Jorjani Biomedicine Journal最新文献

{"title":"Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature","authors":"Mahmoud Mohammadi, L. Kohan, M. Saeidi, M. S. Jazi, S. Mohammadi","doi":"10.52547/jorjanibiomedj.10.2.69","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.69","url":null,"abstract":"Fibrosis is a common and mostly progressive pathological outcome in various chronic inflammatory disorders. Dermal (skin) fibrosis, which is associated with intense skin lesions, is a result of an uncontrolled healing process in the dermis, particularly disproportionate fibroblast proliferation and Extracellular Matrix (ECM) production. Animal models are substantial tools in biomedical investigations and have been considerably employed to evaluate miscellaneous features of diseases that cannot be demonstrated otherwise in humans. To date, various skin fibrosis models have been generated, including the transgene and/or genetic models and chemical and drug-induced models. However, genetic models are sophisticated and need access to convoluted methods. Accordingly, the introduction of affordable and easy to generate fibrosis models in the skin is crucial. Here, we aimed to introduce the chemical/drug-induced skin fibrosis animal models to provide an updated list of available approaches.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74933144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic and Preventive Effects of Aqueous Extracts of Arctium lappa L. and Cichorium intybus L. against Fatty Liver in Rats","authors":"Mohammad Jafari Shiran, S. Naseri, Tahereh Sadeghian-Rizi, S. Khani, M. Shoormij, Seyedeh Simin Dakhilpour","doi":"10.52547/jorjanibiomedj.10.2.53","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.53","url":null,"abstract":"Background and objectives: The fatty liver is a reversible form of fat accumulation in the liver tissue. The burden of this disease is increasing worldwide. Researchers have focused on using herbal medicines due to the lack of proper treatment and numerous side effects of existing chemical medicines. This study aimed to evaluate the therapeutic effects of aqueous extract of Arctium lappa L. (burdock) and Cichorium intybus L. (chicory) on fatty liver in rats fed with a high-fat diet as these plants have been frequently applied in traditional medicine for the treatment of the liver-related diseases. Material and Methods: For this study, 30 Wistar rats weighing 120-220 g were used. The rats were divided into five groups and received 125, 250, 500, and 1000 mL/kg of a mixture of aqueous extracts of burdock and chicory. The biochemical indexes, including aspartate aminotransferase, alanine aminotransferase, and etc. were analyzed. Also, for histologic examination liver tissue samples were stained with hematoxylin-eosin. Results: We showed that the aqueous extract reduced the liver macro-vesicles and microvesicles and symptoms of steatosis without any specific liver complications. We also found that 500 and 1000 mL/kg of extract had the most effective therapeutic effect. Conclusion: In conclusion, our study shows that extract of burdock-chicory has the potential to ameliorate fatty liver in rats fed with a high-fat diet. This study provides evidence that burdock-chicory extract could be considered a potential dietary supplement strategy for preventing and treating fatty liver.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89259786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Microleakage of Self-Adhesive Composite Resin in Pits and Fissures of Extracted Premolar Teeth: An in Vitro Study","authors":"Z. Bahrololoomi, F. Mehravar, N. Halvani, Hamed Saeid","doi":"10.52547/jorjanibiomedj.10.2.62","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.62","url":null,"abstract":"Background and objectives: Microleakage at the interface of tooth structure and fissure sealant plays a crucial role in the failure of the treatment. This in vitro study aimed to determine the microleakage of self-adhesive flowable composite resins as pit and fissure sealants. Material and Methods: Sixty healthy extracted premolar teeth were randomly divided into the four groups (n=15), clinpro sealants (control), flowable composite resin with bonding agent (total-etch), flowable composite resin with a self-etch bonding agent, and self-adhesive composite resin. After thermocycling, the specimens were immersed in 2% methylene blue for 48 hours and then sectioned in the buccolingual direction. The microleakage was assessed by dye penetration using a stereomicroscope at 15X magnification. Data analysis was performed using SPSS version 18.0 and Mann-Whitney and Kruskal-Wallis tests. Results: There was a statistically significant difference in microleakage score between the groups (P-value = 0.006). The lowest mean of the microleakage level was observed in the flowable composite group with total-etch bonding (group 2) at 1.26±0.96, followed by the Clinpro sealant group (group 1) at 1.62±1.20, and then the self-adhesive composite group (group 4) 1.85±1.00. Conclusion: Based on the results of this study, the microleakage of self-adhesive composite resin revealed no significant difference with conventional fissure sealant; however, the microleakage of these composite resins was higher than flowable composite resin with a total-etch bonding agent.