Journal of Bone Metabolism最新文献_第5页

Identification of Bone Metastasis-Related Gene Networks in Lung Cancer: Implications for Bone Metabolism. 肺癌骨转移相关基因网络的鉴定：对骨代谢的影响。

Journal of Bone Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.11005/jbm.25.863

Jungwoo Kim, Seong-Ho Park, Junho K Hur, Sung Bae Park

{"title":"Identification of Bone Metastasis-Related Gene Networks in Lung Cancer: Implications for Bone Metabolism.","authors":"Jungwoo Kim, Seong-Ho Park, Junho K Hur, Sung Bae Park","doi":"10.11005/jbm.25.863","DOIUrl":"10.11005/jbm.25.863","url":null,"abstract":"Background: This study aimed to infer a causal gene network associated with bone metastasis in lung cancer and to validate its reliability through experimental gene expression analysis.Methods: Using DNA microarray data from the Gene Expression Omnibus, we analyzed samples from primary lung cancer and those with bone metastasis. Commonly expressed genes in both groups were identified, and a causal network was inferred using Bayesian network inference with Java Objects based on the Bayesian Dirichlet score. To evaluate the network, we predicted the expression changes of downstream genes following knockdown of a key upstream gene and compared these predictions with mRNA expression levels in fatty acid desaturase 1 (FADS1)-knockdown lung cancer cells.Results: The genes FADS1, cardiotrophin-like cytokine factor 1 (CLCF1), chromosome 4 open reading frame 48, sushi, nidogen and EGF like domains 1, FK506-binding protein 15, and coenzyme Q10A (COQ10A) were identified as directly associated with lung cancer bone metastasis. Among them, FADS1 appeared to have a regulatory role, influencing downstream targets. Notably, CLCF1 and COQ10A showed significantly increased expression in FADS1-knockdown cells, consistent with the network's predictions.Conclusions: These findings suggest that Bayesian network analysis is a reliable machine learning approach for uncovering causal gene relationships in cancer metastasis. Furthermore, FADS1 may serve as a potential therapeutic target in lung cancer bone metastasis. The validity of this network was supported by in vitro experiments using a lung cancer cell line.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 3","pages":"232-243"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Thyroid-Stimulating Hormone Suppression on Bone Mineral Density in Patients with Differentiated Thyroid Carcinoma: A Single Center Retrospective Study. 促甲状腺激素抑制对分化型甲状腺癌患者骨密度的影响：一项单中心回顾性研究

Journal of Bone Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.11005/jbm.25.869

Meihua Jin, Won Sang Yoo

{"title":"Effect of Thyroid-Stimulating Hormone Suppression on Bone Mineral Density in Patients with Differentiated Thyroid Carcinoma: A Single Center Retrospective Study.","authors":"Meihua Jin, Won Sang Yoo","doi":"10.11005/jbm.25.869","DOIUrl":"10.11005/jbm.25.869","url":null,"abstract":"Background: This study evaluated the correlation between the degree and duration of thyroid-stimulating hormone (TSH) suppression and changes in bone mineral density (BMD) in patients who underwent surgery for differentiated thyroid carcinoma (DTC).Methods: We included 65 women who underwent surgery for DTC and had at least two BMD measurements. Changes in BMD were statistically analyzed with a focus on postmenopausal women.Results: The mean patient age was 52.2 years. During the follow-up period, 10 patients (15.4%) received osteoporosis treatment, and six (9.2%) experienced fractures. Analysis of 50 postmenopausal women revealed significant decreases in lumbar spine BMD (P=0.007), femoral neck BMD (P=0.008), and total hip BMD (P=0.010). Patients with TSH suppression <0.5 mU/L exhibited a 1.24%/y decrease in lumbar spine BMD, showing a marked reduction compared to a 0.33%/y decrease in BMD in the group with TSH ≥0.5 mU/L (P=0.025). Linear regression analysis comparing the duration of TSH suppression revealed a significant correlation with lumbar spine BMD (P<0.001). However, no correlation was observed between TSH suppression and decreased femoral neck BMD. Although not significant, the reduction in BMD in the lumbar spine was greater in the calcium and vitamin D non-supplementation group than in the supplementation group (1.31%/y vs. 0.71%/y; P=0.349).Conclusions: Prolonged aggressive TSH suppression significantly affects lumbar spine BMD in patients with DTC. These findings highlight the need to balance TSH suppression with the risk of bone health deterioration, particularly in postmenopausal women.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 3","pages":"221-231"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Complex Landscape of Osteoclastogenesis in Orthodontics. 正畸中破骨细胞发生的复杂景观导航。

