ISRN Pharmaceutics最新文献_第2页

Validation of simultaneous volumetric and HPLC methods for the determination of pridinol mesylate in raw material. 体积法和高效液相色谱法同时测定原料中甲磺酸普地诺含量的验证。

ISRN Pharmaceutics Pub Date : 2013-10-02 eCollection Date: 2013-01-01 DOI: 10.1155/2013/540676

Laura D Simionato, Leonardo Ferello, Sebastián Stamer, Patricia D Zubata, Adriana I Segall

引用次数: 2

Photoinitiated polymerization of 2-hydroxyethyl methacrylate by riboflavin/triethanolamine in aqueous solution: a kinetic study. 核黄素/三乙醇胺在水溶液中光引发聚合2-甲基丙烯酸羟乙酯的动力学研究。

ISRN Pharmaceutics Pub Date : 2013-09-23 eCollection Date: 2013-01-01 DOI: 10.1155/2013/958712

Iqbal Ahmad, Kefi Iqbal, Muhammad Ali Sheraz, Sofia Ahmed, Tania Mirza, Sadia Hafeez Kazi, Mohammad Aminuddin

{"title":"Photoinitiated polymerization of 2-hydroxyethyl methacrylate by riboflavin/triethanolamine in aqueous solution: a kinetic study.","authors":"Iqbal Ahmad, Kefi Iqbal, Muhammad Ali Sheraz, Sofia Ahmed, Tania Mirza, Sadia Hafeez Kazi, Mohammad Aminuddin","doi":"10.1155/2013/958712","DOIUrl":"https://doi.org/10.1155/2013/958712","url":null,"abstract":"The polymerization of 1-3 M 2-hydroxyethyl methacrylate (HEMA) initiated by riboflavin/triethanolamine system has been studied in the pH range 6.0-9.0. An approximate measure of the kinetics of the reaction during the initial stages (~5% HEMA conversion) has been made to avoid the effect of any variations in the volume of the medium. The concentration of HEMA in polymerized solutions has been determined by a UV spectrophotometric method at 208 nm with a precision of ±3%. The initial rate of polymerization of HEMA follows apparent first-order kinetics and the rates increase with pH. This may be due to the presence of a labile proton on the hydroxyl group of HEMA. The second-order rate constants for the interaction of triethanolamine and HEMA lie in the range of 2.36 to 8.67 × 10(-2) M(-1) s(-1) at pH 6.0-9.0 suggesting an increased activity with pH. An increase in the viscosity of HEMA solutions from 1 M to 3 M leads to a decrease in the rate of polymerization probably as a result of the decrease in the reactivity of the flavin triplet state. The effect of pH and viscosity of the medium on the rate of reaction has been evaluated. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":" ","pages":"958712"},"PeriodicalIF":0.0,"publicationDate":"2013-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/958712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40279031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Pharmacosomes: an emerging novel vesicular drug delivery system for poorly soluble synthetic and herbal drugs. 药物小体:一种新兴的囊状药物递送系统，用于难溶性合成药物和草药。

ISRN Pharmaceutics Pub Date : 2013-09-09 DOI: 10.1155/2013/348186

Archana Pandita, Pooja Sharma

引用次数: 53

Formulation Development and Evaluation of Drug Release Kinetics from Colon-Targeted Ibuprofen Tablets Based on Eudragit RL 100-Chitosan Interpolyelectrolyte Complexes. 基于苦楝酸RL - 100-壳聚糖互聚电解质配合物的结肠靶向布洛芬片处方开发及释药动力学评价。

ISRN Pharmaceutics Pub Date : 2013-08-06 eCollection Date: 2013-01-01 DOI: 10.1155/2013/838403

Kenneth Chibuzor Ofokansi, Franklin Chimaobi Kenechukwu

{"title":"Formulation Development and Evaluation of Drug Release Kinetics from Colon-Targeted Ibuprofen Tablets Based on Eudragit RL 100-Chitosan Interpolyelectrolyte Complexes.","authors":"Kenneth Chibuzor Ofokansi, Franklin Chimaobi Kenechukwu","doi":"10.1155/2013/838403","DOIUrl":"https://doi.org/10.1155/2013/838403","url":null,"abstract":"Colon-targeted drug delivery systems (CTDDSs) could be useful for local treatment of inflammatory bowel diseases (IBDs). In this study, various interpolyelectrolyte complexes (IPECs), formed between Eudragit RL100 (EL) and chitosan (CS), by nonstoichiometric method, and tablets based on the IPECs, prepared by wet granulation, were evaluated as potential oral CTDDSs for ibuprofen (IBF). Results obtained showed that the tablets conformed to compendial requirements for acceptance and that CS and EL formed IPECs that showed pH-dependent swelling properties and prolonged the in vitro release of IBF from the tablets in the following descending order: 3 : 2 > 2 : 3 > 1 : 1 ratios of CS and EL. An electrostatic interaction between the carbonyl (-CO-) group of EL and amino (-NH3 (+)) group of CS of the tablets formulated with the IPECs was capable of preventing drug release in the stomach and small intestine and helped in delivering the drug to the colon. Kinetic analysis of drug release profiles showed that the systems predominantly released IBF in a zero-order manner. IPECs based on CS and EL could be exploited successfully for colon-targeted delivery of IBF in the treatment of IBDs. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"838403"},"PeriodicalIF":0.0,"publicationDate":"2013-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/838403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31692819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Nontargeted Identification of the Phenolic and Other Compounds of Saraca asoca by High Performance Liquid Chromatography-Positive Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry. 高效液相色谱-正电喷雾电离和四极杆飞行时间质谱法非靶向鉴定水芹中酚类和其他化合物。

