Journal of Applied Biotechnology & Bioengineering最新文献

{"title":"Degenerative disc disease: causes, symptoms, anatomy, market trends and emerging treatment strategies","authors":"Manshaii Farid, Tawil Bill","doi":"10.15406/jabb.2023.10.00336","DOIUrl":"https://doi.org/10.15406/jabb.2023.10.00336","url":null,"abstract":"","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135453175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic foot ulcers: physiology, disease, market analysis, treatments","authors":"Kafadarian Lina, Tawil Bill","doi":"10.15406/jabb.2023.10.00335","DOIUrl":"https://doi.org/10.15406/jabb.2023.10.00335","url":null,"abstract":"Diabetic foot ulcers (DFU) are a common, yet preventable complication of diabetes that can lead to serious health risks if left untreated. DFUs pose a significant challenge on not only the affected individual but also the community due to their complex pathophysiology and limited, often insufficient treatment options. This paper will provide a holistic review on diabetic foot ulcers, elaborating on their physiology, the current and projected market sizes, and discussing available treatments and products. Tissue engineering is becoming a quite impactful option for treating diabetic wounds, and is the central focus of this review. Additionally, this paper presents pipeline products, as well as a novel product that utilizes the core concepts of regenerative medicine and innovative technology and thus has the potential to overcome many of the limitations associated with existing therapies. Overall, this review serves as a valuable resource for healthcare professionals and researchers interested in diabetic foot ulcers, offering insights into the current state of knowledge and presenting a promising approach that could revolutionize the field","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135598068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pharmacokinetic Profile of Cirpusins®, Extract of Cyperus rotundus in Presence of Bioavailability Enhancer, BioPerine®","authors":"M. Majeed, S. Bani, A. Pandey, M. Ansari, Smitha Thazhathidath","doi":"10.5296/jab.v10i1.20594","DOIUrl":"https://doi.org/10.5296/jab.v10i1.20594","url":null,"abstract":"Obesity, a condition accompanying abnormal or excessive accumulation of fat in the body has become a major public health concern globally. Various herbs hailed from traditional systems of medicine like Ayurveda have gained importance in recent years to combat obesity. One such herb Cyperus rotundus (nutgrass), is known for its beneficial effects in obesity, in Ayurveda. Cirpusins® a patented extract from the dried rhizomes of Cyperus rotundus (standardized for minimum of 6% total identified stilbenes - Piceatannol, Scirpusin A & Scirpusin B) and BioPerine®, a bioavailability enhancer, obtained from the dried fruits of Piper nigrum (standardized to minimum 95% piperine). In this study, we examined the pharmacokinetic profile and bioavailability of Cirpusins® in Sprague-Dawley rats at two different doses (45 and 90 mg/kg) in the presence and absence of BioPerine® respectively. The results signifies that addition of BioPerine® (0.45 mg/kg) with Cirpusins® (45 mg/kg) enhances the bioavailability by reducing the effective dose of Cirpusins® (90 mg/kg) to half.","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81211405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broad spectrum viral molecular drug","authors":"U. Masood","doi":"10.15406/jabb.2021.08.00273","DOIUrl":"https://doi.org/10.15406/jabb.2021.08.00273","url":null,"abstract":"When Virus first enters the human body or human blood stream the virus start circulates throughout the body. The protective surface of virus is study with particular protein called receptor and lipid membrane envelop inside the capsid that contain a genetic material and viral enzyme. Protein on the virus is only able to bind with a cell surface called cell receptor. From the given Diagram viruses Receptor attached with Lipid envelops. The discovery of structure of the any viruses mainly lipase has made the identification of its inhibitors. Lipase which breaks down lipid envelope of virus which in return stops its replication and outbreak.","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87940711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Physico-Chemical Properties of Soils Locality Dobrosloveni, Olt County for Sustainable Agriculture","authors":"A. Stănilă","doi":"10.5296/jab.v9i2.19135","DOIUrl":"https://doi.org/10.5296/jab.v9i2.19135","url":null,"abstract":"The studied territory located in the central-western part of Olt County, belongs to the Caracal Plain and extremely little in the Leu-Rotunda Field in the SW