JNCI Journal of the National Cancer Institute最新文献

{"title":"Response to Semprini.","authors":"Yaguang Wei","doi":"10.1093/jnci/djaf370","DOIUrl":"10.1093/jnci/djaf370","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"368-369"},"PeriodicalIF":7.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stat Bite: cumulative risk of cancer incidence up to ages 50 and 75 by sex in 2022.","authors":"Freddie Bray, Mathieu Laversanne, Salvatore Vaccarella","doi":"10.1093/jnci/djaf354","DOIUrl":"https://doi.org/10.1093/jnci/djaf354","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":"118 2","pages":"370"},"PeriodicalIF":7.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: An observational study of deep learning and automated evaluation of cervical images for cancer screening.","authors":"Mark Schiffman","doi":"10.1093/jnci/djaf348","DOIUrl":"10.1093/jnci/djaf348","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"364-365"},"PeriodicalIF":7.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging pitfalls in pediatric, adolescent, and young adult hodgkin lymphoma: a SEARCH for CAYAHL initiative to bridge multidisciplinary patient care.","authors":"Nawar Dakhallah, Jonas Steglich, Claire Gowdy, Sarah A Milgrom, Adina L Alazraki, Sharon M Castellino, Karin Dieckmann, Jamie E Flerlage, Mallorie B Heneghan, Kara M Kelly, Hollie A Lai, Christine Mauz-Körholz, Kathleen M McCarten, Reena Pabari, Monica Palese, Lars Kurch, Dietrich Stoevesandt, Jennifer Seelisch, Stephan D Voss","doi":"10.1093/jnci/djag016","DOIUrl":"https://doi.org/10.1093/jnci/djag016","url":null,"abstract":"<p><p>Pediatric Hodgkin lymphoma (pHL) is a highly curable malignancy in children, adolescents, and young adults, and current treatment strategies aim to minimize adverse late effects. Many patients are enrolled in clinical trials with centralized review for both initial and interim staging. Although academic guidelines provide a structured framework for image interpretation, real-world clinical scenarios sometimes present imaging pitfalls that require nuanced judgment. Morphologic and metabolic imaging pitfalls refer to misinterpretation of findings that occur during staging, disease evaluation, or post-treatment surveillance. In pHL, such pitfalls may result from suboptimal imaging conditions, concurrent inflammatory, infectious, or other findings. These findings do not indicate neoplastic disease but rather are manifestations of other processes specific to each tissue or organ. This Staging, Evaluation and Response Criteria Harmonization for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (SEARCH for CAYAHL) initiative represents a transatlantic collaboration among multidisciplinary professionals, aiming to disseminate the insights gained from decades of centralized review experience in North American and European clinical trials. This paper aims to optimize patient care by integrating imaging and clinical expertise in disease staging and surveillance. Although not intended as a comprehensive staging guide, it highlights recurrent imaging pitfalls that may lead to incorrect staging or response assessment. By encouraging interdisciplinary exchange, this work seeks to complement existing literature and serve as a troubleshooting guide for situations where clinical realities diverge from academic paradigms.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258,494 men.","authors":"Marisa Da Silva, Josef Fritz, Ahmed Elhakeem, Sylvia H J Jochems, Ming Sun, Innocent B Mboya, Christel Häggström, Jens Wahlström, Karl Michaëlsson, Patrik K E Magnusson, Ylva T Lagerros, Lena Lönnberg, Abbas Chabok, Sölve Elmståhl, Bright I Nwaru, Hannu Kankaanranta, Linnea Hedman, Helena Backman, Sara Hägg, Pär Stattin, Kate Tilling, Tanja Stocks","doi":"10.1093/jnci/djag014","DOIUrl":"https://doi.org/10.1093/jnci/djag014","url":null,"abstract":"<p><strong>Background: </strong>Obesity assessed at a single time point in adulthood has shown no consistent association with prostate cancer (PCa) incidence but has been positively associated with PCa death. We investigated the association of total and age-specific adult weight trajectories with PCa aggressiveness and death.</p><p><strong>Methods: </strong>We analysed data from 258,494 men in Sweden with at least three weight observations between ages 17 and 60. Individual weight trajectories were estimated using linear mixed-effects models with natural cubic and linear splines for age, incorporating random intercepts and slopes. These estimates were included in multivariable-adjusted Cox proportional hazards models.