Journal of Anesthesia and Perioperative Medicine最新文献_第4页

Combined Rifampin and Sulbactam Therapy for Multidrug-Resistant Acinetobacter Baumannii Ventilator-Associated Pneumonia in Pediatric Patients 利福平与舒巴坦联合治疗儿科患者鲍曼不动杆菌呼吸机相关多重耐药肺炎

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-07-01 DOI: 10.24015/JAPM.2018.0072

Jinlan Chen, Yifeng Yang, Kun Xiang, David Li, Hong Liu

{"title":"Combined Rifampin and Sulbactam Therapy for Multidrug-Resistant Acinetobacter Baumannii Ventilator-Associated Pneumonia in Pediatric Patients","authors":"Jinlan Chen, Yifeng Yang, Kun Xiang, David Li, Hong Liu","doi":"10.24015/JAPM.2018.0072","DOIUrl":"https://doi.org/10.24015/JAPM.2018.0072","url":null,"abstract":"Background: With essentially no drug available to control the infection caused by the extensively drug-resistant Acinetobacter baumannii (XDR-Ab) in infants and young children, this study explored the clinical outcomes of pediatric patients with drug-resistant XDR-Ab who were treated with rifampicin in combination with sulbactam sodium. Methods: The data for clinical outcomes, microbiological responses, and side effects were collected and evaluated for 12 critically ill infants and young children diagnosed with ventilator-associated pneumonia caused by XDR-Ab following surgical treatment for congenital heart disease in a pediatric cardiac intensive care unit. This study was approved by local institutional review board (IRB). Results: Two patients died from the complex underlining diseases. The other 10 patients were weaned off the mechanical ventilation successfully within 4–15 days after the start of treatment with rifampicin combined with sulbactam sodium and discharged home. Three cases experienced adverse side effects, including severe rash and elevated aminotransferase level. Conclusion: The combination of rifampicin and sulbactam sodium appeared to be an effective and safe therapy for severe ventilator-associated pneumonia caused by XDR-Ab in infants and young children. Side effects such as skin rashes and elevated aminotransferase levels can be reversed once rifampicin is discontinued in time. (Funded by the Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China; the Departments of Anesthesiology and Pain Medicine of University of California Davis Health; and the National Institutes of Health.)","PeriodicalId":15018,"journal":{"name":"Journal of Anesthesia and Perioperative Medicine","volume":"22 1","pages":"176 - 185"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79735585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cardiopulmonary Exercise Testing for Predicting Early Outcomes after Major Cancer Resection: A Systematic Review 心肺运动试验预测主要癌症切除术后早期预后:系统综述

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-05-29 DOI: 10.24015/JAPM.2018.anhuaiyu_3

S. Lam, A. Hart

{"title":"Cardiopulmonary Exercise Testing for Predicting Early Outcomes after Major Cancer Resection: A Systematic Review","authors":"S. Lam, A. Hart","doi":"10.24015/JAPM.2018.anhuaiyu_3","DOIUrl":"https://doi.org/10.24015/JAPM.2018.anhuaiyu_3","url":null,"abstract":"Background: Postoperative complications after major surgery are thought to be associated with reduced fitness. Surgical cancer patients are often malnourished, cachexic and subject to neoadjuvant chemotherapy resulting in low preoperative fitness levels. This review examined the associations between aerobic fitness, as determined objectively by preoperative cardiopulmonary exercise testing (CPEX), and short-term morbidity after cancer surgery. Methods: A literature search using databases of PubMed, Medline, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and the Cochrane Library for studies that examined associations between preoperative CPEX variables and postoperative complications following surgery for the ten commonest cancers. Results: A total of 21 observational studies were identified with 4957 patients that underwent CPEX testing prior to lung, colorectal, liver, oesophagogastric, bladder and pancreas resections. The median sample size was 105 patients (range 64 - 1684). No studies were found for breast or brain cancers or lymphoma. In lung cancer patients undergoing thoracotomy, a VO2peak ≤ 15ml/kg/min was associated with an increased risk of respiratory complications and death. None of the studies in other cancer types had adequate sample sizes to report on mortality. CPEX testing had mostly poor to average discriminatory accuracy to predict postoperative morbidity in other cancer resection surgeries. Findings across studies were inconsistent, and detection and selective reporting biases were likely to be significant. Conclusion: The utility of CPEX testing prior to cancer surgery is questionable and currently should not be used as a discriminatory tool, except in patients undergoing lung cancer resection by thoracotomy. Larger studies with more robust methodologies are currently required to determine the utility of CPEX.","PeriodicalId":15018,"journal":{"name":"Journal of Anesthesia and Perioperative Medicine","volume":"28 1","pages":"136-148"},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91232086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Anti-HMGB1 Antibody Decreases Surgery-Induced Upregulation of Necroptosis-Associated Proteins in Aged Rats 抗hmgb1抗体降低老年大鼠手术诱导的坏死相关蛋白上调

