Japanese journal of toxicology and environmental health最新文献_第2页

Detection of Senna and Rhubarb Used Only as Drugs from Herbal Teas Advertising Effect of Weight Reduction 草药茶广告中单用番泻、大黄的减肥效果检测

Japanese journal of toxicology and environmental health Pub Date : 1998-06-30 DOI: 10.1248/JHS1956.44.195

T. Seto, H. Shioda, K. Satoh, Tomoko Hamano, Kazuo Onishi

{"title":"Detection of Senna and Rhubarb Used Only as Drugs from Herbal Teas Advertising Effect of Weight Reduction","authors":"T. Seto, H. Shioda, K. Satoh, Tomoko Hamano, Kazuo Onishi","doi":"10.1248/JHS1956.44.195","DOIUrl":"https://doi.org/10.1248/JHS1956.44.195","url":null,"abstract":"Senna leaf, senna pod and rhubarb are the strong laxative crude drugs peculiarly containing such effective components as sennoside A (SA) and sennoside B (SB). These crude drugs are prescribed as ingredients used only as drugs by the notification of Pharmaceutical Affairs Bureau. Therefore, foods containing these drugs are regulated as illegal drugs, unapproved/unpermitted drugs, on the Pharmaceutical Affairs Law. We had successfully identified and detected rhubarb besides senna leaf and senna pod from some of imported herbal teas which were regarded as \"health foods.\"The established method for the identification of these drugs is as follows. As the accurate method for the detection of characteristic common components of SA and SB three dimensional-HPLC (3D-HPLC) and TLC were utilized and they were distinguished each other based on the peculiarities shown below. 1. Rhein 8-glucoside is a characteristic component of rhubarb and successfully detected by 3D-HPLC. 2. On the TLC chromatogram for the identification method of senna or rhubarb described in Japanese Pharmacopoeia (JP), each unique spot could be found, a pale white spot at senna, a remarkable orange-yellow spot usually observed on a mixture of free anthraquinones, chrysophanol, emodin, aloeemodin, etc. at rhubarb. 3. Through magnifying glass, even from cut samples, each characteristic tissue is found, namely pieces of leaves with an entire, acuminate, asymmetric leaf base, swelling veins or some hairs on the senna leaf, glossy pieces of pod changed to dark in place and often retuse seeds on senna pod, and brownish porous pieces of rhubarb. 4. Under a microscope, warty hairs from senna leaves and large clustered crystals (over 50μm) with vessels, pigments and other components from rhubarbs could be respectively observed as described in JP.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"23 1","pages":"195-203"},"PeriodicalIF":0.0,"publicationDate":"1998-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79422785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Screening for Pesticides in Serum from Acutely Poisoned Patients by HPLC-Photo-Diode Array Detection 高效液相色谱-光电二极管阵列检测法筛选急性中毒患者血清中农药

Japanese journal of toxicology and environmental health Pub Date : 1998-06-30 DOI: 10.1248/JHS1956.44.182

Hiromi Mori, Takahiko Sato, H. Nagase, K. Takada, F. Yamazaki

引用次数: 6

Assessing the Metabolic Condition of Bones of Mobile and Immobile Elderly Patients by Determination of Biochemical Markers 用生化指标评价活动与不活动老年患者骨代谢状况

Japanese journal of toxicology and environmental health Pub Date : 1998-06-30 DOI: 10.1248/JHS1956.44.236

K. Yoshihara, Y. Nagayama, Satoru Takahashi, N. Saito, M. Nagata

引用次数: 0

Application of Polyamide Column to the Concentration and Fractional Analysis of Some Organic Compounds Responsible for Environmental Water Pollution 聚酰胺色谱柱在环境水污染有机化合物浓度及分数分析中的应用

Japanese journal of toxicology and environmental health Pub Date : 1998-04-30 DOI: 10.1248/JHS1956.44.92

T. Nakahama, Y. Inouye

引用次数: 0

DIRECT ANALYSIS OF METHAMPHETAMINE AND AMPHATAMINE ENANTIOMERS IN HUMAN URINE BY SEMI-MICROCOLUMN HPLC/ELECTROSPRAY IONIZATION MASS SPECTROMETRY 半微柱高效液相色谱/电喷雾质谱法直接分析人尿中甲基苯丙胺和安非他明对映体

Japanese journal of toxicology and environmental health Pub Date : 1998-04-30 DOI: 10.1248/JHS1956.44.107

