Journal of Allergy and Clinical Immunology最新文献

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Accounting for seasonal variation of nasal gene expression improves transcriptome analysis of asthma 考虑鼻腔基因表达的季节性变化有助于哮喘的转录组分析
IF 14.2 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 DOI: 10.1016/j.jaci.2026.10.003
Tatiana Karp,Alen Faiz,Huib A.M. Kerstjens,Martijn C. Nawijn,Tessa E. Gillett,Yidan Sun,Elin T.G. Kersten,Judith M. Vonk,Hui Wen,Monica Kraft,Bianca Beghé,Klaus F. Rabe,Alessio Piraino,Alberto Papi,Chris E. Brightling,Dave Singh,Janwillem W.H. Kocks,Salman Siddiqui,Gerard H. Koppelman,Maarten van den Berge,Victor Guryev
{"title":"Accounting for seasonal variation of nasal gene expression improves transcriptome analysis of asthma","authors":"Tatiana Karp,Alen Faiz,Huib A.M. Kerstjens,Martijn C. Nawijn,Tessa E. Gillett,Yidan Sun,Elin T.G. Kersten,Judith M. Vonk,Hui Wen,Monica Kraft,Bianca Beghé,Klaus F. Rabe,Alessio Piraino,Alberto Papi,Chris E. Brightling,Dave Singh,Janwillem W.H. Kocks,Salman Siddiqui,Gerard H. Koppelman,Maarten van den Berge,Victor Guryev","doi":"10.1016/j.jaci.2026.10.003","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.10.003","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"1 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information for Readers 读者资讯
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-10-05 DOI: 10.1016/S0091-6749(26)00602-0
{"title":"Information for Readers","authors":"","doi":"10.1016/S0091-6749(26)00602-0","DOIUrl":"10.1016/S0091-6749(26)00602-0","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Page A20"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brief Overview of This Month's JACI 本月JACI的简要概述
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-10-05 DOI: 10.1016/S0091-6749(26)00598-1
{"title":"Brief Overview of This Month's JACI","authors":"","doi":"10.1016/S0091-6749(26)00598-1","DOIUrl":"10.1016/S0091-6749(26)00598-1","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Page A1"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrolides: An old antibiotic with new ambitions in asthma 大环内酯类:一种治疗哮喘的旧抗生素。
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-08-24 DOI: 10.1016/j.jaci.2026.08.010
Merritt L. Fajt MD
{"title":"Macrolides: An old antibiotic with new ambitions in asthma","authors":"Merritt L. Fajt MD","doi":"10.1016/j.jaci.2026.08.010","DOIUrl":"10.1016/j.jaci.2026.08.010","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 957-959"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human mast cells produce DHA-derived bioactive mediators: Resolvins D1, D2, and D4 人肥大细胞产生dha衍生的生物活性介质:分解蛋白D1、D2和D4。
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-07-29 DOI: 10.1016/j.jaci.2026.06.018
Tresa George MSc, Robert Nshimiyimana PhD, David Mankuta MD, MHA, Charles N. Serhan PhD, DSc, Francesca Levi-Schaffer PharmD, PhD
{"title":"Human mast cells produce DHA-derived bioactive mediators: Resolvins D1, D2, and D4","authors":"Tresa George MSc, Robert Nshimiyimana PhD, David Mankuta MD, MHA, Charles N. Serhan PhD, DSc, Francesca Levi-Schaffer PharmD, PhD","doi":"10.1016/j.jaci.2026.06.018","DOIUrl":"10.1016/j.jaci.2026.06.018","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1149-1152"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From CD20 to CD19: The shift from cautious to deeper B-cell depletion in autoimmune diseases 从CD20到CD19:自身免疫性疾病中b细胞从谨慎到深度消耗的转变
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-08-05 DOI: 10.1016/j.jaci.2026.07.015
Etienne Rivière MD, PhD, MA(Ed), Noémie Gensous MD, PhD, Pierre Duffau MD, PhD, Jean-François Viallard MD, PhD, Patrick Blanco MD, PhD, Claire Leibler MD, PhD, Estibaliz Lazaro MD, PhD
{"title":"From CD20 to CD19: The shift from cautious to deeper B-cell depletion in autoimmune diseases","authors":"Etienne Rivière MD, PhD, MA(Ed), Noémie Gensous MD, PhD, Pierre Duffau MD, PhD, Jean-François Viallard MD, PhD, Patrick Blanco MD, PhD, Claire Leibler MD, PhD, Estibaliz Lazaro MD, PhD","doi":"10.1016/j.jaci.2026.07.015","DOIUrl":"10.1016/j.jaci.2026.07.015","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 951-953"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of early-life cohort studies for understanding the origins of asthma and allergic diseases and the contribution of the NIAID 早期生活队列研究对了解哮喘和过敏性疾病起源的重要性以及NIAID的贡献。
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-08-10 DOI: 10.1016/j.jaci.2026.07.020
Patrice M. Becker MD, Patricia C. Fulkerson MD, PhD, Alkis Togias MD
