":"10.11005/jbm.2024.31.1.1","url":null,"abstract":"Sarcopenia, which is characterized by an age-related decline in muscle mass and function, poses significant challenges to geriatric care. Its definition has evolved from muscle-specific criteria to include muscle mass, muscle function, and physical performance, recognizing sarcopenia as a physical frailty. Sarcopenia is associated with adverse outcomes, including mortality, falls, fractures, cognitive decline, and admission to long-term care facilities. Neuromechanical factors, protein-energy balance, and muscle protein synthesis-breakdown mechanisms contribute to its pathophysiology. The identification of sarcopenia involves screening tests and a comprehensive assessment of muscle mass, strength, and physical function. Clinical approaches aligned with the principles of comprehensive geriatric assessment prioritize patient-centered care. This assessment aids in identifying issues related to activities of daily living, cognition, mood, nutrition, and social support, alongside other aspects. The general approach to factors underlying muscle loss and functional decline in patients with sarcopenia includes managing chronic diseases and evaluating administered medications, with interventions including exercise and nutrition, as well as evolving pharmacological options. Ongoing research targeting pathways, such as myostatin-activin and exercise mimetics, holds promise for pharmacological interventions. In summary, sarcopenia requires a multifaceted approach, acknowledging its complex etiology and tailoring interventions to individual patient needs.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"31 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Health Status of Children with Spinal Muscular Atrophy. 脊髓肌肉萎缩症儿童的骨骼健康状况。

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.319

Joanna Yuet-Ling Tung, Tsz-Kit Chow, Monique Wai, Jasmine Lo, Sophelia Hoi Shan Chan

{"title":"Bone Health Status of Children with Spinal Muscular Atrophy.","authors":"Joanna Yuet-Ling Tung, Tsz-Kit Chow, Monique Wai, Jasmine Lo, Sophelia Hoi Shan Chan","doi":"10.11005/jbm.2023.30.4.319","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.319","url":null,"abstract":"Background: Spinal muscular atrophy (SMA) is a group of rare, inherited neuromuscular disorders. Bone health is often a neglected issue in children with SMA. This study aimed to evaluate the bone health status of children with SMA in Hong Kong.Methods: This retrospective study included children with SMA who were managed in the Neuromuscular Disorder Clinics of 2 quaternary centers in Hong Kong. Bone health status was assessed by fracture history, bone mineral density (BMD) measured by dual energy X-ray absorptiometry, and serum 25-hydroxy-vitamin D (25[OH]D) level.Results: Thirty-two children were included (males, 12). The median age was 10.8 years. BMD assessments were performed in 17 patients (SMA type 1=2, type 2=8, type 3=7). Low BMD was observed in 16 out of 17 patients. Four had a history of long bone fractures and were started on bisphosphonates. SMA types, age at last visit, sex, ambulation, and 25(OH)D level were not associated with fracture history or BMD Z-scores. Only one fulfilled the 2019 International Society for Clinical Densitometry (ISCD) pediatric definition of osteoporosis, with both low BMD and a history of clinically significant fracture.Conclusions: Children with SMA on disease-modifying treatments commonly had Low BMD and a history of fractures, but osteoporosis was uncommon according to the 2019 ISCD pediatric definition. A special definition of osteoporosis may be needed for this high-risk group.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"319-327"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138794609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea. 骨质疏松症患者骨转换标志物的有效性和实用性：韩国一项多中心研究

Journal of Bone Metabolism Pub Date : 2023-11-01 Epub Date: 2023-11-30 DOI: 10.11005/jbm.2023.30.4.311

Jun-Il Yoo, So Young Park, Deog-Yoon Kim, Jeonghoon Ha, Yumie Rhee, Namki Hong, Jung-Taek Kim, Hyon-Seung Yi, Bu Kyung Kim, Young-Kyun Lee, Yong-Chan Ha, Yun Kyung Jeon, Ha-Young Kim, Seong Hee Ahn, Seongbin Hong, Sang-Yeob Lee

{"title":"Effectiveness and Usefulness of Bone Turnover Marker in Osteoporosis Patients: A Multicenter Study in Korea.","authors":"Jun-Il Yoo, So Young Park, Deog-Yoon Kim, Jeonghoon Ha, Yumie Rhee, Namki Hong, Jung-Taek Kim, Hyon-Seung Yi, Bu Kyung Kim, Young-Kyun Lee, Yong-Chan Ha, Yun Kyung Jeon, Ha-Young Kim, Seong Hee Ahn, Seongbin Hong, Sang-Yeob Lee","doi":"10.11005/jbm.2023.30.4.311","DOIUrl":"https://doi.org/10.11005/jbm.2023.30.4.311","url":null,"abstract":"Background: This study aimed to investigate real-world data of C-terminal telopeptide (CTX), propeptide of type I collagen (P1NP), and osteocalcin through present multicenter clinical study, and retrospectively analyze the usefulness of bone turnover markers (BTMs) in Koreans.Methods: The study focused on pre- and post-menopausal patients diagnosed with osteoporosis and excluded patients without certain test results or with test intervals of over 1 year. The demographic data and 3 BTMs (CTX, P1NP, and osteocalcin) were collected. The patients were classified by demographic characteristics and the BTM concentrations were analyzed by the group.Results: Among women with no history of fractures, the levels of P1NP (N=2,100) were 43.544±36.902, CTX (N=1,855) were 0.373 ±0.927, and osteocalcin (N=219) were 10.81 ±20.631. Among men with no history of fractures, the levels of P1NP (N=221) were 48.498±52.892, CTX (N=201) were 0.370±0.351, and osteocalcin (N=15) were 7.868 ±10.674. Treatment with teriparatide increased the P1NP levels after 3 months in both men and women, with a 50% increase observed in women. Similarly, treatment with denosumab decreased the CTX levels after 3 months in both men and women, with a reduction of 50% observed in women.Conclusions: The results of this study can contribute to the accurate assessment of bone replacement status in Koreans. We also provide the P1NP level in the Korean population for future comparative studies with other populations.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"30 4","pages":"311-317"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138794610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0