Journal of Bone Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.11005/jbm.25.883

Sandra Sagar, Genickson Jeyaraj, Pratibha Ramani

引用次数: 0

Side-to-Side Differences in Bone Mineral Density, Bone Mineral Content, and Lean Mass in Healthy Subjects. 健康受试者骨矿物质密度、骨矿物质含量和瘦体重的侧对侧差异。

Journal of Bone Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.11005/jbm.25.865

María Lorena Brance, Silvana Di Gregorio, Luis A Ramírez Stieben, Luis Miguel Del Río Barquero, Lucas R Brun

{"title":"Side-to-Side Differences in Bone Mineral Density, Bone Mineral Content, and Lean Mass in Healthy Subjects.","authors":"María Lorena Brance, Silvana Di Gregorio, Luis A Ramírez Stieben, Luis Miguel Del Río Barquero, Lucas R Brun","doi":"10.11005/jbm.25.865","DOIUrl":"10.11005/jbm.25.865","url":null,"abstract":"Background: Limb dominance is influenced by daily activity and muscle strength. Previous studies have demonstrated lateral differences in bone mineral density (BMD), bone mineral content (BMC), and lean mass as a result of asymmetric mechanical loading. Understanding these variations is crucial, especially in conditions with regional bone demineralization, where the contralateral limb can serve as a reference. We aimed to analyze side-to-side differences in BMD, BMC, and lean mass, as measured by dual energy X-ray absorptiometry (DXA), in healthy subjects.Methods: A cross-sectional study included 802 whole-body composition assessments in Spanish adults (20-80 years). Athletes and individuals with bone metabolism disorders were excluded. Hand and foot dominance were self-reported. BMD, BMC, and lean mass were measured using a DXA scanner (Lunar Prodigy).Results: The sample (57.1% women, 42.9% men; mean age, 53.0±16.7 years) showed strong correlations between dominant and non-dominant limbs (r>0.90). The dominant upper limb had significantly higher BMD (~4%), BMC (~5-6%), and lean mass (~3-4%) in both sexes. In women, the dominant lower limb showed slight differences (~1%), while in men, only lean mass was significantly higher. Aging led to BMD and BMC reductions after a peak in the fourth decade in women and the third in men. Lean mass showed a higher decline in men in both upper and lower limbs.Conclusions: Limb dominance affects body composition differently between sexes, primarily in the upper limb, potentially due to differences in physical activity or mechanical loading. This study provides insight into how laterality and aging influence body composition in healthy individuals.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 3","pages":"212-220"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Tyrosine Kinase Inhibitors in Modulating Chondrocyte Activity and Cartilage Diseases. 酪氨酸激酶抑制剂在调节软骨细胞活性和软骨疾病中的作用。

Journal of Bone Metabolism Pub Date : 2025-08-01 Epub Date: 2025-08-31 DOI: 10.11005/jbm.25.873

