ChemPlusChem最新文献

{"title":"Front Cover: Cyanines Substituted on the Polymethine Chain: Synthesis, Resulting Properties, and Application Use Cases (ChemPlusChem 12/2025)","authors":"Rebecca Strada,&nbsp;David Dunlop,&nbsp;Peter Šebej","doi":"10.1002/cplu.70091","DOIUrl":"https://doi.org/10.1002/cplu.70091","url":null,"abstract":"<p><b>Cyanines are versatile polymethine dyes</b> used in imaging, sensing, and photonics. Functionalizing their polymethine chain is a powerful yet underexplored way to modulate their properties. This review covers recent advances in chain-substituted cyanines, from synthesis to applications, highlighting how substituents on their polymethine chain affect their spectroscopic properties. More information can be found in the Review by Peter Šebej, Rebecca Strada, and David Dunlop (DOI: 10.1002/cplu.202500279).\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"90 12","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cplu.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring RNA G-Quadruplex Stability in the Gas Phase: Insights from Native Mass Spectrometry","authors":"Anna Ploner,&nbsp;Sarah Viola Heel,&nbsp;Kathrin Breuker","doi":"10.1002/cplu.202500679","DOIUrl":"10.1002/cplu.202500679","url":null,"abstract":"<p>Native mass spectrometry (MS) of ribonucleic acids (RNA) is a developing technique for the study of RNA structure and interactions that can provide important information on binding stoichiometry and binding motifs. However, the stabilities of key structural elements of RNA, including G-quadruplex structures, during and after desolvation are not well understood. Efforts to improve our understanding of RNA structures in the gas phase are complicated by the fact that the most common technique for transferring RNA from solution to the gas phase, electrospray ionization (ESI), typically produces ions with a relatively wide distribution of net charges. Here, we have studied two tetramolecular RNA G-quadruplexes with very different stabilities in solution by native MS. For both K⁺ and ⁺NH₄ as central cations, we found that the ratio of quadruplex to monomer ions in the ESI spectra was higher for the RNA G-quadruplex that exhibited higher stability in solution, regardless of ion net charge. These data for native MS of RNA in negative ion mode contrast with data from native MS of proteins in positive ion mode, for which lower and higher net charge is often associated with folded and unfolded structures, respectively. We next probed the stabilities of the gaseous RNA G-quadruplex ions using collisionally activated dissociation (CAD). For quadruplex ions with K⁺ as central cations, we observed a steady decrease in stability with increasing net charge, consistent with Coulombic repulsion weakening the hydrogen bonding networks and the interactions between the central cations and the nucleobases forming the central channel of the quadruplex. Importantly, for quadruplex ions with the same net charge and for both K⁺ and ⁺NH₄ as central cations, the RNA G-quadruplex that exhibited higher stability in solution also demonstrated higher stability in the gas phase. Furthermore, we demonstrate that for quadruplexes with lower net charge and K+ as central cations, covalent bond cleavage occurs at lower energies available for dissociation than strand separation.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electron Paramagnetic Resonance Detection of Singlet Oxygen: Opportunities and Pitfalls of Sterically Hindered Amine Trapping Agents","authors":"Chun-Yin Lau,&nbsp;Goutham Rangarajan,&nbsp;Rohit Pal,&nbsp;Ramin Farnood","doi":"10.1002/cplu.202500325","DOIUrl":"10.1002/cplu.202500325","url":null,"abstract":"<p>Singlet oxygen (¹O₂), a nonradical reactive oxygen species, has shown great potential for driving redox reactions. Electron paramagnetic resonance (EPR) spectroscopy has become a widely utilized tool for identifying the adducts formed by ¹O₂ with sterically hindered amines and indirectly determining the concentrations of ¹O₂. However, the characteristic 1:1:1 triplet EPR signal of ¹O₂ adduct can arise from other molecules and impurities. In this work, we demonstrate the presence of <i>N</i>-oxyl impurities in commercial 2,2,6,6-tetramethylpiperidine (TEMP) derivatives can lead to overestimation of ¹O₂ in redox