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84128973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endurance Training and Consumption of Hydroalcoholic Zingiber Officinale Extract Regulated PPARγ, PGC1-ɑ/TNF-ɑ Expression Level in Myocardial Infarction Rats","authors":"Monireh Omomi, F. Taghian, G. Sharifi","doi":"10.52547/jorjanibiomedj.10.2.24","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.24","url":null,"abstract":"Background and objectives: Zingiber officinale extract can control cardiovascular risk factors. Moreover, endurance training may effectively rehabilitate myocardial infarction by strengthening the myocardial muscle tissue. In-silico analysis identified essential genes involved in the heart damage process based on data from the DisGeNET database. Hence, we estimated the affinity of chemical and bioactive molecules for PPARγ. Therefore, this study aimed to investigate the effect of endurance exercise alone or combined with Zingiber officinale extract on Myocardial infarction rats. Material and Methods: Twenty-five male rats were randomly divided into five groups, including (1) group of Myocardial Infarctions (MI) induced by subcutaneous injection of isoproterenol, (2) Myocardial Infarction+Exercise (MI+EX), (3) Myocardial Infarction+Zingiber Officinale extraction administered orally (MI+GE), (4) myocardial infarction+exercise+Zingiber Officinale extract (MI+EX+GE), and (5) Control group. The qPCR-Real Time technique was used to measure the expression of PGC1- ɑ , PPARγ, and TNF- ɑ genes. We evaluated the concentration of Troponin-1 as a vital myocardial ischemia marker. Results: In bioinformatics analysis, we found that the PPARγ, PGC1- ɑ , and TNF- ɑ pathways were critical in heart injury. Also, the effects of Zingiber officinale on heart tissue were detected through PPARγ by drug design. Endurance training combined with Zingiber officinale consumption reduced the expression of TNF- ɑ , Troponin-1 and increased the PGC1- ɑ , PPARγ genes. Furthermore, consumption of Zingiber officinale extraction improved the levels of PGC1- ɑ , PPARγ, TNF- ɑ , and Troponin-1. Conclusion: Our data indicated that six weeks of endurance training and consumption of Zingiber officinale extract could reduce the relative expression of the TNF- ɑ and significantly increase the level of PGC1- ɑ , PPARγ.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83220319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative Impact of Silymarin on the Male Reproductive System: An Updated Systematic Review","authors":"F. Hosseinabadi, T. Faraji, M. Malmir, Hanieh Mohamadi","doi":"10.52547/jorjanibiomedj.10.2.10","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.10","url":null,"abstract":"Background and objectives: Numerous studies have evaluated the effects of silymarin on sperm quality and its neutralization impact of various toxins on the male reproductive system. However, these studies as a whole have not been summarized and categorized yet. Silymarin is a flavonoid and known as a powerful antioxidant compound in the treatment of many diseases including liver disorders, rhinitis, diabetes, and testis disorders. The study aimed to discuss the impact of silymarin on the male reproductive system. Material and Methods: From Apr 1998 to Feb 2020, related articles were extracted from databases of Web of Science (WOS), PubMed, Google Scholar, Science Direct, Scopus, EBSCO, and grey literature by seeking MeSH words including Silymarin, Milk thistle, Silybum marianum, testis, Spermatogenesis, and Sex hormones. Results: Silymarin withholds damage to the testicular germinal epithelium and comforts the spermatogenesis process by amplification the antioxidant system, decreasing lipid peroxidation and oxidative stress, and preventing the expression of pro-apoptotic genes, increasing testosterone and gonadotropins. Conclusion: In outcome, based on the results, silymarin can boost fertility in sterility males by its talented antioxidant features.