Journal of Allergy and Clinical Immunology最新文献

{"title":"Maternal whole-food, plant-based nutrition: Implications for human milk composition and infant allergy risk.","authors":"Sonak Daulat","doi":"10.1016/j.jaci.2026.03.023","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.03.023","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Chantal C M den Elzen, Ariana Carvalho, Daniel P Potaczek, Holger Garn, Betty C A M van Esch","doi":"10.1016/j.jaci.2026.03.024","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.03.024","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA-B alleles confer susceptibility to sulfasalazine-induced severe cutaneous adverse reactions.","authors":"Chuang-Wei Wang, Wei-Ti Chen, Chun-Bing Chen, Chia-Yu Chu, Rosaline Chung-Yee Hui, Chun-Wei Lu, Tsu-Man Chiu, Shuen-Iu Hung, Huang Yu Huei, Wichittra Tassaneeyakul, Siew-Eng Choon, Nontaya Nakkam, Chonlaphat Sukasem, Yeong-Jian Jan Wu, Hsin-Yu Chung, Jr-Hau Lung, Jeng-Shou Chang, Yun-Shien Lee, Ya-Ching Chang, Kuang-Hui Yu, Yu-Chuan Teng, Shang-Hung Lin, Kuo-Chu Lai, Hsin-Han Hou, Jennifer Wu, Min-Hui Chi, Hua-En Lee, Yang Yu-Wei Lin, Yu-Jr Lin, Wen-Hung Chung","doi":"10.1016/j.jaci.2026.04.017","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.04.017","url":null,"abstract":"<p><strong>Background: </strong>Sulfasalazine is a disease-modifying antirheumatic drug used to treat arthritis and ankylosing spondylitis. However, it may cause life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms.</p><p><strong>Objective: </strong>Genetic predisposition to sulfasalazine-induced SCARs was assessed.</p><p><strong>Methods: </strong>This multicountry genetic study involved discovery, replication, and meta-analysis cohorts. The discovery cohort comprised 62 cases of sulfasalazine-induced SCARs and 75 sulfasalazine-tolerant subjects as well as 657 population controls from China and Taiwan who underwent whole-exome sequencing. The replication cohort comprised additional 17 cases and 2038 population controls from Taiwan who underwent HLA genotyping. The meta-analysis cohort comprised a total of 105 cases from Japan, Thailand, Malaysia, Taiwan, and China, together with 23,743 country-matched population controls. Functional immune mechanisms were explored with ex vivo lymphocyte activation assays.</p><p><strong>Results: </strong>In the discovery cohort, rs9266217 in HLA-B exhibited the strongest association. HLA genotyping in replication cohort and phenotype stratification found 4 HLA-B alleles that jointly yielded 84.8% sensitivity (P = 2.3 × 10^-24) in predicting sulfasalazine-induced SCARs in the Chinese population. Meta-analysis across 4 Asian countries confirmed significant associations for 3 alleles. Functional assays showed that sulfasalazine or its active metabolite, sulfapyridine, markedly increased granulysin release from CD8⁺ T cells of affected patients, supporting an HLA-restricted reaction.</p><p><strong>Conclusion: </strong>Multiple HLA-B alleles (B*39:01, B*13:01, and B*38:02) are strongly associated with sulfasalazine-induced SCARs in Asians.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond scale in food allergy genetics.","authors":"Leah Kottyan","doi":"10.1016/j.jaci.2026.04.019","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.04.019","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of rurality, child opportunity, and distance with use of pediatric asthma specialists.","authors":"James Bohnhoff, Anya Cutler, Elizabeth A Jacobs, Wanda Phipatanakul, Yvonne Jonk","doi":"10.1016/j.jaci.2026.04.020","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.04.020","url":null,"abstract":"<p><strong>Background: </strong>Receipt of asthma specialty care reduces children's asthma morbidity, but children living in rural, socioeconomically disadvantaged, and remote areas face potential barriers to accessing specialists.</p><p><strong>Objective: </strong>To evaluate the associations of rurality, Child Opportunity Index (COI), and distance with pediatric asthma specialist utilization among children with an indication for specialist referral.</p><p><strong>Methods: </strong>In this retrospective cohort study using 2015-2021 Maine Health Data Organization All-Payer Claims Data, we identified children (<18 years) with asthma and one of the following indications for specialist referral: a complicating comorbidity, higher-level controller medications, 3 or more courses of systemic corticosteroids within a year, or a respiratory hospitalization. We performed multivariate logistic regressions to calculate the adjusted associations between use of pediatric asthma specialists (physicians or advanced practice providers specializing in allergy-immunology or pediatric pulmonology) in the year after indication and children's rurality, COI, and driving time to specialists.</p><p><strong>Results: </strong>Among 12,014 children with indications for pediatric asthma specialist referral, 47% lived in micropolitan or rural areas and 15% lived over 1 hour from any specialist. 