JNCI Journal of the National Cancer Institute最新文献

{"title":"RE: Impact of beta-blockers on prognostic outcomes in solid cancers: a systematic review and meta-analysis.","authors":"Alisha Sharma, Adam S Komorowski, Katarzyna J Jerzak","doi":"10.1093/jnci/djag162","DOIUrl":"10.1093/jnci/djag162","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"1762-1763"},"PeriodicalIF":7.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overlapping genetic etiology of pediatric and adult germ cell tumors.","authors":"Shannon M Sullivan, John Lane, Abigail Standafer, James Mcfeeters, Aubrey K Hubbard, Erica K Langer, Anthony J Hooten, Michelle A Roesler, Joanna J Gell, Mark Krailo, A Lindsay Frazier, James F Amatruda, Nathan Pankratz, Jenny N Poynter","doi":"10.1093/jnci/djag097","DOIUrl":"10.1093/jnci/djag097","url":null,"abstract":"<p><strong>Background: </strong>Germ cell tumors are heterogeneous neoplasms arising from primordial germ cells. Although genome-wide association studies have identified numerous susceptibility loci for adult testicular germ cell tumors, the heritable basis of pediatric testicular germ cell tumors and germ cell tumors that arise outside the testes remain poorly understood.</p><p><strong>Methods: </strong>We conducted a multi-ancestry genome-wide association study of pediatric germ cell tumors, including 1927 cases from the Germ Cell Tumor Epidemiology Study and 10 601 controls. Cases were diagnosed with testicular (n = 678), ovarian (n = 441), intracranial (n = 435), and extragonadal (n = 373) germ cell tumor between the ages of 0 and 19 years.</p><p><strong>Results: </strong>We identified 4 loci reaching genome-wide significance, including variants near BAK1 (chr 6: rs3831846), SPRY4 (chr 5: rs12515244), DMRT1 (chromosome [chr] 9: rs10815910), and DEPTOR (chr 8: rs13277786). Additional genome-wide statistically significant associations were identified in subgroup analyses, including 6 loci for intracranial germ cell tumors (rs2758612 [PMF1/BGLAP], rs9854760 [PLCL2], rs6851498 [KIT], rs11816992 on chromosome 10, rs3830273 [TFAM], and rs13054014 [LZTR1]), 1 locus for testicular germ cell tumor (rs1907702 [KITLG]), and 1 locus for males (rs4610628 [MAD1L1]). After Bonferroni correction, 18 of 78 previously reported testicular germ cell tumor loci were significantly associated with germ cell tumor overall or in at least 1 subgroup with a particularly strong correlation between testicular germ cell tumor and intracranial germ cell tumor effect estimates (rho = 0.63, P = 5.5 × 10-10). Expression quantitative trait locus (QTL) analyses identified candidate genes in the regions identified on chromosome 6 (BAK1, LINC003366, and ITPR3) and chromosome 8 (DEPTOR and RP11-760H22.2).</p><p><strong>Conclusions: </strong>Our data support a role for germline genetic variation in the development of germ cell tumors in locations outside the testes and highlight shared genetic architecture across age group and tumor location.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"1657-1669"},"PeriodicalIF":7.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Private equity acquisitions and cancer care: nothing to see here? Not so fast.","authors":"Jazzmyne Montgomery, Vahakn B Shahinian","doi":"10.1093/jnci/djag144","DOIUrl":"10.1093/jnci/djag144","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"1563-1565"},"PeriodicalIF":7.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Impact of KRAS codon-specific mutations on survival in metastatic CRC on trifluridine-tipiracil with/without bevacizumab.","authors":"Yang Zhang","doi":"10.1093/jnci/djag298","DOIUrl":"https://doi.org/10.1093/jnci/djag298","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between genomic classifier scores and initial management of localized prostate cancer in the United States.","authors":"Michael S Leapman, Rong Wang, Preston C Sprenkle, Isaac Y Kim, Stacy Loeb, Tyler M Seibert, Matthew R Cooperberg, Peter H Gann, Kevin Ginsburg, William J Catalona, Michaela A Dinan, Cary P Gross, Xiaomei Ma","doi":"10.1093/jnci/djag247","DOIUrl":"https://doi.org/10.1093/jnci/djag247","url":null,"abstract":"<p><strong>Background: </strong>Tissue-based gene expression assays provide prognostic information in prostate cancer, but their influence on decisions regarding immediate treatment versus conservative management, including active surveillance (AS) and watchful waiting (WW), remains uncertain.</p><p><strong>Methods: </strong>Using a linkage with the Surveillance, Epidemiology, and End Results program, we evaluated the association between a 22-gene genomic classifier (GC) and initial management among patients with low or intermediate clinical-risk prostate cancer diagnosed from 2015 through 2018. Initial management was classified as immediate therapy or AS/WW, and GC scores were grouped as low (<0.45), intermediate (0.45-0.60), or high (>0.60). Multivariable logistic regression assessed associations between GC category and immediate treatment, stratified by clinical-risk group and adjusted for demographic and clinical covariates.