Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans.

Vijay D Wagh, Onkar J Deshmukh
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引用次数: 39

Abstract

Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant : cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesicle size, entrapment efficiency, and drug release were markedly dependent on surfactant : cholesterol ratio and quantity of ethanol used. Permeation of the drug through the skin was affected by cholesterol content in formulation. Itraconazole niosome were having larger zone of inhibition than marketed formulation when activity was checked against C. albicans. Niosomes may be a promising carrier for topical delivery of Itraconazole especially due to their simple production.

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伊曲康唑小体给药系统及其抗白色念珠菌活性研究。
乳小体在局部给药系统中具有潜在的应用前景。本研究的目的是制备和评价伊曲康唑的酶体。采用因子设计对表面活性剂胆固醇比和乙醇用量进行了研究。对配制的纳米粒进行囊泡大小、包封效率、药物释放、皮肤渗透和抗真菌活性的评估。囊泡大小、包封效率和药物释放显著依赖于表面活性剂:胆固醇比和乙醇用量。药物通过皮肤的渗透受制剂中胆固醇含量的影响。伊曲康唑niosome对白色念珠菌的抑制范围比市售制剂大。乳小体制备简单,是一种很有前途的伊曲康唑局部给药载体。
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