Journal of acquired immune deficiency syndromes最新文献

Host Nuclear Genome Copy Number Variations Identify High-Risk Anal Precancers in People Living with HIV. 宿主核基因组拷贝数变异识别出艾滋病病毒感染者的高危肛门癌前病变。

Journal of acquired immune deficiency syndromes Pub Date : 2024-04-15 DOI: 10.1097/QAI.0000000000003409

T. Mutetwa, Yuxin Liu, Richard Silvera, Michelle Evans, Michael Yurich, Joseph Tripodi, Issa Leonard, Jane Houldsworth, Zeynep Gümüş, Anne M. Bowcock, Keith Sigel, M. Gaisa, P. Polak

{"title":"Host Nuclear Genome Copy Number Variations Identify High-Risk Anal Precancers in People Living with HIV.","authors":"T. Mutetwa, Yuxin Liu, Richard Silvera, Michelle Evans, Michael Yurich, Joseph Tripodi, Issa Leonard, Jane Houldsworth, Zeynep Gümüş, Anne M. Bowcock, Keith Sigel, M. Gaisa, P. Polak","doi":"10.1097/QAI.0000000000003409","DOIUrl":"https://doi.org/10.1097/QAI.0000000000003409","url":null,"abstract":"BACKGROUND\u0000People living with HIV (PLWH) have substantially increased incidence of anal precancer and cancer. There are very little data regarding genomic disturbances in anal precancers among PLWH. Here, we identified specific chromosomal variants in anal squamous intraepithelial lesions.\u0000\u0000\u0000METHODS\u0000We collected 63 anal biopsy specimens (27 low-grade intraepithelial lesions [LSIL] and 36 high-grade intraepithelial lesions [HSIL]) from PLWH obtained as part of anal cancer screening in our NYC-based health system. Data on patient demographics, anal cytological and high-risk human papillomavirus (HR-HPV) diagnoses were collected. Specimens were tested for a panel of chromosomal alterations associated with HPV-induced oncogenesis using Fluorescence In-Situ Hybridization (FISH) and analyses compared the associations of these alterations with clinical characteristics.\u0000\u0000\u0000RESULTS\u0000Gains of 3q26, 5p15, 20q13 and cen7 were detected in 42%, 31%, 31%, and 19% of HSIL compared to 7%, 0%, 4%, and 0% of LSIL, respectively. Where at least one abnormality was seen, 89% had a 3q26 gain. In lesions with 5p15 gains, 20q13 gains co-occurred in 91% of cases, while cen7 gain only co-occurred with the other three alterations. Sensitivity and specificity of any alteration to predict HSIL was 47% (95% CI: 30-65%) and 93% (95% CI: 76%-99%) respectively.\u0000\u0000\u0000CONCLUSIONS\u0000Genomic alterations seen in HPV-associated cancers may help distinguish anal LSIL from HSIL. 3q26 amplification may be an early component of anal carcinogenesis, preceding 5p16, 20q13 and/or chr7.\u0000\u0000\u0000IMPACT\u0000We share insights on potential genomic biomarkers for discriminating high-risk anal precancers.","PeriodicalId":14827,"journal":{"name":"Journal of acquired immune deficiency syndromes","volume":"291 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of COVID-19 on People Living with HIV: Data from Five Medical Monitoring Project Sites, 2020-2022. COVID-19 对艾滋病毒感染者的影响：2020-2022 年五个医疗监测项目点的数据。

Journal of acquired immune deficiency syndromes Pub Date : 2024-04-02 DOI: 10.1097/QAI.0000000000003403

Steven J Erly, Tim W Menza, Lauren Granillo, Michael Navejas, C. Udeagu, Kathleen Brady A Md, Lindsay K Hixson, Shavvy Raj-Sing, Tanner Nassau, Chelsey Kaasa, Susan Buskin