ISRN Pharmaceutics Pub Date : 2013-08-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/293935

Ashwani Mittal, Preeti Kadyan, Anjum Gahlaut, Rajesh Dabur

{"title":"Nontargeted Identification of the Phenolic and Other Compounds of Saraca asoca by High Performance Liquid Chromatography-Positive Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.","authors":"Ashwani Mittal, Preeti Kadyan, Anjum Gahlaut, Rajesh Dabur","doi":"10.1155/2013/293935","DOIUrl":"https://doi.org/10.1155/2013/293935","url":null,"abstract":"High performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer was used for separation and identification of phenolic and other compounds in the water extracts of Saraca asoca (Roxb.), De. Wilde. The aim of the study was to identify and evaluate the distribution of phenolic compounds in the different parts of the plant. The identity of compounds was established through the comparison with standards and characteristic base peaks as well as other daughter ions. In crude extracts, 34 catechin derivatives, 34 flavonoids, and 17 other compounds were identified. Interestingly, further analysis of compounds showed plant part specific unique pattern of metabolites; that is, regenerated bark is observed to be the best source for catechin/catechin derivative while flowers were found to be the source for wide variety of flavonoids. Moreover, these plant part specific compounds can be used as biomarkers for the identification of plant material or herbal drugs. Overall, the present study provides for the first time a comprehensive analysis of the phenolic components of this herb which may be helpful not only to understand their usage but also to contribute to quality control as well. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"293935"},"PeriodicalIF":0.0,"publicationDate":"2013-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/293935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31692818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Comparison of various generations of superporous hydrogels based on chitosan-acrylamide and in vitro drug release. 不同代壳聚糖丙烯酰胺基超孔水凝胶的体外释药比较。

ISRN Pharmaceutics Pub Date : 2013-07-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/624841

Shikha Bhalla, Manju Nagpal

{"title":"Comparison of various generations of superporous hydrogels based on chitosan-acrylamide and in vitro drug release.","authors":"Shikha Bhalla, Manju Nagpal","doi":"10.1155/2013/624841","DOIUrl":"https://doi.org/10.1155/2013/624841","url":null,"abstract":"The aim of the current research work was to prepare and evaluate different generations of superporous hydrogels (SPH) of acrylamide and chitosan using gas blowing technique and evaluate them for swelling, mechanical properties, FTIR, SEM, XRD, and in vitro drug release. The ingredients used were acrylamide, N,N'-methylene bisacrylamide, chitosan, Pluronic F127, ammonium per sulfate-N,N,N',N'-tetramethylenediamine, and sodium bicarbonate. All ingredients were mixed sequentially with thorough stirring. The effect of different drying conditions on properties of SPH was also evaluated. Ethanol treated batched showed maximum swelling properties due to uniform pores as indicated in SEM studies. Equilibrium swelling time was less than 10 min in all batches. Freeze drying led to lowering of density which is also supported by porosity and void fraction data. Maximum mechanical strength was found in superporous hydrogel interpenetrating networks due to crosslinked polymeric network. 70% drug was released at the end of 2 h, and further the release was sustained till the end of 24 h. In vitro drug release kinetics showed that drug release occurs by diffusion and follows Super Case II transport indicating that mechanism of drug release is not clear. Superporous hydrogel interpenetrating networks can be successfully used as sustained release gastroretentive devices. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"624841"},"PeriodicalIF":0.0,"publicationDate":"2013-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/624841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31690584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. 呼吸系统疾病用硫酸沙丁胺醇快速崩解片的处方研制与评价。

ISRN Pharmaceutics Pub Date : 2013-07-15 eCollection Date: 2013-01-01 DOI: 10.1155/2013/674507

