JAMA Network Open最新文献

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PARP Inhibitors in Metastatic Castrate-Resistant Prostate Cancer. PARP抑制剂在转移性去势抵抗性前列腺癌中的作用
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34973
Charles L Bennett, June M McKoy
{"title":"PARP Inhibitors in Metastatic Castrate-Resistant Prostate Cancer.","authors":"Charles L Bennett, June M McKoy","doi":"10.1001/jamanetworkopen.2025.34973","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.34973","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534973"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Ambient AI Scribe Revolution-Early Gains and Open Questions. 环境人工智能书写革命——早期收获和开放问题。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34982
Kaustav P Shah, Kevin B Johnson
{"title":"The Ambient AI Scribe Revolution-Early Gains and Open Questions.","authors":"Kaustav P Shah, Kevin B Johnson","doi":"10.1001/jamanetworkopen.2025.34982","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.34982","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534982"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profiles in Nonverbal Learning Disability, Academic Skills, and Psychiatric Diagnoses in Children. 儿童非语言学习障碍、学术技能和精神诊断的概况。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.33848
Amy E Margolis, Jacob DeRosa, Minji Kang, Prudence W Fisher, Lauren Thomas, Caroline Southwick, Jessica Broitman, John M Davis, Aki Nikolaidis, Michael P Milham
{"title":"Profiles in Nonverbal Learning Disability, Academic Skills, and Psychiatric Diagnoses in Children.","authors":"Amy E Margolis, Jacob DeRosa, Minji Kang, Prudence W Fisher, Lauren Thomas, Caroline Southwick, Jessica Broitman, John M Davis, Aki Nikolaidis, Michael P Milham","doi":"10.1001/jamanetworkopen.2025.33848","DOIUrl":"10.1001/jamanetworkopen.2025.33848","url":null,"abstract":"<p><strong>Importance: </strong>Nonverbal learning disability (NVLD) has been described since the 1960s, with varying subtypes proposed to address clinical heterogeneity.</p><p><strong>Objective: </strong>To identify profiles of NVLD to improve clinical practice and increase rigor in research by parsing clinical heterogeneity.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional study used data from the Healthy Brain Network (HBN; release 8, years 2017 and 2021), a study of brain development and youth mental health that enrolls a community sample of New York, New York, children and adolescents (ages 5-21 years), to identify youths who met the research-defined criteria for NVLD. HBN recruits for desire to participate in research or perceived clinical concern, yielding a high proportion of youths with behavioral, learning, or emotional problems. An unsupervised clustering approach, Louvain community detection, was applied to the diagnostic parameters that defined NVLD. Profiles were described by patterns of strengths and weaknesses across diagnostic tests and by associations with clinical symptoms. Data were analyzed between April 22 and September 27, 2021.</p><p><strong>Exposure: </strong>Perceived clinical concern.</p><p><strong>Main outcomes and measures: </strong>The outcome of interest was NVLD profiles; hypotheses were generated prior to data analysis.</p><p><strong>Results: </strong>Among 1640 children and adolescents with complete data in the HBN, 180 participants (110 [61%] male; 86 participants [48%] age 10-14 years; range, 6-17 years) met the research criteria for NVLD. Four profiles emerged: profile 1 (44 children) included deficits in both dimensions of visual-spatial processing (mean [SD] Wechsler Visual-Spatial Index [VSI], 96.11 [11.91]; Fluid Reasoning Index [FRI], 77.18 [7.94]), highest inattention (mean [SD], 1.23 [1.05]]; P = .001) and aggression scores (mean [SD], 65.03 [15.89]; P = .001), and lowest reading comprehension scores (mean [SD], 93.81 [10.31]; P = .001); profile 2 (37 children) included deficits in VSI (mean [SD], 78.27 [13.55]) but not FRI, the highest math scores (mean [SD], 101.16 [17.57]; P = .001) and rate of anxiety disorder (odds ratio, 2.19; 95% CI, 1.31-3.66; P = .02), and the lowest rate of specific learning disorder (odds ratio, 0.20; 95% CI, 0.05-0.84; P = .01); profile 3 (35 children) included deficits in FRI (mean [SD], 88.6 [12.63]) and highest reading comprehension scores (mean [SD], 101.8 [14.12]; P < .001); profile 4 had no deficits in VSI or FRI, lowest verbal intelligence (mean [SD], 87.12 [13.07]; P = .001), and no functional impairments. In profiles with visual-spatial deficits (profiles 1, 2, and 3), VSI and FRI scores were positively associated with scores on measures of functional impairment, eg, FRI and math in profile 2 (Pearson r = .33; P < .001).