JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia最新文献

{"title":"NEFROLITIASIS PADA ANAK USIA TIGA TAHUN DI RSUD DR. HI. ABDUL MOELOEK, LAMPUNG: SEBUAH LAPORAN KASUS","authors":"Angga Hendro Priyono, Exsa Hadibrata","doi":"10.53366/jimki.v7i2.80","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.80","url":null,"abstract":"ABSTRACT  Background: The incidence of nephrolithiasis in children increases over time. It has been reported an increase of 6 to 10% per year for the last twenty-five years. Research in developing country showed that urinary tract infection and metabolic disorders were the caused of nephrolithiasis. Illustration Case: Three years 10 months old boy had a complaint of pain in plank region followed by tea-like urine since two months ago. Physical examination showed that he appeared to be moderately ill and compos mentis. His physical examinations were normal except positive ballotement and positive costoverebral angle (CVA) pain in the right flank region. Laboratory finding showed positive eritrocyte in urinalysis. Ultrasonography and abdominal CT-scan consistent with nephrolithiasis. Management: Pyelolitotomy was performed under general anesthesia. Postoperatively, patient treated in a pediatric surgery room and observation was carried out. He was given  D5NS 500 ml administered 20 drops per minute microdrip IV, paracetamol 3 x 225 mg IV, and cefotaxime injection 2 x 500 mg IV after a skin test first.  Result and Follow Up: An irregular stone 1,5 cm x 1 cm in size consist of 45% ammonium urate, 31% sodium urate monohydrate, and 24% amorphous calcium phosphate carbonate was found. Discussion: Nephrolithiasis in children occurs due to several related conditions such as genetics, ethnicity, climate, and nutrition. Complications can be prevented by managing and controlling appropriate risk factors.","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88129848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUBUNGAN OBESITAS TERHADAP KESEIMBANGAN POSTURAL","authors":"D. Fitria, Khairunisa Berawi","doi":"10.53366/jimki.v7i2.68","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.68","url":null,"abstract":"Pendahuluan: Obesitas merupakan suatu keadaan dengan akumulasi lemak yang tidak normal atau berlebihan di jaringan adiposa sehingga dapat mengganggu kesehatan dan menjadi salah satu penyakit yang sukar diatasi. Prevalensi obesitas mencapai hampir 3 kali lipat dalam kurun waktu lebih dari 40 tahun (pada tahun 1975–2016). Sementara  di Indonesia, prevalensi obesitas mencapai 15,4% pada tahun 2013. Tulisan ini bertujuan untuk mengetahui apakah terdapat hubungan obesitas terhadap keseimbangan postural.  Metode penelitian: Metode penelitian yang digunakan adalah dengan meninjau artikel dengan kata kunci obesitas dan keseimbangan postural.  Pembahasan: Obesitas merupakan suatu kelainan kompleks pengaturan nafsu makan dan metabolisme energi yang dikendalikan beberapa faktor biologik spesifik . Keseimbangan didefinisikan sebagai suatu kemampuan untuk mengontrol pusat gravitasi agar tetap berada di atas landasan penopang. Obesitas memengaruhi keseimbangan dari segi anatomi, yakni perubahan postur yang terjadi adalah menurunnya lingkup gerak sendi (LGS), berkurangnya elastisitas pada ligamen dan otot, serta berubahnya center of gravity (CoG). Individu yang obesitas memiliki tingkat kestabilan yang kurang daripada individu yang memiliki berat badan normal sehingga mengurangi kinerja gerakan ekstremitas atas.  Kesimpulan: Data menunjukkan bahwa terdapat hubungan obesitas terhadap keseimbangan postural dimana pada individu yang obesitas memiliki kontrol postural yang tidak baik daripada individu dengan berat badan normal. Namun, penelitian lebih lanjut diperlukan untuk mengetahui jenis obesitas yang lebih memiliki hubungan erat dengan keseimbangan postural. ","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87056753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUASI DAN MANAJEMEN INFERTILITAS PRIA","authors":"Leni Amelia, S. Rahmanisa","doi":"10.53366/jimki.v7i2.84","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.84","url":null,"abstract":"Infertilitas