ISRN Pharmaceutics最新文献_第3页

Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent. Gd(3+)- dtpa - meglumi -阴离子线性球状树突状物G1:新型纳米低毒肿瘤分子MR显像剂。

ISRN Pharmaceutics Pub Date : 2013-01-01 Epub Date: 2013-02-26 DOI: 10.1155/2013/378452

Tahmineh Darvish Mohamadi, Massoud Amanlou, Negar Ghalandarlaki, Bita Mehravi, Mehdi Shafiee Ardestani, Parichehr Yaghmaei

{"title":"Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent.","authors":"Tahmineh Darvish Mohamadi, Massoud Amanlou, Negar Ghalandarlaki, Bita Mehravi, Mehdi Shafiee Ardestani, Parichehr Yaghmaei","doi":"10.1155/2013/378452","DOIUrl":"https://doi.org/10.1155/2013/378452","url":null,"abstract":"Despite the great efforts in the areas of early diagnosis and treatment of cancer, this disease continues to grow and is still a global killer. Cancer treatment efficiency is relatively high in the early stages of the disease. Therefore, early diagnosis is a key factor in cancer treatment. Among the various diagnostic methods, molecular imaging is one of the fastest and safest ones. Because of its unique characteristics, magnetic resonance imaging has a special position in most researches. To increase the contrast of MR images, many pharmaceuticals have been known and used so far. Gadopentetate (with commercial name Magnevist) is the first magnetic resonance imaging contrast media that has been approved by the US Food and Drug Administration. In this study, gadopentetate was first synthesized and then attached to a tree-like polymer called dendrimer which is formed by polyethylene glycol core and surrounding citric acid groups. Stability studies of the drug were carried out to ensure proper synthesis. Then, the uptake of the drug into liver hepatocellular cell line and the drug cytotoxicity were evaluated. Finally, in vitro and in vivo MR imaging were performed with the new synthetic drug. Based on the findings of this research, connecting gadopentetate to dendrimer surface produces a stronger, safer, and more efficient contrast media. Gd(III)-diethylenetriamine pentaacetate-meglumine-dendrimer drug has the ability to enter cells and does not produce significant cytotoxicity. It also increases the relaxivity of tissue and enhances the MR images contrast. The obtained results confirm the hypothesis that the binding of gadopentetate to citric acid dendrimer produces a new, biodegradable, stable, and strong version of the old contrast media.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":" ","pages":"378452"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/378452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40230016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Design and development of novel dual-compartment capsule for improved gastroretention. 改善胃潴留的新型双室胶囊的设计与研制。

ISRN Pharmaceutics Pub Date : 2013-01-01 Epub Date: 2013-01-27 DOI: 10.1155/2013/752471

Ganesh B Patil, Saurabh S Singh, Ketan P Ramani, Vivekanand K Chatap, Prashant K Deshmukh

{"title":"Design and development of novel dual-compartment capsule for improved gastroretention.","authors":"Ganesh B Patil, Saurabh S Singh, Ketan P Ramani, Vivekanand K Chatap, Prashant K Deshmukh","doi":"10.1155/2013/752471","DOIUrl":"https://doi.org/10.1155/2013/752471","url":null,"abstract":"The aim of the proposed research work was to develop a novel dual-compartment capsule (NDCC) with polymeric disc for gastroretentive dosage form, which will ultimately result in better solubility and bioavailability of Ofloxacin. Floating ring caps were formulated by using different natural polymers, separating ring band and swellable polymer located at the bottom of capsule. Formulated ring caps were assessed for coating thickness, In vitro buoyancy, In vitro drug release, release kinetics and stability studies. Coating attained by the capsule shell was found to be 0.0643 mm. Depending on nature of natural polymer used, most of the formulations showed buoyancy for more than 9 hrs. Developed formulation demonstrated considerably higher drug release up to 9 hrs. The developed formulation F(E2) depicted the drug release according to Korsmeyer-Peppas model. There was not any significant change in performance characteristics of developed ring caps after subjecting them to stability studies. The present study suggests that the use of NDCC for oral delivery of Ofloxacin could be an alternative to improve its systemic availability which could be regulated by the floating approach. The designed dosage system can have futuristic applications over payloads which require stomach-specific delivery.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"752471"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/752471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31257599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

In Silico Prediction of Interactions between Site II on Human Serum Albumin and Profen Drugs. 人血清白蛋白II位点与洛芬类药物相互作用的计算机预测。

ISRN Pharmaceutics Pub Date : 2013-01-01 Epub Date: 2013-03-06 DOI: 10.1155/2013/818364

Hideto Isogai, Noriaki Hirayama

引用次数: 11

Cytological aspects on the effects of a nasal spray consisting of standardized extract of citrus lemon and essential oils in allergic rhinopathy. 由标准柑橘柠檬提取物和精油组成的鼻喷雾剂在过敏性鼻病中的作用的细胞学方面。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/404606

