Jornal de pediatria最新文献

{"title":"Lumbopelvic stabilization-based physiotherapy and rehabilitation and urotherapy for lower urinary tract dysfunction in Duchenne Muscular Dystrophy: a randomized controlled trial","authors":"Demet Öztürk ,&nbsp;Aynur Ayşe Karaduman ,&nbsp;Türkan Akbayrak","doi":"10.1016/j.jped.2026.101511","DOIUrl":"10.1016/j.jped.2026.101511","url":null,"abstract":"<div><h3>Objective</h3><div>This randomized controlled trial investigated the effectiveness of supervised lumbopelvic stabilization and urotherapy on factors associated with lower urinary tract symptoms in children with Duchenne Muscular Dystrophy and lower urinary tract dysfunction (LUTD).</div></div><div><h3>Method</h3><div>The study included 32 children aged 5–12 years, who were ambulatory and had a Dysfunctional Voiding and Incontinence Symptom Scale (DVISS) of 8.5 or higher. Lower urinary tract symptoms were assessed using the DVISS, a three-day bladder diary, and a nocturnal enuresis diary. Bowel symptoms were assessed with a seven-day bowel diary. Moreover, physical performance tests, the strength of pelvis-related muscle groups, and participation in activities of daily living were evaluated using validated measurement tools. Participants were randomized into two groups: the active control group (n:16, weight:25.81±9.53 kg, height:121.25±18.22 cm) received only urotherapy, while the treatment group (n:16, weight:25.88±9.67 kg, height: 122.69±16.63 cm) additionally performed lumbopelvic stabilization-based exercises for eight weeks under the supervision of a physiotherapist.</div></div><div><h3>Results</h3><div>Urotherapy significantly reduced LUTD severity (<em>p</em> &lt; 0.001), enuresis frequency (<em>p</em> = 0.014), and the number of symptoms associated with LUTD (<em>p</em> = 0.001). However, adding lumbopelvic stabilization exercises conferred no superiority over urotherapy alone (<em>p</em> &gt; 0.05). Supervised lumbopelvic stabilization improved functional mobility (<em>p</em> &lt; 0.003), muscle strength (<em>p</em> &lt; 0.05), and participation in activities of daily living (<em>p</em> &lt; 0.049). However, neither urotherapy nor lumbopelvic stabilization training had a significant effect on Gower’s time or daytime voiding frequency (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Both interventions were effective in improving bladder and bowel outcomes in children with Duchenne Muscular Dystrophy and LUTD, with no superiority observed on lower urinary tract symptoms.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101511"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary protein intake and asthma in US children and adolescents: a cross-sectional analysis of NHANES data","authors":"Lingyu Li,&nbsp;Peipei Tian,&nbsp;Yanmei Teng,&nbsp;Rui Wang,&nbsp;Mingxiao Zhang,&nbsp;Qiuyu Ma","doi":"10.1016/j.jped.2025.101495","DOIUrl":"10.1016/j.jped.2025.101495","url":null,"abstract":"<div><h3>Objective</h3><div>Evidence regarding total dietary protein intake remains inconsistent and limited for the US pediatric population. This study utilizes nationally representative data to examine the association between total dietary protein intake and asthma prevalence, thereby addressing this research gap.</div></div><div><h3>Method</h3><div>A cross-sectional study that involved 4825 people used data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The relationship between total protein intake and asthma was investigated using multiple linear regression models. The linear relationship between the two was tested using a restricted cubic spline. Stratified analysis further confirms the stability of the findings.</div></div><div><h3>Results</h3><div>All eligible participants (N = 4,825; mean age 10.6 ± 2.9 years; 49.7% male) were analyzed. The fully-adjusted model revealed a positive association between total protein consumption and asthma after controlling for confounders. Compared to the lowest intake quartile Q1 (≤ 3.966 mg/day), adjusted odds ratios for asthma in Q2 (3.967-6.364 mg/day) and Q3 (≥ 6.365 mg/day) were 0.097 (95%CI:0.97-1.44, p = 0.097) and 0.036 (95%CI:1.01-1.55, p = 0.036), respectively. A dose-response relationship (p = 0.037) emerged between total protein consumption and asthma risk.</div></div><div><h3>Conclusion</h3><div>Total dietary protein intake demonstrated a positive association with asthma among US children and adolescents. These findings are statistically significant.