systems. Additionally, the relatively low water solubility of TEMP may cause underestimation of ¹O₂ in aqueous media, while more soluble 4-substituted derivatives (4-amino, 4-oxo, and 4-hydroxy TEMP) undergo untargeted oxidation, forming products besides their corresponding <i>N</i>-oxyl derivatives. This study proposes vacuum distillation of TEMP to minimize paramagnetic impurities and recommend the combined use of EPR and mass spectrometry (MS) for accurate identification of <i>N</i>-oxyl adducts, particularly for 4-substituted TEMP in aqueous media. Our findings on the solubility and oxidation behavior of TEMP derivatives provide an improved and robust detection and quantification strategy of singlet oxygen (¹O₂) in aqueous environment.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12807558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and Theoretical Examination of DNA-Binding Properties of Ruthenium(II)–Hydrazine Complexes","authors":"Dušan Dimić,&nbsp;Aleksandra Rakić,&nbsp;Katarina Stojanović,&nbsp;Goran N. Kaluđerović,&nbsp;Jasmina Dimitrić Marković,&nbsp;Dejan Milenković","doi":"10.1002/cplu.202500399","DOIUrl":"10.1002/cplu.202500399","url":null,"abstract":"<p>The DNA-binding properties of four Ru^II–hydrazine complexes [{RuCl(η⁶-<i>p</i>-cymene)}₂(μ-Cl)(μ-L¹-κ²<i>N</i>,<i>N′</i>)]Cl (1, L¹: 3,4-dimethylphenylhydrazine) and [RuCl₂(<i>η</i>⁶-<i>p</i>-cymene)(L¹⁻³-κ<i>N</i>)] complexes (2, L¹; 3, L3: 3-chlorophenylhydrazine; 4, L³: 3-nitrophenylhydrazine) were explored through a combination of fluorescence spectroscopy, molecular docking, and Our own N-layered Integrated molecular Orbital and Molecular Mechanic (ONIOM)-based quantum mechanics/molecular mechanics (QM/MM) simulations. Ethidium bromide (EtBr) displacement assays revealed that all compounds interact with DNA, with calculated quenching constants (<i>K</i>_SV) ranging from 2.44 to 4.79 × 10⁴M. The results led to the conclusion that all complexes interact with DNA with similar strength, although subtle differences were explained by the present structural groups and molecular electrostatic potential (MEP) maps. The presence of nitro and chloro substituents was important for the weak interactions with DNA, leading to partial removal of EtBr. Computational studies supported the experimental findings. Molecular docking confirmed minor groove binding for all four complexes, with favorable interaction geometries and binding energies. Complex 3 stood out, with the most negative docking score (Δ<i>G</i>_bind = –38.2 kJ mol⁻¹). The docking simulations with RNA, triplex DNA/RNA, and quadruplex DNA/RNA additionally proved that the size of the complex and the presence of substituents were determinants of selectivity. Further refinement using ONIOM-based QM/MM calculations yielded interaction energies with DNA that matched previous results, identifying compound 3 as the most stable DNA-binding species (Δ<i>E</i> = –532.7 kJ mol⁻¹). The correlation between spectroscopic and theoretical results highlights the role of Ru^II-hydrazine ligand structure in modulating DNA affinity. Complex 3, bearing electron-donating hydrazine functionality and favorable spatial orientation, emerged as a promising candidate for further development in DNA-targeted therapies.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145712729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research and Industry for Human Health Enabled by Detergent Chemistry","authors":"Leonhard H. Urner","doi":"10.1002/cplu.202500690","DOIUrl":"10.1002/cplu.202500690","url":null,"abstract":"<p>Research and applications relevant to human health are enabled by detergent chemistry. A multifaceted overview of this field is yet missing. To close this gap, this topical collection provides an overview of recent advances in detergent chemistry covering progress in synthesis, supramolecular characterization, and application. Our collection shows that detergent chemists operate usually interdisciplinary. Connecting molecular structures of detergents with properties relevant to applications is at the center of scientific exploitation. Detergent chemists deliver solutions to research and industry that aim at securing well-being, hygiene, and new pharmaceuticals.