Journal of Biochemical Technology最新文献_第7页

Fetuin-A as Metabolic Biomarker in Patients at Higher Risk of Heart Failure 胎儿素a作为心力衰竭高危患者的代谢生物标志物

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/eehtfacomp

A. Berezin, Viacheslav Alexeyevich Poliasnyi, Ludmila Andreevna Kovalevskaya, Svitlana Ivanchenko, Alireza Pahlevanzade, P. Panigrahi, A. Berezin

引用次数: 1

Cocoa pod Inspired Green Synthesis of Nanosilver Decorated on Biochar with Dual-Function in Absorption and Antibacterial 以可可荚为灵感的生物炭装饰纳米银的绿色合成

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/eqnvknjl3k

Bui Thu Ha, N. Hoa, H. V. Tien, N. P. Anh, N. Minh, D. N. Linh, N. Tri

引用次数: 0

Influence of Sowing Time on Chemical Composition and Nutritional Value of Annual Herbs in Mixed Crops 播期对混作一年生草本植物化学成分和营养价值的影响

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/ezx0y895yb

E. Kondratenko, O. M. Soboleva, A. S. Berezina, T. Miroshina, D. Raushkina, Nikita Raushkin

引用次数: 2

The Relationship between Choledocholithiasis and Liver Enzymes in Elderly Patients 老年患者胆总管结石与肝酶的关系

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/rgom9stoee

Almohamad Almahmud Tamim, A. Klimov

引用次数: 0

Features of the Bone System Formation of Carcasses of Simmental and Crossbreed Steers 西门塔尔和杂交阉牛胴体骨系统形成的特征

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/2xqs6hobdz

I. Prokhorov, O. Kalmykova, T. Kubatbekov, Y. Yuldashbaev, Anatoly Kaledin, S. V. Savchuk

引用次数: 0

A New Naked-Spelt Variety to Enhance Human Immune Function 一种增强人体免疫功能的裸拼新品种

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/D2JTS9FB5R

S. Temirbekova, Y. Afanasieva, M. Begeulov, Ivan Kulikov, O. Beloshapkina, I. Sardarova

引用次数: 0

Centella Asiatica Effect in A High Fat and Fructose Diet-Induced Model of Metabolic Disorder in Rats 积雪草对高脂高果糖饮食诱导大鼠代谢紊乱模型的影响

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/GZEDDEXLEH

P. Hasimun, Y. Mulyani, H. Zakaria, A. R. Setiawan

引用次数: 0

Behavioral Peculiarities of the Equidae Family in the Conditions of the Moscow Zoo Stud Farm 莫斯科动物园种马场条件下马科动物的行为特征

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/oog0g3ci88

A. A. Ksenofontova, O. A. Voinova, A. A. Ivanov, D. Ksenofontov, S. V. Savchuk, Tatiana Vladimirovna Sakovtseva, T. Kubatbekov

引用次数: 0

Theoretical Investigation of Some Donepezil-based Derivatives as Dual Inhibitors for beta-Amyloid- and Cholinesterase Enzymes 多奈哌齐衍生物作为-淀粉样酶和胆碱酯酶双重抑制剂的理论研究

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/xekyd9bmjr

Assia Meziane, A. Ghomri, S. Bouchentouf, M. El‐Shazly

{"title":"Theoretical Investigation of Some Donepezil-based Derivatives as Dual Inhibitors for beta-Amyloid- and Cholinesterase Enzymes","authors":"Assia Meziane, A. Ghomri, S. Bouchentouf, M. El‐Shazly","doi":"10.51847/xekyd9bmjr","DOIUrl":"https://doi.org/10.51847/xekyd9bmjr","url":null,"abstract":"To treat Alzheimer’s Disease (AD), which is the most prevalent form of dementia, cholinesterase enzymes (AChE and BuChE) and amyloid-beta (Aβ) are attractive targets. In this work, different computational approach namely Density Functional Theory (DFT), Molecular Docking, and multi-QSAR modeling were performed on 22 donepezil-based derivatives which were reported as potent dual Aβ and (AChE and BuChE) inhibitors. The molecular geometries of the studied derivatives were carried out using GAUSSIAN 09 software with the level of theory (DFT, 6/31g*). The dual inhibitors adopted minimum energy. The results pointed out the importance of the inhibitors' geometries in enzyme inhibition. The QSAR models elaborated by means of Molecular Operating Environment (MOE) package, showed good statistical values for targets AChE (R2adj = 0.976, q2 = 0.871, RMS = 0.130), BuChE (R2adj = 0.976, q2 = 0.554, RMS = 0.092) and Aβ (R2adj = 0.861, q2 = 0.525, RMS = 0.113). To identify the binding pattern between the ligands and target enzymes, we implemented molecular docking studies for the datasets. The obtained information was related to the essential structural features that were related to the QSAR of the predicted models.","PeriodicalId":15062,"journal":{"name":"Journal of Biochemical Technology","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70840093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum 妊娠兔肾上腺雌激素受体(er)免疫定位的研究

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Journal of Biochemical Technology Pub Date : 2021-01-01 DOI: 10.51847/80jyiklt8c

Naoual Hammoudi, Souad Boulahbel, S. Chentouh, Y. Bentayeb, H. Djebaili, Amina Wissame Hadjeris, N. Gherraf

{"title":"Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum","authors":"Naoual Hammoudi, Souad Boulahbel, S. Chentouh, Y. Bentayeb, H. Djebaili, Amina Wissame Hadjeris, N. Gherraf","doi":"10.51847/80jyiklt8c","DOIUrl":"https://doi.org/10.51847/80jyiklt8c","url":null,"abstract":"This research deals with the organic extracts impact of Bunium incrassatum on the immune expression of estrogen receptors that is the assessment of the effect of organic extracts from the seeds of Bunium incrassatum (Apiaceae) on the immune labelling of estrogen receptors in the adrenal gland of pregnant rabbits from the local population (Oryctolagus cuniculus).The work was carried out on pregnant rabbits during the last third of gestation (from day 17 to day 27 of gestation). The animals were divided into four groups which received daily oral doses: 50, 100, and 200 mg/kg/day, respectively. The group with dose 0 was taken as a control. After treatment, the rabbits were sacrificed (28 day of gestation). Their organs were removed, defatted, and weighed then fixed in 10% formalin and the blood was collected in tubes with heparin. For immunohistochemistry, mouse monoclonal antibodies were used to determine the ER presence in the adrenal gland of rabbits. Theresults indicated that treatment with organic extract of Bunium incrassatum induced an increased rate of change in the thickness of the adrenal cortex in the treated groups compared to the control. A strong immune expression of estrogen receptors was observed in the groups treated with 50 and 100 mg / kg / day compared to the group treated with 200 mg/ kg/day. It can be concluded that estradiol has a direct effect on adrenal function in pregnant rabbits. Likewise, the components of the organic extract from the roots of Bunium incrassatum have modulatory activities for ER.","PeriodicalId":15062,"journal":{"name":"Journal of Biochemical Technology","volume":"159 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1