Journal of Advanced Scientific Research最新文献_第3页

A NEW RP-HPLC METHOD FOR ESTIMATION OF VERICIGUAT IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM 一种新的 RP-HPLC 方法用于估算散装药物和药物剂型中的 vericiguat

Journal of Advanced Scientific Research Pub Date : 2023-10-31 DOI: 10.55218/jasr.202314906

P. Pravalika, G. Jephthah, A. R. Reddy, T. R. Rao

引用次数: 0

APPLICATIONS OF GREEN CHEMISTRY PRINCIPLES IN TEXTILE WET PROCESSING 绿色化学原理在纺织品湿加工中的应用

Journal of Advanced Scientific Research Pub Date : 2023-10-31 DOI: 10.55218/jasr.202314901

Anjali Sehrawat

引用次数: 0

ANACYCLUS PYRETHRUM: A BRIEF OVERVIEW OF PHYTOCHEMISTRY, TRADITIONAL USES, AND POTENTIAL THERAPEUTIC PROPERTIES Anacyclus 除虫菊：植物化学、传统用途和潜在治疗特性概述

Journal of Advanced Scientific Research Pub Date : 2023-10-31 DOI: 10.55218/jasr.202314902

Vishal Thakur, Apoorva Pathania, Harmandeep Kour, Anu Radha Pathania

{"title":"ANACYCLUS PYRETHRUM: A BRIEF OVERVIEW OF PHYTOCHEMISTRY, TRADITIONAL USES, AND POTENTIAL THERAPEUTIC PROPERTIES","authors":"Vishal Thakur, Apoorva Pathania, Harmandeep Kour, Anu Radha Pathania","doi":"10.55218/jasr.202314902","DOIUrl":"https://doi.org/10.55218/jasr.202314902","url":null,"abstract":"Since ancient times, Anacyclus pyrethrum has been utilized as an aphrodisiac. In Ayurvedic medicine, the plant is used toboost libido and enhance sexual performance. Pyrethrins and anacyclins, among other plant substances, improve vaginalblood flow and sensation. It raises libido and promotes hormone synthesis. The plant is also claimed to have powerfulantioxidant qualities that enhance overall well-being. In addition to being used for its intended purpose, Anacycluspyrethrum is thought to provide potential health advantages. It functions as an oxygen inhibitor and has anti-inflammatoryqualities that might help in the fight against chronic illnesses, including cancer and heart disease. Additionally, someresearch has revealed that the herb may have neuroprotective qualities, making it a viable therapy for brain diseases likeAlzheimer's. The herb Anacyclus pyrethrum has a long history of use as a traditional medicine. It is a powerful naturalmedicine thanks to its aphrodisiac effects and oral health advantages. Additionally, the possible health advantages outsideof its regular use make for an intriguing research topic.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139309249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HISTOPATHOLOGICAL EFFECT OF CHLORPYRIFOS PESTICIDE ON LIVER AND KIDNEY OF FRESH WATER FISH CATLA CATLA 毒死蜱农药对淡水鱼鲶鱼肝脏和肾脏的组织病理学影响

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314809

K. U. Rani

{"title":"HISTOPATHOLOGICAL EFFECT OF CHLORPYRIFOS PESTICIDE ON LIVER AND KIDNEY OF FRESH WATER FISH CATLA CATLA","authors":"K. U. Rani","doi":"10.55218/jasr.202314809","DOIUrl":"https://doi.org/10.55218/jasr.202314809","url":null,"abstract":"All the natural water bodies are continuously being contaminated with toxic chemicals from industrial, agricultural and domestic activities. Chlorpyrifos is one of the most widely used organophosphate pesticides. Excessive application of pesticides from agricultural fields contaminate aquatic medium, resulting in serious damage to non-target species, including fish. The fish as a bioindicator of aquatic medium plays an important role in the monitoring of water pollution. Histopathology is an important tool for evaluating the action of any toxicant at tissue level. The focus of the present study is to measure the histological changes in liver and kidney of the fresh water fish Catla catla exposed to sub lethal concentrations of chlorpyrifos 1/15th of the 96 hour LC50 values for the period of 10 and 20 days. The fish exposed to chlorpyrifos showed mild vacuolar hepatocytes, dilation of central vein, vaculor degenerative changes, mild hyperaemia and severe hyperaemia of central vein in the liver tissue slide. The changes observed in kidney slide due to the impact of chlorpyrifos toxicity are hemorrhage, degenerative changes in between tubules, constriction of primary tubule, vacuolardegenerative changes, necrosis in epithelial lining of proximal tubules, chlorpyrifos compound induced.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ELTROMBOPAG OLAMINE IN BULK AND TABLET DOSAGE FORM 建立和验证可见分光光度法测定散剂和片剂中艾曲波帕乙醇胺的含量

