Ameliorative Impact of Silymarin on the Male Reproductive System: An Updated Systematic Review

Jorjani Biomedicine Journal Pub Date : 2022-05-01 DOI:10.52547/jorjanibiomedj.10.2.10

F. Hosseinabadi, T. Faraji, M. Malmir, Hanieh Mohamadi

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引用次数: 1

Abstract

Background and objectives: Numerous studies have evaluated the effects of silymarin on sperm quality and its neutralization impact of various toxins on the male reproductive system. However, these studies as a whole have not been summarized and categorized yet. Silymarin is a flavonoid and known as a powerful antioxidant compound in the treatment of many diseases including liver disorders, rhinitis, diabetes, and testis disorders. The study aimed to discuss the impact of silymarin on the male reproductive system. Material and Methods: From Apr 1998 to Feb 2020, related articles were extracted from databases of Web of Science (WOS), PubMed, Google Scholar, Science Direct, Scopus, EBSCO, and grey literature by seeking MeSH words including Silymarin, Milk thistle, Silybum marianum, testis, Spermatogenesis, and Sex hormones. Results: Silymarin withholds damage to the testicular germinal epithelium and comforts the spermatogenesis process by amplification the antioxidant system, decreasing lipid peroxidation and oxidative stress, and preventing the expression of pro-apoptotic genes, increasing testosterone and gonadotropins. Conclusion: In outcome, based on the results, silymarin can boost fertility in sterility males by its talented antioxidant features.

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水飞蓟素对男性生殖系统的改善作用:最新的系统综述

背景与目的:大量研究评估了水飞蓟素对精子质量的影响及其对男性生殖系统中各种毒素的中和作用。然而，这些研究作为一个整体尚未得到总结和分类。水飞蓟素是一种类黄酮，被认为是一种强大的抗氧化化合物，可以治疗许多疾病，包括肝脏疾病、鼻炎、糖尿病和睾丸疾病。该研究旨在探讨水飞蓟素对男性生殖系统的影响。材料与方法:从Web of Science (WOS)、PubMed、Google Scholar、Science Direct、Scopus、EBSCO和灰色文献中检索MeSH词，检索水飞蓟素(Silymarin)、水飞蓟(Milk thistle)、水飞蓟(Silybum marianum)、睾丸(testis)、精子发生(spermatgenesis)、性激素(Sex hormone)等相关文献。结果:水飞蓟素通过增强抗氧化系统，减少脂质过氧化和氧化应激，抑制促凋亡基因的表达，增加睾酮和促性腺激素，抑制对睾丸生殖上皮的损伤，调节精子发生过程。结论:综上所述，水飞蓟素可通过其良好的抗氧化作用提高不育雄性的生育能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Jorjani Biomedicine Journal

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