Journal of Advances in Medicine and Medical Research最新文献

{"title":"Determinants of Survival and Prognostic Factors in Patients with Prostate Cancer: A Retrospective Analysis (2009-2018)","authors":"Carla S. M. de Freitas, Amanda Damasceno de Souza, Fabiana Rocha-Silva, Thaís Almeida Marques-Silva, A. N. Soares","doi":"10.9734/jammr/2024/v36i55433","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55433","url":null,"abstract":"Objective: To evaluate prognostic factors and survival determinants of patients with prostate cancer (PC) admitted to an oncology hospital.\u0000Methods: Retrospective cohort study on 3,450 medical records of patients undergoing cancer treatment from 2009 to 2018, with follow-up until 2020, at the Center for High Complexity in Oncology (CACON), Muriaé, Minas Gerais, Brazil. Overall survival was estimated using the Kaplan-Meier method. For paired comparisons, the log-rank test was used. For multivariate analysis, the Cox Proportional Hazards method.\u0000Results: From 2009 to 2018, 3,450 patients with PC were identified; the predominant profile of multiracial men (45.9%), with an average age of 72 years, no family history of cancer (39.6%), clinical stage II (57.70%), low Gleason score <=6 (52 .7%) and PSA level <10 ng/ml (40.9%). The probability of survival was estimated at 36, 48, and 60 months. Longer survival was found in men aged <60 - 36 (95% CI: 97); 48 (95% CI: 96); 60 (95% CI: 96). Gleason score: <=6 - 36 (95% CI: 98); 48 (95% CI: 97); 60 (95% CI: 96). Stage I: 36 (95% CI: 99); 48 (95% CI: 99); 60 (95% CI: 99). Initial treatment – Radiotherapy: 36 (95% CI: 97); 48 (95% CI: 96); 60 (95% CI: 96). PSA: <10 (ng/ml) 36 (95% CI: 99); 48 (95% CI: 98); 60 (95% CI: 98).\u0000Conclusion: The individuals evaluated in this study had survival rates at 60 months higher than those observed in the national and world average for PC and prognostic factors, age >70 years, stage III and IV, elevated Gleason, and PSA >10 ng/ml. The results allow the use of new early diagnosis and treatment measures in the public network – Unified Health System (SUS), as well as proposing new control strategies and health promotion actions, aiming to reduce the morbidity and mortality of patients with PC.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Outcomes of Biologic Therapies for Fistulizing Crohn's Disease: A Systematic Review","authors":"Chidera Emmanuel Okezie, Angioshuye Asinde, Roshan Goswami, Clara C. Okpara, M. Goshe, Opeyemi Oluwatobi Bamikole, Tope Mwuese Anyiman, Chiedozie Steven Nzotta, Chiamaka Vivien Uzochukwu, Sajid Razaq, Khudija Nayab, Chidera Precious Chukwuneta, O. E. Chioma, Ifeyinwa Monica Oraekwute, Farzana Rahman","doi":"10.9734/jammr/2024/v36i55434","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55434","url":null,"abstract":"Background: Fistulizing Crohn's Disease (FCD) is a distinct and aggressive subset of Crohn's Disease, contributing to substantial morbidity, hospitalizations, and reduced patient well-being. The intricate interplay of factors influencing FCD outcomes warrants an in-depth exploration to refine patient care and therapeutic strategies. The aim of this paper is to conduct a comprehensive systematic review to critically evaluate the effectiveness, safety, and cost-effectiveness of biologic therapies and other interventions for FCD \u0000Methods: In line with the PRISMA Statement 2020 guidelines, we conducted a systematic review. We extensively searched databases including PubMed, Embase, and Cochrane Library, with the last search update on November 5, 2023. Studies evaluating FCD patients were examined, emphasizing the disease's clinical burden and influential parameters. Observational studies that underlined treatments and various FCD management strategies correlating with clinical outcomes were primarily considered for inclusion. \u0000Results: Beginning with an initial review of 438 studies, ten met the inclusion criteria and were incorporated into this systematic review. A total of 1122 patients were included. Spanning the years 2014–2022, the incorporated studies delve into diverse FCD treatment modalities. These range from the use of anti-TNF agents, surgical procedures, stem cell therapies, drug amalgamations, to intensifying dosing regimens. The synthesized findings from these studies carve out a progressively evolving treatment milieu for Crohn's disease, emphasizing the indispensability of individualized and empirically supported therapeutic avenues. \u0000Conclusion: FCD presents a formidable challenge in the realm of inflammatory bowel diseases, impacting patient outcomes. This review accentuates the pivotal nature of comprehensive care, early intervention, and addressing intricate disease mechanisms. The collated evidence highlights an imperative for innovative care modalities, targeted therapeutic endeavors, and tailored interventions to manage FCD more effectively and improve patient prognosis.