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314808

Gangu Sreelatha, S. Rg, T. Harshana, Y. D. Spandana, Y. A. Reddy

引用次数: 0

Dr DEVELOPMENT OF POSACONAZOLE DELAYED RELEASE FORMULATION FOR MUCORMYCOSIS BY HOT MELT EXTRUSION USING QBD APPROACH 博士采用 QBD 方法开发用于治疗子宫肌瘤的泊沙那唑缓释制剂（HOT MELT EXTRUSION BY QBD APPROACH

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314805

Tisha Pandav, Tejal Devare, Pankaj Pant, Ashwin Mali

{"title":"Dr DEVELOPMENT OF POSACONAZOLE DELAYED RELEASE FORMULATION FOR MUCORMYCOSIS BY HOT MELT EXTRUSION USING QBD APPROACH","authors":"Tisha Pandav, Tejal Devare, Pankaj Pant, Ashwin Mali","doi":"10.55218/jasr.202314805","DOIUrl":"https://doi.org/10.55218/jasr.202314805","url":null,"abstract":"Amorphous solid dispersion (ASD) by hot-melt extrusion (HME) is an industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical actives. The creation of HME-based ASDs was significantly impacted by the implementation of Quality by Design (QbD). The objective of the study was to develop an ASD of posaconazole for the effective management of mucormycosis. The impact of change in levels of extra granular materials were identified as critical quality attributes (CQA's) for the development of delayed release tablet. A 23 full factorial design was employed to study the impact of independent variables HPMCAS (X1), HPC(X2) and CCS (X3) as CQA’s on the dependent variables such as hardness (Y1) and Disintegration Time (Y2) and % Drug release (Y3). The design was analyzed by using ANOVA by using MINITAB software. The influence of the extra granular components on the dissolution of tablet was closely evaluated while finalizing the optimized batch. The extrudes were also evaluated by FTIR, XRD and DSC analysis which confirmed the purity and in-situ conversion from crystalline to amorphous form ofthe drug. Systematic development of a bioavailable and stable ASD of posaconazole was achieved by studying the CQA’s at different levels by using the QbD and from the stability data, the optimized batch F4 was found to be stable up to 3 months at accelerated conditions40°C/75%Rh.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POSSIBLE REACTIONS ON COUMARIN MOLECULE 香豆素分子可能发生的反应

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314802

Suvarna S Bahiram, Santosh R Tambe, Swati Hatagale, S. K. Mahajan, K. Surana

引用次数: 0

SIGNIFICANCE OF EARLY DIAGNOSIS OF PSYCHIATRIC DISORDERS IN SLEEP APNEA PATIENTS 早期诊断睡眠呼吸暂停患者精神障碍的意义

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314801

Anwesha Banerjee, Divya Pandya, Arpita Maitra, Snehasish Basu, Ashish Rao, Priyanka Dausage