part, both as divisions of the Romanati Plain.Locality presents a predominant relief of plain low altitude that is characterized by alluvio-proluvial plains moderately fragmented with local terraces, covered with loess-like deposit but relief of saucer.The soil cover of the territory under study is the direct reflection of all environmental factors, each having a role in the pedogenetic processes. Climate, as a pedogenetic factor, acted by its components, namely: temperature, precipitation, evapotranspiration, global radiation.Forest steppe vegetation was the supply of organic matter and biomass, because the hydrological regime is deficient, but especially the lithological substrate (loess-like complex) to steer solification to types characteristic of the cernisols class.Under the influence of environmental factors and pedogenetic processes within the locality Dobrosloveni it formed a wide range of soils, namely: protisols, cernisols, luvisols and hydrisols.","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81952522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light spectrum and indolebutyric acid (IBA) in rhizogenesis in herbaceous cuttings of guava trees","authors":"Hérica Chisté, M. Sandoval, Paixão, Loren Chisté José Matias Gomes, E. R. Schmildt, Antonio Resende, Fernandes","doi":"10.15406/jabb.2021.08.00268","DOIUrl":"https://doi.org/10.15406/jabb.2021.08.00268","url":null,"abstract":"Background: In the production of seedlings, success in the market is due to a quality product. Well-developed seedlings with a good root system, appear as a key factor to guarantee suitable products. Light can be used as a stimulating factor for rooting, in adequate light quality. Photoselective screens can be used to make rooting more efficient. Methods: To evaluate this factor, herbaceous cuttings of Guava Tree “Paluma” were used, exposed to different wavelengths in mini-greenhouses covered with cellophane of the colors: green, yellow, red, blue, transparent and orange, and subjected to five treatments with Indolebutyric Acid (IBA) (0, 1000, 2000, 3000 and 4000 mg.kg-1), grown in a 3: 2: 1 substrate (sand: earth: bioplant®), in a randomized block design, with a 6x5 factorial and four replications with 10 cuttings in each treatment. Ninety days after staking, the following variables were evaluated: cuttings survival, number of leaves; number of sprouts; largest sprout length; root length; root volume; green mass of leaves and root; dry mass of sprout and root. Results: The orange and red light spectra were superior in rooting the guava cuttings, and may be an option in covering the seedling production nurseries of this fruit tree. Conclusion: The use of IBA neutralized the luminous influence of the light spectra with non-significant results for the interaction.","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82990385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Screening and in Vitro Evaluation of the Antibacterial Activity of Organic Extracts from the Root Bark of Cussonia arborea (Araliaceae)","authors":"L. M. Moungang, L. Sidjui, Hervé Narcisse Bayaga, Josséline Ndambedia Mfouapon, Ondoua Nguélé, H. Gonsu, B. Ngameni","doi":"10.5296/jab.v9i2.19102","DOIUrl":"https://doi.org/10.5296/jab.v9i2.19102","url":null,"abstract":"Objective: To assess the usefulness of Cussonia arborea in the treatment of bacterial infectious diseases.Study Design: Experimental analytical study.Place and Duration of Study: The study was done in the Laboratory of Hydrobiology and Environment of the Faculty of Sciences, University of Yaounde1; the Bacteriology Laboratory of the Yaoundé University Teaching Hospital; the Laboratory of Pharmacognosy and Pharmaceutical Chemistry of the Faculty of Medicine and Biomedical Sciences and the Laboratory of Organic Chemistry of the Faculty of Sciences of the University of Yaoundé I. The study was done in a period of six months.Methodology: The root bark of Cussonia arborea was collected in the village Yambéta (Central Region, Cameroon), dried and pulverized. Thereafter, two extractions were performed by embedding 200 g of powder in 2000 mL of 96° ethanol, and in a hydro-ethanolic mixture (30/70, v/v), respectively. Qualitative phytochemical screening was performed. Minimum inhibitory and bacterial toxicity were determined by macro-dilution in liquid medium on Staphylococcus aureus, Salmonella sp, Shigella sp and Proteus mirabilis provided by the Laboratory of Hydrobiology and Environment of the Faculty of Sciences, University of Yaounde1 and the Bacteriology Laboratory of the Yaoundé University Teaching Hospital.Results: Phytochemical screening revealed the presence of polyphenols (flavonoids, and tannins), alkaloids, quinones, saponins