Deepak Sharma

{"title":"Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders.","authors":"Deepak Sharma","doi":"10.1155/2013/674507","DOIUrl":"https://doi.org/10.1155/2013/674507","url":null,"abstract":"Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of salbutamol sulphate for respiratory disorders for pediatrics. As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient's acceptability. Hence, the present investigation were undertaken with a view to develop a fast disintegrating tablet of salbutamol sulphate which offers a new range of products having desired characteristics and intended benefits. Superdisintegrants such as sodium starch glycolate was optimized. Different binders were optimized along with optimized superdisintegrant concentration. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time, and uniformity of content. Optimized formulation was evaluated by in vitro dissolution test, drug-excipient compatibility, and accelerated stability study. It was concluded that fast disintegrating tablets of salbutamol sulphate were formulated successfully with desired characteristics which disintegrated rapidly; provided rapid onset of action; and enhanced the patient convenience and compliance. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"674507"},"PeriodicalIF":0.0,"publicationDate":"2013-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/674507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31667659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Suitability of Biomorphic Silicon Carbide Ceramics as Drug Delivery Systems against Bacterial Biofilms. 生物形态碳化硅陶瓷作为抗细菌生物膜药物传递系统的适用性。

ISRN Pharmaceutics Pub Date : 2013-07-07 Print Date: 2013-01-01 DOI: 10.1155/2013/104529

P Díaz-Rodríguez, A Pérez-Estévez, R Seoane, P González, J Serra, M Landin

{"title":"Suitability of Biomorphic Silicon Carbide Ceramics as Drug Delivery Systems against Bacterial Biofilms.","authors":"P Díaz-Rodríguez, A Pérez-Estévez, R Seoane, P González, J Serra, M Landin","doi":"10.1155/2013/104529","DOIUrl":"https://doi.org/10.1155/2013/104529","url":null,"abstract":"The present work is aimed at getting a new insight into biomorphic silicon carbides (bioSiCs) as bone replacement materials. BioSiCs from a variety of precursors were produced, characterized, and loaded with a broad-spectrum antibiotic. The capacity of loaded bioSiCs for preventing and/or treating preformed S. aureus biofilms has been studied. The differences in precursor characteristics are maintained after the ceramic production process. All bioSiCs allow the loading process by capillarity, giving loaded materials with drug release profiles dependent on their microstructure. The amount of antibiotic released in liquid medium during the first six hours depends on bioSiC porosity, but it could exceed the minimum inhibitory concentration of Staphylococcus aureus, for all the materials studied, thus preventing the proliferation of bacteria. Differences in the external surface and the number and size of open external pores of bioSiCs contribute towards the variations in the effect against bacteria when experiments are carried out using solid media. The internal structure and surface properties of all the systems seem to facilitate the therapeutic activity of the antibiotic on the preformed biofilms, reducing the number of viable bacteria present in the biofilm compared to controls. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"104529"},"PeriodicalIF":0.0,"publicationDate":"2013-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/104529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Microemulsion: new insights into the ocular drug delivery. 微乳剂：眼部给药的新视角。

ISRN Pharmaceutics Pub Date : 2013-06-27 Print Date: 2013-01-01 DOI: 10.1155/2013/826798

Rahul Rama Hegde, Anurag Verma, Amitava Ghosh

{"title":"Microemulsion: new insights into the ocular drug delivery.","authors":"Rahul Rama Hegde, Anurag Verma, Amitava Ghosh","doi":"10.1155/2013/826798","DOIUrl":"10.1155/2013/826798","url":null,"abstract":"Delivery of drugs into eyes using conventional drug delivery systems, such as solutions, is a considerable challenge to the treatment of ocular diseases. Drug loss from the ocular surface by lachrymal fluid secretion, lachrymal fluid-eye barriers, and blood-ocular barriers are main obstacles. A number of ophthalmic drug delivery carriers have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. The potential use of microemulsions as an ocular drug delivery carrier offers several favorable pharmaceutical and biopharmaceutical properties such as their excellent thermodynamic stability, phase transition to liquid-crystal state, very low surface tension, and small droplet size, which may result in improved ocular drug retention, extended duration of action, high ocular absorption, and permeation of loaded drugs. Further, both lipophilic and hydrophilic characteristics are present in microemulsions, so that the loaded drugs can diffuse passively as well get significantly partitioned in the variable lipophilic-hydrophilic corneal barrier. This review will provide an insight into previous studies on microemulsions for ocular delivery of drugs using various nonionic surfactants, cosurfactants, and associated irritation potential on the ocular surface. The reported in vivo experiments have shown a delayed effect of drug incorporated in microemulsion and an increase in the corneal permeation of the drug. ","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2013 ","pages":"826798"},"PeriodicalIF":0.0,"publicationDate":"2013-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31649871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability of betaine capsules. 甜菜碱胶囊的稳定性。

ISRN Pharmaceutics Pub Date : 2013-06-03 Print Date: 2013-01-01 DOI: 10.1155/2013/458625

Mirza Akram Hossain, Stéphanie Boily, Natasha Beauregard, Jean-Marc Forest, Grégoire Leclair

引用次数: 0