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-05-28 DOI: 10.24015/japm.2018.0050

Hongkang Zhou, Shuibing Zhang, Yuan Le, Jufang Huang, Jianbin Tong, W. Ouyang

{"title":"Anti-HMGB1 Antibody Decreases Surgery-Induced Upregulation of Necroptosis-Associated Proteins in Aged Rats","authors":"Hongkang Zhou, Shuibing Zhang, Yuan Le, Jufang Huang, Jianbin Tong, W. Ouyang","doi":"10.24015/japm.2018.0050","DOIUrl":"https://doi.org/10.24015/japm.2018.0050","url":null,"abstract":"the molecular mechanism on how systemic HMGB1 neutralization improves POCD is not fully elucidated. Necroptosis could cause sterile inflammation and negatively associates with the cognitive score in Alzheimer ’ s disease. Thus we detected the effects of anti-HMGB1 antibody on the necroptosis-associated protein expressions dur-ing the POCD of aged rats. under sevoflurane anesthesia and analgesia were performed. Immunoglobulin G (1 mg/kg) and HMGB1 neutralizing antibody (1 mg/kg) were injected via tail right before and 6 hours after surgery. The expression of necroptosis-associated proteins (HSP90, CDC37, and RIP3) in the prefrontal cortex of brain was detected by western blot and immunofluorescence. Oxidative stress was measured by dihydroethidium staining. Results: Systemic administration of anti-HMGB1 antibody decreased the levels of reactive oxygen species (ROS) and reduced the expression of HSP90, CDC37, and RIP3 in prefrontal cortex neurons of brains after surgery (P < 0.05, respectively). Moreover, acetylated HSP90 (ACHSP90) which is a negative regulator of necroptosis was significantly decreased by treatments of anti-HMGB1 neutralization antibody (P < 0.05). Conclusion: Systemic administration of anti-HMGB1 antibody may improve POCD through reducing reactive oxygen species and decreasing necroptosis in the prefrontal cortex of the aged brain. (Funded by the National Natural Science Foundation of China and Central South University Postdoctoral Foundation in Changsha, China.) ABSTRACT","PeriodicalId":15018,"journal":{"name":"Journal of Anesthesia and Perioperative Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79946489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Perioperative and Anesthetic Adverse Events in Thailand (PAAd THAI) Incident Reporting Study: Perioperative Oxygen Desaturation 泰国围手术期和麻醉不良事件(PAAd THAI)事件报告研究:围手术期氧饱和度

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-05-28 DOI: 10.24015/japm.2018.0051

P. Pin-on, Krit Panjasawatwong, Anantachote Vimuktanandana, W. Sriraj, Chuthamat Somchat, Dujduen Sriramatr

引用次数: 0

Anesthesia for Patients with Obstructive Jaundice 梗阻性黄疸患者的麻醉

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-05-28 DOI: 10.24015/JAPM.2018.0058

Yue Long, W. Mi, Weifeng Yu

引用次数: 1

Real-Time Ultrasound-Guided Paramedian Epidural Access Using a Paramedian Transverse Oblique Scan: A Prospective Case Series 实时超声引导下的辅助人员使用辅助人员横向斜位扫描硬膜外通路:前瞻性病例系列

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-03-28 DOI: 10.24015/JAPM.2018.0031

Yun Wang, Gengshi Wang, D. Ma, Huili Li

引用次数: 1

The Future of Ultrasound Education: A Medical Student’s Perspective 超声教育的未来:医学生的观点

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-03-28 DOI: 10.24015/JAPM.2018.0016

Brandon Wilson, M. Sharon, Joseph Minardi

引用次数: 0

Myocardial Strain: A Primer for Anesthesiologists 心肌应变:麻醉师入门

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-03-28 DOI: 10.24015/JAPM.2018.0032

C. Shi, Wenxi Tang, Zhuan Zhang, Jiapeng Huang

引用次数: 0

Perioperative Point-of-Care Ultrasound for the Anesthesiologist 麻醉医师的围手术期护理点超声

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-03-28 DOI: 10.24015/JAPM.2017.0090

S. Haskins, Ansara M. Vaz, S. Garvin

引用次数: 4

Perioperative Point-of-Care Ultrasound Training: A Survey of Anesthesia Academic Programs in United States and China 围手术期护理点超声训练:美国和中国麻醉学术项目的调查

Journal of Anesthesia and Perioperative Medicine Pub Date : 2018-03-28 DOI: 10.24015/japm.2018.0030

J. Cannon, Daniel C Sizemore, Yang Zhou, G. Mckelvey, Min Li, E. Chidiac, Xiang-yang Guo, A. Reynolds, Hong Wang

引用次数: 2