</p><p><strong>Conclusions and relevance: </strong>In this cross-sectional study of heterogeneity in NVLD, 3 profiles ","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2533848"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adolescents' Daily Race-Related Online Experiences and Mental Health Outcomes. 青少年日常与种族相关的在线体验和心理健康结果
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.36870
Brendesha M Tynes, Taylor McGee, Devin English
{"title":"Adolescents' Daily Race-Related Online Experiences and Mental Health Outcomes.","authors":"Brendesha M Tynes, Taylor McGee, Devin English","doi":"10.1001/jamanetworkopen.2025.36870","DOIUrl":"10.1001/jamanetworkopen.2025.36870","url":null,"abstract":"<p><strong>Importance: </strong>Despite the rise in exposure to both positive and negative race-related experiences online, research on how these experiences are associated with mental health outcomes is limited.</p><p><strong>Objective: </strong>To examine the associations between negative online race-related experiences (online racial discrimination, traumatic events online, and algorithmic and filter bias), positive racial socialization messages, and mental health outcomes (depressive and anxiety symptoms).</p><p><strong>Design, setting, and participants: </strong>This survey study examined data from a nationally representative, intensive longitudinal 7-day daily dairy, collected as part of the National Survey of Critical Digital Literacy. Surveys were administered daily, with a 24-hour response window, in December 2020. Participants included Black or Black biracial or multiracial (parent-identified) adolescents. Participants were part of a larger nationally representative sample of 1138 adolescents, aged 11 to 19 years of various racial and ethnic backgrounds, recruited through Ipsos' KnowledgePanel. One eligible adolescent per household was randomly selected to participate. Analyses were conducted in August 2021 and revised in July 2025.</p><p><strong>Main outcomes and measures: </strong>To examine the daily associations between online race-related experiences and mental health outcomes, dynamic structural equation models were estimated for the longitudinal data.</p><p><strong>Results: </strong>Results were drawn from survey responses of 141 Black and Black biracial or multiracial adolescents (mean [SD] age, 14.74 [2.51] years; 80 [56.7%] female). Adolescents reported a total of 6 online race-related experiences per day, including 3.2 that are considered online racism and 2.8 that are positive. The study found experiences of online racial discrimination (γ = 0.12; 95% credible interval [CrI], 0.01-0.21), algorithmic bias (γ = 0.11; 95% CrI, 0.02-0.19), and traumatic events online (γ = 0.10; 95% CrI, 0.01-0.19) were positively associated with next day anxiety symptoms. Online racial discrimination (γ = 0.20; 95% CrI, 0.01-0.33]), traumatic events online (γ = 0.10; 95% CI, 0.04-0.15), and algorithmic bias (γ = 0.13; 95% CrI, 0.03-0.22) were positively associated with next-day depressive symptoms. Positive racial socialization experiences were not associated with mental health outcomes.</p><p><strong>Conclusions and relevance: </strong>In this survey study of online race-related experiences, Black adolescents, on average, reported experiencing 6 per day. Negative experiences were associated with poor mental health. Because young people can experience algorithms almost constantly, this study suggests more research is needed on related daily mental health outcomes.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2536870"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicare Savings Program Take-Up Estimates and Profile of Enrolled and Unenrolled Individuals. 医疗保险储蓄计划的估算和登记和未登记个人的概况。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.35408
Sarah Kotb, Amanda Su, Anna D Sinaiko
