Journal of Allergy and Clinical Immunology最新文献

{"title":"Impact Of Race on Baseline Asthma Severity and Response to Biologic Therapy in the First 12 Months Post Biologic Initiation","authors":"Monica Littlejohn PharmD, MHA , Autumn Zuckerman PharmD, BCPS, CSP , Katie Cruchelow PhD , Leena Choi PhD , Nicolas Gargurevich MS , Robert Lubwama , Richard Stanford , Caresse Campbell , Manny Nunez , Wei-Han Cheng , Natalia Petruski-Ivleva","doi":"10.1016/j.jaci.2024.12.078","DOIUrl":"10.1016/j.jaci.2024.12.078","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB23"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Atopic Comorbidities on Approval Time for Biologics in Patients with Moderate-to-Severe Asthma","authors":"Jin Ning Tian BS , Kateryna Karpoff BS , Aashna Pandya BA , Sunit Jariwala","doi":"10.1016/j.jaci.2024.12.081","DOIUrl":"10.1016/j.jaci.2024.12.081","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB24"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penicillin Allergy Labels in the Medical Record: Where Does Accurate Data Exist?","authors":"Samantha Novotny MD , Luke Legakis MD, PhD , Jane Liao MD , Katelyn Wong MD , Cosby Stone MD, MPH , Ami Belmont MD","doi":"10.1016/j.jaci.2024.12.041","DOIUrl":"10.1016/j.jaci.2024.12.041","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB12"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hypogammaglobulinemia in Large Myositis Cohort","authors":"Polly Huang MD , William Kelly BS , Julia Paik MD, MHS , Jemima Albayda MD , Christopher Mecoli MD, MHS , Brit Adler MD , Andrew Mammen MD, PhD , Antoine Azar MD , Lisa Christopher-Stine MD, MPH","doi":"10.1016/j.jaci.2024.12.096","DOIUrl":"10.1016/j.jaci.2024.12.096","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB29"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous Iron Reactions: Lessons For The Allergist","authors":"Jordon Jaggers MD , Cosby Stone MD, MPH , Matthew Krantz MD , Elizabeth Phillips MD, FAAAAI, FIDSA","doi":"10.1016/j.jaci.2024.12.024","DOIUrl":"10.1016/j.jaci.2024.12.024","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB6"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Value of Antibiotic Allergy Evaluations in a Pediatric Solid Organ Transplant Population","authors":"Jim Liu MD , Timothy Chow MD , Rory Nicolaides MD","doi":"10.1016/j.jaci.2024.12.043","DOIUrl":"10.1016/j.jaci.2024.12.043","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB12"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and trends of Carboplatin Allergy in Gynecological Malignancy Patients at a single tertiary hospital in Hong Kong","authors":"Gordon Kwok Ho Chu MBBS, MRCP , Philip Li","doi":"10.1016/j.jaci.2024.12.029","DOIUrl":"10.1016/j.jaci.2024.12.029","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB8"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Drug Allergies In Patients With Sickle Cell Disease","authors":"Vinh-an Vo MD , Renee Crawford DO , Sanjay Shah MD , Christine Rukasin MD","doi":"10.1016/j.jaci.2024.12.030","DOIUrl":"10.1016/j.jaci.2024.12.030","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Page AB8"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness of dupilumab in a European cohort of chronic rhinosinusitis with nasal polyps (CHRINOSOR)","authors":"Sven F. Seys PhD ,&nbsp;Sven Schneider MD, PhD ,&nbsp;Joost de Kinderen MBA, MSc, MA ,&nbsp;Sietze Reitsma MD, PhD ,&nbsp;Carlo Cavaliere MD, PhD ,&nbsp;Peter-Valentin Tomazic MD, PhD ,&nbsp;Christina Morgenstern PhD ,&nbsp;Geoffrey Mortuaire MD, PhD ,&nbsp;Martin Wagenmann MD, PhD ,&nbsp;Giulia Bettio MSc ,&nbsp;Andrea Ciofalo MD, PhD ,&nbsp;Zuzana Diamant MD, PhD ,&nbsp;Julia Eckl-Dorna MD, PhD ,&nbsp;Wytske J. Fokkens MD, PhD ,&nbsp;Clemens Holzmeister MD ,&nbsp;Gert Mariën MSc ,&nbsp;Simonetta Masieri MD, PhD ,&nbsp;Josje Otten MD ,&nbsp;Kathrin Scheckenbach MD ,&nbsp;Aldine Tu MSc ,&nbsp;Laura Van Gerven MD, PhD","doi":"10.1016/j.jaci.2024.10.016","DOIUrl":"10.1016/j.jaci.2024.10.016","url":null,"abstract":"<div><h3>Background</h3><div>Pivotal studies with dupilumab demonstrated clinically relevant improvements in nasal polyp score, symptom score, and quality-of-life score in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).