Khalil A Hadid, Muthanna K Zaki, Fawaz A Alassaf, Mohammed N Abed

{"title":"Role of Tyrosine Kinase Inhibitors in Modulating Chondrocyte Activity and Cartilage Diseases.","authors":"Khalil A Hadid, Muthanna K Zaki, Fawaz A Alassaf, Mohammed N Abed","doi":"10.11005/jbm.25.873","DOIUrl":"10.11005/jbm.25.873","url":null,"abstract":"Tyrosine kinases (TK) are critical enzymes involved in cellular processes in the joints, such as proliferation, differentiation, and apoptosis. These inhibitors target key pathways involved in cartilage degeneration and inflammation, offering hope for improved management of these conditions. This review examines the role of TK inhibitors in modulating chondrocyte activity and explores their therapeutic potential in cartilage-related diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). A search has been conducted across several relevant publications using the terms cartilage regeneration, chondrocyte activity, OA, RA, and TK inhibitors in PubMed and Google Scholar to construct this review. TK inhibitors have the potential to manage inflammatory and degenerative joint disorders. Tofacitinib, gefitinib, imatinib and other TK inhibitors have anti-inflammatory effects through various pathways, aiding in treating cartilage diseases. Tofacitinib and baricitinib are already approved for RA, while other TK inhibitors are under continuous investigation for approval in RA and OA. Nonetheless, certain obstacles like serious side effects, limited joint-specificity, and inadequate clinical research impede their utilization. Despite these challenges, TK inhibitors signify a promising treatment strategy for joint diseases, presenting the potential to improve disease management strategies and promote cartilage regeneration.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 3","pages":"155-166"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Radiological Worsening in Patients with Vertebral Fragility Fractures and the Associated Factors. 椎体脆性骨折患者放射学高度恶化及其相关因素。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.25.835

Mauricio Soto-Subiabre, Victor Mayoral, Lidia Valencia-Muntalà, Carlos González, Carmen Gómez-Vaquero

{"title":"High Radiological Worsening in Patients with Vertebral Fragility Fractures and the Associated Factors.","authors":"Mauricio Soto-Subiabre, Victor Mayoral, Lidia Valencia-Muntalà, Carlos González, Carmen Gómez-Vaquero","doi":"10.11005/jbm.25.835","DOIUrl":"10.11005/jbm.25.835","url":null,"abstract":"Background: To investigate the contribution of radiological characteristics of baseline fragility vertebral fractures (FVF) and clinical characteristics to the development of radiological worsening (RW).Methods: Patients were recruited between 2015 and 2018. The primary outcome was the identification of RW in a radiological second image, defined as the progression of prevalent FVF, new FVF, or both. Data on fracture risk fractures, bone mineral density, analgesia requirements, and antiosteoporosis treatment were recorded. The radiological features of baseline FVF included fracture number, location(s), severity grade (Genant method), kyphosis angle, and spine index deformity.Results: A total of 223 patients with at least one follow-up radiological evaluation were included. Another 199 patients had no radiological follow-up. Of those with follow-up, 69% presented RW, accounting for 36.5% of the total cohort (422 patients). The incidence rate of RW was 73.8/1,000 patient-years. Among those with RW, 61% showed progression of FVF, 27% developed new FVF, and 12% had both. The multivariate analysis demonstrated that multiple FVF and worse grades of FVF at baseline were variables significantly associated with RW. Baseline characteristics of FVF that increased the risk of RW by progression of FVF was grade 1 (odds ratio [OR], 3.22; 95% confidence interval [CI], 1.47-7.02) and grade 2 (OR, 1.97; 95% CI, 1.05-3.68) and by new FVF was grade 3 (OR, 3.19; 95% CI, 1.39-7.33) FVF.Conclusions: Approximately one-third of patients with FVF experienced RW, with progression of FVF being the most common event. A higher number of FVF and a greater severity at baseline are associated with RW.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"143-154"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive Effect of Yerba Mate (Ilex paraguariensis) Consumption on Bone Mineral Density in Postmenopausal Women Assessed by Dual Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling. 双能x线三维模型评估巴拉圭茶对绝经后妇女骨密度的积极影响

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.24.827

Lucas R Brun, Muriel M Henríquez, Luis A Ramírez Stieben, Mariana Cusumano, Jorge Homero Wilches-Visbal, Fernando Daniel Saraví, María Lorena Brance