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 2","pages":"Article 101495"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical characteristics associated with enterovirus D68 respiratory diseases in Asian children: a systematic review and meta-analysis","authors":"Xiaojing Lu ,&nbsp;Bingbing Li ,&nbsp;Shufang Li ,&nbsp;Lihong Wang ,&nbsp;Guangen Guo ,&nbsp;Yanli Zhang ,&nbsp;Jiajia Duan ,&nbsp;Changlian Zhu","doi":"10.1016/j.jped.2025.101475","DOIUrl":"10.1016/j.jped.2025.101475","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to determine the epidemiology and clinical characteristics of EV-D68-associated respiratory diseases among Asian children.</div></div><div><h3>Sources</h3><div>The PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), VIP, WanFang, and SinoMed electronic databases were searched from inception to February 28, 2025, to identify relevant articles. Studies reporting the detection rate of enterovirus D68 (EV-D68) in pediatric patients with respiratory tract infections were included. The methodological quality regarding the risk of bias was assessed according to the approach proposed by the Joanna Briggs Institute.</div></div><div><h3>Summary of the findings</h3><div>Twenty studies involving 47,451 participants were included; additionally, 450 participants were positive for EV-D68 infection. The detection rate of EV-D68 ranged from 0.23 % to 10.56 %, with a pooled prevalence of 1.29 % (95 % CI 0.88–1.78 %), but significant heterogeneity (<em>I</em>² = 94.20 %, <em>p</em> &lt; 0.001) indicated that this estimate was context-dependent. Subgroup analyses revealed that detection rates varied substantially by country, study period, and income level. Pneumonia is the most common respiratory disease presentation. EV-D68 is most prevalent during the summer and autumn.</div></div><div><h3>Conclusion</h3><div>This is the first review to focus specifically on Asian children, which suggests that EV-D68 detection rates vary significantly across Asian populations and are especially influenced by geographic location and surveillance timing. EV-D68 infection in children is most frequently associated with pneumonia. These findings support targeted regional surveillance networks during the summer-autumn seasons to improve clinical diagnostics and public health responses.</div></div><div><h3>Trial Registration</h3><div>PROSPERO Identifier: CRD42023449889.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101475"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Precipice: continuous renal replacement therapy in critically Ill children with oncologic diseases","authors":"Shina Menon","doi":"10.1016/j.jped.2026.101505","DOIUrl":"10.1016/j.jped.2026.101505","url":null,"abstract":"","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101505"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U-shaped association between hemoglobin to red blood cell distribution width ratio and all-cause mortality among critically ill pediatric patients","authors":"Weichao He ,&nbsp;Jie Liu ,&nbsp;Rui Jiang ,&nbsp;Xinyu Yang ,&nbsp;Xujie Zhang ,&nbsp;Ruoyu Cao ,&nbsp;Zhenshui Hu ,&nbsp;Xiaolan Zhang ,&nbsp;Yan Gao","doi":"10.1016/j.jped.2025.101491","DOIUrl":"10.1016/j.jped.2025.101491","url":null,"abstract":"<div><h3>Objective</h3><div>The lower hemoglobin to red blood cell distribution width ratio (HRR) is associated with an increased risk of mortality in adult patients, but its relationship with clinical progress in the Pediatric Intensive Care Unit (PICU) is unclear. The authors aimed to investigate the association between HRR and all-cause mortality among pediatric patients.</div></div><div><h3>Methods</h3><div>The authors conducted a retrospective cohort study by analyzing the PIC database from 2010 to 2018.HRR was calculated based on laboratory tests conducted within the first 24 hours of PICU admission. The primary outcome was 28-day in-hospital all-cause mortality. Multivariable logistic regression models, restricted cubic spline, and threshold effects analysis were applied to assess the relationship between HRR and mortality in this cohort.</div></div><div><h3>Results</h3><div>A total of 8015 patients with an average age of the participants was1.5 (0.4, 4.8) years, and 3547 (44.3%) individuals were female. The 28-day in-hospital all-cause mortality was 4.1% (330/8015). The relationship between HRR and mortality was U-shaped, which had a threshold of around 8.91. The effect size on the left and right sides of the inflection point, was 0.803 (95% CI 0.742-0.869, p &lt; 0.001) and 1.421 (95% CI 1.159-1.743, p &lt; 0.001), respectively. No significant interactions were observed between HRR and all-cause mortality, except in patients with high lactate (p for interaction &gt; 0.05). The results of the sensitivity analysis remained stable.</div></div><div><h3>Conclusions</h3><div>There is a U-shaped relationship between HRR and 28-day in-hospital all-cause mortality in critically ill pediatric. With a lower mortality risk at an HRR of 8.91.