{"title":"Impact of COVID-19 on People Living with HIV: Data from Five Medical Monitoring Project Sites, 2020-2022.","authors":"Steven J Erly, Tim W Menza, Lauren Granillo, Michael Navejas, C. Udeagu, Kathleen Brady A Md, Lindsay K Hixson, Shavvy Raj-Sing, Tanner Nassau, Chelsey Kaasa, Susan Buskin","doi":"10.1097/QAI.0000000000003403","DOIUrl":"https://doi.org/10.1097/QAI.0000000000003403","url":null,"abstract":"BACKGROUND\u0000The COVID-19 pandemic disrupted global economic and healthcare systems. People living with HIV (PLWH) represent a marginalized and stigmatized population who may have been particularly impacted. The purpose of this analysis was to describe the impact of the COVID-19 pandemic on PLWH in the United States.\u0000\u0000\u0000SETTING\u0000United States.\u0000\u0000\u0000METHODS\u0000We analyzed surveys of behavioral and clinical characteristics of PLWH residing in five states that participated in the Medical Monitoring Project between 2020 and 2022. We described the impact of COVID-19 illness, testing and diagnoses, receipt of medical care, social service access, employment, and preventive measures by project site and demographic characteristics.\u0000\u0000\u0000RESULTS\u0000Unweighted data from 1715 PLWH were analyzed. A high proportion of PLWH had medical care disrupted by the pandemic; 31% of PLWH missed medical appointments, 26% missed routine labs, and 7% missed antiretroviral therapy doses. 30% of PLWH reported losing wages and 19% reported difficulty in accessing social services. Overall, 88% reported receiving at least one dose of COVID-19 vaccine, but vaccine uptake was low among younger, Black and Hispanic or Latina/o/x PLWH.\u0000\u0000\u0000CONCLUSION\u0000This descriptive analysis reinforces previous findings that show that COVID-19 negatively impacted PLWH and their ability to obtain medical care. Additional efforts will be critical to ameliorating the longer-term impacts of COVID-19 on the health of PLWH and supporting PLWH through future pandemics and healthcare system disruptions.","PeriodicalId":14827,"journal":{"name":"Journal of acquired immune deficiency syndromes","volume":"13 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV-exposed, uninfected infants in Uganda experience poorer growth and body composition trajectories than HIV-unexposed infants. 在乌干达，与未感染艾滋病毒的婴儿相比，暴露于艾滋病毒的未感染婴儿的生长和身体成分轨迹较差。

Journal of acquired immune deficiency syndromes Pub Date : 2020-05-29 DOI: 10.1093/cdn/nzaa054_095

Charlotte E Lane, E. Widen, Shalean M. Collins, S. Young

{"title":"HIV-exposed, uninfected infants in Uganda experience poorer growth and body composition trajectories than HIV-unexposed infants.","authors":"Charlotte E Lane, E. Widen, Shalean M. Collins, S. Young","doi":"10.1093/cdn/nzaa054_095","DOIUrl":"https://doi.org/10.1093/cdn/nzaa054_095","url":null,"abstract":"BACKGROUND\u0000HIV-uninfected infants of HIV-positive women may experience worse growth and health outcomes than infants of HIV-negative women, but this has not been thoroughly investigated under the WHO's most recent recommendations to reduce vertical transmission.\u0000\u0000\u0000OBJECTIVE\u0000To determine if HIV-exposed and -uninfected (HEU) infants whose mothers received Option B+ have higher odds of experiencing suboptimal growth trajectories than HIV-unexposed, -uninfected infants and if this relationship is affected by food insecurity.\u0000\u0000\u0000DESIGN\u0000Repeated anthropometric measures were taken on 238 infants (HEU=86) at 1 week and 1,3,6,9, and 12 months after delivery in Gulu, Uganda. Latent class growth mixture modeling was used to develop trajectories for length-for-age z-scores (LAZ), weight-for-length z-scores, mid-upper arm circumference (MUAC), sum of skinfolds, and arm fat area. Multinomial logistic models were built to predict odds of trajectory class membership, controlling for socioeconomic factors.\u0000\u0000\u0000RESULTS\u0000HEU infants had greater odds of being in the shortest two LAZ trajectory classes (OR=3.80[1.22,11.82], OR=8.72 [1.80,42.09]) and higher odds of being in smallest sum of skinfolds trajectory class (OR=3.85[1.39,10.59]) vs. unexposed infants. Among HEU infants, increasing food insecurity was associated with lower odds of being in the lowest sum of skinfolds class (OR=0.86[0.76,0.98]).\u0000\u0000\u0000CONCLUSIONS\u0000There continues to be differences in growth patterns by HIV-exposure under the new set of WHO guidelines for the prevention of mother-to-child transmission of HIV and the feeding of HEU infants in low-resource settings that are not readily identified through traditional mixed effects modeling. Food insecurity was not associated with class membership, but differentially affected adiposity by HIV-exposure status.","PeriodicalId":14827,"journal":{"name":"Journal of acquired immune deficiency syndromes","volume":"4 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141202166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Nucleotide binding by the HIV-1 integrase protein in vitro. HIV-1整合酶蛋白在体外的核苷酸结合。