{"title":"Positive Effect of Yerba Mate (Ilex paraguariensis) Consumption on Bone Mineral Density in Postmenopausal Women Assessed by Dual Energy X-Ray Absorptiometry-Based 3-Dimensional Modeling.","authors":"Lucas R Brun, Muriel M Henríquez, Luis A Ramírez Stieben, Mariana Cusumano, Jorge Homero Wilches-Visbal, Fernando Daniel Saraví, María Lorena Brance","doi":"10.11005/jbm.24.827","DOIUrl":"10.11005/jbm.24.827","url":null,"abstract":"Background: Yerba mate (YM) drinking is associated with higher lumbar spine and femoral neck bone mineral density (BMD) in postmenopausal women. We analyzed its effect on total hip BMD and reported the contribution of the trabecular and cortical components to this effect.Methods: A control group of 147 non-drinkers was compared to 153 YM drinkers. Left hip BMD was measured using dual energy X-ray absorptiometry (DXA), and three-dimensional (3D)-Shaper software was used to estimate integral volumetric BMD (vBMD), cortical surface BMD (sBMD), and trabecular vBMD through 3D modeling.Results: No significant difference was found between groups in either age (p=0.746) or body mass index (BMI; p=0.329). The YM group had significantly higher total hip BMD, integral vBMD, cortical sBMD, and trabecular BMD (all p<0.0001). The frequency of DXA-based osteoporosis diagnosis was lower in YM drinkers (3.3% vs. 10.9%; odds ratio [OR], 0.276). The rate of low-impact fractures was significantly reduced in YM drinkers (5.9% vs. 12.9%; OR, 2.197). Linear regression analyses revealed that cortical and trabecular parameters correlated positively with BMI and negatively with age in both groups. The slope of the lines did not differ between groups, but the elevation was uniformly higher in the YM group (p=0.0004 to p<0.0001).Conclusions: Our study provides novel insights into YM consumption and bone health in postmenopausal women. We confirm its positive association with BMD and demonstrate, for the first time, that both cortical and trabecular compartments contribute to this effect. Our findings also suggest a potential protective role of YM against osteoporosis and fragility fractures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"123-132"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertebral Fractures Identified by Lateral Spine Dual Energy X-Ray Absorptiometry Scans and Mortality Risk in Adults. 成人侧脊柱双能x线吸收扫描鉴定的椎体骨折和死亡风险。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.24.831

Carlos H Orces

{"title":"Vertebral Fractures Identified by Lateral Spine Dual Energy X-Ray Absorptiometry Scans and Mortality Risk in Adults.","authors":"Carlos H Orces","doi":"10.11005/jbm.24.831","DOIUrl":"10.11005/jbm.24.831","url":null,"abstract":"Background: Vertebral fractures identified by radiographic morphometry are associated with increased mortality risk. However, there is limited data regarding the association between vertebral fractures detected by lateral spine dual energy X-ray absorptiometry (DXA) scans and the risk of mortality.Methods: The present study was based on data from participants aged 40 years and older in the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey (NHANES). Vertebral fracture assessment (VFA) performed using lateral spine DXA scans was used to provide fracture information of the vertebrae from T4 to L4. Vertebral fracture severity was categorized according to Genant's semiquantitative technique and the NHANES 2019 public-use linked mortality files were used to determine mortality status.Results: Of 3,219 participants, the prevalence of vertebral fractures identified by VFA was 5.5% (95% confidence interval [CI], 4.7-6.5). During a median follow-up of 71.0 months, 277 participants died, 18.2% (95% CI, 12.2-26.3) with vertebral fractures and 6.3% (95% CI, 5.0-8.0) without fractures (p<0.0001). Cox regression analysis demonstrated that participants with moderate to severe vertebral fractures (>25% height loss) were 1.7 times more likely to die compared with their counterparts without (hazard ratio [HR], 1.79; 95% CI, 1.05-3.04). Notably, in a subgroup analysis, older adults (HR, 2.16; 95% CI, 1.41-3.30) and men with vertebral fractures (HR, 2.28; 95% CI, 1.49-3.47) had a 2-fold greater mortality risk compared to those without vertebral fractures.Conclusions: Vertebral fracture severity identified by VFA was significantly associated with greater all-cause mortality risk. This association was also observed among men and older adults with any baseline vertebral fractures.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"133-142"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Fish Bone Powders on the Bone Density in Corticosteroid-Induced Osteoporosis Rats. 鱼骨粉对皮质激素所致骨质疏松大鼠骨密度的影响。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.11005/jbm.24.819