2,296 children (19%) utilized specialists within a year of their indication. In adjusted analyses, children were significantly less likely to utilize specialists if they lived in small town (aOR 0.54, 95% CI 1.09-1.39) or isolated small rural areas (aOR 0.82, 95% CI 0.71-0.94), areas with a COI less than \"very high\" (for \"very low\", aOR 0.65, 95% CI 0.56-0.75), or farther from specialists (aOR 0.62 per hour, 95% CI 0.57-0.68).</p><p><strong>Conclusion: </strong>Children in rural areas, in areas of low socioeconomic opportunity, and far from specialists are at an increased risk of not receiving indicated asthma specialist care.</p><p><strong>Clinical implications: </strong>Fewer children living in rural, remote, and socioeconomically disadvantaged areas received indicated pediatric asthma specialty care, highlighting the need for efforts to improve access among these populations.</p><p><strong>Capsule summary: </strong>In this review of statewide medical claims data only 19% of children with an indication for asthma specialty care utilized specialists within one year, with lower rates among rural, remote, and socioeconomically disadvantaged children.</p>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotypes of chronic spontaneous urticaria in children","authors":"Cristiana Indolfi MD ,&nbsp;Angela Klain MD ,&nbsp;Alessandra Perrotta MD,&nbsp;Giulio Dinardo MD,&nbsp;Carolina Grella MD,&nbsp;Michele Miraglia del Giudice Prof","doi":"10.1016/j.jaci.2025.11.015","DOIUrl":"10.1016/j.jaci.2025.11.015","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"157 5","pages":"Pages 1230-1231"},"PeriodicalIF":11.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internalizing sex differences in allergic disease: A sex-dependent airway epithelial immune network","authors":"Yayoi Tada MD, PhD,&nbsp;Masahiro Kamata MD, PhD","doi":"10.1016/j.jaci.2026.02.045","DOIUrl":"10.1016/j.jaci.2026.02.045","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"157 5","pages":"Pages 1028-1030"},"PeriodicalIF":11.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News & Notes-AAAAI","authors":"","doi":"10.1016/S0091-6749(26)00230-7","DOIUrl":"10.1016/S0091-6749(26)00230-7","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"157 5","pages":"Pages A24-A25"},"PeriodicalIF":11.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0091-6749(26)00229-0","DOIUrl":"10.1016/S0091-6749(26)00229-0","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"157 5","pages":"Page A23"},"PeriodicalIF":11.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome-wide association study of sex effects identifies sex-specific nasal epithelial gene expression profiles for total IgE","authors":"Molin Yue PhD ,&nbsp;Yidan Sun MS ,&nbsp;Yueh Ying Han PhD ,&nbsp;Glorisa Canino PhD ,&nbsp;Erick Forno MD, MPH, ATSF ,&nbsp;Judith M. Vonk PhD ,&nbsp;Elin T.G. Kersten MD, PhD ,&nbsp;Wei Chen PhD, ATSF ,&nbsp;Gerard H. Koppelman MD, PhD ,&nbsp;Juan C. Celedón MD, DrPH","doi":"10.1016/j.jaci.2025.12.1003","DOIUrl":"10.1016/j.jaci.2025.12.1003","url":null,"abstract":"<div><h3>Background</h3><div>Asthma is the most common chronic respiratory disease in children, with known sex differences in prevalence and severity that shift after puberty. Total IgE, a marker of type 2–high asthma, also differs by sex and age and may contribute to these disparities.</div></div><div><h3>Methods</h3><div>We tested whether nasal epithelial gene expression differs by sex and interacts with total IgE in ways that may inform asthma pathogenesis in a transcriptome-wide association study in nasal epithelial samples from participants in two cohorts: EVA-PR (including 398 Puerto Rican youths aged 12-20 years) and PIAMA (including 303 Dutch adolescents aged 16 years).</div></div><div><h3>Results</h3><div>Differential expression analysis by sex identified 406 genes at a false discovery rate–adjusted <em>P</em> value of &lt;.05, with 225 upregulated and 181 downregulated in female compared to male subjects. Top differentially expressed genes included hormone- and immune-related genes such as <em>THRB, IL17REL,</em> and <em>CD207</em>. Among these, 6 genes (<em>MNDA, IFIT1, IFIT2, SLC22A17, JAG2,</em> and <em>MT3</em>) showed significant sex-by-total IgE interaction effects on expression. Pathway enrichment analyses revealed that female subjects had activation of eukaryotic translation pathways (eg, <em>EIF2</em> signaling), while male subjects showed activation of immune-related pathways (eg, interferon signaling). Additionally, 19 pathways were enriched in the sex-by-IgE interaction model, including <em>TREM1</em> and cytokine storm signaling.</div></div><div><h3>Conclusions</h3><div>Our findings provide new insights into sex-specific regulation of gene expression in airway epithelium and its interaction with total IgE, helping to explain observed sex differences in asthma. This underscores the need to consider sex as a biological variable in asthma research and points to potential targets for precision medicine approaches.</div></div>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"157 5","pages":"Pages 1043-1051"},"PeriodicalIF":11.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}