{"title":"The importance of early-life cohort studies for understanding the origins of asthma and allergic diseases and the contribution of the NIAID","authors":"Patrice M. Becker MD, Patricia C. Fulkerson MD, PhD, Alkis Togias MD","doi":"10.1016/j.jaci.2026.07.020","DOIUrl":"10.1016/j.jaci.2026.07.020","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 954-956"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-macrophage cross talk in IL-33–driven type 2 lung inflammation: Advances, gaps, and future directions il -33驱动的2型肺部炎症中的血小板-巨噬细胞串扰:进展、差距和未来方向
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-08-20 DOI: 10.1016/j.jaci.2026.06.022
Isaac Kirubakaran Sundar PhD
{"title":"Platelet-macrophage cross talk in IL-33–driven type 2 lung inflammation: Advances, gaps, and future directions","authors":"Isaac Kirubakaran Sundar PhD","doi":"10.1016/j.jaci.2026.06.022","DOIUrl":"10.1016/j.jaci.2026.06.022","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1156-1157"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-trimester asthma controller medications and malformation risk: Bias, biologic plausibility, and unmeasured confounding 妊娠早期哮喘控制药物与畸形风险:偏倚、生物学合理性和未测量的混杂。
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-07-31 DOI: 10.1016/j.jaci.2026.06.024
Zhigang Hu MD, Xinyu Song MD, Fanjun Zeng MSC
{"title":"First-trimester asthma controller medications and malformation risk: Bias, biologic plausibility, and unmeasured confounding","authors":"Zhigang Hu MD, Xinyu Song MD, Fanjun Zeng MSC","doi":"10.1016/j.jaci.2026.06.024","DOIUrl":"10.1016/j.jaci.2026.06.024","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1158-1159"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of a chronic spontaneous urticaria–relevant IgE-mediated mouse model based on passive cutaneous anaphylaxis and its transcriptome analysis 基于被动皮肤过敏反应的慢性自发性荨麻疹相关ige介导小鼠模型的构建及其转录组分析。
IF 11.7 1区 医学
Journal of Allergy and Clinical Immunology Pub Date : 2026-10-01 Epub Date: 2026-07-31 DOI: 10.1016/j.jaci.2026.07.010
Yuqing Li MS, Yihui Chen PhD, Chunyan Li PhD, Rongjing Dong PhD, Jiao Zhang PhD, Siqi Liu PhD, Yurong Luo PhD, Yuqi Hu MS, Guannan Zhu PhD, Weining Huang PhD, Yunsheng Liang PhD, Lei Zhu PhD
{"title":"Construction of a chronic spontaneous urticaria–relevant IgE-mediated mouse model based on passive cutaneous anaphylaxis and its transcriptome analysis","authors":"Yuqing Li MS,&nbsp;Yihui Chen PhD,&nbsp;Chunyan Li PhD,&nbsp;Rongjing Dong PhD,&nbsp;Jiao Zhang PhD,&nbsp;Siqi Liu PhD,&nbsp;Yurong Luo PhD,&nbsp;Yuqi Hu MS,&nbsp;Guannan Zhu PhD,&nbsp;Weining Huang PhD,&nbsp;Yunsheng Liang PhD,&nbsp;Lei Zhu PhD","doi":"10.1016/j.jaci.2026.07.010","DOIUrl":"10.1016/j.jaci.2026.07.010","url":null,"abstract":"<div><h3>Background</h3><div>Chronic spontaneous urticaria (CSU) is a common immune-related skin disorder with an unclear pathogenesis and no universally accepted animal model. The passive cutaneous anaphylaxis (PCA) model is the commonly used model in CSU research.</div></div><div><h3>Methods</h3><div>To propose a modification to the PCA model to improve its alignment with CSU, we established a recurrent PCA (Re-PCA) model via 6 repeated injections of 2,4-dinitrophenyl–human serum albumin (DNP-HSA)-specific IgE and DNP-HSA and compared it to the PCA model. We assessed vascular permeability, scratch frequency scoring, histologic staining, flow cytometry, reverse transcription PCR, enzyme-linked immunosorbent assay, and RNA sequencing to compare phenotypic differences.</div></div><div><h3>Results</h3><div>The Re-PCA model exhibited more stable and significant skin changes associated with chronic urticaria compared to the PCA model. Lesional tissues of Re-PCA mice showed significantly increased degranulated mast cells and increased immune cell infiltration. Compared to the PCA group, peripheral blood histamine and tryptase levels of Re-PCA mice were significantly elevated. The utilization of histamine receptor blocker, c-Kit- and BTK-targeting drugs abrogated the phenotype of PCA and Re-PCA models. The gene expression profile of the Re-PCA lesions revealed enrichment of more genes and signaling pathways associated with CSU.</div></div><div><h3>Conclusions</h3><div>Our recurrent IgE-mediated mouse model exhibited greater immunologic and transcriptional relevance to CSU than the commonly used PCA model, which will facilitate research into the pathogenesis of CSU and advance our understanding of its underlying mechanisms.</div></div>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1032-1046"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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