Journal of Advanced Pharmacy Research最新文献

{"title":"Validation of Symmetrical Two-Dose Parallel Line Assay Model for Nystatin Potency Determination in Pharmaceutical Product","authors":"M. Eissa, Engy R. Rashed, Daila Eissa","doi":"10.21608/aprh.2021.86555.1138","DOIUrl":"https://doi.org/10.21608/aprh.2021.86555.1138","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81294046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Lipoidal Matter Investigation of three Abutilon Species Aerial Parts","authors":"Nermine Mohammed, A. Kamal, M. Saleh, E. Haggag","doi":"10.21608/aprh.2021.84409.1136","DOIUrl":"https://doi.org/10.21608/aprh.2021.84409.1136","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89035761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIF-1α & NF-κB downregulation by S-Carvone mitigate hypoxia and inflammation in CoCl2 treated cells","authors":"D. Moustafa","doi":"10.21608/aprh.2021.85254.1137","DOIUrl":"https://doi.org/10.21608/aprh.2021.85254.1137","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81660751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in herbal-based nanomedicine for anti-inflammatory purposes","authors":"Y. Abo-Zeid, R. Diab, R. Sanad, Wedad Skran","doi":"10.21608/aprh.2021.79946.1135","DOIUrl":"https://doi.org/10.21608/aprh.2021.79946.1135","url":null,"abstract":"","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74908539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview on bacterial resistance and nanoparticles to overcome bacterial resistance","authors":"Y. Abo-Zeid, A. Amer, B. El-Houssieny, M. Mahmoud, W. Sakran","doi":"10.21608/aprh.2021.76488.1131","DOIUrl":"https://doi.org/10.21608/aprh.2021.76488.1131","url":null,"abstract":"Microbial infections have been the leading cause of death throughout history. This was changed when antibiotics were discovered, causing an increase in life expectancy from 48 years to 72 years. However, this golden era might end very soon. Bacteria have evolved resistance against antibiotics using different pathways. Therefore, restrictive policies about using antibiotics should be implemented by the healthcare system to prevent the further spread of bacterial resistance. However, these policies might not be enough without discovering or synthesizing new antibiotics. Antibiotics synthesis or discovery is a lengthy, tedious multistage process. Moreover, the development of bacterial resistance against any newly developed antibiotics takes around 10 years. Therefore, there is a need to find another strategy to retain the current available antibiotics activity against micro-organisms. Nanotechnology is a cutting-edge science that has been emerged few decades ago, it is concerned with producing fibers or particles in the nanometer scale. In literatures, nanoparticles were shown to improve the drug solubility, bioavailability, modify drug pharmacokinetics, increase drug stability, target drug into certain sites and moreover, were proven to overcome some developed resistance mechanisms against anticancer drug (e.g. Efflux mechanism). Recently, nanotechnology techniques have been applied to combat microbial infections and they were proven to be able to overcome the bacterial developing resistance mechanism.  In this review, we are presenting a historical background of antibiotics and discussing some bacterial developed resistance mechanisms as well as stating different nano-based formulations that were developed and proved to be effectively potentiate the antibiotic activity against some resistant micro-organisms.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74865841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of microbial recovery for some pharmaceutical raw materials and passive monitoring at production area and microbiology laboratory at Egyptian pharmaceutical company","authors":"M. Mohamed, M. Azab, A. Fouda, S. Hassan, Salah Abdelbary","doi":"10.21608/aprh.2021.72862.1127","DOIUrl":"https://doi.org/10.21608/aprh.2021.72862.1127","url":null,"abstract":"Objective: This study aims to evaluate the validity of pharmaceutical raw materials obtained from an Egyptian pharmaceutical factory to ensure the accuracy of the examination findings before they are used in the manufacturing process. On the other hand, it also aims to determine the environmental microbial count at the microbiology laboratory and production areas to prevent microbial contamination during production and during microbiological analysis. Methods: Assessment of microbiological quality control