Journal of Allergy and Clinical Immunology最新文献

{"title":"The 2025 AAAAI Foundation Faculty Development awardees.","authors":"Zuhair K Ballas","doi":"10.1016/j.jaci.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.009","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing in on epithelial barrier dysfunction in chronic rhinosinusitis.","authors":"Nora A Barrett","doi":"10.1016/j.jaci.2025.02.039","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.02.039","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Heterogeneity of Asthma: Decoding Subtypes of Asthma.","authors":"Anne L Fuhlbrigge, Sunita Sharma","doi":"10.1016/j.jaci.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.008","url":null,"abstract":"<p><p>Asthma is a heterogeneous disease with diverse underlying mechanisms contributing to disease susceptibility and progression. Asthma endotypes and phenotypes have emerged as critical frameworks to help understand the variation in disease presentation and response to therapies. Phenotypes are the observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment. Asthma endotypes are distinct subsets of asthma that are characterized by specific biological pathways, including differences in inflammatory pathways, genetic predisposition, and immune response. Identifying asthma endotypes and the associated clinical phenotypes are pivotal for the development of personalized treatment strategies, as it enables clinicians to select more effective therapies based on specific biological mechanisms. This review explores asthma endotypes and their associated phenotypes and the ongoing effort to refine diagnostic tools and therapeutic personalized approaches, aiming to improve outcomes for patients with asthma.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum.","authors":"","doi":"10.1016/j.jaci.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.002","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and mechanistic advancements in aspirin exacerbated respiratory disease.","authors":"Shabnam Elahi, Anju T Peters, Atsushi Kato, Whitney W Stevens","doi":"10.1016/j.jaci.2025.03.006","DOIUrl":"10.1016/j.jaci.2025.03.006","url":null,"abstract":"<p><p>Aspirin-exacerbated respiratory diseas e (AERD) is characterized by the clinical triad of chronic rhinosinusitis with nasal polyps, asthma, and a hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs). AERD is estimated to occur in as many as 15% of patients with chronic rhinosinusitis with nasal polyps and/or asthma. Uniquely, patients with AERD develop respiratory symptoms within 30 to 180 minutes after ingesting NSAIDs such as aspirin or ibuprofen. However, even in the absence of NSAIDs, patients tend to have more severe upper and lower respiratory disease. The underlying pathogenic mechanisms contributing to AERD are complex and intertwined; they include a systemic dysregulation in arachidonic acid metabolism, an aberrant inflammatory response, a disruption in the respiratory epithelial barrier, and an imbalance between the formation and degradation of fibrin locally in nasal polyps. This review will highlight novel mechanistic findings contributing to the pathogenesis of AERD. In addition, recent advancements in the clinical understanding and management of patients with AERD will be discussed.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRGPRX2 gain-of-function mutation drives enhanced mast cell reactivity in chronic spontaneous urticaria.","authors":"Dan Ye, Yuxin Zhang, Xi Zhao, Hongmei Zhou, Jiahua Guo, Mengyao Yang, Xinwu Niu, Xiaopeng Wang, Jingyi Yuan, Jianwen Ren, Songmei Geng, Weihui Zeng, Zhao Wang","doi":"10.1016/j.jaci.2025.03.007","DOIUrl":"10.1016/j.jaci.2025.03.007","url":null,"abstract":"<p><strong>Background: </strong>Mast cell (MC) activation plays a central role in the pathogenesis of chronic spontaneous urticaria (CSU). Mutations in MC receptors have been suggested as a potential mechanism underlying CSU. MRGPRX2 has been proposed to contribute to the pathogenesis of CSU. However, the relationship between mutations in MRGPRX2 and their impact on disease severity and receptor function remains poorly understood.</p><p><strong>Objective: </strong>We sought to investigate the prevalence and functional impact of MRGPRX2 mutations in CSU patients.</p><p><strong>Methods: </strong>The study included 80 patients with CSU. Peripheral blood was collected for DNA sequencing in the coding exon of MRGPRX2. Weekly Urticaria Activity Score and laboratory test results were recorded, and serum MRGPRX2 levels were measured by ELISA. RBL-2H3 cells were transfected with wild-type MRGPRX2 and mutant variants. Flow cytometry and immunofluorescence staining were used to assess MRGPRX2 cell surface expression. Functional assays were performed to measure degranulation by β-hexosaminidase release, calcium mobilization, and cytokine synthesis by quantitative RT-PCR. Additionally, phosphorylation of signaling kinases was detected by Western blotting.