and, cardiac glycosides. However, coumarins were absent in the two extracts. The minimum inhibitory concentrations of the extracts ranged from 25 to 100 mg/mL, and the minimum bactericidal concentrations from 25 to 200 mg/mL. The ethanolic extract was bactericidal against Proteus mirabilis and Staphylococcus aureus, but bacteriostatic against Salmonella sp and Shigella sp. The hydro-ethanolic extract was bacteriostatic against Shigella sp and bactericidal against the other strains.Conclusion: The groups of polyphenols, alkaloids, quinones, saponins and, cardiac glycosides contained in the two extracts can justify the antibacterial activity observed against Staphylococcus aureus, Salmonella sp, Shigella sp and Proteus mirabilis.","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"728 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85409453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronews: mobile application to support children with microcephaly","authors":"Lysandro Pinto Borges, Geyse do Espirito, Santo Rezende, Adicinéia Aparecida de Oliveira, Vicente Jose Santiago Costa Oliveira","doi":"10.15406/jabb.2021.08.00266","DOIUrl":"https://doi.org/10.15406/jabb.2021.08.00266","url":null,"abstract":"As for their parents, on the other hand, after receiving the diagnosis, they begin their journey in search of causal explanations and therapeutic responses for the diagnosis of SCZV and focus on daily care, consultations and therapeutic follow-up, always in search of well-being. of your child. In practice, mothers feel overwhelmed by having to divide themselves into multiple tasks, with the obligation to take care of the house, children, accompany the child in consultations and therapies.7","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89168304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a gene that makes a protein by using a cell free protein synthesis system","authors":"U. Masood","doi":"10.15406/jabb.2021.08.00264","DOIUrl":"https://doi.org/10.15406/jabb.2021.08.00264","url":null,"abstract":"A living cell could be genetically modified to perform a function such as the production of a protein. However, these genetic modifications often conflict with normal cellular function and result in a mutation. Defects can be overcome through removing the bacterial membrane which leaves the lysate that is performing both transcription and translation. The cell free-protein synthesis is also known as in vitro protein synthesis and is the production of a protein without using a living cell. The gene is acting as instructions to make the protein. If we can isolate a gene and then apply a cell free protein synthesis system after synthesis the protein and run on gel-electrophoresis we can identify a gene on the basis of the protein. Gel electrophoresis is a laboratory technique used to ______ contrasting proteins according to molecular size and charge.","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74717606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Azospirillum brasilense and mycorrhizal soil fungi on topinambur grown in a greenhouse","authors":"Diana Gabriela, Andrada Horacio, Batallán Morales Silvana, Espeche Acosta Eliana, Rizo Melisa, Del Valle Eleodoro, Brandán de Weht Celia","doi":"10.15406/jabb.2021.08.00261","DOIUrl":"https://doi.org/10.15406/jabb.2021.08.00261","url":null,"abstract":"To determine the effect of Azospirillum brasilense and soil mycorrhizal fungi on the nutrition of the Jerusalem artichoke crop (Helianthus tuberosus L.), evaluations of agronomic parameters and the health status of the plants were carried out, under greenhouse conditions. The tests were carried out, at the moment of the implantation of the culture: the tubers were inoculated with A. brasilense and with native mycorrhizal fungi, generating four treatments including the control and the co-inoculation of the consortium of the microorganisms under study (T0: control or control without inoculation; T1: inoculation with native A. brasilense; T2: inoculation with native mycorrhizal fungi and T3: joint inoculation with A. brasilense and native mycorrhizal fungi. The results indicate that co-inoculation with A. brasilense and with native mycorrhizal fungi increased plant growth in height, leaf area, biomass, dry matter, and yields significantly in greenhouse production. It was determined that the application of the selected microorganisms has a plant growth-promoting effect, increasing the productivity of cultivated topinambur in the greenhouse","PeriodicalId":15033,"journal":{"name":"Journal of Applied Biotechnology & Bioengineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84591789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}