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Luminescent Properties of Trifluoromethyl-Functionalized Biscyclometalated Gold(III) Complexes","authors":"Sandhya Verma,&nbsp;Brad Neimann,&nbsp;Kausala Mylvaganam,&nbsp;Koushik Venkatesan","doi":"10.1002/cplu.202500446","DOIUrl":"10.1002/cplu.202500446","url":null,"abstract":"<p>Gold(III) complexes have gained prominence as photofunctional materials due to their tunable photophysical properties and potential in advanced optoelectronic applications. While traditionally gold(III) complexes have been known to exhibit phosphorescence emission, recent advancements have revealed that gold(III) complexes can also display thermally activated delayed fluorescence (TADF), enabling near-unity internal quantum efficiencies and full exciton utilization. However, gold(III) biscyclometalated complexes incorporating trifluoromethyl groups and displaying TADF-type emission have been lacking. We report biscyclometalated gold(III) C^N^C complexes incorporating electron-withdrawing trifluoromethyl (CF₃) groups with TADF-type emission. Both aryl and alkynyl ligands were employed to investigate the balance between structural stability and donor–acceptor spatial separation. Detailed photophysical studies reveal TADF-type emission behavior in these complexes with quantum yields as high as 70% in solution with high radiative rates in the order of 10⁶ s⁻¹. These complexes exhibit promising photophysical properties suitable for high-efficiency organic light-emitting diode applications, providing valuable design strategies for next-generation TADF emitters based on gold(III) scaffolds.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroactive Copper–Cyanurate Coordination Polymer for Thiosulfate Monitoring in Biological Fluids","authors":"Muhammad Subhan,&nbsp;Muhammad Musharraf Naeem,&nbsp;Muhammad Farhan,&nbsp;Sadia Atta,&nbsp;Imran Shakir,&nbsp;Adeel Afzal","doi":"10.1002/cplu.202500564","DOIUrl":"10.1002/cplu.202500564","url":null,"abstract":"<p>The precise and noninvasive detection of thiosulfate, an essential antidote for cyanide poisoning, is critical for both clinical toxicology and environmental monitoring. In this work, the development of an electroactive copper–cyanurate (Cu–CYA) coordination polymer, engineered as a highly sensitive and selective electrochemical sensor for thiosulfate detection in biological fluids, is reported. The sensor material is synthesized via a straightforward coordination-driven self-assembly process, yielding a porous framework with abundant active sites, excellent redox properties, and superior electron transfer capability. Comprehensive physicochemical characterization confirms the structural integrity and favorable interfacial kinetics of the Cu–CYA/graphite pencil electrode (GPE) sensor. Cyclic voltammetry and differential pulse voltammetry analyses reveal a robust and linear response to thiosulfate concentrations ranging from 100 to 500 nM, with a remarkable sensitivity of 2.94 µA cm⁻² nM⁻¹ and an exceptionally low limit of detection of 0.32 nM. The sensor exhibits high selectivity against potential interferents and maintains 93.3% of its initial response after 30 days, underscoring its long-term functional reliability. Notably, real sample analysis using human saliva demonstrates a mean recovery of 97.5%, validating the sensor's practical applicability in complex biological matrices. This study establishes Cu–CYA as a powerful electrochemical sensing platform for thiosulfate monitoring, offering new prospects for portable diagnostics in healthcare and environmental safety.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Role of Calcium Ions in the Removal of Nanoplastics ( ̴607 nm) by Flocculation-Enhanced Sedimentation using Alginate","authors":"Anna Bastrzyk,&nbsp;Katarzyna Gołębiowska,&nbsp;Julia Wołoszyn,&nbsp;Barbara Mendrek,&nbsp;Anna Celny,&nbsp;Agnieszka Kowalczuk,&nbsp;Elżbieta Grządka","doi":"10.1002/cplu.202500609","DOIUrl":"10.1002/cplu.202500609","url":null,"abstract":"<p>The removal of nanoplastics (NPs) from aquatic environments remains a significant challenge due to their persistence and potential ecological risks. Flocculation, together with coagulation and sedimentation, is widely used as a phase-separation technique in industrial water treatment. In this study, alginate (ALG)-enhanced sedimentation of polystyrene (PS) NPs under varying CaCl₂ concentrations was investigated via turbidimetric analysis. The destabilization mechanism was assessed through floc morphology, zeta potential measurements, attenuated total reflectance-Fourier transform infrared spectra, and scanning electron microscope/energy-dispersive X-ray spectroscopy analysis. The rheological properties of ALG solutions in the presence of CaCl₂ were expressed as complex viscosity. To better simulate environmentally relevant conditions, we employed a novel PS-NP dispersion without commercial stabilizers. The results show that ALG effectively destabilizes the system at moderate and high coagulant ionic strengths, with an optimal dosage of 10 ppm ALG. Calcium ions can interact with ALG chains through the formation of intermolecular complexes. At the highest CaCl₂ concentration, changes in the system's rheological properties altered floc morphology and delayed sedimentation. This study highlights the potential of natural bioflocculants such as ALG for removing PS-NPs from calcium-rich waters and reducing reliance on synthetic coagulants.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanochemistry: A Transformative Technique for the Synthesis of Polar Organometallics from Zero-Valent Metals","authors":"Jagadeesh Varma Nallaparaju,&nbsp;Riina Aav,&nbsp;Dzmitry Kananovich","doi":"10.1002/cplu.202500445","DOIUrl":"10.1002/cplu.202500445","url":null,"abstract":"<p>The generation and synthetic applications of polar organometallic reagents have traditionally relied on organic solvents. Recently, mechanochemistry has emerged as a conceptually new approach in the field, using mechanical forces for the activation of bulk zero-valent metals and enabling a solvent-free or solvent-minimized synthesis of polar organometallics. This transformative approach brings several advantages over traditional methods, such as eliminating the need for strictly anhydrous conditions and inert atmospheres, removing solvent compatibility issues, and improving the reactivity profiles of polar organometallic reagents, thereby addressing long-standing challenges in the field. This concept article brings into focus the key developments in the mechanochemical generation of polar organometallics (derivatives of zinc, magnesium, calcium, barium, and lithium), highlighting the main advantages of this approach and emphasizing the current challenges.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioderived Reduced Graphene Oxide from Sterculia foetida for Efficient Adsorptive Dye Removal and Electrochemical Characterization","authors":"Mohammed Shamil O.,&nbsp;Muhammed Safeer Naduvil Kovilakath,&nbsp;Shanavas Yoosuf,&nbsp;Shalina Begum Tharayil,&nbsp;Mohammed Shibile,&nbsp;Shamshad Ashraf M. T.,&nbsp;Minza Maharoof,&nbsp;Nema M. Muhammed,&nbsp;Pranav P.,&nbsp;Shifana V.","doi":"10.1002/cplu.202500622","DOIUrl":"10.1002/cplu.202500622","url":null,"abstract":"<p>Pervasive use of dyes in industries leads to contamination of water, which results in potential hazards to humans and the environment. In contrast to photodegradation method, adsorption-based dye removal is considered an efficient and cost-effective way with no secondary environmental hazardous by-product. In the present study, environmentally benign method was used for preparation of reduced graphene oxide (rGO), an efficient adsorbent. A low-cost and facile method starting from biochar of <i>Sterculia foetida</i> was used for obtaining rGO nanosheet. Morphological, vibrational and structural transformation suggest possible transformation of biochar to rGO. Adsorption capacity studies of rGO using methylene blue (MB) reveal that rGO is a promising adsorbent. 0.2 mg mL⁻¹ of rGO marks 94.04% dye removal of 2.5 ppm MB solution. It follows pseudo-second-order kinetics depicting both physisorption and chemisorption. Further studies were also performed to investigate the electrochemical behavior of rGO for supercapacitor applications. The double-layer capacitance obtained for rGO (2.08 × 10⁻⁴ mF cm⁻²) is ∼1.5 times higher as compared to that of bare glassy carbon electrode (GCE: 1.37 × 10⁻⁴ mF cm⁻²). The higher adsorption of ions is the main reason for the enhanced double-layer capacitance of rGO.</p>","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":"91 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}