Anesthesia for Patients with Obstructive Jaundice

Abstract

including changes in blood biochemistry and metabolism, coagulation, infection, liver injury, renal dysfunction, cardiovascular instability, malnutrition, stress ulcer, bacterial translocation, immunosuppression and other adverse events, all of which may increase the mortality and morbidity during the perioperative period. The alterations in pharmacological proper-ties of many narcotic drugs caused by obstructive jaundice vary widely. And the require-ments of many anesthesia-related drugs, such as rocuronium, desflurane and etomidate, are reduced in patients with obstructive jaundice. Conclusion: Pathophysiological changes associated with obstructive jaundice need to be improved preoperatively. Anesthesiologists should be aware of the importance of rational use of narcotic drugs in patients with obstructive jaundice during operation. Multidisci-plinary collaboration is required for the treatment of such patients perioperatively. (Funded by the National Natural Science Foundation of China.) ABSTRACT