Japanese journal of toxicology and environmental health最新文献_第3页

Genotoxicity of 2-Amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) in Drosophila melanogaster and Enhancement of DNA Damaging Activity by Pretreatment with β-Naphthoflavone and Ethanol 2-氨基-1-甲基-6-苯咪唑[4,5 -b]吡啶(PhIP)对黑腹果蝇的遗传毒性及β-萘黄酮和乙醇预处理对DNA损伤活性的增强

Japanese journal of toxicology and environmental health Pub Date : 1998-02-28 DOI: 10.1248/JHS1956.44.34

T. Kasai, Takeshi Kitamura, Yukoh Takahashi, A. Mondo, T. Hirayama, Tetsushi Watanabe

引用次数: 0

Remodeling of Vascular Endothelial Glycocalyx by Basic Fibroblast Growth Factor (Proceedings of the 23rd Symposium on Toxicology and Environmental Health) 碱性成纤维细胞生长因子重塑血管内皮糖萼(第23届毒理学与环境卫生学术研讨会论文集)

Japanese journal of toxicology and environmental health Pub Date : 1998-02-28 DOI: 10.1248/JHS1956.44.P30

T. Kaji, A. Miyamoto, S. Miyajima, C. Yamamoto, Y. Fujiwara, F. Koizumi

引用次数: 0

Effect of P450-Inducers on the Hepatotoxicity of 2-Hexenal on the Leakage of Lactate Dehydrogenase from Primary Cultured Rat Hepatocytes p450诱导剂对2-己烯醛对原代培养大鼠肝细胞乳酸脱氢酶渗漏肝毒性的影响

Japanese journal of toxicology and environmental health Pub Date : 1997-12-31 DOI: 10.1248/JHS1956.43.331

T. Hirayama, A. Yoshikawa, T. Kasai, Tetsushi Watanabe, S. Ogawa

{"title":"Effect of P450-Inducers on the Hepatotoxicity of 2-Hexenal on the Leakage of Lactate Dehydrogenase from Primary Cultured Rat Hepatocytes","authors":"T. Hirayama, A. Yoshikawa, T. Kasai, Tetsushi Watanabe, S. Ogawa","doi":"10.1248/JHS1956.43.331","DOIUrl":"https://doi.org/10.1248/JHS1956.43.331","url":null,"abstract":"We have already reported the effect of several carbonyl compounds such as alkanals, 2-alkenals, glyoxals and malondialdehyde, which are formed from oxidized lipids, on the leakage of hepatic enzymes from primary cultured rat hepatocytes. In the case of 2-alkenals, the leakage of lactate dehydrogenase (LDH) took place in a dose-dependent manner and the hepatotoxicity was inhibited by the addition of ascorbic acid and glutathione. In this paper, we investigated the effects of P450-inducers on the hepatotoxicity of 2-hexenal, since the hepatotoxicity of 0.5 mM 2-hexenal against untreated hepatocytes was reduced to 36.7% and 46.3% by the addition of 10μM cimetidine and 1μM α-naphthoflavone, respectively. 3-Methylcholanthrene (MC), phenobarbital (PB), β-naphthoflavone (NF) and dexamethasone (DEX) were used as P450-inducers. In the treatment with 0.5 mM 2-hexenal, the LDH leakage of 3-MC induced hepatocytes was enhanced to 1.4-fold that of non-induced hepatocytes. In the 3-MC induced hepatocytes, the hepatotoxicity of 0.5 mM 2-hexenal was reduced to 38% with α-NF (0.1 μM). Therefore, it is suggested that 2-hexenal is metabolized to hepatotoxic substances by microsomal CYP 1A2 species.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"31 1","pages":"331-335"},"PeriodicalIF":0.0,"publicationDate":"1997-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73360856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Characteristics of N-Alkyl-2-alkylthiopyridinium and N-Alkyl-4-alkylthiopyridinium Salts n -烷基-2-烷基硫代吡啶和n -烷基-4-烷基硫代吡啶盐的抗菌特性

