Journal of Allergy and Clinical Immunology最新文献

{"title":"Epinephrine delivery devices: Pharmacokinetics and pharmacodynamics.","authors":"John M Kelso","doi":"10.1016/j.jaci.2025.03.030","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.030","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"91 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons from the clinical use of ex vivo T-lymphopoiesis assays.","authors":"Grace Evans,Zainab M Golwala,Juan Moises Ocampo-Godinez,Alexandra Y Kreins","doi":"10.1016/j.jaci.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.04.008","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"9 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the diagnosis of SCID through in vitro T-cell development: experience in two centers in North America.","authors":"Clara Soulard,Francesca Pala,Marita Bosticardo,Elie Haddad","doi":"10.1016/j.jaci.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.04.021","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"222 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective JAK1 inhibition remits multiorgan autoimmunity in a patient with refractory autoimmune polyendocrine syndrome type 1.","authors":"Yannis Hadjiyannis,Madison N Martinez,Joseph Pechacek,Ibrahim Abukhiran,Deanna Riley,Stefania Pittaluga,Elena M Morariu,Michail S Lionakis,David G Binion,Reed Van Deusen","doi":"10.1016/j.jaci.2025.03.026","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.026","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"1 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification of the efficacy of tezepelumab in the phase 2a COURSE trial.","authors":"Dave Singh,MeiLan K Han,Jean-Pierre Llanos,Neil Martin,Amit Parulekar,Konstantinos Kostikas,Sandhia S Ponnarambil","doi":"10.1016/j.jaci.2024.12.1086","DOIUrl":"https://doi.org/10.1016/j.jaci.2024.12.1086","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"32 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabotypes are linked to uncontrolled childhood asthma, gut microbiota, and systemic inflammation.","authors":"Mahmoud I Abdel-Aziz,Simone Hashimoto,Anne H Neerincx,Eric G Haarman,Alexander Cecil,Jutta Lintelmann,Michael Witting,Stefanie M Hauck,Nikki Kerssemakers,Joris C Verster,Corinna Bang,Andre Franke,Barbara S Dierdorp,Tamara Dekker,Nariman K A Metwally,Jan Willem Duitman,René Lutter,Mario Gorenjak,Antoaneta A Toncheva,Parastoo Kheiroddin,Susanne Harner,Susanne Brandstetter,Christine Wolff,Paula Corcuera-Elosegui,Leyre López-Fernández,Javier Perez-Garcia,Mario Martin Almeida,Olaia Sardón-Prado,Maria Pino-Yanes,Uroš Potočnik,Michael Kabesch,Susanne J H Vijverberg,Aletta D Kraneveld,Anke H Maitland-van der Zee,","doi":"10.1016/j.jaci.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.04.017","url":null,"abstract":"BACKGROUNDChildhood asthma has been linked to distinct metabolomic profiles.OBJECTIVETo identify phenotypes (metabotypes) in children with moderate-to-severe asthma through integrative fecal and serum metabolome analysis.METHODSChildren from the Systems Pharmacology Approach to Uncontrolled Pediatric Asthma cohort with Global Initiative for Asthma treatment step ≥3 were recruited. Asthma control was defined by the Asthma Control Test and annual exacerbation history. Targeted metabolomics profiling of feces and serum was performed using liquid chromatography and flow injection electrospray ionization-triple quadrupole mass spectrometry. Similarity Network Fusion integrated fecal and serum metabolome profiles, followed by spectral clustering. Clusters were analyzed for differences in asthma characteristics, food diaries, fecal microbiota composition, and levels of serum inflammatory markers and blood cells.RESULTSIntegrative fecal and serum metabolome analysis of 92 children with moderate-to-severe asthma (median age: 11.5 years, 34% female) revealed three metabotypes. Metabotype1 had the lowest percentage of allergic rhinitis, with elevated serum ceramides and triglycerides. Metabotype2 had higher odds of asthma control, the highest percentage of children with ≥4 months of breastfeeding, reduced sugar intake, lowest levels of blood neutrophils and serum inflammatory markers, and with elevated serum acylcarnitines and ω-3 fatty acids. Metabotype3 included the highest percentage of uncontrolled asthma patients, with decreased serum cholesteryl esters, phosphatidylcholines, and sphingomyelins, elevated fecal amino acids, and reduced fecal microbiota diversity.CONCLUSIONSMetabotypes in children with moderate-to-severe asthma are linked to asthma control, distinct fecal microbiota and systemic inflammatory patterns. The findings suggest that metabotyping can be valuable in precision medicine approaches for asthma.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"19 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converging Paths Towards Unified Therapeutic Approaches in Atopic Dermatitis, Vitiligo, and Alopecia Areata.","authors":"Lea Tordjman,Kayla D Mashoudy,Tali Czarnowicki","doi":"10.1016/j.jaci.