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01

J R Lipford, S T Worland, C M Farnet

{"title":"Nucleotide binding by the HIV-1 integrase protein in vitro.","authors":"J R Lipford, S T Worland, C M Farnet","doi":"","DOIUrl":"","url":null,"abstract":"Recombinant human immunodeficiency virus type 1 (HIV-1) integrase was shown to bind ATP and other nucleoside triphosphates and nucleotide analogs in vitro. Cross-linking of ATP and the photoaffinity analog 8-azido-ATP to integrase occurred in a UV dose-dependent manner. Covalent binding of ATP to integrase was also achieved without UV irradiation when the nucleotide was oxidized to the 2',3'-dialdehyde derivative (oxidized ATP) prior to incubation with the protein, indicating the presence of a reactive lysine residue in the nucleotide binding region of the protein. A number of experimental observations indicate that nucleotides and DNA substrates bind at the same or overlapping site(s) on the integrase protein. For example, the binding of nucleotides or nucleotide analogs to integrase was blocked by prior incubation with DNA substrates, and the covalent cross-linking of 8-azido-ATP to integrase inhibited the DNA binding and oligonucleotide cleavage activities of the protein. Oxidized ATP inhibited the oligonucleotide cleavage activity of integrase at concentrations that had no effect on DNA binding, suggesting that oxidized nucleotides may specifically target the catalytic center of the enzyme. These studies indicate that nucleotide analogs may serve as probes for the DNA binding and catalytic sites of the enzyme and may serve as models for the design of active site inhibitors of retroviral integrase.","PeriodicalId":14827,"journal":{"name":"Journal of acquired immune deficiency syndromes","volume":"7 12","pages":"1215-23"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18963445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiretroviral therapy is associated with a decrease in unintegrated HIV-1 DNA in pediatric patients. 抗逆转录病毒治疗与儿科患者未整合HIV-1 DNA的减少有关。