M. Katagi, M. Nishikawa, M. Tatsuno, T. Miyazawa, H. Tsuchihashi, A. Suzuki, O. Shirota

{"title":"DIRECT ANALYSIS OF METHAMPHETAMINE AND AMPHATAMINE ENANTIOMERS IN HUMAN URINE BY SEMI-MICROCOLUMN HPLC/ELECTROSPRAY IONIZATION MASS SPECTROMETRY","authors":"M. Katagi, M. Nishikawa, M. Tatsuno, T. Miyazawa, H. Tsuchihashi, A. Suzuki, O. Shirota","doi":"10.1248/JHS1956.44.107","DOIUrl":"https://doi.org/10.1248/JHS1956.44.107","url":null,"abstract":"Semi-microcolumn high performance liquid chromatography (HPLC) with a columnswitching system was connected to electrospray ionization mass spectrometry (ESI-MS) for the analysis of methamphetamine (MA) and amphetamine (AP), a main metabolite of MA. Urine samples were directly introduced to the system. After removal of other components of the sample matrix by the column-switching process, both MA and AP were successfully analyzed with enantiomeric resolution by the use of β-cyclodextrin phenylcarbamate-bonded (phCD) semi-microcolumn, accompanied by spectral information obtained with ESI-MS. Linear calibration curves were obtained for all the analytes throughout the concentration range from 1 ng/ml to 5 μg/ml. The relative standard deviation for peak area ranged from 1.41 to 2.07% at 0.1 μg/ml for the four enantiomer peaks. Detection limits observed for MA and AP enantiomers were 20 ng/ml and 50 ng/ml in the spectrum scanning mode, and 0.5 ng/ml and 1 ng/ml in the single ion monitoring (SIM) mode, respectively. The HPLC/ESI-MS system studied here appeared highly sensitive and useful towards its forensic applications.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"32 1","pages":"107-115"},"PeriodicalIF":0.0,"publicationDate":"1998-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85230293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Enhancement of Lysosomal Enzymes by the Pyrethroids, Fenvalerate and trans-Cypermethrin. 拟除虫菊酯、氰菊酯和反式氯氰菊酯对溶酶体酶的增强作用。

Japanese journal of toxicology and environmental health Pub Date : 1998-04-30 DOI: 10.1248/JHS1956.44.83

M. Balbaa, E. E. Abdelhamid, Khaled Bassiouny

引用次数: 9

HPLC/Chemiluminescence Detection of Methamphetamine and Amphetamine in Black and White Hair Samples HPLC/化学发光法检测黑白毛发样品中甲基苯丙胺和安非他明的含量

Japanese journal of toxicology and environmental health Pub Date : 1998-04-30 DOI: 10.1248/JHS1956.44.116

N. Takayama, Seishi Tanaka, R. Kizu, K. Hayakawa

引用次数: 9

Metabolic Pathway of Benzoic Acid in an Acinetobacter Sp. That Mineralizes 4-Chlorobenzoic Acid 矿化4-氯苯甲酸的不动杆菌Sp.中苯甲酸的代谢途径

Japanese journal of toxicology and environmental health Pub Date : 1998-02-28 DOI: 10.1248/JHS1956.44.25

Kikuo Kobayashi, K. Hirayama, S. Tobita

{"title":"Metabolic Pathway of Benzoic Acid in an Acinetobacter Sp. That Mineralizes 4-Chlorobenzoic Acid","authors":"Kikuo Kobayashi, K. Hirayama, S. Tobita","doi":"10.1248/JHS1956.44.25","DOIUrl":"https://doi.org/10.1248/JHS1956.44.25","url":null,"abstract":"We used intact cells and cell extracts to investigate the metabolic pathway of benzoic acid (BA) in Acinetobacter sp. strain ST-1, which dehalogenates 4-chlorobenzoic acid (4-CBA) hydrolytically and then mineralizes it via the β-ketoadipate pathway. Strain ST-1 degraded BA easily, yielding cis, cis-muconic acid and β-ketoadipic acid. A cell extract prepared from cells grown with BA transformed catechol into cis, cis-muconic acid and β-ketoadipic acid, but an extract of cells grown on 4-CBA lacked catechol 1, 2-dioxygenase activity. These results show that BA and 4-CBA are degraded in strain ST-1 by different pathways up to a common intermediate, β-ketoadipic acid, and that BA induces catechol 1, 2-dioxygenase. Therefore, the strain degraded BA via catechol to cis, cis-muconic acid and then to β-ketoadipic acid. The degradation pathways of BA and 4-CBA in strain ST-1 may be linked by the formation of β-ketoadipic acid, and then proceed along the β-ketoadipate pathway, even although the key intermediates before the ring fission are different, namely, catechol for BA and protocatechuic acid for 4-CBA.","PeriodicalId":14851,"journal":{"name":"Japanese journal of toxicology and environmental health","volume":"82 1","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"1998-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90758492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Participation of Hsp72 in DNA Damage by Dimethylarsenics : Possible Relationship between Hsp72 and Apoptosis Induced in Pulmonary Cultured Cells (Proceedings of the 23rd Symposium on Toxicology and Environmental Health) 热休克蛋白72参与二甲基larsenics对DNA的损伤:热休克蛋白72与肺培养细胞凋亡的可能关系(第23届毒理学与环境卫生学术研讨会论文集)

Japanese journal of toxicology and environmental health Pub Date : 1998-02-28 DOI: 10.1248/JHS1956.44.P6

Koichi Kato, K. Yamanaka, A. Hasegawa, S. Okada

引用次数: 0

Determination of Sulfate in Environmental Water by Spectrophotometric Flow Injection Analysis 流动注射分光光度法测定环境水中硫酸盐

Japanese journal of toxicology and environmental health Pub Date : 1998-02-28 DOI: 10.1248/JHS1956.44.49

T. Korenaga, Yi Yang, Ken-ichi Shibata, J. Motonaka, S. Ikeda

引用次数: 3