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.04.016","url":null,"abstract":"Emerging evidence reveals significant epidemiological, genetic, and immunological connections between atopic dermatitis, vitiligo, and alopecia areata, challenging previously established notions of their distinct pathogenic and molecular signatures. Exploring these commonalities not only enhances our understanding of each disease's pathogenesis but also supports the development of unified treatment strategies for these frequently co-occurring disorders. This review examines key immune players shared across the three conditions, including cytokines, immune cells, and signaling pathways. Building on these insights, we also evaluate a range of therapeutic options-ranging from FDA-approved treatments to those currently in clinical trials-alongside proposed future therapeutic targets. This comprehensive approach aims to advance our management of these interconnected autoimmune and inflammatory disorders with greater precision. What do we know? •Atopic dermatitis, vitiligo, and alopecia areata share epidemiological overlap, with notable co-occurrence observed in patients across these conditions. •While distinct in their clinical presentations, these three conditions exhibit genetic and immunological overlap, such as shared cytokine axes dysregulation. •Targeted therapies, including various JAK inhibitors, have demonstrated efficacy across all three conditions, highlighting a potential for unified therapeutic strategies when these conditions co-occur. What is still unknown? •The role of converging cytokines and immune pathways in the development of atopic dermatitis, vitiligo, and alopecia areata is not yet fully understood. Understanding these intersections could pave the way for transformative advancements in managing these co-occurring diseases.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"16 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From \"one airway, one disease\" to \"one airway, many diseases\".","authors":"Jean Bousquet,Josep M Anto,Tari Haahtela,Bernardo Sousa-Pinto,Mario Morais-Almeida","doi":"10.1016/j.jaci.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.022","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"53 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing birth cohorts to decode asthma.","authors":"Andrea Apter,Tina Hartert","doi":"10.1016/j.jaci.2025.04.015","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.04.015","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"69 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of climate change on aerobiology, rhinitis, and allergen immunotherapy: Work Group Report from the Aerobiology, Rhinitis, Rhinosinusitis & Ocular Allergy, and Immunotherapy, Allergen Standardization & Allergy Diagnostics Committees of the American Academy of Allergy, Asthma & Immunology.","authors":"Tolly E G Epstein,Andrew C Rorie,German D Ramon,Anjeni Keswani,Jonathan Bernstein,Rosa Codina,Christopher Codispoti,Timothy Craig,Mark Dykewicz,Denisa Ferastraoaru,Daniel Katz,Jean Kim,Désirée Larenas-Linnemann,Anil Nanda,Anh Nguyen,Mahesh Padukudru Anand,Amber Patterson,Punita Ponda,Elina Toskala,Anita N Wasan","doi":"10.1016/j.jaci.2025.01.048","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.01.048","url":null,"abstract":"Climate change is imposing a profound effect on health conditions triggered by environmental exposures. Climate change has affected aeroallergens in numerous ways, including: (1) changes in the vegetation microbiome distribution, (2) increases in C4 grasses globally, (3) increased occurrence of acute weather events, (4) increases in ambient temperature that amplify fungal spore concentration and pollen season duration, and (5) increased allergenicity of pollen and fungi due to exposure to higher levels of carbon dioxide, ozone, and diesel exhaust particles. In addition, greenhouse gases and air pollutants disrupt the epithelial barrier, trigger eosinophilic inflammation, and serve as adjuvants that stimulate IgE-mediated responses. All of these factors have influenced the prevalence and morbidity of allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis. Data regarding changes in aeroallergen exposures due to climate change are lacking, and longitudinal sensitization data are rarely available. Allergists need to adapt diagnostic and treatment strategies to limit aeroallergen and air pollutant exposure and facilitate desensitization. Steps needed to address these challenges include: (1) expanding local measurement of pollen and fungal spores, (2) increasing the intensity of allergen avoidance measures, (3) addressing supply chain issues, and (4) promoting collaboration between allergists, insurance companies, aeroallergen manufacturers, and regulatory agencies.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"1 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}