Lydia Ferrara, Daniele Naviglio, Arturo Armone Caruso

{"title":"Cytological aspects on the effects of a nasal spray consisting of standardized extract of citrus lemon and essential oils in allergic rhinopathy.","authors":"Lydia Ferrara, Daniele Naviglio, Arturo Armone Caruso","doi":"10.5402/2012/404606","DOIUrl":"https://doi.org/10.5402/2012/404606","url":null,"abstract":"In this paper, a new formulation of nasal spray was set up based on the extract of lemon pulp, obtained by using a new solid-liquid technology of extraction, added to pure Aloe juice, soluble propoli, and essential oils of Ravensara and Niaouly. It was tested in a clinical study in which 100 subjects were recruited for a period of one month. Nasal scraping was used for collecting samples and after the application of the May-Grünwald Giemsa standard technique, glass slides were analysed by using optical microscope with a 1000x oil immersion. A control group constituted of ten people was recruited as control and this group was administered with physiological solution (saline solution). The comparison of results obtained before and after the application of nasal spray showed a total reduction of eosinophils granulocytes and mast cells; clinical data were confirmed by improvement of clinical pictures of patients. The lemon-based nasal spray was a good alternative to conventional medicine for the treatment of perennial and seasonal allergic and vasomotor rhinopathy.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2012 ","pages":"404606"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/404606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation. 盐酸昂丹司琼微乳经皮给药:配方和体外皮肤渗透。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/428396

Jadupati Malakar, Amit Kumar Nayak, Aalok Basu

引用次数: 21

A review of hot-melt extrusion: process technology to pharmaceutical products. 医药产品热熔挤压工艺技术综述。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/436763

Mohammed Maniruzzaman, Joshua S Boateng, Martin J Snowden, Dennis Douroumis

引用次数: 247

Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans. 伊曲康唑小体给药系统及其抗白色念珠菌活性研究。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/653465

Vijay D Wagh, Onkar J Deshmukh

引用次数: 39

Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections. 荆芥精油对常见食源性感染的化学成分及抑菌活性研究。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/591953

Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, Reza Khashei

引用次数: 45

The role of the immune system in nevirapine-induced subclinical liver injury of a rat model. 免疫系统在奈韦拉平诱导大鼠亚临床肝损伤模型中的作用。

ISRN Pharmaceutics Pub Date : 2012-01-01 DOI: 10.5402/2012/932542

Zanelle Bekker, Andrew Walubo, Jan B du Plessis

{"title":"The role of the immune system in nevirapine-induced subclinical liver injury of a rat model.","authors":"Zanelle Bekker, Andrew Walubo, Jan B du Plessis","doi":"10.5402/2012/932542","DOIUrl":"https://doi.org/10.5402/2012/932542","url":null,"abstract":"In this study, the role of the immune system in nevirapine- (NVP-) induced subclinical liver injury was investigated by observing for changes of some immune parameters during the initial stages of NVP-induced hepatotoxicity in a rat model. In the acute phase, two test-groups of 10 Sprague-Dawley rats each were administered with bacterial lipopolysaccharide (LPS) or saline (S) intraperitoneally, followed by oral NVP, after which 5 rats from each group were sacrificed at 6 and 24 hours. For the chronic phase, two groups of 15 rats each received daily NVP, and on days 7, 14, and 21, five rats from each group were administered with either LPS or S, followed by that day's NVP dose, and were sacrificed 24 hours later. NVP caused liver injury up to seven days and progressively increased IL-2 and IFN-γ levels and lymphocyte count over the 21 days. NVP-induced liver injury was characterized by apoptosis and degeneration changes, while, for LPS, it was cell swelling, leukostasis, and portal inflammation. Coadministration of NVP and LPS attenuated NVP-induced liver injury. In conclusion, the immune system is involved in NVP toxicity, and the LPS effects may lay the clue to development of therapeutic strategies against NVP-induced hepatotoxicity.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2012 ","pages":"932542"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/932542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Response surface optimization of sustained release metformin-hydrochloride matrix tablets: influence of some hydrophillic polymers on the release. 盐酸二甲双胍缓释基质片的响应面优化：一些亲水聚合物对释放的影响

ISRN Pharmaceutics Pub Date : 2012-01-01 Epub Date: 2012-09-04 DOI: 10.5402/2012/364261

Amitava Roy, Kalpana Roy, Sarbani Roy, Jyotirmoy Deb, Amitava Ghosh, Kazi Asraf Ali

{"title":"Response surface optimization of sustained release metformin-hydrochloride matrix tablets: influence of some hydrophillic polymers on the release.","authors":"Amitava Roy, Kalpana Roy, Sarbani Roy, Jyotirmoy Deb, Amitava Ghosh, Kazi Asraf Ali","doi":"10.5402/2012/364261","DOIUrl":"10.5402/2012/364261","url":null,"abstract":"The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique. In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were X(60), X(120), T(50), T(90), n, and b values obtained from dissolution kinetics data. The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism. The drug release was found to reveal zero order kinetics. The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels. There were no significant drug-polymer interactions as revealed by infrared spectra. It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2012 ","pages":"364261"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0