adalah suatu masalah secara psikis yang memengaruhi sekitar 15% dari semuapasangan. Kedua pasangan khususnya pria harus dievaluasi bersamaan, karena faktorpria adalah penyebab utama atau berkontribusi sekitar 40% hingga 60% pada kasusinfertilitas. Selain mendeteksi kelainan yang dapat diobati, evaluasi pria dengan infertilsangat penting untuk menegakkan diagnosis yang mengancam jiwa terkait dengan gejalainfertilitasnya, serta kondisi genetik yang terkait dengan infertilitas pria yang dapatditularkan ke keturunan dengan reproduksi yang dibantu alat. Tes diagnostik dan teknikbedah baru telah dikembangkan dan disempurnakan, menghasilkan hasil pengobatanpada pasien yang lebih baik. Kemajuan teknologi dan ilmu pengetahuan yang meluas,teknik reproduksi seperti injeksi sperma intrasitoplasma telah menciptakan alternatif bagipasangan yang sebelumnya hanya memiliki sedikit harapan untuk memiliki keturunan.Praktisi infertilitas harus memiliki pemahaman menyeluruh tentang kelebihan danketerbatasan berbagai tes laboratorium serta indikasi, biaya, dan tingkat keberhasilansemua opsi pengobatan. Langkah pertama dalam evaluasi adalah riwayat menyeluruh danpemeriksaan fisik dengan inisiasi studi laboratorium dasar.","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81958504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEMANFAATAN SENYAWA ANTIATEROGENIK JAMUR TIRAM PUTIH (PLEUROTUS SPP.) DALAM PENCEGAHAN ATEROSKLEROSIS","authors":"Neema Putri Prameswari","doi":"10.53366/jimki.v7i2.65","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.65","url":null,"abstract":"Pendahuluan: Aterosklerosis merupakan kondisi yang disebabkan oleh proses inflamasi kronis yang menyebabkan pembentukan plak pembuluh darah. Terjadinya aterosklerosis diakibatkan oleh beberapa faktor seperti hiperkolestrolemia, stress oksidatif, dan hipertensi. Aterosklerosis yang terjadi pada pembuluh darah dapat menyebabkan Penyakit Jantung Koroner (PJK) yang juga mampu menyebabkan kematian. Jamur tiram putih (Pleurotus spp.), yang bisa dengan mudah ditemukan di Indonesia, dinilai memiliki kandungan bioaktif yang mampu mencegah aterosklerosis. Tujuan: untuk mengetahui potensi dan pemanfaatan jamur tiram putih (Pleurotus spp.) dalam pencegahan aterosklerosis melalui penurunan kadar profil lipid aterogenik. Metode: artikel dibuat dengan metode literature review, melibatkan 16 pustaka baik buku dan jurnal nasional atau internasional. Hasil: Jamur tiram putih (Pleurotus spp.) mengandung senyawa bioaktif bersifat antiaterogenik yaitu lovastatin. Senyawa lovastatin yang terkandung dalam jamur tiram putih terbukti dapat menurunkan kadar kolesterol total trigliserida, dan low density lipoprotein (LDL).  Pembahasan: Kemampuan jamur tiram putih untuk mencegah terjadinya aterosklerosis disebabkan kandungan lovastatin yang dimilikinya. Mekanisme kerja lovastatin dalam mencegah aterosklerosis yaitu menurunkan profil lipid aterogenik dengan menghambat kerja enzim 3-hidroksi-3-metilglutaril koenzim A (HMG-KoA) reduktase sehingga mampu menghambat proses biosintesis kolesterol.  Simpulan: Jamur tiram putih (Pleurotus spp.) dapat menjadi alternatif yang mudah didapat, murah, dan mudah dalam mencegah terjadinya aterosklerosis. ","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90966428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FAKTOR RISIKO COMPUTER VISION SYNDROME PADA MAHASISWA JURUSAN ILMU KOMPUTER FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNIVERSITAS LAMPUNG","authors":"Debby Cinthya Damiri Valentina, M. Yusran, Riyan Wahyudo, R. Himayani","doi":"10.53366/jimki.v7i2.50","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.50","url":null,"abstract":"ABSTRACT \u0000  \u0000Introduction: Computer vision syndrome (CVS) is a syndrome that occur due to excessive interaction with computers. Individual, environmental, and computer related risk factors increase CVS prevalence and cause eyes, visual, and extraocular related symptoms. This research aims to observe the relation between risk factors and CVS prevalence in students of Computer