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Cardiovascular Efficacy & Safety of NSAIDs: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Arhum Mahmood, Raheel Chaudhry, Mustafa M Moazam, Mohammed T. Zahee, Imdad Ullah","doi":"10.9734/jammr/2024/v36i55427","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55427","url":null,"abstract":"NSAIDs, or nonsteroidal anti-inflammatory medications, are popular and efficient analgesis and frequent mainstay treatements for inflammatory disorders. However, their cardiovascular safety is questionable. The aims of the current study were: (1) to evaluate the comparative cardiovascular efficacy of NSAIDs; (2) to investigate the cardiovascular safety and risks associated with NSAID use; (3) to highlight the importance of alternative therapies for patients who display contraindications to NSAID. A number of digital databases were explored to retrieve relevant studies. These consist of ClinicalTrials.gov, PubMed, Google Scholar, ScienceDirect, etc. The final sample consisted of 17 primary studies.A total of 12/17 (71%) studies advocated the efficacy and safety of NSAIDs. The remaining 2/17 (11%) showed that there was no discernible difference between the NSAID and non-NSAID groups in terms of mortality, cardio-respiratory morbidity, and cardiovascular risk. A forest plot was created using data from eight distinct studies. The results for the incidence of cardiovascular events were found to be statistically significant. The heterogeneity was calculated to be Tau2= 0.15; Chi2=117.67; df=6; I2=95%. The overall effect size was found to be Z=0.08 (p<0.94); the Hazard Ratio was found to be 0.84, CI=95% (CI, 0.72 = 0.98). Certain agents have a higher risk of causing unfavorable cardiovascular events, although other agents might have a safer profile. Clinicians must have this comprehensive knowledge to balance the therapeutic benefits of NSAIDs with any potential cardiovascular hazards when making judgments.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"47 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Cancer Screening in the Metropolitan Region I, State of Pará, Amazon: A Retrospective Ecological Study on Public Health in Pará","authors":"Thiago Augusto Ferreira dos Anjos, A. M. Monteiro, Kézia Dias Lopes, Raquel Gomes da Silva, Marcela Raíssa Asevedo Dergan","doi":"10.9734/jammr/2024/v36i55428","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55428","url":null,"abstract":"Objective: To analyze the coverage of cytopathological examination of the cervix in women between 25 and 64 years of age in Metropolitan Region I, State of Pará, from 2017 to 2021. Methodology: Secondary and public data, registered in the System, were extracted. Cancer Information, considering the historical series from 2017 to 2021.\u0000Results: A total of 150,424 uterine cervix exams were performed by women aged between 25 and 64 years. There was a variation in the offer of exams in the municipalities, with an increase in the years 2017, 2018 and 2019, while in the years 2020 and 2021, the numbers were reduced, without reaching the state goal agreed in most municipalities. Among the cytological changes in the exam, atypical ones in glandular cells predominated with 52.4%, followed by invasive squamous cell carcinoma with 31.1%. As for the type of intraepithelial lesion, a higher proportion of low-grade lesions was identified, with 82.5%.\u0000Conclusion: Weaknesses in Cervical Cancer (CC) screening may be correlated with low supply and demand for the test, as well as the unsatisfactory quality of the collected samples.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"39 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140700486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Dynamometric Variables of the Pelvic Floor Muscles Differ between Women with and without Stress Urinary Incontinence? A Blind, Cross-sectional Study","authors":"K. M. Amorim, Elora dos Santos Silva de Lima, Caroline Razera Ferreira, Alisson Monteiro de Freitas, Luis Eduardo Peixoto Rosa dos Santos, C. Amorim, D. Biasotto-Gonzalez, F. Politti","doi":"10.9734/jammr/2024/v36i55429","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55429","url":null,"abstract":"Objective: The aim of the present study was to compare pelvic floor muscles (PFM) contraction variables between women with and without stress urinary incontinence (SUI).\u0000Materials and Methods: This cross-sectional study evaluated the PFM of 17 healthy women and 17 women with SUI during a single test session using a vaginal dynamometer. Outcomes: peak time (time at which peak force occurred after the onset of contraction), passive force (baseline), maximum contraction force, impulse of contraction, average force and endurance time. Dada was recording during a single test session using a vaginal dynamometer.