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101491"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet quality in Brazilian adolescents with cystic fibrosis","authors":"Chiara Pascon ,&nbsp;Maria Angela Bellomo-Brandão ,&nbsp;José Dirceu Ribeiro ,&nbsp;Elizete Aparecida Lomazi","doi":"10.1016/j.jped.2025.101488","DOIUrl":"10.1016/j.jped.2025.101488","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the quality of the diet and its relationship with lung function and nutritional status in adolescents with cystic fibrosis (CF).</div></div><div><h3>Methods</h3><div>A questionnaire was applied to 47 adolescents (12–19 years old) followed at a university reference center. Lung function impairment was classified as mild (FEV1pp ≥ 60%), moderate (FEV1pp 41–59%), or severe (FEV1pp &lt; 40%) using spirometry. Food consumption frequency was classified as rarely, 1-2 times/week, 3-4 times/week, or ≥ 5 times/week. Linear regression analysis was used to model the relationship between lung function, BMI/age Z-score, and food frequency. Principal component analysis (PCA) was performed to identify patterns of diet quality.</div></div><div><h3>Results</h3><div>The mean BMI/age Z-score was -0.62. Approximately 60% of adolescents had FEV1 ≥ 60%, and 21% had severe impairment (FEV1 &lt; 40%). Better BMI/age Z-score was observed in groups with higher consumption frequencies of vegetables and fruit (≥ 5/week), white meat (&gt; 3-4/week), and oil (&gt; 3-4/week). Linear regression models identified significant relationships: BMI/age Z-Score = -3.25+ 0.8182*meat_b+0.5082*vegetables_fruit (p &lt; 0.001): Increased white meat, fruit, and vegetable consumption positively influenced the BMI/age Z-Score; lung function = 0.6927 + 0.3356*vegetables-0.2406*fruit_vegetables-0.4550*fast_food (p &lt; 0.001): Lower consumption of fruit and vegetables and higher fast-food intake were associated with more severe lung function; and lung function = 0.39376 -0.32345 *ZSCORE (p &lt; 0.0001): The BMI/age Z-Score positively influenced lung function. PCA confirmed the positive relationship between fruit, vegetables, and white meat consumption and BMI/age Z-score.</div></div><div><h3>Conclusion</h3><div>Higher consumption of fruit, vegetables, and meat has a positive influence on the BMI/age Z-score and lung function among adolescents with CF.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101488"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary recommendations for people with cystic fibrosis, a relevantly changing field","authors":"Jochen G. Mainz ,&nbsp;Carlos Zagoya","doi":"10.1016/j.jped.2026.101500","DOIUrl":"10.1016/j.jped.2026.101500","url":null,"abstract":"","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101500"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of continuous renal replacement therapy in critically ill children with cancer and multiple organ dysfunction syndrome","authors":"Fernanda P.L.F. Veiga ,&nbsp;Orlei R. Araujo ,&nbsp;Alessandra S. Araujo ,&nbsp;Marcela S. Bicalho ,&nbsp;Maria C. Andrade ,&nbsp;Dafne C.B. Silva","doi":"10.1016/j.jped.2025.101473","DOIUrl":"10.1016/j.jped.2025.101473","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the demographic and clinical characteristics of pediatric cancer patients receiving continuous renal replacement therapy (CRRT) and to analyze its effect on biochemical markers.</div></div><div><h3>Methods</h3><div>The authors conducted a cohort study of patients with multiple organ dysfunction syndrome (MODS) who received CRRT in a pediatric oncology intensive care unit. Biochemical measurements were compared at CRRT initiation (D0), after 72 h (D3), and during the final 72 h of therapy.</div></div><div><h3>Results</h3><div>Fifty-nine cases were analyzed. Hospital mortality was 67.7 %, and the median duration of CRRT was 9 days. Fluid overload was present in 51 % of patients; the mean KDIGO score was 2 (SD: 1). Mechanical ventilation was required in 79.7 %. Among survivors, significant improvements were observed in pH (mean 7.34 on D0 vs. 7.41 on D3; <em>p</em> = 0.012; effect size: 0.72) and bicarbonate (mean 22.17 on D0 vs. 27.1 on D3; <em>p</em> = 0.003; effect size: 0.77). In non-survivors, lactate levels increased over time (mean 2.3 on D0 vs. 5.37 on the last day; <em>p</em> = 0.03; effect size: 0.49). Generalized estimating equation models identified bicarbonate (OR: 0.05), pH (OR: 0.92), PCO₂ (OR: 176), and lactate (OR: 9.8) as significant predictors of in-hospital death. Logistic regression showed that mechanical ventilation (OR: 8.48) and fluid overload in the final 72 h (OR: 1.15) were associated with mortality.