{"title":"Medicare Savings Program Take-Up Estimates and Profile of Enrolled and Unenrolled Individuals.","authors":"Sarah Kotb, Amanda Su, Anna D Sinaiko","doi":"10.1001/jamanetworkopen.2025.35408","DOIUrl":"10.1001/jamanetworkopen.2025.35408","url":null,"abstract":"<p><strong>Importance: </strong>Medicare enrollees with low income report challenges affording out-of-pocket costs for health care. Although the Medicare Savings Programs (MSPs) were established to provide financial support, recent patterns in program take-up are understudied.</p><p><strong>Objectives: </strong>To provide national and state-level estimates of take-up of the MSPs from 2018 to 2020 and describe the profile of enrolled and unenrolled individuals eligible for the MSPs.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional analysis used data from the Medicare Current Beneficiary Survey (MCBS), a nationally representative survey of community-dwelling Medicare beneficiaries. Respondents from 2018 to 2020 who completed the income and assets questionnaire, which allowed assessment of MSP eligibility, were analyzed. Data were analyzed in July 2024.</p><p><strong>Exposures: </strong>Eligibility for the MSPs.</p><p><strong>Main outcomes and measures: </strong>The take-up rate of the MSPs, defined as the proportion of eligible beneficiaries enrolled in the program. The MCBS survey weights were applied to create a subsample that was nationally representative of the community-dwelling Medicare population.</p><p><strong>Results: </strong>The primary sample included 26 240 respondent-year observations, representing 179 221 355 beneficiary-years (14.0% [95% CI, 13.4%-14.5%] of respondents were <65 years, 55.1% [95% CI, 54.1%-56.0%] were female, and 37.7% [95% CI, 36.0%-39.4%] had a high school education or lower). A total of 20.9% (95% CI, 19.8%-22.0%) of the primary sample was eligible for the MSPs. Of those eligible, 56.7% (95% CI, 54.5%-59.0%) were enrolled. Take-up rates varied widely across states, ranging from 41.5% (95% CI, 25.7%-57.3%) in Ohio to 72.9% (95% CI, 67.6%-78.2%) in California. Take-up among Medicare Advantage beneficiaries was higher than among those in traditional Medicare (61.3% vs 52.9%; difference, 8.4 percentage points [pp] [95% CI, 3.5-13.2 pp]). Compared with eligible beneficiaries who were not enrolled, enrolled individuals had greater economic insecurity, including being 30.0 pp (95% CI, 25.4-34.6 pp) more likely to report income below 100% of the federal poverty level and 16.4 pp (95% CI, 13.2-19.6 pp) more likely to report assets less than $3000.</p><p><strong>Conclusions and relevance: </strong>This cross-sectional study of Medicare beneficiaries suggests that MSP take-up remains incomplete and varied across states despite policy efforts. A policy to encourage participation in the MSPs among eligible populations that target less socially and financially vulnerable-although still with low income and eligible for the MSPs-individuals may be more likely to be associated with gains in the MSP take-up.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2535408"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excess Adiposity Without Obesity in a High-Risk Population. 高危人群中非肥胖的过度肥胖
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.35194
Alexandra B Palmer, Rashedeh Roshani, Joseph B McCormick, Susan P Fisher-Hoch, Jennifer E Below, Kari E North, Penny Gordon-Larsen
{"title":"Excess Adiposity Without Obesity in a High-Risk Population.","authors":"Alexandra B Palmer, Rashedeh Roshani, Joseph B McCormick, Susan P Fisher-Hoch, Jennifer E Below, Kari E North, Penny Gordon-Larsen","doi":"10.1001/jamanetworkopen.2025.35194","DOIUrl":"10.1001/jamanetworkopen.2025.35194","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2535194"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-Augmented Electron Microscopy for Glomerular Disease Diagnosis. ai增强电子显微镜在肾小球疾病诊断中的应用。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34997
Wisit Cheungpasitporn, Alton B Farris
{"title":"AI-Augmented Electron Microscopy for Glomerular Disease Diagnosis.","authors":"Wisit Cheungpasitporn, Alton B Farris","doi":"10.1001/jamanetworkopen.2025.34997","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.34997","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534997"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 Booster Vaccine Messaging in Emergency Departments: A Cluster Randomized Clinical Trial. 急诊部门COVID-19加强疫苗信息传递:一项随机临床试验
