Journal of Allergy and Clinical Immunology最新文献

Analysis of airway inflammation demonstrates a mechanism for T2-biologic failure in asthma. 气道炎症分析揭示了哮喘患者t2生物学功能衰竭的机制。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-29 DOI: 10.1016/j.jaci.2025.05.031

P Jane McDowell,Adnan Azim,John Busby,Sarah Diver,Freda Yang,Catherine Borg,Vanessa Brown,Rahul Shrimanker,Koirobi Haldar,Rekha Chaudhuri,Christopher E Brightling,Ian D Pavord,Peter Howarth,James Chalmers,Liam G Heaney,

{"title":"Analysis of airway inflammation demonstrates a mechanism for T2-biologic failure in asthma.","authors":"P Jane McDowell,Adnan Azim,John Busby,Sarah Diver,Freda Yang,Catherine Borg,Vanessa Brown,Rahul Shrimanker,Koirobi Haldar,Rekha Chaudhuri,Christopher E Brightling,Ian D Pavord,Peter Howarth,James Chalmers,Liam G Heaney,","doi":"10.1016/j.jaci.2025.05.031","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.05.031","url":null,"abstract":"BACKGROUNDTargeted T2 biologics have transformed asthma care, but the clinical response to biologic therapy varies between patients.OBJECTIVEAssess airways inflammation in T2-high asthma patients treated with anti-IL5 biologics to investigate if differential mechanisms of airway inflammation explains varied response to biologics.METHODSProteomic analysis (Olink®, 1463 protein panel) & high sensitivity cytokine analysis (ELISAs) were performed on induced sputum from T2-high, severe asthma patients in the UK multicentre Mepolizumab EXacerbation (MEX) study. Samples included were pre-mepolizumab (n=28), stable on mepolizumab (n= 43) & at first exacerbation (n=26).RESULTSClustering of sputum proteins while stable on mepolizumab identified two clusters. Cluster 1 had increased differentially expressed sputum proteins pre-mepolizumab, stable on mepolizumab & at exacerbation. Cluster 1 were younger at diagnosis, had a longer duration of asthma, lower FEV1% & higher ACQ5 on mepolizumab. Cluster 1 had increased expression of pro-inflammatory cytokines (IL1β, IL6, sIL6R), epithelial alarmins (TSLP, IL 33) and neutrophil activation (MPO, NE & Neutrophil extracellular trap (NET). All patients were T2-high with no difference in FeNO, eosinophil number or activity (EDN) across the two clusters.CONCLUSIONIn a cohort of T2-high severe asthma patients, a subgroup of patients with long duration of disease had worse clinical parameters, increased sputum proteins with increased markers of neutrophil activity, proinflammatory cytokines and epithelial alarmins even when stable on mepolizumab. This suggests the presence of biology not treated by targeted T2-biologics which may contribute to poorer outcomes on biologics and could be a treatable airways trait in severe asthma.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"26 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspectives and challenges of using AI in immunodeficiencies. 利用人工智能治疗免疫缺陷的当前观点和挑战。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-28 DOI: 10.1016/j.jaci.2025.06.015

Jacques G Rivière,Roser Cantenys Saba,Gerard Carot-Sans,Jordi Piera-Jiménez,Manish J Butte,Pere Soler-Palacín,Xiao P Peng

引用次数: 0

The 2024 Anaphylaxis Consensus Report: A New Jacket for a Known Disease to Boost Awareness and Standardization. 2024年过敏反应共识报告：为一种已知疾病提供新的外衣，以提高认识和标准化。

IF 11.4 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-24 DOI: 10.1016/j.jaci.2025.06.017

Dominique Bullens, Rik Schrijvers

引用次数: 0

The 2024 Anaphylaxis Consensus Report: A New Jacket for a Known Disease to Boost Awareness and Standardization. 2024年过敏反应共识报告：为一种已知疾病提供新的外衣，以提高认识和标准化。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-24 DOI: 10.1016/j.jaci.2025.06.017

Dominique Bullens,Rik Schrijvers

引用次数: 0

Comparison of an FDA-approved peanut oral immunotherapy product with peanut food products. fda批准的花生口服免疫疗法产品与花生食品产品的比较。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-24 DOI: 10.1016/j.jaci.2025.05.026

Thomas B Casale,Cosby A Stone,Martin D Chapman,Stephen A Tilles,Anne-Marie Irani,Jaime Sánchez-López,Thierry Batard,Laurent Mascarell

引用次数: 0

Collagen XXIII (COL23A1): A novel risk factor for eczema herpeticum. 胶原蛋白XXIII (COL23A1)：疱疹性湿疹的一个新的危险因素。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-23 DOI: 10.1016/j.jaci.2025.06.011

Shruti Chopra,Jana Zeitvogel,Stephan Traidl,Ilona Klug,Elke Rodriguez,Inken Harder,Wolfgang Lieb,Stephan Weidinger,Thomas F Schulz,Beate Sodeik,Katinka Döhner,Lennart M Roesner,Thomas Werfel