according to pharmacopeia as plate method by using TSB media with a concentration of 0.1% tween 80, for passive monitoring using settled plate (TSA) media. Results: the percentage of microbial recovery for lactose monohydrate was 89%, 85%, 94%, 92%, 91%, and 91%, while Croscarmellose recorded 81%, 85%, 85%, 85%, and 88%, Mannitol recorded 86%, 85%, 91%, 83%, 86%, and 88%, Magnesium stearate recorded 91%, 85%, 94%, 89%, and 91%, and finally, Talc Powder recorded 94%, 85%, 94%, 91%, 87% and 85% for Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli respectively for each pharmaceutical raw material. Methods of analysis recorded under acceptance criteria in the selected pharmaceutical factory according to pharmacopeia. On the other hand, the microbial quality of air for the production area selected by an Egyptian pharmaceutical company was under acceptance limits. Conclusion: All quality control methods and assessments of pharmaceutical raw materials, laboratories, and production areas must be performed to measure and control microbial contamination in the pharmaceutical industry and then produce high-quality pharmaceutical products free of microbial contamination, and methods of analysis must be recorded under acceptance criteria in the selected pharmaceutical factory according to pharmacopeia. On the other hand, the microbial quality of the air for the production area and microbiology laboratory that was selected by an Egyptian pharmaceutical company was under accepted limits. All quality control methods and assessments of pharmaceutical raw materials, laboratories, and production areas must be performed to measure and control microbial contamination in the pharmaceutical industry and then produce high-quality pharmaceutical products free of microbial contamination.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75743772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, In Silico and In Vitro Antimicrobial Evaluation of Cyanoketene S,N-Acetals and Their Pyrazoles Against Staphylococcus Aureus DNA Gyrase Enzyme","authors":"Shimaa M Ali, A. Faraag, Hossam R Elgiushy, Taghred Said, A. Askar, Ashraf S. Hassan, K. Abouzid, Sherif Fouad","doi":"10.21608/aprh.2021.76173.1130","DOIUrl":"https://doi.org/10.21608/aprh.2021.76173.1130","url":null,"abstract":"Objectives: The continuous reporting of bacterial resistance to antibiotics is an ongoing challenge that can be life-threatening. Actions to develop new chemicals to overcome the bacterial resistance has gained a significant importance. Methods: A series of ketene S,N-acetals 4a-k and their pyrazoles 6a-k were synthesized and their structures were established by spectral data. Membrane permeability predictions and in vitro antimicrobial activity against multi-drug resistant (MDR) Gram-positive bacteria and other microorganisms was determined. The binding affinity with DNA gyrase was assessed using in silico studies in comparison to ciprofloxacin then tthe gyrase inhibition assay was conducted to detect the mode of action. Results: All the synthesized compounds have a good affinity to pass through the phospholipid membrane of Staphylococcus aureus (S. aureus). Compound 6g exhibited the most potent antibacterial activity with MIC values ranged between 16 and 32 µg/mL. The compound also showed a higher binding affinity than ciprofloxacin with DNA gyrase in the in silico studies and this effect was clearly shown by a very good IC50 value of the gyrase inhibition assay. Conclusions: According to our data, compound 6g is a possible candidate to act against MDR bacteria and its main mode of action is through inhibition of the gyrase enzyme, further modifications are still required to enhance its activity.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75709404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the effect of Egyptian propolis on antimicrobial properties of glass ionomer cement","authors":"Yomna Elghazouly, A. Amer","doi":"10.21608/aprh.2021.74157.1128","DOIUrl":"https://doi.org/10.21608/aprh.2021.74157.1128","url":null,"abstract":"Background: Dental caries is a major concern to the dentist. Many bacterial subspecies are associated with caries, but Streptococcus mutans is still the most important bacterium in the initiation and progress of this disease. the direction toward natural products for medicinal purposes has gained much attention, as these natural products have proven to be effective with less toxic side effects. Studies have also shown other important properties in propolis such as