\u0000Results: The following PFM contraction variables were evaluated: Analysis of covariance (ANCOVA) with the Bonferroni post hoc test was used to compare the dynamometric data between groups (control and SUI), considering age and number of childbirths as co-variables. Significant difference was observed between groups with regard to endurance (F = 4.87, P < .03; ANCOVA test), whereas no significant differences were found for the other variables analyzed.\u0000Conclusion: The endurance time of PFM contraction is shorter in women with SUI, whereas variables related to the intensity of pelvic floor muscle contraction force and time from the onset to peak contraction of these muscles are similar between women with and without stress urinary incontinence.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"34 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the COVID-19 Pandemic on Oral and Maxillofacial Care in Health Units in Belém, Brazil","authors":"Gabriel Oliveira Aguiar Santos, Marilia Oliveira Coelho Dutra Leal, Renato Assis Machado, C. Jodas, A. Bachesk, R. G. Teixeira","doi":"10.9734/jammr/2024/v36i55430","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55430","url":null,"abstract":"Aims: This study aims to assess the influence of the pandemic on oral and maxillofacial surgical procedures in Dental Specialty Centers (CEOs) within the Metropolitan Region of Belém, Pará, Brazil.\u0000Study Design: A retrospective cross-sectional epidemiological investigation was conducted using a comparative statistical approach.\u0000Place and Duration of Study: Data from 2019 to 2020 on non-urgent surgical procedures in selected CEOs were collected from the DATASUS platform and compared to the number of confirmed COVID-19 cases in Belém, Pará\u0000Methodology: Descriptive statistics and inferential analyses, including ANOVA and t-tests, were used to evaluate the impact of the pandemic on the number of surgical procedures conducted.\u0000Results: The total number of patients treated at the CEOs in 2019 was 30,013, which decreased to 15,952 in 2020, resulting in a 46.8% reduction. The analysis showed that different CEOs exhibited varying trends in the number of procedures performed, with a significant association between the pandemic and procedure numbers. Most surgical procedures experienced a decline from 2019 to 2020. Still, specific procedures showed substantial increases, such as excision of skin and mucosal lesions, treatment of facial neuralgia, and drainage of abscesses in the mouth and appendages.\u0000Conclusion: The COVID-19 pandemic significantly impacted the oral and maxillofacial surgical procedures rate at Dental Specialty Centers in the Metropolitan Region of Belém, Pará, Brazil. While overall procedures decreased, specific non-urgent procedures demonstrated variations, influenced by the evolving pandemic and public health measures.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"43 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum Psychopathological Disorders","authors":"Y. Bouguermouh, F. Manseur","doi":"10.9734/jammr/2024/v36i55425","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55425","url":null,"abstract":"Pregnancy and the postpartum period are times of psychological vulnerability. The postpartum period is particularly prone to complications. The objective of this article is to provide an overview of psychopathological disorders during the postpartum period.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computerized Assessment of Readiness (Focos/Prontos System) and Its Multifactor Screening for Worker’s Fatigue and Productivity: A Case-Control and Cross-sectional Study","authors":"Marcela Souza Lima Paulo, Hebert Wilson Santos Cabral, Jade Kill, Wallysson Francis Soares, Me, Elisa Smith Barbiero Medeiros, Thais Costa Jesus, Alexandre Lemos","doi":"10.9734/jammr/2024/v36i55426","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55426","url":null,"abstract":"We present here a brief review of what has been published about fatigue, highlighting its multifactorial nature and the lack of objective markers that make it difficult to establish a consensus on measurement methods and present the Computerized Evaluation of Work Readiness (FOCOS/Prontos System), aiming to assess the correlation between the computerized assessment performance and signs of fatigue, using the Chalder instrument. The study applied the Chalder Fatigue Scale to 552 employees of a Brazilian mining company, with a final sample consisting of 334 individuals divided into a 'clinical group' (G1) with signs of fatigue and a 'control group' (G0) without fatigue. The study aimed to analyze readiness profiles between the clinical and control groups using statistical tests like the Mann-Whitney U-test and Welch's t-test, with significance set at p-value <0.05. Results showed significant differences in daily readiness, cognitive impacts, and risky behaviors before and after self-reporting