</p><p><strong>Results: </strong>Among 2,547 patients, 286 of 1,030 (27.8%) with low- and 1,113 of 1,517 (73.4%) with intermediate clinical-risk prostate cancer received initial treatment. Use of initial treatment increased with higher GC category. Among patients with low and intermediate clinical-risk prostate cancer, respectively, 20.5% and 57.5% with low GC, 28.3% and 75.8% with intermediate GC, and 46.2% and 88.3% with high GC scores received initial treatment. Higher GC category was independently associated with greater odds of immediate treatment versus AS/WW (versus low GC: intermediate GC, odds ratio [OR] 1.98, 95% confidence interval [CI] 1.57-2.49, p < 0.001; high GC, OR 4.42, 95% CI 3.41-5.71, p < 0.001).</p><p><strong>Conclusions: </strong>Higher GC scores were associated with greater use of immediate treatment and less use of AS/WW, underscoring the need to determine whether GC testing also predicts long-term outcomes among patients managed with AS.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive validity of a 10-item frailty index based on a comprehensive geriatric assessment (FI-CGA-10) in older Japanese adults with cancer.","authors":"Tomohiro F Nishijima, Mototsugu Shimokawa, Kohei Arimizu, Taito Esaki, Masaru Morita, Hyman B Muss","doi":"10.1093/jnci/djag304","DOIUrl":"https://doi.org/10.1093/jnci/djag304","url":null,"abstract":"<p><strong>Background: </strong>The 10-Item Frailty Index Based on a Comprehensive Geriatric Assessment (FI-CGA-10) is a content- and construct-validated measure for quantifying frailty from a CGA. For criterion validation, we assessed its predictive validity for overall survival (OS) in older adults with cancer.</p><p><strong>Methods: </strong>This prospective cohort study included 1,630 patients with cancer who underwent CGA at a geriatric oncology service (median age 80 years). The FI-CGA-10 comprises ten CGA domains; deficits in each domain were scored 0 (no problem), 0.5 (minor problem), or 1.0 (major problem). Domain scores were summed, divided by 10 (range 0-1), and categorized as fit (<0.20), pre-frail (0.20-0.35), or frail (>0.35). Two Cox proportional hazards models estimated hazard ratios (HRs) for OS: a base model (age, sex, cancer type, and stage) and the base model plus FI-CGA-10 as a categorical variable. Model performance was compared using the likelihood-ratio (LR) test and Harrell's c-index.</p><p><strong>Results: </strong>Overall, 22% were fit, 38% pre-frail, and 40% frail; 28% died within one year. Adding FI-CGA-10 to the base model improved prediction (LR χ² = 140.7; P < .001) and increased the c-index from 0.70 to 0.76 (P < .001). Adjusted HRs for pre-frail and frail (vs. fit) were 2.26 (95% CI, 1.61-3.19) and 5.06 (95% CI, 3.64-7.04), respectively. 1-year OS was 87% (fit), 74% (pre-frail), and 55% (frail). Major problems across all ten domains and minor problems in six domains were associated with worse OS in adjusted models.</p><p><strong>Conclusion: </strong>This study provides evidence supporting the predictive validity of the FI-CGA-10 for OS.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Zhang.","authors":"Giulia Maddalena, Scott Kopetz, Kanwal Raghav","doi":"10.1093/jnci/djag299","DOIUrl":"https://doi.org/10.1093/jnci/djag299","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Chen and Huang.","authors":"Hyun Yong Koh, Omid Jafari, Ang Li","doi":"10.1093/jnci/djag301","DOIUrl":"https://doi.org/10.1093/jnci/djag301","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Cancer-associated arterial thromboembolism: real-world burden from a nationwide electronic health record database.","authors":"Shanjiang Chen, Anwu Huang","doi":"10.1093/jnci/djag300","DOIUrl":"https://doi.org/10.1093/jnci/djag300","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the impact of tobacco and alcohol use on cancer-related health outcomes.","authors":"Hang Zhou, Babalola Faseru, Farhad Islami, Nigar Nargis, Maria Elena Martinez, Roy A Jensen, S Gail Eckhardt, Roy S Herbst","doi":"10.1093/jnci/djag138","DOIUrl":"https://doi.org/10.1093/jnci/djag138","url":null,"abstract":"<p><p>Tobacco and alcohol use are significant modifiable risk factors contributing to cancer morbidity and mortality globally. Recognizing the synergistic effects of these substances and their implications for cancer prevention and treatment, a national workshop titled \"Addressing the Impact of Tobacco and Alcohol Use on Cancer-Related Health Outcomes\" was convened in Washington, DC, in March 2025. This workshop brought together leading researchers in behavioral, basic, and clinical sciences, clinicians, public health practitioners, health economists, policymakers, patient advocates, and community stakeholders to review current evidence, identify gaps in practice and policy, and develop actionable recommendations. The goal of the workshop was to examine the evidence linking tobacco and alcohol use to cancer incidence and outcomes and to explore strategies for reducing their use to lower cancer risk and improve health outcomes. This commentary summarizes key themes from five sessions, including epidemiological insights, lessons from tobacco control policy, opportunities for alcohol policy, evidence-based cessation interventions, and strategies to address stigma and gaps in research and practice. The workshop underscored the need for integrated public health strategies, informed by lessons learned from tobacco control, to mitigate the cancer burden attributable to tobacco and alcohol use.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}