Annis Catur Adi, Wizara Salisa, Sri Fatmawati, Emyr Reisha Isaura, Heni Rachmawati

{"title":"The Influence of Fish Bone Powders on the Bone Density in Corticosteroid-Induced Osteoporosis Rats.","authors":"Annis Catur Adi, Wizara Salisa, Sri Fatmawati, Emyr Reisha Isaura, Heni Rachmawati","doi":"10.11005/jbm.24.819","DOIUrl":"10.11005/jbm.24.819","url":null,"abstract":"Background: The adequacy of calcium from food consumption is difficult to meet because of its low absorption rate, causing an increased risk of osteoporosis. One of the ways to increase calcium absorption is to increase its solubility by decreasing its particle size. This study aimed to observe the influence of particle size and mineral composition of various fish bone powders on bone density enhancement after oral administration to corticosteroid-induced osteoporosis rats.Methods: The test stages carried out include manufacturing fish bone flour and nanonization, characterization (particle size and nutritional content), conducting experimental tests on rats using blood serum samples, and observing bone growth and density. The types of fish studied were catfish, snakehead fish, mackerel, and snapper.Results: Nanonization processing has been proven to reduce the size of flour particles, increase its nutritional and mineral content, and maximize the calcium absorption rate in rats. The results of the test on experimental animals induced osteoporosis showed that rats given the intervention of milling snapper fish bone meal produced the best outcomes in body length, body mass index, calcium, magnesium, and serum phosphorus (P<0.05). While in bone parameters, catfish bone meal was the most optimal in encouraging bone density percentage.Conclusions: In conclusion, to increase serum minerals and bone density optimally, in addition to reducing particle size, the ratio of mineral content also needs to be considered.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"103-113"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tibial Mechanoadaptation in Male Mice is Modularised and Retained in Aging. 雄性小鼠的胫骨机械适应性模块化并在衰老过程中保持不变。

Journal of Bone Metabolism Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI: 10.11005/jbm.24.817

Roberto Lopes de Souza, Samuel Monzem, Andrew Anthony Pitsillides

{"title":"Tibial Mechanoadaptation in Male Mice is Modularised and Retained in Aging.","authors":"Roberto Lopes de Souza, Samuel Monzem, Andrew Anthony Pitsillides","doi":"10.11005/jbm.24.817","DOIUrl":"10.11005/jbm.24.817","url":null,"abstract":"Background: The murine tibia is a remarkable bone in which to study mechanoadaptive responses. Studies into age-related shifts in these responses do not, however, fully explain sex-specific bone architectural changes related to age. Here, we generate data from male subjects to evaluate whether load-induced skeletal responses are modularised and age-related.Methods: Tibiae in young (12-week-old), mature (22-week-old), and aged (18-month-old) C57Bl/6 male mice were subjected to pre-calibrated right limb (left, control) loading for 2 weeks. Cortical bone formation was measured in young and mature mice at 3 positions, and new bone formation was evaluated in aged mice at a single location. Micro-computed tomography scans were used to measure trabecular changes.Results: We found that loading increased cortical formation at all tibial positions in young, and all except the most distal position in mature mice. Intriguingly, total cortical formation was also significantly greater in loaded tibiae in aged males. Loading failed to modify trabecular mass/architecture at any age.Conclusions: We conclude that load-induced cortical responses are partially retained, whereas trabecular bone appears resistant to loading in males of all ages. These data indicate modular patterns of mechanoadaptation across bone compartments that align with the emergence of age-related skeletal frailty.","PeriodicalId":15070,"journal":{"name":"Journal of Bone Metabolism","volume":"32 2","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0