{"title":"Collagen XXIII (COL23A1): A novel risk factor for eczema herpeticum.","authors":"Shruti Chopra,Jana Zeitvogel,Stephan Traidl,Ilona Klug,Elke Rodriguez,Inken Harder,Wolfgang Lieb,Stephan Weidinger,Thomas F Schulz,Beate Sodeik,Katinka Döhner,Lennart M Roesner,Thomas Werfel","doi":"10.1016/j.jaci.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.06.011","url":null,"abstract":"BACKGROUNDEczema herpeticum (EH) is a potentially life-threatening disseminated skin infection caused by herpes simplex virus (HSV) in a subset of atopic dermatitis (AD) patients. The occurrence of EH in a subset of AD patients and its frequent recurrence imply the importance of genetic factors in its pathogenesis.OBJECTIVEWe aimed to identify novel genetic risk factors for EH and to study their impact on HSV-1 infection.METHODSUsing whole exome sequencing we identified a heterozygous single nucleotide polymorphism (SNP) in the COL23A1 gene (encoding Collagen type XXIII alpha 1 chain or COL23A1) that was associated with EH and validated it by PCR in a larger cohort. We studied the effect of upregulated COL23A1 expression on HSV-1 infection in primary keratinocytes and HaCaT cells and performed bulk RNA sequencing to address the underlying mechanism.RESULTSEH-patient-derived primary keratinocytes carrying this heterozygous SNP rs2973744 had elevated COL23A1 mRNA and protein levels as well as an increased susceptibility to HSV-1. Increasing the COL23A1 levels experimentally enhanced HSV-1 infection in human keratinocytes. COL23A1 overexpression elevated syndecan-1 and nectin-1 levels on the cell surface, which are HSV-1 attachment and entry factors, respectively, and downregulated genes involved in antiviral responses such as IL1R1, IL32, TLR4, IRF1, S100A9, C3, and CFH.CONCLUSIONThe SNP rs2973744 enhances COL23A1 expression in ADEH+-derived keratinocytes. Upregulation of COL23A1 promotes HSV-1 infection presumably by upregulating the HSV-1 attachment and entry factors syndecan-1 and nectin-1 on the cell surface and attenuating antiviral responses of keratinocytes.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"51 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Artificial Intelligence for Medical Education in Allergy and Immunology. 利用人工智能进行过敏和免疫学医学教育。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-23 DOI: 10.1016/j.jaci.2025.06.016

Saif Pasha,Calvin Harris,Cole Pieroni,Paneez Khoury

引用次数: 0

The crucial impact of NIH funding on allergy/immunology patient care and research. 美国国立卫生研究院资助对过敏/免疫学患者护理和研究的关键影响。

IF 11.4 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-23 DOI: 10.1016/j.jaci.2025.06.003

Nora A Barrett, Anna Nowak-Wegrzyn, Leonard B Bacharier, Priya Bansal, Lynda G Kabbash, Jordan S Orange, Paul V Williams, Frank S Virant, Carla M Davis, Rebecca Brandt, Thomas A Fleisher

引用次数: 0

Subclinical inflammation precedes atopic dermatitis relapses. 亚临床炎症先于特应性皮炎复发。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-23 DOI: 10.1016/j.jaci.2025.03.033

Benjamin Al,Nicholas Holzscheck,Stephan Traidl,Sina Freimooser,Lennart M Roesner,Hendrik Mießner,Oliver Dittrich-Breiholz,Hendrik Reuter,Thomas Werfel,Judith A Seidel

{"title":"Subclinical inflammation precedes atopic dermatitis relapses.","authors":"Benjamin Al,Nicholas Holzscheck,Stephan Traidl,Sina Freimooser,Lennart M Roesner,Hendrik Mießner,Oliver Dittrich-Breiholz,Hendrik Reuter,Thomas Werfel,Judith A Seidel","doi":"10.1016/j.jaci.2025.03.033","DOIUrl":"https://doi.org/10.1016/j.jaci.2025.03.033","url":null,"abstract":"BACKGROUNDAtopic dermatitis (AD), a widespread inflammatory skin disease, is characterized by disease recurrence, even after successful treatment. Past clinical research has mainly focused on understanding the active disease state as opposed to what drives and triggers AD relapses in the first place.OBJECTIVETo elucidate the unknown molecular mechanisms behind AD relapses.METHODSAn observational clinical study with patients in remission was conducted, comparing biopsies from skin that would relapse within the next weeks with skin that stayed in remission using single-cell-RNA sequencing and immunohistochemistry analyses.RESULTSSigns of subclinical inflammation were present in the clinically healthy appearing pre-relapse state. On the one hand, we detected molecular signals reminiscent of active AD, such as epidermal barrier dysregulation, chemokine signaling, increased vascular permeability and first signs of T cell activity and infiltration. On the other hand, we also observed signals for processes specific to the pre-relapse state, including epidermal growth factor receptor (EGFR) signaling and macrophage phagocytosis.CONCLUSIONTaken together, this work uncovers novel aspects of AD development, and putatively paves the way for new therapeutic approaches that are specifically designed to prevent AD recurrence.","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"51 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymic pioneers: Charting the origin, identity and fate of human thymus seeding progenitors. 胸腺先驱：绘制人类胸腺播种祖先的起源，身份和命运。

IF 14.2 1区医学

Journal of Allergy and Clinical Immunology Pub Date : 2025-06-23 DOI: 10.1016/j.jaci.2025.06.014

Kai Ling Liang,Lena Boehme,Silke Paepens,Maryam Hassan,Tom Taghon

引用次数: 0