</div></div><div><h3>Objective</h3><div>We evaluated the effectiveness of dupilumab in a large-scale CRSwNP cohort from 6 European tertiary-care centers.</div></div><div><h3>Methodology</h3><div>Nasal polyp score, Sinonasal Outcome Test 22 score, visual analog scale for total sinus symptoms, loss of smell, and nasal blockage, and Asthma Control Test (ACT) score were collected from hospital records and assessed at baseline and again at 24 and 52 weeks’ treatment with dupilumab in CRSwNP patients. Treatment effectiveness was evaluated in relation to demographic and lifestyle factors, sinus surgery history, presence of comorbidities, and blood eosinophil counts (BEC). Treatment response was evaluated according to European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) 2021 criteria.</div></div><div><h3>Results</h3><div>All patient outcomes improved at 24 and 52 weeks’ treatment compared to baseline. Dupilumab showed effectiveness independent of age, sex, body mass index, smoking status, prior sinus surgery, presence of asthma, nonsteroidal anti-inflammatory drug–exacerbated respiratory disease, allergy, or baseline BEC. A total of 92.5% and 94.4% showed an improvement in at least 1 EUFOREA criterion at 24 and 52 weeks, respectively; 54.4% and 68.2% met all 4 of the more stringent EUFOREA criteria at 24 and 52 weeks, respectively.</div></div><div><h3>Conclusions</h3><div>Real-world evaluation of dupilumab effectiveness demonstrates a robust and sustained response in at least two thirds of patients at 52 weeks’ treatment. Favorable treatment response was independent of the number of sinus surgery procedures, major comorbidities, or baseline systemic levels of type 2 inflammation.</div></div>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Pages 451-460"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel diagnostics in food allergy","authors":"Holly Boyd MBBS MSc ,&nbsp;Alexandra F. Santos MD, PhD","doi":"10.1016/j.jaci.2024.12.1071","DOIUrl":"10.1016/j.jaci.2024.12.1071","url":null,"abstract":"<div><div>Food allergy is increasing in prevalence, posing significant challenges for individuals and their families and adversely affecting their quality of life. Misdiagnosis can lead to unnecessary dietary and social limitations and increased food allergy risk, whereas failure to diagnose may result in life-threatening anaphylaxis. Therefore, a precise diagnosis is of the utmost importance; however, barriers exist at every stage of the diagnostic process. Diagnosis of food allergy relies on clinical history, IgE sensitization tests, and oral food challenge. Component testing and identification of optimal cutoffs have improved diagnostic accuracy. Nevertheless, many patients still require an oral food challenge, and better tests are needed to reduce this need. Novel ways of detecting biomarkers, such as the basophil activation test and peptide-specific IgE level, are transitioning into clinical practice. Future approaches may include the use of alternative biologic samples, novel laboratory technologies, and analytic tools (including artificial intelligence) to integrate test results and clinical information. Conscientious use of existing tests, access to tests with superior diagnostic accuracy, and combination of tests, can lead to improved precision of diagnosis of food allergy and timely introduction of tolerated foods into the diet. This review summarizes recent advances in novel approaches to food allergy diagnosis that can enhance clinical decision making both now and in the future.</div></div>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"155 2","pages":"Pages 275-285"},"PeriodicalIF":11.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}