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01

R M Donovan, C E Bush, S M Smereck, E Moore, F Cohen, L D Saravolatz

{"title":"Antiretroviral therapy is associated with a decrease in unintegrated HIV-1 DNA in pediatric patients.","authors":"R M Donovan, C E Bush, S M Smereck, E Moore, F Cohen, L D Saravolatz","doi":"","DOIUrl":"","url":null,"abstract":"Good markers for monitoring the efficacy of antiretroviral therapy in children do not currently exist. This study examined the effect of antiretroviral therapy on human immunodeficiency virus (HIV-1) unintegrated DNA (uDNA), integrated DNA (iDNA), percent uDNA, immune complex dissociated (ICD) p24 antigenemia, and plasma viral titer. Seven children were followed at therapy initiation and at approximately 3- and 10-month intervals. HIV-1 uDNA was detected in all children prior to start of therapy (average percent uDNA, 43%). At 3 months, the percent HIV uDNA decreased in all patients to an average of 18% (p = 0.01) and at 10 months decreased to an average of 1%. In contrast, the amount of HIV iDNA was relatively constant after initiation of therapy. ICD HIV p24 antigen was detected in all patients prior to therapy (average, 538 pg/ml). Over the study period, the ICD p24 antigen level decreased in three patients and remained relatively unchanged in four patients. Plasma cultures of HIV-1 were positive in only one of the seven patients prior to therapy. Among the methods evaluated, measurement of uDNA was the only parameter which reliable decreased after initiation of nucleoside therapy.","PeriodicalId":14827,"journal":{"name":"Journal of acquired immune deficiency syndromes","volume":"7 12","pages":"1237-41"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18963448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in HIV risk behavior among French heterosexuals: patterns of sexual monogamy and condom use between 1988 and 1991. 法国异性恋者艾滋病风险行为的变化:1988年至1991年间的一夫一妻制和避孕套使用模式。

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01 DOI: 10.1097/00126334-199412000-00015

M Guiguet, F LePont, O Retel, A J Valleron

引用次数: 4

Trends in risk behavior and HIV seroprevalence in heterosexual injection drug users in San Francisco, 1986-1992. 1986-1992年旧金山异性注射吸毒者的危险行为和HIV血清流行趋势。

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01

J K Watters

{"title":"Trends in risk behavior and HIV seroprevalence in heterosexual injection drug users in San Francisco, 1986-1992.","authors":"J K Watters","doi":"","DOIUrl":"","url":null,"abstract":"We examine changes and stability in risk behaviors and HIV-1 seroprevalence among heterosexual injection drug users (IDUs) over 13 cross-sectional surveys, 1986-1992. Interviews (n = 5,956) were conducted with IDUs in street settings and drug detoxification clinics over 6.5 years, and respondents were tested for HIV-1 antibody. Trends in use of condoms and bleach and HIV seroprevalence were assessed using multiple logistic and linear regression analyses. The percentage of time condoms were reportedly used during intercourse among men increased from 4.5% to 31.0%. Among the declining population of IDUs who reported needle sharing, reported use of bleach increased from 3% to 89%. Significant changes in use of bleach 100% of the time were reported: 29.8% in 1988, 52.8% in 1990, and 40.0% in 1992. HIV seroprevalence doubled from 7% in 1986 to 14% in 1987. Post-1987 fluctuations in HIV seroprevalence were not significant. Significant changes in risk behaviors among IDUs were reported over the study period. These changes coincided with the implementation of HIV prevention in San Francisco, including outreach programs, HIV testing and counseling, bleach distribution, and syringe exchange. The moderate and stable rate of HIV seroprevalence beginning in 1987 parallels self-reported reductions in risk behavior.","PeriodicalId":14827,"journal":{"name":"Journal of acquired immune deficiency syndromes","volume":"7 12","pages":"1276-81"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18960773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HTLV-I-associated myelopathy in Venezuela. 委内瑞拉htlv - 1相关脊髓病

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01 DOI: 10.1097/00126334-199412000-00014

M Zabaleta, J Peralta, J Birges, N Bianco, G Echeverria de Perez

引用次数: 6

Improved detection of HTLV-II antibody using a whole viral lysate-based EIA. 利用基于全病毒裂解物的EIA改进了HTLV-II抗体的检测。

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01 DOI: 10.1097/00126334-199412000-00016

R L Kline, D Vlahov, T C Quinn

引用次数: 6

Absence of GVH diseases in AIDS. 艾滋病患者中没有GVH疾病。

Journal of acquired immune deficiency syndromes Pub Date : 1994-12-01

J A Habeshaw, A G Dalgleish, E F Hounsell

引用次数: 0