Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003最新文献_第6页

Discovering compact and highly discriminative features or combinations of drug activities using support vector machines 使用支持向量机发现紧凑和高度判别的特征或药物活动组合

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227321

Hwanjo Yu, Jiong Yang, Wen Wang, Jiawei Han

{"title":"Discovering compact and highly discriminative features or combinations of drug activities using support vector machines","authors":"Hwanjo Yu, Jiong Yang, Wen Wang, Jiawei Han","doi":"10.1109/CSB.2003.1227321","DOIUrl":"https://doi.org/10.1109/CSB.2003.1227321","url":null,"abstract":"Nowadays, high throughput experimental techniques make it feasible to examine and collect massive data at the molecular level. These data, typically mapped to a very high dimensional feature space, carry rich information about functionalities of certain chemical or biological entities and can be used to infer valuable knowledge for the purposes of classification and prediction. Typically, a small number of features or feature combinations may play determinant roles in functional discrimination. The identification of such features or feature combinations is of great importance. In this paper, we study the problem of discovering compact and highly discriminative features or feature combinations from a rich feature collection. We employ the support vector machine as the classification means and aim at finding compact feature combinations. Comparing to previous methods on feature selection, which identify features solely based on their individual roles in the classification, our method is able to identify minimal feature combinations that ultimately have determinant roles in a systematic fashion. Experimental study on drug activity data shows that our method can discover descriptors that are not necessarily significant individually but are most significant collectively.","PeriodicalId":147883,"journal":{"name":"Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134117664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

A semantic mediation approach for problems in computational molecular biology 计算分子生物学问题的语义调解方法

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227339

M. Chagoyen, M. E. Kurul, P. A. D. Alarcón, S. Santini, Bertram Ludäscher, J. Carazo, Amarnath Gupta

引用次数: 0

cWINNOWER algorithm for finding fuzzy DNA motifs cWINNOWER算法寻找模糊DNA基序

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227326

S. Liang

引用次数: 59

Pathway bioinformatics 途径生物信息学

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227294

P. Karp

引用次数: 1

Automatic recognition of regions of intrinsically poor multiple alignment using machine learning 利用机器学习自动识别本质上较差的多重对齐区域

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227381

Yunfeng Shan, E. Milios, A. Roger, C. Blouin, E. Susko

引用次数: 6

An exact algorithm for determining protein backbone structure from NH residual dipolar couplings 从NH残余偶极偶联中确定蛋白质主结构的精确算法

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227422

Lincong Wang, Ramgopal R. Mettu, R. Lilien, B. Donald

引用次数: 3

Motifs and modules in cellular signal processing: applications to microbial stress response pathways 细胞信号处理中的基序和模块:在微生物应激反应途径中的应用

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227299

A. Arkin

引用次数: 0

Microbial functional genomics: pulling together a variety of approaches and concepts 微生物功能基因组学:汇集各种方法和概念

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227291

J. Claverie

引用次数: 0

A parallel genetic algorithm for physical mapping of chromosomes 染色体物理映射的并行遗传算法

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227410

S. Bhandarkar, Jinling Huang, J. Arnold

引用次数: 3

Mapping discontinuous antibody epitopes to reveal protein structure and changes in structure related to function 定位不连续抗体表位，揭示蛋白质结构和与功能相关的结构变化

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-08-11 DOI: 10.1109/CSB.2003.1227415

B. Mumey, T. Angel, Bonnie Kirkpatrick, B. W. Bailey, P. Hargrave, A. J. Jesaitis, E. Dratz

引用次数: 3