Science Major of Mathematics and Natural Sciences Faculty of Lampung University. Method: This research was an analitic survey with cross sectional study. Samples consisted of 56 students of 2014-2016 class year using proportional stratified random sampling techniques. This research used questionnaires and direct measurement of eyes distance and angle gaze of respondents. Collected datas then were analyzed by using univariate and bivariate analysis. Result: The prevalence of CVS obtained from samples was 39 students (69,6%). Statistic tests between risk factors and CVS are listed as follow, gender (p=0,909 OR=1,069), working years (p=0,007 OR=6,188), daily duration of computer exposures (p=0,022 OR=7,708), wearing spectacles (p=0,043 OR=8,000), taking a break (p=0,111 OR=2,786), eyes distance (p=0,028 OR=3,750), and angle gaze (p=0,047 OR=5,000). Conclusion: The significantly related risk factors to CVS were working years, daily duration of exposures, wearing spectacles, eyes distance, and angle gaze towards computer monitors. \u0000  \u0000Keywords: computer vision syndrome, risk factors","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"282 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81404108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANGIOTENSIN CONVERTING ENZYME INHIBITOR SEBAGAI TERAPI PASIEN HIPERTENSI PRIMER DENGAN OBESITAS","authors":"Muhamad Jiofansyah","doi":"10.53366/jimki.v7i2.55","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.55","url":null,"abstract":"Hypertension and obesity are the diseases that’s corelate to each other. The Bridge thatconnects between hypertension and obesity lies on Renin Angiotensin System (RAS) andleptin and adiponectin hormone system. RAS function to regulate the osmolarity of theblood circulation to control blood pressure. Leptin is a hormone that inhibit food intake.Adiponectin secreted by adipose cells to regulate blood glucose and performing theoxidation of fatty acid. In recent studies found that there’s a correlation betweenangiotensinogen with adiponectin. Then the question emerge about an intervention on RAScould have an effect on adiponectin, the hormone that’s corelate to obesity. A study fromFontana et.al found that there’s a correlation on using ACE inhibitor with leptin andadiponectin. Subjects with primary hypertension with 8 weeks enalapril therapy shows anincrease in adiponectin level, whilst the control group didnt show any significant change.There isn’t any correlation between subject and control on leptin level. This journal maypresent the theories that may lead to explaining about the correlation between hypertensionand obesity, and if ACE Inhibitor is the right therapy for primary hypertension patient withan obesity or not.","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"449 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79685897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KERACUNAN PESTISIDA KRONIK PADA PETANI","authors":"Vonisya Mutia, Rasmi Zaskiah Oktarlina","doi":"10.53366/jimki.v7i2.53","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.53","url":null,"abstract":"Indonesia merupakan negara agraris artinya sektor pertanian memegang peran penting dalam perekonomian di Indonesia, menyebabkan penduduk Indonesia mayoritas pekerjaannya adalah petani. Pestisida didefinisikan sebagai zat atau bahan kimia yang digunakan terutama di bidang pertanian, kehutanan, hortikultura dan di lahan publik untuk meningkatkan hasil panen, sehingga penggunaan pestisida hampir selalu digunakan pada setiap petani. \u0000Terjadi peningkatan yang stabil dalam jumlah pestisida yang dipasarkan untuk penggunaan pertanian di seluruh dunia. Penggunaan pestisida di Afrika hanya mencapai 4% dari pasar pestisida global, dengan perkiraan kasar 75.000 hingga 100.000 ton bahan aktif pestisida yang digunakan dibandingkan dengan sekitar 350.000 ton di Eropa. Ini menyiratkan bahwa karena volume pestisida yang digunakan di Afrika lebih rendah daripada di tempat lain, risiko dan dampaknya harus rendah.