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90870597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Interval and Continued Trainings with Citrus Aurantium on Pain Threshold and Motor Balance in Elderly Rats","authors":"O. Salehi, Mayam Kheirdeh, Fatemeh Farkhaie, M. Noura, Rasoul Jamali Fashi, Abdolali Rakhshanizadeh","doi":"10.52547/jorjanibiomedj.10.2.1","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.1","url":null,"abstract":"Background and objectives: Aging is a natural phenomenon associated with a decrease in physical fitness factors and increases in chronic pain. The present study aimed to investigate the effect of High Interval Intensity Training (HIIT) and Moderate Intensity Continued Training (MICT) with Citrus Aurantium (CA) consumption on pain threshold and motor balance in elderly rats. Material and Methods: Forty-nine elderly rats were randomly divided into 1) control, 2) MICT, 3) HIIT, 4) MICT+CA, 5) HIIT+CA, 6) CA and 7) sham groups. Groups 3 and 5 performed HIIT at a speed of 25-25 m/min, and groups 2 and 4 performed MICT at a speed of 25-20 m/min; also, groups 4-6 received 300 mg/kg/day CA peritoneally. The pain and motor balance tests were evaluated using a hot plate and rotarod devices respectively. The Kolmogorov-Smirnov test was used to investigate the normal distribution of findings and one-way ANOVA with Tukey’s post- hoc tests was used to analyze of findings (P≤0.05). Results: CA, MICT, HIIT, MICT+CA, and HIIT+CA significantly increased pain threshold and motor balance (P<0.05); MICT+CA (P<0.05) and HIIT+CA (P<0.05) significantly increased pain threshold compared to CA, MICT, and HIIT, and HIIT+CA significantly increased pain threshold compared to MICT+CA (P<0.05). Conclusion: Although CA, MICT, and HIIT alone can enhance pain threshold and motor balance nevertheless it appears that MICT+CA and HIIT+CA have a better effect on the increase of pain threshold, so the effects of HIIT+CA can be higher than MICT+CA.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76289122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Auricular Acupressure on Postpartum Perineal Pain: A Systematic Review","authors":"Zohreh Hosseini Marznaki, Zainab Alimoradi, M. Hakimi, M. Haghighi, Samad Karkhah","doi":"10.52547/jorjanibiomedj.10.2.45","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.45","url":null,"abstract":"Background and objectives: One of the potentially effective methods for relieving postpartum perineal pain is auricular acupressure. This review aimed to evaluate the clinical effect of auricular acupressure on postpartum perineal pain in a systematic review. Material and Methods: An extensive systematic search was performed on online electronic databases, including Scopus, PubMed/MEDLINE, ProQuest, Web of Science, and Cochrane using the keywords related to the purpose, from the earliest to June 30, 2021. Results: Of 263 articles, three studies were included in the review. A total of 386 women with a mean age of 29.79 years were included in the review. Of the participants, 192 women were in the intervention group. Of the studies included, two studies evaluated auricular acupressure, and one study evaluated battlefield auricular acupuncture plus standard analgesia. Overall, the number of acupressure points varied from 3 to 5. In most cases, auricular acupressure was used at points of Shen Men (n=3) and the external genital area (n=2). Overall, auricular acupressure in one study out of three studies had a significant effect on reducing postpartum perineal pain. Two out of three studies reported no side effects of auricular acupressure for participants. Conclusion: It seems that auricular acupressure can be used as a simple, low-cost, and practical intervention to reduce postpartum perineal pain. However, future well-designed studies are needed to confirm the findings of this systematic review.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75847661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Exercise and Folate Nano-Liposomes on D1 and D2 Receptor Gene Expression in the Brain of Alzheimer's Rats","authors":"F. Nameni, Fateme Firoozmand","doi":"10.52547/jorjanibiomedj.10.2.36","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.2.36","url":null,"abstract":"Background and objectives: Alzheimer's is a neurodegenerative disorder characterized by memory loss and cognitive dysfunction. Research has shown that blood metal levels and physical activity may be crucial to injury and possibly Alzheimer's treatment. This study aimed to evaluate the effects of high-intensity interval training (HIIT) and folate Nano liposomes on the expression of D1 and D2 genes in the hippocampal tissue of Alzheimer's rats. Material and Methods: Thirty-five male Wistar rats at eight weeks of age were randomly divided into five groups (healthy control, Alzheimer's control, Alzheimer's + HIIT, Alzheimer's + Nano-liposome folate, Alzheimer's + HIIT + Nano-liposome folate). After Alzheimer's induction, exercise program protocol and folate Nano liposomes were performed as supplements in the groups. After the last training session, the mice were anesthetized, and the hippocampus was examined. D1 and D2 receptor gene expression were examined by the Real-time-PCR method. Results: The results showed that the highest increase in D1 and D2 receptor gene expression was in the Alzheimer's group, and the lowest growth was in the Alzheimer's+HIIT+ Nano liposome group (P<0.05). Conclusion: Resistance training and Nano-liposome folate decreased D1 and D2 receptor gene expression after Alzheimer's induction. This reduction may be due to the modulatory effects of physical activity and Nanomedicines in preventing or reducing pathological conditions.