fatigue. The Prontos System demonstrated predictive value for fatigue-related risks and accident prevention measures, highlighting its role in enhancing workplace safety and productivity. The study highlights the importance of daily and continuous fatigue assessment using the FOCOS/Prontos System to track signs of fatigue, as well as productivity. The system's multidimensional approach enriches fatigue prediction and classification accuracy. Integrating instruments enhances fatigue management, allowing for proactive intervention based on temporal analysis of readiness parameters and behaviors associated with fatigue. The study emphasizes the complexity of fatigue and its correlation with accidents, advocating for ongoing monitoring as a preventive and performance optimization strategy, thus promoting a safer and healthier work environment.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"96 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140707610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Pharmacy Students' Learning in Clinical Pharmacy During Internship","authors":"Jaqueline de Jesus Aschenbrenner, Camila Moraes Marques, Beatriz Essenfelder Borges, Maria Rosa Machado Prado","doi":"10.9734/jammr/2024/v36i55424","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55424","url":null,"abstract":"The internship is the moment when students experience professional practice in a real learning environment, providing the opportunity to acquire knowledge that was lacking during their undergraduate studies. The aim of this study was to assess the knowledge of clinical pharmacy among pharmacy students who had completed an internship in clinical pharmacy during their undergraduate studies. This research was carried out using a quasi-experimental methodology, in which the participants were 23 pharmacy students who had experienced an internship in clinical pharmacy. Data was collected using a questionnaire with answers based on the Likert® Scale, applied before the start of the internship and at the end of it. The variation between answers was the determining factor for the knowledge apprehension metric. From the results found, it was observed that the students increased their positive responses in relation to learning the proposed Clinical Pharmaceutical Services. There was a gain in knowledge during the internship period, demonstrating that this is a favorable resource for teaching clinical pharmacy.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140715493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spin Analysis in Randomized Clinical Trials of Physiotherapeutic Treatment for Temporomandibular Disorders: A Systematic Review Protocol","authors":"Lais Silva Ferreira, Luciana Cavalcante Urze Prado, Fernanda Cardoso Nakamoto, Alcylene Carla de Jesus dos Santos, Cid André Fidelis de Paula Gomes, F. Politti, D. Biasotto-Gonzalez","doi":"10.9734/jammr/2024/v36i55423","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i55423","url":null,"abstract":"Objective: To investigate whether clinical trials of physiotherapeutic interventions for treating temporomandibular disorders (TMD) contained spin and whether there was consistency between the abstract and the full text.\u0000Study Design:  Systematic Review Protocol. (PROSPERO ID: CRD42022369637)\u0000Methodology: Study selection and data extraction assessments were conducted independently and in duplicate. The sample will be composed of randomized controlled clinical trials of physiotherapeutic treatment for TMD as one of the treatments, regardless of whether it is muscular, articular, or mixed; and have at least pain and mandibular range of motion as outcome measures. Without language restriction, 2010 to 2025 is the year of publication, which allows a comparative analysis between the abstract and the full text. The analysis will be performed independently and in duplicate. In case of disagreement, a third reviewer will be consulted to reach a consensus through discussion. The electronic databases used were PubMed/Medline, EMBASE, CINAHL, CENTRAL, PEDro, SPORTDiscus, and LILACS. A search strategy developed for PubMed/Medline will be adapted for each database. Two checklists will be used to analyze the studies: Consolidated Standards of Reporting Trials (CONSORT) for abstract (CONSORT-A) to evaluate the completeness of reporting of the abstracts and the spin checklist to evaluate the presence and consistency of spin in abstract. The risk of bias was assessed using the PEDro scale independently and in duplicate.\u0000Results: The results will be presented in tables and flowcharts.\u0000Conclusion: Inconsistencies between the abstract and full text require investigation to alert clinicians, researchers, and readers.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"50 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140723550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}