[4] Namun, peningkatan morbiditas dan mortalitas akibat keracunan pestisida merupakan masalah besar terutama dengan pendataan yang tidak baik dari otoritas kesehatan.","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85000507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENGARUH PEMBERIAN EKSTRAK ETANOL RIMPANG LENGKUAS (ALPINIA GALANGA) TERHADAP GAMBARAN HISTOPATOLOGI OTAK MENCIT (MUS MUSCULUS L) YANG DIINDUKSI MONOSODIUM GLUTAMATE","authors":"Emeraldha Theodorus, Muhartono Muhartono, Giska Tri Putri","doi":"10.53366/jimki.v7i2.59","DOIUrl":"https://doi.org/10.53366/jimki.v7i2.59","url":null,"abstract":"Abstract  \u0000Background: Monosodium glutamate (MSG) induced brain damage characterized by microscopic neuronal necrosis and clinically neurologic deficits. Galangal has flavonoid that serves as an antioxidant that can protect the brain. Objective: To determine the effect of ethanol extract of galangal rhizome (Alpinia galanga) on brain histopathological appearance in the mice (Mus musculus L) induced by Monosodium glutamate (MSG). \u0000Methods: This study used 30 mice that were divided into 5 groups. K(-) is not given any treatment, K(+) is given intraperitoneal MSG 4 mg/grBB, P1 is given intraperitoneal MSG 4 mg/grBB and oral galangal extract 14 mg/ 20grBB, P2 is given intraperitoneal MSG 4 mg/grBB and oral galangal extract 28 mg/ 20grBB, and P3 P1 is given intraperitoneal MSG 4 mg/grBB and oral galangal extract 56 mg/ 20grBB. \u0000Results: The average number of brain neuronal necrosis were K(-) 3,8; K(+) 5,4; P1 5,4; P2 5; dan P3 4,8. The One-Way ANOVA result showed that the p-value =……. 0,015. \u0000Conclusion: There are no difference in the effect of ethanol extract of galangal rhizome (Alpinia galanga) on brain histopathological appearance in the mice (Mus musculus L) induced by Monosodium glutamate (MSG).","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89818437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASPIRIN DOSIS RENDAH SEBAGAI USAHA PREVENTIF UNTUK IBU YANG BERISIKO TINGGI TERKENA PREEKLAMPSIA","authors":"Fakhira Arminda, Rodiani Rodiani","doi":"10.53366/JIMKI.V8I1.36","DOIUrl":"https://doi.org/10.53366/JIMKI.V8I1.36","url":null,"abstract":"ABSTRAK  Pendahuluan: Preeklampsia merupakan salah satu penyebab utama kematian ibu hamil, janin, dan neonatus, terutama di negara-negara dengan pendapatan rendah dan sedang. Seorang ibu hamil dikatakan berisiko tinggi terkena preeklampsia apabila memiliki riwayat preeklampsia sebelumnya, hipertensi kronis, diabetes melitus, ataupun penyakit autoimun seperti systemic lupus erythematosus dan sindrom antifosfolipid. Komplikasi pada preeklampsia tentunya dapat meningkatkan angka mortalitas dan morbiditas ibu. Aspirin dosis rendah merupakan salah satu solusi untuk mencegah preeklampsia.  Pembahasan: Aspirin bekerja dengan cara menginhibisi cycloocxygenase, yaitu suatu enzim yang bertanggung jawab untuk mengubah asam arakidonat menjadi prostaglandin. Enzim yang berperan dalam jalur cyclooxygenase yaitu COX-1 dan COX-2 (juga disebut prostaglandin H sintase) yang memediasi produksi prostaglandin, prostasiklin, dan tromboksan. Aspirin dapat menginhibisi COX-1 hanya dengan dosis rendah, sedangkan untuk COX-2 membutuhkan dosis yang lebih tinggi. COX-1 memediasi produksi TXA2 (tromboksan) yang meregulasi agragasi platelet dan vasokonstriksi sehingga dapat mencegah preeklampsia. Selain itu, pada kondisi hipoksia, aspirin juga dapat menginhibisi ekspresi sFlt-1 pada trofoblas sehingga menunjukan efek proangiogenik pada obat ini.  Kesimpulan: Pemberian aspirin dapat menjadi usaha preventif terhadap kejadian preeklampsia dengan dosis 75-150 mg perhari, diberikan malam hari pada ibu dengan usia gestasi 16-20 minggu diberikan sampai usia gestasi 36 minggu bagi pasien risiko tinggi preeklampsia.   Kata Kunci: aspirin, cyclooxygenase, preeklampsia, tromboksan   ABSTRACT   Introduction: Preeclampsia is one of the leading causes of death in pregnant women, fetuses, and neonates, especially in countries with low and moderate incomes. Pregnant woman with history of chronic hypertension, diabetes mellitus, or autoimmune diseases such as systemic lupus erythematosus and systemic antiphospholipids is a woman with high risk of preeclampsia. The complications that caused by preeclampsia of course can increase mother’s mortality and morbidity. Low-dose aspirin is one of the solutions for the prevention of preeclampsia.  