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75064623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical Challenges and Coping Strategies about Issues Related to The Healthcare System and Social Issues During the COVID-19 Pandemic: A Narrative Review","authors":"Sahar Miri, Samad Karkhah, Pooyan Ghorbani Vajargah, Amirabbas Mollaei, Atefeh Falakdami, Poorya Takasi, A. Emami Zeydi, Mohammad Javad Ghazanfari","doi":"10.52547/jorjanibiomedj.10.1.84","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.1.84","url":null,"abstract":"Background and Objective : Since December 2019, the widespread outbreak of COVID-19 has led to a major public health issue worldwide. With the spread of the COVID-19 pandemic, a series of ethically challenging issues arose that put pressure on healthcare systems around the world. This narrative review aims to comprehensively review the literature focusing on ethical challenges and coping strategies about issues related to the healthcare system and social issues during the COVID-19 pandemic. Material and Methods: This narrative review was conducted via international databases including PubMed/MEDLINE, Web of Science, and Scopus using keywords extracted from medical subject headings such as \"COVID-19\", \"2019-nCoV disease\", \"2019 novel coronavirus infection\", \"Ethics\", \"Bioethical Issues\", \"Morals\", \"Coping Skills\", \"Coping Skill\", \"Coping Strategies\", and \"Coping Strategy\" from December 2019 to January 2022. Results: In general, ethical issues during the COVID-19 pandemic can be divided into two categories: 1) issues related to the healthcare system and 2) social issues. Issues related to the healthcare system can be divided into two categories: 1) lack of resources, equipment and facilities, and manpower, and 2) problems in patient care such as triage and informed consent. Social issues can be divided into four categories: 1) community engagement, 2) crisis management capacity in remote rural communities, 3) discrimination and health equity, and 4) vaccination. Coping with ethical challenges in crises such as COVID-19 requires changing health empowerment policies and strategies based on evidence-based research. On the other hand, overcome on these challenges requires interdisciplinary collaboration and fast efficient decisions. Conclusion: Overall, the present study introduced ethical challenges and coping strategies during the COVID 19 pandemic. The experience gained from this pandemic can be considered by managers and policymakers of health care systems for coping with ethical challenges.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78112768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features and Methods of Making Nanofibers by Electrospinning, Phase Separation and Self-assembly","authors":"M. Kheyrandish, Fahime Bafande, Mehdi Sheikh Arabi","doi":"10.52547/jorjanibiomedj.10.1.13","DOIUrl":"https://doi.org/10.52547/jorjanibiomedj.10.1.13","url":null,"abstract":"One of the major challenges in the field of tissue engineering is the production of scaffolding in nano-scale. The study of structural-functional connections in pathological and normal tissues with biologically active alternatives or engineered materials has been developed. Extracellular Matrix (ECM) is a suitable environment consisting of gelatin, elastin and collagen types I, II and III, etc., which are provided to cells for wound healing, embryonic development, cell growth and organogenesis, and. They also play a role in transmitting structural integrity and overall strength to tissues. In tissues, ECM manufacturers are structurally 50 to 500 nm in diameter; nanotechnology must be used to create scaffolds or ECM analogues. Recent advances in nanotechnology have led to the development of ECM-engineered analogues in various ways. To date, three self-assembly, phase separation and electrospinning techniques have been developed to activate nanofiber scaffolds. With these advances and the construction of a \"biomimetic\" environment, engineered tissue or scaffolding is now possible for a variety of tissues. This study will discuss the three existing methods for creating Tissue engineering scaffolds that are able to mimic new tissue, as well as the discovery of materials for use in scaffolding.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74663947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}