</p><p><strong>Results: </strong>Over a median follow-up of 25 years, 22,055 men were diagnosed with PCa and 4,547 died from the disease. Steep weight gain was inversely associated with PCa diagnosed during the PSA testing era (1997 onwards) and via asymptomatic PSA testing, but not with aggressive PCa. Among men with PCa, steep weight gain was associated with increased risk of PCa death (HR quintile 5 vs. 1 = 1.23, 95% CI = 1.08 to 1.40), primarily driven by weight gain between ages 45 and 60 (HR per 1 kg/year = 1.31, 95% CI = 1.10 to 1.57).</p><p><strong>Conclusions: </strong>The associations observed for incident PCa appear to be influenced by PSA testing uptake; however, the extent to which detection bias contributes remains uncertain. Conversely, late midlife weight gain was associated with an elevated risk of PCa death, underscoring the importance of weight management during this period as a potentially modifiable factor for reducing PCa death.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer recurrence and mortality among survivors of childhood cancer.","authors":"Cindy Im, Hasibul Hasan, Aparna Srinivasan, Emily Stene, Aaron J Mcdonald, Chaya S Moskowitz, Tara O Henderson, Gregory T Armstrong, Yutaka Yasui, Rita Nanda, Kevin C Oeffinger, Joseph P Neglia, Anne Blaes, Lucie M Turcotte","doi":"10.1093/jnci/djag005","DOIUrl":"10.1093/jnci/djag005","url":null,"abstract":"<p><p>Childhood cancer survivors are at high risk for developing breast cancer (BC) as a treatment-related neoplasm. Their risk for, and survival after, BC recurrence has not been characterized. In this study, female survivors had a ten-year BC recurrence risk of 14% (95% CI: 10-20%), similar to controls with sporadic BC matched by age, race, ethnicity, and disease characteristics (N = 201 pairs; P = .62). Among survivors with recurrent BC (N = 68), first BCs were largely early stage (0/I/II: 77%). Nearly half (47%) underwent bilateral mastectomies, with 81% performed before recurrence, predominantly from distant metastases. Survivors' ten-year mortality risk after BC recurrence was 89% (95% CI: 61-97%), significantly exceeding controls (40%, 95% CI: 16-57%; P = .0013), for an adjusted 2.8-fold greater risk. BC was the leading cause of death in these survivors; the ten-year cause-specific mortality probability was 67% (95% CI: 53-83%). Comprehensive investigations of BC recurrence drivers and adverse outcomes in this population are needed.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer incidence rates by birth cohort against the backdrop of human papillomavirus vaccination in the United States.","authors":"Chenxi Jiang, Philip S Rosenberg, Ahmedin Jemal, Hyuna Sung","doi":"10.1093/jnci/djaf374","DOIUrl":"https://doi.org/10.1093/jnci/djaf374","url":null,"abstract":"<p><p>Previous cervical cancer incidence trend analyses primarily used period-based approaches, limiting assessment of generational risk shifts against the backdrop of human papillomavirus (HPV) vaccination. Using U.S. Cancer Statistics data and age-period-cohort modeling, we estimated fitted incidence rates at ages 30-31 across birth cohorts (1917-1919 to 1999-2001), adjusted for period deviation. Incidence rates decreased by 1.9% per birth year (95%CI, -1.8% to -2.1%) up to 1951-1953 cohorts, then decelerated to 0.3% annually (95%CI, -0.4% to -0.2%). Starting with 1987-1989 cohort, incidence rates dropped sharply by 10.5% annually (95%CI, -12.7% to -8.4%). Compared with 1970-1979 cohorts, 1990-1999 cohorts had a 54% lower incidence rate (10.2 vs 4.7 per 100,000; rate ratio = 0.46; 95%CI, 0.42 to 0.50). The markedly lower risk among post-1987-1989 cohorts suggests a future reduction in population-level burden as these cohorts age. The finding also has implications for reinforcing HPV vaccination efforts and informing discussions on raising the screening initiation age.</p>","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Impact of daily adaptive head and neck radiotherapy on toxicity and quality of life: results of the DARTBOARD phase II randomized trial.","authors":"Francesco Fiorica","doi":"10.1093/jnci/djaf300","DOIUrl":"10.1093/jnci/djaf300","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"183"},"PeriodicalIF":7.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Fiorica.","authors":"David J Sher, Dominic H Moon","doi":"10.1093/jnci/djaf306","DOIUrl":"10.1093/jnci/djaf306","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"184"},"PeriodicalIF":7.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk in the aging cancer survivor population.","authors":"Susan F Dent, Heather Moore, Avirup Guha","doi":"10.1093/jnci/djaf299","DOIUrl":"10.1093/jnci/djaf299","url":null,"abstract":"","PeriodicalId":14809,"journal":{"name":"JNCI Journal of the National Cancer Institute","volume":" ","pages":"4-6"},"PeriodicalIF":7.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}