</p><p><strong>Results: </strong>Missense variants of MRGPRX2 185A>G (n = 8, 10%) and 185A>G+46A>C co-mutations (n = 23, 28.75%) were identified in patients with CSU. Patients carrying 185A>G mutation had a significantly higher weekly Urticaria Activity Score and lower circulating basophil and lymphocyte counts than patients with wild-type MRGPRX2. The 185A>G mutation, but not 185A>G+46A>C, was associated with increased MRGPRX2 expression in both patients with CSU and RBL-2H3 cells expressing the 185A>G mutation. Cells transfected with the 185A>G mutation demonstrated increased MC degranulation, calcium mobilization, cytokine synthesis, and extracellular signal-regulated kinase phosphorylation on MRGPRX2 activation, whereas the 46A>C+185A>G co-mutation did not show these changes.</p><p><strong>Conclusion: </strong>The 185A>G mutation in MRGPRX2 contributes to a gain-of-function phenotype that is associated with enhanced disease activity in patients with CSU.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating hypogammaglobulinemia after CD19 CAR T-cell therapy.","authors":"Pui-Ying Leong, Poi Kuo, James Cheng-Chung Wei","doi":"10.1016/j.jaci.2025.02.019","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.02.019","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IRF2BP2 Deficiency: An important form of common variable immunodeficiency with inflammation.","authors":"Chioma Udemgba, Bethany Pillay, Samantha Shafer, Angelika Alberstadt, Michael Abers, Olivier Gilliaux, Karin Chen, William Rae, Leif Hanitsch, Horst Von Bernuth, Joao Farela Neves, Nikita Raje, Leen Moens, P Martin van Hagen, Jenna Bergerson, Nicholas Hartog, Tim Niehues, Gregor Dückers, Emilia Falcone, Michael Keller, Amy Hsu, Isabelle Meyts, Steven M Holland","doi":"10.1016/j.jaci.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.02.038","url":null,"abstract":"<p><strong>Background: </strong>Interferon regulatory factor-2 binding protein-2 (IRF2BP2) is a transcription factor that plays an important role in regulating immune pathways, angiogenesis, apoptosis, and cell differentiation. Defects in this gene have been implicated in immunodeficiency.</p><p><strong>Objective: </strong>To deepen the understanding of the clinical implications of IRF2BP2 variants, we sought to clinically characterize and functionally test thirty-four individuals with IRF2BP2 variants.</p><p><strong>Methods: </strong>We collected 34 subjects across 18 families with mutations in IRF2BP2. Records were abstracted for clinical phenotypes. Functional testing was performed on peripheral blood mononuclear cells (PBMCs). Nuclear factor of activated T cells (NFAT) luciferase gene reporter constructs and quantitative cDNA determinations were used to evaluate repressor activity associated with ectopic expression of various IRF2BP2 mutant constructs in Jurkat cells.</p><p><strong>Results: </strong>Most subjects had immunodeficiency (91%, n = 30/33) with variable gastrointestinal (65%, n= 20/31) and inflammatory or autoimmune features (57%, n=17/30), including chronic abdominal pain, colitis, diarrhea, constipation, vitiligo, alopecia, and migratory rashes. There was a reduced frequency of memory B-cells with poor immunoglobulin production and reduced calcium flux in response to B-cell receptor stimuli. PBMCs had increased apoptosis in vitro compared to healthy controls. Impaired IRF2BP2 repression of NFAT activation was observed using patient-derived mutant IRF2BP2 constructs compared to wild-type. Similarly, TNF-α transcript levels were higher using patient-derived mutations compared to wild-type IRF2BP2 constructs.</p><p><strong>Conclusions: </strong>IRF2BP2 deficiency causes a complex immunodeficiency including gastrointestinal and inflammatory disorders as well as impaired B-cell maturation. Impaired repression of the NFAT pathway appears to enhance proinflammatory signaling through proinflammatory cytokine expression.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Chang-Gyu Jung, Seong Ho Cho","doi":"10.1016/j.jaci.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.02.010","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper airway comorbidities of asthma in patients with aspirin-exacerbated respiratory disease.","authors":"Piotr Szatkowski, Lucyna Mastalerz","doi":"10.1016/j.jaci.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.02.009","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}