antibacterial, antifungal, antiviral, anti-inflammatory, anesthetic, and ability to promote healing. Objective: To study the effect of propolis ethanolic extract (EEP) on enhancing the antimicrobial activity of glass ionomer cement (GIC). Methods: Two EEP 25% & 50% concentrations were evaluated for antimicrobial activity, in combination with GIC using agar Disk Diffusion test and broth microdilution test. Results: The diameter of the inhibition zone increased with 25% EEP & 50% EEP over the control by 14.4% and 19.6%, respectively. While increasing the concentration from 25% to 50% resulted in only 5% increase in the inhibition zone. MIC calculation for the three groups revealed, the combination of GIC and EEP has reduced the mic against Streptococcus mutans by two folds. Conclusion: The addition of propolis in different concentrations to GIC increased the antibacterial effect. 25% EEP gave the best antibacterial action with the lowest concentration.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80708937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Possible Effects of Green Coffee Bean Extract on Progression of Experimental Diabetes in Different Organs; A Review Article","authors":"D. Abdel Mohsen, Ahmed M. A. Akabawy, Ahmed Abdemoneim, Hatem K. Amin","doi":"10.21608/aprh.2021.77827.1133","DOIUrl":"https://doi.org/10.21608/aprh.2021.77827.1133","url":null,"abstract":"Green coffee bean water extract consumption has been stated to have a contrary association with type 2 diabetes and metabolic syndrome. Chlorogenic acid (CGA), an important biologically active dietary polyphenol, is produced by certain plant species and is a major component of coffee. Reduction in the risk of a variety of diseases following CGA consumption has been mentioned in recent basic and clinical research studies. This systematic review discusses in vivo animal and human studies of the physiological and biochemical effects of CGA on biomarkers of diabetic complication and the possible alterations produced by the administration of different doses of green coffee on biomarkers related to renal, testicular, and neurological antioxidant systems.","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75325448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids.","authors":"Hoda Elkafas,&nbsp;Osama Badary,&nbsp;Engy Elmorsy,&nbsp;Rehab Kamel,&nbsp;Qiwei Yang,&nbsp;Ayman Al-Hendy","doi":"10.21608/aprh.2021.66748.1124","DOIUrl":"https://doi.org/10.21608/aprh.2021.66748.1124","url":null,"abstract":"<p><p>Uterine fibroids (UFs) are the most prevalent gynecologic neoplasm, affecting 70-80% of women over their lifespan. Although UFs are benign they can become life-threatening and require invasive surgeries such as myomectomy and hysterectomy. Notwithstanding the significant negative influence UFs have on female reproductive health, very little is known about early events that initiate tumor development. Several risk factors for UFs have been identified including vitamin D deficiency, inflammation, DNA repair deficiency, and environmental exposures to endocrine-disrupting chemicals (EDCs). EDCs have come under scrutiny recently due to their role in UF development. Epidemiologic studies have found an association between increased risk for early UF diagnosis and <i>in utero</i> EDC exposure. Environmental exposure to EDCs during uterine development increases UF incidence in a UF animal model. Notably, several studies demonstrated that abnormal myometrial stem cells (MMSCs) are the cell origin for UFs development. Our recent studies demonstrated that early-life EDC exposure reprogrammed the MMSCs toward a pro-fibroid landscape and altered the DNA repair and inflammation pathways. Notably, Vitamin D3 (VITD3) as a natural compound shrank the UF growth concomitantly with the reversion of several abnormal biological pathways and ameliorated the developmental exposure-induced DNA damage and pro-inflammation pathway in primed MMSCs. This review highlights and emphasizes the importance of multiple pathway interactions in the context of hypovitaminosis D at the MMSCs level and provides proof-of-concept information that can help develop a safe, long-term, durable, and non-surgical therapeutic option for UFs.</p>","PeriodicalId":15017,"journal":{"name":"Journal of Advanced Pharmacy Research","volume":"5 2","pages":"260-275"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570385/pdf/nihms-1713991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39852111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}