</div></div><div><h3>Conclusions</h3><div>While CRRT’s impact on mortality in MODS remains uncertain, it improved biochemical markers. The findings suggest that metabolic and lactic acidosis, fluid overload, and mechanical ventilation may be modifiable targets to reduce mortality.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101473"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early childhood blood pressure trajectories in very low birth weight offspring: is there a legacy of maternal hypertension?","authors":"Daiane de Oliveira Pereira Vergani ,&nbsp;José Mauro Madi ,&nbsp;Lucas Girotto de Aguiar ,&nbsp;Vitória Rovatti Canello ,&nbsp;Thiago Crocoli Balbinot ,&nbsp;Letícia Lorenzet ,&nbsp;Luciano da Silva Selistre ,&nbsp;Vandréa Carla de Souza","doi":"10.1016/j.jped.2025.101482","DOIUrl":"10.1016/j.jped.2025.101482","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between maternal hypertensive disorders of pregnancy (HDP) and blood pressure (BP) in preterm children born with very low birth weight (VLBW, &lt; 1500 g).</div></div><div><h3>Methods</h3><div>Longitudinal cohort study of VLBW preterm infants from birth to early childhood. Systolic and diastolic blood pressure (SBP and DBP), and their age-, height- and sex-adjusted percentiles (SBP%, DBP%), were assessed at multiple time points. Linear quantile mixed models estimated BP trajectories across the 25th, 50th, and 75th quantiles, stratified by maternal HDP exposure.</div></div><div><h3>Results</h3><div>Among 277 infants, 121 (43.6 %) were exposed to HDP. Median gestational age was 30 weeks (IQR: 28 - 32), and median birth weight was 1180 g (IQR: 985, 1340), 128 (46.2 %) were male. Maternal HDP was not significantly associated with SBP or DBP at any quantile. BP increased modestly with age across all quantiles. SBP increased by 0.06, 1.55, and 2.58 mmHg; DBP by 1.77, 1.80, and 3.06 mmHg at the 25th, 50th, and 75th quantiles, respectively. Conversely, SBP% and DBP% declined with age, indicating a relative downward shift in BP percentiles over time. This decline was more pronounced for DBP%, especially in the lower quantiles.</div></div><div><h3>Conclusion</h3><div>In this cohort of VLBW preterm children, maternal HDP was associated with modest differences in blood pressure, though not statistically significant. These findings suggest that the cardiovascular effects of prenatal hypertensive exposure may be delayed, subtle, or modulated by postnatal factors. Long-term follow-up is essential to clarify these trajectories and guide early prevention efforts.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101482"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145700931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Children with autism spectrum disorder and alterations in eating behavior: could it be gastroesophageal reflux disease?","authors":"Christine Audet de Almeida ,&nbsp;Eduardo Sampaio Siqueira ,&nbsp;Marcelo do Rego Maciel Souto Maior ,&nbsp;Kátia Galeão Brandt","doi":"10.1016/j.jped.2025.101487","DOIUrl":"10.1016/j.jped.2025.101487","url":null,"abstract":"<div><h3>Objective</h3><div>Describe the occurrence of warning signs of gastroesophageal reflux disease (GERD) and esophagitis in children with eating behavior (EB) alterations associated with autism spectrum disorder (ASD).</div></div><div><h3>Method</h3><div>Descriptive study of 115 children aged 3 to 12 years, followed at a tertiary hospital and previously diagnosed with ASD. The BRCA-TEA instrument was applied to identify children with EB alterations, and the 17-ATN-GISSI instrument was applied to identify those with warning signs of GERD. The selected children were invited for a medical consultation to identify those with suspected esophagitis and an indication for upper gastrointestinal (GI) endoscopy with biopsies.</div></div><div><h3>Results</h3><div>Sixty-nine children (60 %) were classified with alterations in the EB and, among these, 62 (89.8 %) presented warning signs of GERD. Eighteen children had suspected esophagitis and an indication for upper GI endoscopy. Among the 8 children who underwent the exam, 1 child had grade A erosive esophagitis, 1 child had grade B erosive esophagitis, and 1 child had eosinophilic esophagitis.</div></div><div><h3>Conclusion</h3><div>A high frequency of EB alterations was found in children with ASD. The high frequency of GERD warning signs may be related to EB alterations in this group. Cases of esophagitis highlight the possibility of an organic disease. In these cases, performing upper GI endoscopy with biopsies is essential for diagnosis.</div></div>","PeriodicalId":14867,"journal":{"name":"Jornal de pediatria","volume":"102 1","pages":"Article 101487"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145700991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}