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.37655
Melanie F Molina, Stephanie A Eucker, Kristin L Rising, Efrat R Kean, Zubaid Rafique, Heba Mesbah, David V Glidden, Mireya I Arreguin, Christopher Alvarez, Robert M Rodriguez
{"title":"COVID-19 Booster Vaccine Messaging in Emergency Departments: A Cluster Randomized Clinical Trial.","authors":"Melanie F Molina, Stephanie A Eucker, Kristin L Rising, Efrat R Kean, Zubaid Rafique, Heba Mesbah, David V Glidden, Mireya I Arreguin, Christopher Alvarez, Robert M Rodriguez","doi":"10.1001/jamanetworkopen.2025.37655","DOIUrl":"10.1001/jamanetworkopen.2025.37655","url":null,"abstract":"<p><strong>Importance: </strong>Patient uptake of updated COVID-19 vaccines is crucial for reducing severe outcomes, yet national uptake remains low.</p><p><strong>Objective: </strong>To determine if tailored messaging or simple inquiry about vaccine acceptance increases 30-day uptake of updated COVID-19 vaccines among emergency department (ED) patients.</p><p><strong>Design, setting, and participants: </strong>This 3-arm, cluster randomized clinical trial conducted from January 29 to June 18, 2024, enrolled adult ED patients who had not received a COVID-19 vaccine in the prior 6 months across 6 EDs in San Francisco, California; Philadelphia, Pennsylvania; Houston, Texas; and Durham, North Carolina.</p><p><strong>Interventions: </strong>Intervention M involved tailored messaging about updated COVID-19 vaccines and inquiry about vaccine acceptance. Intervention Q involved only inquiry about vaccine acceptance. Usual care (no messaging or vaccine acceptance questions) served as the control.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was updated COVID-19 vaccine receipt within 30 days of the ED visit, assessed via electronic health record review and follow-up telephone calls. Secondary outcomes included vaccine acceptance and vaccination during the ED visit. Outcomes were also compared between study sites that had the updated COVID-19 vaccine available and those that did not.</p><p><strong>Results: </strong>Of 852 participants (median age, 47 years [IQR, 33-63 years]; 464 [54.5%] women), 247 (29.0%) were in the intervention M group, 273 (32.0%) in the intervention Q group, and 332 (39.0%) in the control group. Vaccine uptake at 30 days was not significantly higher in either the intervention M group compared with control (14 participants [5.7%] vs 10 [3.0%]; absolute difference, 2.7 percentage points [pp] [95% CI, -0.8 to 6.3 pp]) or the intervention Q group compared with control (11 [4.0%] vs 10 [3.0%]; absolute difference, 1.0 pp [95% CI, -2.0 to 4.2 pp]). However, at sites where vaccines were available, the intervention M group had higher uptake compared with control (13 of 132 [9.8%] vs 5 of 150 [3.3%]; absolute difference, 6.5 pp [95% CI, 0.5-12.5 pp]).</p><p><strong>Conclusions and relevance: </strong>In this cluster randomized clinical trial of adult ED patients, tailored messaging and simple inquiry alone did not significantly increase 30-day updated COVID-19 vaccine uptake among patients. The slight increase in uptake among participants in the EDs that had access to the updated COVID-19 vaccines suggested that vaccine availability was an effect modifier, underscoring the importance of opportunity and convenience in vaccine delivery.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT06156215.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2537655"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12529187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiometabolic Outcomes Among Adults With Abdominal Obesity and Normal Body Mass Index. 腹部肥胖和正常体重指数成人的心脏代谢结局。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.37942
Kedir Y Ahmed, Setognal B Aychiluhm, Subash Thapa, Teketo Kassaw Tegegne, Daniel Bekele Ketema, Zemenu Yohannes Kassa, Getiye Dejenu Kibret, Bereket Duko, Desalegn Markos Shifti, Meless G Bore, Zekariyas Sahile Nezenega, Asres Bedaso, Aklilu Habte Hailegebireal, Habtamu Mellie Bizuayehu, Abel F Dadi, Tesfalidet Beyene, Mohd Farooq Shaikh, Tahir A Hassen, Abdulbasit Seid, Feleke H Astawesegn, Sewunet Admasu Belachew, Cheru Tesema Leshargie, Fentaw T Berhe, Utpal K Mondal, Damien Little, Kasuni Akalanka Hewa Marambage, Shakeel Mahmood, Allen G Ross