Discussion: Aspirin works by inhibiting cyclooxygenase, an enzyme that is responsible for converting arachidonic acid to prostaglandins. The enzymes involved in the cyclooxygenase pathway are COX-1 and COX-2 (also called prostaglandin H synthase) which mediate the production of prostaglandins, prostacyclin, and thromboxane. Aspirin can inhibit COX-1 only with a low dose, whereas for COX-2 requires a higher dose. COX1 mediates the production of TXA2 (thromboxane) which regulates platelet and vasoconstrictive aggression to prevent preeclampsia. Furthermore, in hypoxic conditions, aspirin can also inhibit the expression of sFlt-1 on the trophoblast, thus showing a proangiogenic effect on this drug.  Conclusion: 75-150 mg per day of Aspirin can be a preventive ","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79078041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENGARUH GENETIK, GAYA HIDUP DAN LINGKUNGAN PADA KEJADIAN LEUKEMIA MIELOBLASTIK AKUT","authors":"Shania Ocha Sativa","doi":"10.53366/JIMKI.V8I1.42","DOIUrl":"https://doi.org/10.53366/JIMKI.V8I1.42","url":null,"abstract":"ABSTRAK Leukemia Mieloblastik Akut merupakan salah satu kelainan sel darah berupa keganasan yang ditandai dengan proliferasi dan pertumbuhan dari sel hematopoietik yang imatur di dalam sum-sum tulang dan darah. Pasien dengan AML memiliki gejala khas seperti mudah lelah, sulit bernapas atau sesak, perdarahan, dan tanda-tanda infeksi yang merupakan akibat dari kegagalan sumsum tulang. Penyakit ini dapat didiagnosis dengan pemeriksaan darah lengkap, analisis darah tepi, serta pemeriksaan sampel sumsum tulang. Insidensi penyakit ini tinggi pada orang dewasa. Hampir 80% kasus leukemia akut terjadi pada orang dewasa dan 20% kasus leukemia akut terjadi pada anak-anak. Kejadiannya meningkat seiring dengan bertambahnya usia seseorang. Oleh karena penyebab pasti dari leukemia belum diketahui, beberapa faktor risiko terkait pernyakit ini telah diidentifikasi. Beberapa faktor risiko absolut dan relatif dari leukemia akut dikelompokkan menjadi faktor genetik, gaya hidup dan lingkungan. Merokok, obesitas, konsumsi alkohol serta asupan makanan berpengaruh terhadap perkembangan dari leukemia sendiri. Faktor risiko lingkungan yang dapat menyebabkan AML ialah paparan benzen, radiasi ionisasi dosis tinggi, agen kemoterapetik, dan paparan zat atau bahan elektromagnetik. Kata Kunci:  Faktor Risiko, Keganasan, Leukemia Mieloblastik Akut  ABSTRACT Acute Myeloblastic Leukemia (AML) is a blood cell disorder in the form of malignancy characterized by the proliferation and growth of immature hematopoietic cells in the bone marrow and blood. Patients with AML have typical symptoms such as fatigue, difficulty breathing or tightness, bleeding, and signs of infection that result from bone marrow failure. The disease can be diagnosed by a complete blood count, peripheral blood analysis, and examination of bone marrow samples. The incidence of this disease is high in adults. Nearly 80% of cases of acute leukemia occur in adults and 20% of cases of acute leukemia occur in children. The incidence increases with age. Because the exact cause of leukemia is unknown, several risk factors associated with this disease have been identified. Some absolute and relative risk factors for acute leukemia are grouped into genetic, lifestyle and environmental factors. Smoking, obesity, alcohol consumption and food intake influence the development of leukemia itself. Environmental risk factors that can cause AML are benzene exposure, high dose ionizing radiation, chemotherapeutic agents, and exposure to substances or electromagnetic materials. Keywords:  Risk Factor, Malignancy, Acute Myeloid Leukemia  ","PeriodicalId":14697,"journal":{"name":"JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89554845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}