Japanese journal of toxicology and environmental health Pub Date : 1997-10-31 DOI: 10.1248/JHS1956.43.251

K. Okazaki, T. Maeda, H. Nagamune, H. Kourai

{"title":"Antibacterial Characteristics of N-Alkyl-2-alkylthiopyridinium and N-Alkyl-4-alkylthiopyridinium Salts","authors":"K. Okazaki, T. Maeda, H. Nagamune, H. Kourai","doi":"10.1248/JHS1956.43.251","DOIUrl":"https://doi.org/10.1248/JHS1956.43.251","url":null,"abstract":"N-Alkyl-2-alkylthiopyridinium (2TPX-n : X=I or Br, n=6-18) and N-alkyl-4-alkylthiopyridinium salts (4TPX-n), which have an electron-releasing group on the pyridine ring, were synthesized. Both 2TPBr-12 and 4TPBr-12 showed a wide and potent bactericidal spectrum of activity against Gram-negative bacteria (9 strains) and Gram-positive bacteria (3 strains), compared with N-dodecylpyridinium iodide (P-12) which has no substituents. The activity of these new compounds was not correlated with the hydrophobicity of the bacterial cell surface. This suggests that the bactericidal mechanism of 2TPBr-12 and 4TPBr-12 is different from that of P-12. The bactericidal and bacteriostatic activity of the new compounds against Escherichia coli K12 W3110 was closely influenced by their alkyl chain length. Since they have two hydrophobic alkyl chains in their structure, it seems that hydrophobic association between the molecule of 2TPX-n or 4TPX-n and medium components in the minimum inhibitory concentration measurement system caused the reduction in their apparent concentration. The bactericidal activity of these compounds was dependent on their bacterioclastic activity, and less dependent on their hydrophobicity (RM).","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"28 1","pages":"251-260"},"PeriodicalIF":0.0,"publicationDate":"1997-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87307987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Recent Circumstances of Standards for Indoor Air Environment 室内空气环境标准近况

Japanese journal of toxicology and environmental health Pub Date : 1997-06-30 DOI: 10.1248/JHS1956.43.162

I. Ichikawa, T. Matsumura

{"title":"Recent Circumstances of Standards for Indoor Air Environment","authors":"I. Ichikawa, T. Matsumura","doi":"10.1248/JHS1956.43.162","DOIUrl":"https://doi.org/10.1248/JHS1956.43.162","url":null,"abstract":"Since the end of 1960s, with an increase in the economic growth, a large amount of chemical products made from fossil fuel have been used. In addition to the development and the modification of the products for building materials containing many kinds of hazardous chemicals, the techniques for the airtight construction of houses have been remarkably developed. In the latter half of 1970s, among people living in U.S.A. and northern Europe a new syndrome with headache, dizziness, and eye irritation, etc., which was later called as a sick building syndrome (SBS), has emerged. This syndrome was found to be caused by concentrated multiple pollutants such as volatile organic compounds (VOCs) and allergens from fungi and ticks in high airtight rooms with lower ventilation. Recently, the number of patients suffering from biological allergens and VOCs tends to increase. But in Japan the standard values we have in the law on the sanitary management for buildings are limited to those for such three materials as carbon dioxide (CO2), carbon monoxide (CO) and suspended particulate matter (SPM). Therefore, we describe in this report the necessity of the establishment of a new law on the indoor environmental standards for the prevention of our health against some kinds of indoor pollutants such as VOCs in cluding formaldehyde, nitrogen dioxide (NO2), ozone (O3) and asbestos produced not only in offices and working places but also in houses.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"86 1","pages":"162-173"},"PeriodicalIF":0.0,"publicationDate":"1997-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87109715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Improvement of Electrode of Tritium Enrichment Cell and Application to Tritium Monitoring in Environmental Surface Water at South Osaka Area 氚富集电池电极的改进及其在大阪南部地表水环境氚监测中的应用

