Tatiana Karp,Alen Faiz,Huib A.M. Kerstjens,Martijn C. Nawijn,Tessa E. Gillett,Yidan Sun,Elin T.G. Kersten,Judith M. Vonk,Hui Wen,Monica Kraft,Bianca Beghé,Klaus F. Rabe,Alessio Piraino,Alberto Papi,Chris E. Brightling,Dave Singh,Janwillem W.H. Kocks,Salman Siddiqui,Gerard H. Koppelman,Maarten van den Berge,Victor Guryev
{"title":"Accounting for seasonal variation of nasal gene expression improves transcriptome analysis of asthma","authors":"Tatiana Karp,Alen Faiz,Huib A.M. Kerstjens,Martijn C. Nawijn,Tessa E. Gillett,Yidan Sun,Elin T.G. Kersten,Judith M. Vonk,Hui Wen,Monica Kraft,Bianca Beghé,Klaus F. Rabe,Alessio Piraino,Alberto Papi,Chris E. Brightling,Dave Singh,Janwillem W.H. Kocks,Salman Siddiqui,Gerard H. Koppelman,Maarten van den Berge,Victor Guryev","doi":"10.1016/j.jaci.2026.10.003","DOIUrl":"https://doi.org/10.1016/j.jaci.2026.10.003","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"1 1","pages":""},"PeriodicalIF":14.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Readers","authors":"","doi":"10.1016/S0091-6749(26)00602-0","DOIUrl":"10.1016/S0091-6749(26)00602-0","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Page A20"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brief Overview of This Month's JACI","authors":"","doi":"10.1016/S0091-6749(26)00598-1","DOIUrl":"10.1016/S0091-6749(26)00598-1","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Page A1"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Macrolides: An old antibiotic with new ambitions in asthma","authors":"Merritt L. Fajt MD","doi":"10.1016/j.jaci.2026.08.010","DOIUrl":"10.1016/j.jaci.2026.08.010","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 957-959"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrice M. Becker MD, Patricia C. Fulkerson MD, PhD, Alkis Togias MD
{"title":"The importance of early-life cohort studies for understanding the origins of asthma and allergic diseases and the contribution of the NIAID","authors":"Patrice M. Becker MD, Patricia C. Fulkerson MD, PhD, Alkis Togias MD","doi":"10.1016/j.jaci.2026.07.020","DOIUrl":"10.1016/j.jaci.2026.07.020","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 954-956"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Platelet-macrophage cross talk in IL-33–driven type 2 lung inflammation: Advances, gaps, and future directions","authors":"Isaac Kirubakaran Sundar PhD","doi":"10.1016/j.jaci.2026.06.022","DOIUrl":"10.1016/j.jaci.2026.06.022","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1156-1157"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First-trimester asthma controller medications and malformation risk: Bias, biologic plausibility, and unmeasured confounding","authors":"Zhigang Hu MD, Xinyu Song MD, Fanjun Zeng MSC","doi":"10.1016/j.jaci.2026.06.024","DOIUrl":"10.1016/j.jaci.2026.06.024","url":null,"abstract":"","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1158-1159"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuqing Li MS, Yihui Chen PhD, Chunyan Li PhD, Rongjing Dong PhD, Jiao Zhang PhD, Siqi Liu PhD, Yurong Luo PhD, Yuqi Hu MS, Guannan Zhu PhD, Weining Huang PhD, Yunsheng Liang PhD, Lei Zhu PhD
{"title":"Construction of a chronic spontaneous urticaria–relevant IgE-mediated mouse model based on passive cutaneous anaphylaxis and its transcriptome analysis","authors":"Yuqing Li MS, Yihui Chen PhD, Chunyan Li PhD, Rongjing Dong PhD, Jiao Zhang PhD, Siqi Liu PhD, Yurong Luo PhD, Yuqi Hu MS, Guannan Zhu PhD, Weining Huang PhD, Yunsheng Liang PhD, Lei Zhu PhD","doi":"10.1016/j.jaci.2026.07.010","DOIUrl":"10.1016/j.jaci.2026.07.010","url":null,"abstract":"<div><h3>Background</h3><div>Chronic spontaneous urticaria (CSU) is a common immune-related skin disorder with an unclear pathogenesis and no universally accepted animal model. The passive cutaneous anaphylaxis (PCA) model is the commonly used model in CSU research.</div></div><div><h3>Methods</h3><div>To propose a modification to the PCA model to improve its alignment with CSU, we established a recurrent PCA (Re-PCA) model via 6 repeated injections of 2,4-dinitrophenyl–human serum albumin (DNP-HSA)-specific IgE and DNP-HSA and compared it to the PCA model. We assessed vascular permeability, scratch frequency scoring, histologic staining, flow cytometry, reverse transcription PCR, enzyme-linked immunosorbent assay, and RNA sequencing to compare phenotypic differences.</div></div><div><h3>Results</h3><div>The Re-PCA model exhibited more stable and significant skin changes associated with chronic urticaria compared to the PCA model. Lesional tissues of Re-PCA mice showed significantly increased degranulated mast cells and increased immune cell infiltration. Compared to the PCA group, peripheral blood histamine and tryptase levels of Re-PCA mice were significantly elevated. The utilization of histamine receptor blocker, c-Kit- and BTK-targeting drugs abrogated the phenotype of PCA and Re-PCA models. The gene expression profile of the Re-PCA lesions revealed enrichment of more genes and signaling pathways associated with CSU.</div></div><div><h3>Conclusions</h3><div>Our recurrent IgE-mediated mouse model exhibited greater immunologic and transcriptional relevance to CSU than the commonly used PCA model, which will facilitate research into the pathogenesis of CSU and advance our understanding of its underlying mechanisms.</div></div>","PeriodicalId":14936,"journal":{"name":"Journal of Allergy and Clinical Immunology","volume":"158 4","pages":"Pages 1032-1046"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}