Journal of Biotechnology and Biomedicine最新文献_第10页

Specific Epithet-Composite Name 特定的修饰复合名称

Journal of Biotechnology and Biomedicine Pub Date : 2019-01-01 DOI: 10.26502/JBB.2642-9128008

I. Ilieva

引用次数: 0

The Effect of Fusarium Oxysporum and Macrophomina Phaseolina on the Proximate Composition of Jatropha Curcas Seed a Biofuel Plant 尖孢镰刀菌和菜绿巨霉对麻疯树种子近似成分的影响

Journal of Biotechnology and Biomedicine Pub Date : 2019-01-01 DOI: 10.26502/jbb.2642-9128004

Isalar Oluwatoyin F, Ataga Anthony E

引用次数: 0

Anti-Infective Properties of Anti-Cancer Cationic Peptides containing Survivin or Apolipoprotein E Sequences 含有Survivin或载脂蛋白E序列的抗癌阳离子肽的抗感染特性

Journal of Biotechnology and Biomedicine Pub Date : 2019-01-01 DOI: 10.26502/jbb.2642-91280019

B. Périchon, A AlphonseGarcia

{"title":"Anti-Infective Properties of Anti-Cancer Cationic Peptides containing Survivin or Apolipoprotein E Sequences","authors":"B. Périchon, A AlphonseGarcia","doi":"10.26502/jbb.2642-91280019","DOIUrl":"https://doi.org/10.26502/jbb.2642-91280019","url":null,"abstract":"Specific intracellular pathways regulated by Apolipoprotein E (ApoE), a PP2A activator or survivin, an inhibitor of Heat Shock Proteins (HSP), can impact human diseases including cancers. In this study, we have initially observed that anti-tumor Tat-survivin (shepherdin-Tat), and ApoE mimetics, Cog or Tat-Cog &Cog-Tat, peptides contained cationic sequences that share similar physical characteristics with LL17-32, a short active sequence of the anti-microbial human cathelecidin peptide. Furthermore, to investigate the potential host defense properties of these peptidic sequences we have comparatively analyzed anti-tumor and anti-bacterial properties of shepherdin-Tat and ApoE mimetic peptides with the human LL17-32 cathelecidin sequence using U87G cells, a relevant human glioblastoma model, and a Group B Streptococcus agalactiae NEM316 ΔdltA that is highly sensitive to human LL17-32 cathelecidin. This study highligts two major insights indicating that similarly, to LL37 or LL17-32 cathelecidin sequences, shepherdin-Tat and ApoE mimetic peptides firstly impairs the growth of S. agalactiae NEM 316 dltA strain, and secondly inhibited the survival of human glioblastoma U87G cells. In conclusion, together, our results clearly indicate that cationic peptides with survivin and ApoE anti-tumor sequences, including scrambled shepherdinTat, a previously described biologically inactive anti-cancer molecule, behave as cathelecidin-like anti-infective host defense molecules. In addition, we identified hybrid Cog-Tat/Tat-Cog peptides as potential and highly potent therapeutic molecules with anti-glioblastoma and anti-bacterial effects.","PeriodicalId":15066,"journal":{"name":"Journal of Biotechnology and Biomedicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78548463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of the “Bacteria-Parasite Interaction” in Animal Health and their Participation in the Control of Parasites “细菌-寄生虫相互作用”对动物健康的影响及其对寄生虫控制的参与

Journal of Biotechnology and Biomedicine Pub Date : 2019-01-01 DOI: 10.26502/jbb.2642-91280017

Emmanuel Dunstand-Guzmán, L. Lina-García, Sandra Maricela Cuate-Rosas, G. Peña-Chora

{"title":"Impact of the “Bacteria-Parasite Interaction” in Animal Health and their Participation in the Control of Parasites","authors":"Emmanuel Dunstand-Guzmán, L. Lina-García, Sandra Maricela Cuate-Rosas, G. Peña-Chora","doi":"10.26502/jbb.2642-91280017","DOIUrl":"https://doi.org/10.26502/jbb.2642-91280017","url":null,"abstract":"The parasite infections of animals (production and pets) affect the health and quality of animal life, the parasites frequently present a microbiome associated which play several functions, like nutrition, reproduction or defense against the host immune system, and in some cases are opportunistic microorganisms. These bacteria might cause secondary infections to animals, so the parasite can become a vector of pathogenic bacterial, reason why the understanding of the \"bacteria-parasite interaction” is important to combating of parasitic infestations. The current resistance to conventional dewormers or ixodicides, are issue in parasitology; attack a vital bacteria of parasites through antibiotics possibly can be a control alternative, at the same way, the use of bacteria capable to control to parasitic diseases by antagonist interaction, like lethal toxins or adhesion at the site invasion of the parasites, are alternatives to explore. Understand the bacteria-parasite interaction will help us to the control of parasitic diseases in an integral form, as well know as the bacterial infections that can develop from the parasitic infestation. The use of antagonist bacterial is a biotechnological option in the control of parasites as therapy on the animal biomedicine, so in this review, we have a general idea of the “bacteria-parasite interaction\" and their impact on the animal’s health.","PeriodicalId":15066,"journal":{"name":"Journal of Biotechnology and Biomedicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91057042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Significant Aspect of Rv0378 Gene of Mycobacterium tuberculosis H37Rv Reveals the PE_PGRS like Properties by Computational Approaches 结核分枝杆菌H37Rv Rv0378基因的重要特征用计算方法揭示PE_PGRS样特性

Journal of Biotechnology and Biomedicine Pub Date : 2019-01-01 DOI: 10.26502/jbb.2642-9128007

Beg Ma, Athar F, Meena Ls

{"title":"Significant Aspect of Rv0378 Gene of Mycobacterium tuberculosis H37Rv Reveals the PE_PGRS like Properties by Computational Approaches","authors":"Beg Ma, Athar F, Meena Ls","doi":"10.26502/jbb.2642-9128007","DOIUrl":"https://doi.org/10.26502/jbb.2642-9128007","url":null,"abstract":"Rv0378 is a conserved hypothetical gene of Mycobacterium tuberculosis H37Rv (M. tuberculosis H37Rv). This gene has been predicted to possess some PE_PGRS like characteristics. M. tuberculosis H37Rv contains a group of PE_PGRS qualities, with various identified motifs, encoding firmly related proteins that are outstandingly rich in glycine and alanine. These genes are predicted to be one of the key regulators for the pathogenic mechanism of this bacterium by the evidence of their absence in other a virulent strain. This manuscript noted some of the most valuable aspects about hypothetical protein Rv0378 being function as a PE_PGRS protein. The major insights of this study include interaction study, modelling by using I-TASSER, validation of the model by RAMPAGE analysis and prediction of metal binding sites by using Insilico approaches. The study shows that this gene is majorly a coiled structure with very short lengths and had a similarity with other already confirmed PE_PGRS proteins. The structure is validated by the bioinformatics approach. Interaction study by STRING shows that this protein interacts with its neighboring partner and secE2 protein which is a transporter protein. Prediction of ligand binding site confirms that this gene binds with calcium and magnesium with very high affinity which focus our step ahead in the direction of this gene as PE_PGRS protein and essential for pathogenesis. This study will be helpful in the experimental design to work in this field and if found correct as predicted, thus this work might be helpful in the direction of the treatment of this disease.","PeriodicalId":15066,"journal":{"name":"Journal of Biotechnology and Biomedicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79366831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8