{"title":"SIGNIFICANCE OF EARLY DIAGNOSIS OF PSYCHIATRIC DISORDERS IN SLEEP APNEA PATIENTS","authors":"Anwesha Banerjee, Divya Pandya, Arpita Maitra, Snehasish Basu, Ashish Rao, Priyanka Dausage","doi":"10.55218/jasr.202314801","DOIUrl":"https://doi.org/10.55218/jasr.202314801","url":null,"abstract":"Obstructive Sleep Apnea (OSA) is a debilitating condition stemming from disruption to the respiratory system during sleep. At present, the nature of the relationship between OSA and mood, specifically depression and anxiety, is still unclear. The purpose of this paper is to shed some light on this relationship. There is an urgent need to better understand the roles of psychological illness in OSA. Well-designed longitudinal studies are needed to examine temporal relationships between the OSA, and psychological diseases and further research is needed to establish the role of confounders, and effect modifiers such as gender, in any apparent relationship. Sleep clinicians are advised to consider psychological diseases a likely cause of sleepiness and fatigue. Several possible causal mechanisms linking OSA, and depression have been proposed but not established. Patients who have depression as well as OSA appear worse off than those with OSA only, and depressive symptoms persist in at least some patients in short term studies of treatment forOSA. Direct treatment of psychological diseases in OSA might improve acceptance of therapy, reduce sleepiness, and fatigue and improve quality of life, but intervention trials are required to answer this question.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROLE OF COX-2 IN ORAL CANCER AND IN-SILICO DOCKING OF NATURAL FRAGMENTED AND DRUG BASED LIGANDS OF COX-2 FOR INHIBITION OF PROGRESSION OF ORAL CANCER COX-2 在口腔癌中的作用以及 COX-2 的天然片段和药物配体在抑制口腔癌进展方面的硅对接研究

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314807

Arpita Maitra, S. Das, R.R Paul, Mousumi Pal

{"title":"ROLE OF COX-2 IN ORAL CANCER AND IN-SILICO DOCKING OF NATURAL FRAGMENTED AND DRUG BASED LIGANDS OF COX-2 FOR INHIBITION OF PROGRESSION OF ORAL CANCER","authors":"Arpita Maitra, S. Das, R.R Paul, Mousumi Pal","doi":"10.55218/jasr.202314807","DOIUrl":"https://doi.org/10.55218/jasr.202314807","url":null,"abstract":"Oral cancer is known for its devastating effects which need to be addressed at the molecular level to achieve the best possible outcomes. An upsurge in the COX-2 levels amongst premalignant & malignant tissues may be attributed to increased transcription along with enhanced mRNA stability. Compelling research evidence is being shown with respect to complexes which have dual COX-2/COX-1 inhibitors are beneficial in chemotherapeutic procedures of cancer.Amongst 15 compounds, we found the highest binding capacity to be -10.9 in rutaecarpine as per the ADV webserver and -11.2 in VX-809 (Lumacaftor) as per the ProdigY webserver. Highest hydrophobicity was seen in OSR, LMR & ECG weighing 389.33, 452.41 & 458.37 with the most common amino acids being Leu (338), Ser (339), Val (509), Val (335). In respect to the molar refractivity, OSR & LMR presented with 92.01 & 113.98 values, whereas the lipophilisity was found to be 2.46 & 3.08 respectively with toxicity score (assessed by toxi M score & ProTox), being 0.929 & 0.944 by ToxiM score & 4 in both compounds by ProTox class.Characteristic properties such as the hydrophobicity, hydrophilicity, molecular weight, number of H-bond acceptors, Num of H-bond donors, molar refractivity, lipophilisity (ilogP), drug likeliness and toxicity score play an important role in understanding drug-drug interactions at the molecular level which helps in determining the pharmacological actions and its application in humans. Therefore, further research in the field is recommended to comprehend the drug reactions & their outcome.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMPACT OF HEMODIALYSIS ON HEALTH-RELATED QUALITY OF LIFE OF THE PATIENT 血液透析对患者健康相关生活质量的影响

Journal of Advanced Scientific Research Pub Date : 2023-10-02 DOI: 10.55218/jasr.202314803

B. Evangileen, Gundala Meenakshi, Jannu Umesh Kumar, Vemula Priyanka, G. Dhanalakshmi

引用次数: 0