{"title":"Cardiometabolic Outcomes Among Adults With Abdominal Obesity and Normal Body Mass Index.","authors":"Kedir Y Ahmed, Setognal B Aychiluhm, Subash Thapa, Teketo Kassaw Tegegne, Daniel Bekele Ketema, Zemenu Yohannes Kassa, Getiye Dejenu Kibret, Bereket Duko, Desalegn Markos Shifti, Meless G Bore, Zekariyas Sahile Nezenega, Asres Bedaso, Aklilu Habte Hailegebireal, Habtamu Mellie Bizuayehu, Abel F Dadi, Tesfalidet Beyene, Mohd Farooq Shaikh, Tahir A Hassen, Abdulbasit Seid, Feleke H Astawesegn, Sewunet Admasu Belachew, Cheru Tesema Leshargie, Fentaw T Berhe, Utpal K Mondal, Damien Little, Kasuni Akalanka Hewa Marambage, Shakeel Mahmood, Allen G Ross","doi":"10.1001/jamanetworkopen.2025.37942","DOIUrl":"10.1001/jamanetworkopen.2025.37942","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Cardiometabolic disorders are the leading causes of death and disability worldwide, with abdominal obesity being a major contributor to these conditions. Data on normal-weight abdominal obesity and its association with cardiometabolic outcomes are limited.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the global prevalence of normal-weight abdominal obesity and its association with cardiometabolic outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This cross-sectional study used data from the World Health Organization Stepwise Approach to Surveillance of Noncommunicable Disease Risk Factors survey datasets between 2000 and 2020. The surveys were from 91 countries across Africa, the Americas, the Eastern Mediterranean region, Europe, Southeast Asia, and the Western Pacific region. Adults aged 15 to 69 years or 18 to 69 years (based on participating countries' national definitions of adult) were included. The data were analyzed between April 2024 and January 2025.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;Normal-weight abdominal obesity, which is defined as a normal body mass index (BMI) of 18.5 to 24.9 (calculated as weight in kilograms divided by height in meters squared) but high waist circumference (female, ≥80 cm; male, ≥94 cm).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The main outcomes were hypertension, diabetes, cholesterol, and triglycerides. Associations with these cardiometabolic outcomes were quantified using multivariable binary logistic regression models.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included 471 228 participants (mean [SD] age, 40.4 [15.9] years; 57.8% female). Globally, 21.7% (95% CI, 21.5%-21.8%) of participants with a normal BMI had abdominal obesity, ranging from 15.3% (95% CI, 15.0%-15.7%) in the Western Pacific region to 32.6% (95% CI, 31.9%-33.3%) in the Eastern Mediterranean region. Lebanon had the highest prevalence of normal-weight abdominal obesity (58.4%; 95% CI, 54.1%-62.6%), while Mozambique had the lowest (6.9%; 95% CI, 5.9%-8.1%). Factors associated with abdominal obesity included primary and secondary or higher education (odds ratio [OR], 1.53 [95% CI, 1.50-1.57] and 2.38 [95% CI, 2.33-2.43], respectively), unemployment (OR, 1.25 [95% CI, 1.23-1.27]), low fruits and vegetables intake (OR, 1.22 [95% CI, 1.20-1.24]), and physical inactivity (OR, 1.60 [95% CI, 1.57-1.63]). Additionally, having a normal BMI and abdominal obesity was consistently associated with hypertension (OR, 1.29 [95% CI, 1.25-1.33]), diabetes (OR, 1.81 [95% CI, 1.72-1.90]), high total cholesterol (OR, 1.39 [95% CI, 1.35-1.44]), and high triglycerides (OR, 1.56 [95% CI, 1.48-1.64]).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;In this cross-sectional study, more than 1 in 5 adults worldwide with a normal BMI had abdominal obesity. Relying solely on BMI may be insufficient to identify these high-risk individuals and provide timely interventions. The findings have implications for t","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2537942"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12534855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Errors in Abstract and Methods. 摘要与方法中的错误。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.42056
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