Japanese journal of toxicology and environmental health Pub Date : 1997-04-30 DOI: 10.1248/JHS1956.43.114

Syojiro Kimura, A. Iwamoto, M. Inagaki

{"title":"Improvement of Electrode of Tritium Enrichment Cell and Application to Tritium Monitoring in Environmental Surface Water at South Osaka Area","authors":"Syojiro Kimura, A. Iwamoto, M. Inagaki","doi":"10.1248/JHS1956.43.114","DOIUrl":"https://doi.org/10.1248/JHS1956.43.114","url":null,"abstract":"The experimental studies on the improvement of electrode materials used for the electrolytic enrichment of tritium and on the establishment of rapid procedure for the analysis of tritium and its application to tritium monitoring in environmental surface water at south Osaka area were carried out. The more efficient recovery rate and reappearance of tritium were obtained by the trial of the exchange of the electrode material from nickel (Ni) to iron (Fe) at high current condition. However, by considering the electrolytic corrosiveness of iron, a combined multi plate electrode of Fe (-)-Ni (+) (an effective surface area ; 63cm2) was adopted. In the case of such operational conditions that a current density ; 180 mA/cm2 and a cooling temperature ; 5°C using a 100 ml glass cell inserted into the electrode, time required for decreasing the volume of sample solution from 100 ml to 15 ml was more than 22 h. In addition the recovery rate and the concentration ratio of tritium were 90% and 6 times respectively. Then, the tritium activity of the water sample could be counted rapidly with a relative counting error of ±20% for 4 h in a low level liquid scintillation counter. By the trial using the above mentioned method for the tritium monitoring in environmental surface water at south Osaka area from 1986 to 1992, it was proved that the tritium activities decreased to the naturally producing level of tritium (BG) during this term and the decreasing half times of tritium concentration in this area by dilution were about 4 years.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"37 1","pages":"114-122"},"PeriodicalIF":0.0,"publicationDate":"1997-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85379890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intercalation of Six β-Carboline Derivatives into DNA 六种β-碳碱衍生物插入DNA

Japanese journal of toxicology and environmental health Pub Date : 1997-04-30 DOI: 10.1248/JHS1956.43.83

Z. Taira, Shingo Kanzawa, Chiemi Dohara, S. Ishida, M. Matsumoto, Y. Sakiya

引用次数: 59

Effects of Potassium Sorbate on the Decrease of Cellular GSH Levels in Cultured Rat Hepatocytes (Proceedings of the 22nd Symposium on Toxicology and Environmental Health) 山梨酸钾对培养大鼠肝细胞GSH水平降低的影响(第22届毒理学与环境卫生学术研讨会论文集)

Japanese journal of toxicology and environmental health Pub Date : 1997-02-28 DOI: 10.1248/JHS1956.43.P16

N. Sugihara, K. Furuno

引用次数: 0

Possible Origin of Testicular Damage by Phthalic Acid Esters (Proceedings of the 22nd Symposium on Toxicology and Environmental Health) 邻苯二甲酸酯对睾丸损伤的可能来源(第22届毒理学与环境卫生研讨会论文集)

Japanese journal of toxicology and environmental health Pub Date : 1997-02-28 DOI: 10.1248/JHS1956.43.P21

M. Fukuoka, S. Niimi, Tetsu Kobayashi, Yu Zhou, T. Hayakawa

引用次数: 8

Development of a Portable Cocaine-Selective Electrode (Proceedings of the 22nd Symposium on Toxicology and Environmental Health) 便携式可卡因选择电极的研制(第22届毒理学与环境卫生学术研讨会论文集)

Japanese journal of toxicology and environmental health Pub Date : 1997-02-28 DOI: 10.1248/JHS1956.43.P17

Kiyoyuki Watanabe, K. Okada, H. Oda, T. Katsu

引用次数: 1