JAMA Network Open最新文献

{"title":"Emergency Department and Observation Revisits and the Hospital Readmission Reduction Program.","authors":"Bimatshu Pyakuryal, Prasun Pudasainee, Alisha Sharma, Narendra Veerapaneni, Sanjay Singh, Barbara Slawski, Pinky Jha, Sanjay Bhandari","doi":"10.1001/jamanetworkopen.2025.24135","DOIUrl":"10.1001/jamanetworkopen.2025.24135","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2524135"},"PeriodicalIF":9.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring.","authors":"Dogukan Koc, Adriana P C Hermans, Bing Xu, Ryan L Muetzel, Hanan El Marroun, Henning Tiemeier","doi":"10.1001/jamanetworkopen.2025.23978","DOIUrl":"10.1001/jamanetworkopen.2025.23978","url":null,"abstract":"<p><strong>Importance: </strong>Maternal depressive symptoms during the perinatal period have been associated with offspring neurodevelopment. However, the longitudinal association of prenatal and postnatal maternal depressive symptoms with the developmental change in functional brain networks among offspring remains unclear.</p><p><strong>Objective: </strong>To examine the associations of prenatal and postnatal maternal depressive symptoms with offspring functional brain connectivity development from midchildhood to adolescence.</p><p><strong>Design, setting, and participants: </strong>This single-site, population-based prospective cohort was embedded in the Generation R Study, conducted in Rotterdam, the Netherlands. All pregnant individuals with an expected delivery date between April 1, 2002, and January 31, 2006, were invited to participate. The study included 2825 mother-child dyads with 3627 resting-state functional magnetic resonance imaging (fMRI) scans. Participants were eligible if they had valid resting-state fMRI data from at least 1 of the 2 waves of neuroimaging. Maternal depressive symptoms were assessed during pregnancy and in the early postnatal period. Offspring underwent 2 neuroimaging assessments at age 9 to 15 years. Data were analyzed from February to December 2024.</p><p><strong>Exposure: </strong>Maternal depressive symptoms were assessed using the Brief Symptom Inventory during midpregnancy and at 2 and 6 months post partum. Depressive symptom levels were analyzed both continuously and as clinically relevant dichotomized categories.</p><p><strong>Main outcomes and measures: </strong>The primary outcomes were brainwide graph theory metrics, including integration (global efficiency) and segregation (modularity, clustering coefficient) derived from resting-state functional connectivity (RSFC). Secondary outcomes included within-RSFC and between-RSFC networks, defined by the Gordon parcellation.</p><p><strong>Results: </strong>The study included 2825 mother-child dyads (mean [SD] maternal age at intake, 31.1 [4.7] years; 1496 female children [53.0%]). Prenatal depressive symptoms were associated with greater increases in global efficiency (β = 0.004, SE = 0.000; false discovery rate [FDR]-corrected P = .002), modularity (β = 0.003, SE = 0.000; FDR-corrected P = .002), and within-network default mode network connectivity (β = 0.010, SE = 0.001; FDR-corrected P = .002) from midchildhood to adolescence. Postnatal depressive symptoms showed no significant association with offspring functional connectivity measures. Baseline internalizing problems were associated with greater increases in global efficiency among children exposed to clinically relevant prenatal depressive symptoms (β = 0.243, SE = 0.37; FDR-corrected P = .001).</p><p><strong>Conclusions and relevance: </strong>In this population-based cohort study of 9- to-15-year-old children, prenatal maternal depressive symptoms were associated with differences in the trajector","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2523978"},"PeriodicalIF":9.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe Gun Storage and Youth Suicide-The Sum of Their Regrets.","authors":"Jeffrey W Swanson","doi":"10.1001/jamanetworkopen.2025.19271","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.19271","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2519271"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated Out-of-Pocket Costs for Patients With Common Cancers and Private Insurance.","authors":"Liam Rose, Ganesh Rajasekar, Anjali Nambiar, Alexa Pohl, Kathryn J Ruddy, Katherine Arnow, Manali Patel, Arden M Morris","doi":"10.1001/jamanetworkopen.2025.21575","DOIUrl":"10.1001/jamanetworkopen.2025.21575","url":null,"abstract":"<p><strong>Importance: </strong>Cancer imposes a substantial economic burden on patients that may be worse in patients with higher-stage disease due to the need for more therapy.</p><p><strong>Objective: </strong>To investigate the out-of-pocket costs (OOPCs) attributable to the initial treatment of common cancers among privately insured individuals diagnosed at different stages.</p><p><strong>Design, setting, and participants: </strong>This retrospective cohort study used administrative claims data of a large national insurer in the US linked to the Surveillance, Epidemiology, and End Results (SEER) cancer registry to compare OOPCs of individuals diagnosed with breast, colorectal, and lung cancer at different stages with OOPCs of similar individuals without cancer using difference-in-differences methods. Individuals living in the US between 2008 and 2022, aged younger than 65 years, insured through a large national private health insurer, and with 6 or more months of continuous enrollment were included. Data were analyzed from June 2024 through February 2025.</p><p><strong>Exposure: </strong>The presence or absence of an incident cancer diagnosis and disease stage from the SEER registry diagnosed from 2008 to 2019.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was OOPCs among individuals with breast, colorectal, and lung cancer diagnosed at different disease stages compared with those with no cancer diagnosis.</p><p><strong>Results: </strong>The cohort consisted of 46 158 patients (mean [SD] age at diagnosis, 46 [12] years; 30 733 female [66.6%]; 2543 Asian [5.5%], 4114 Black [8.9%], 3590 Hispanic [7.8%], and 31 099 White [67.4%]), including 19 656 patients with cancer and 26 502 patients without cancer in the control group. Among patients with cancer, 14 581 patients had breast cancer, 2842 patients had colorectal cancer, and 2233 patients had lung cancer. An incident cancer diagnosis was associated with a mean increase in OOPCs of $592.53 per month (95% CI, $528.01-$627.04 per month) for the 6 months after the diagnosis. Cost monotonically increased with stage at diagnosis (mean OOPC increase range, $462.01 per month [95% CI, $417.92-$506.11 per month] for stage 0 to $719.97 per month [95% CI, $626.11-$813.83 per month] for stage 4).</p><p><strong>Conclusions and relevance: </strong>In this study of individuals with private insurance, patients faced high OOPCs after an incident diagnosis of cancer, with patients with more advanced cancer having the highest OOPCs. Further research is needed to determine the clinical and financial effects of increased OOPCs for patients with cancer.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2521575"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking Cessation and Symptom Burden in Patients After Oncologic Surgery.","authors":"Katherine K S Rieth, AnaPaula Cupertino, Michael Shen, Hongying Sun, Luke Peppone","doi":"10.1001/jamanetworkopen.2025.22769","DOIUrl":"10.1001/jamanetworkopen.2025.22769","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2522769"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking Psychopathology Dimensions Through Passive Smartphone Sensing-Promises, Pitfalls, and Pathways to Clinical Integration.","authors":"Christian A Webb, Hadar Fisher","doi":"10.1001/jamanetworkopen.2025.19054","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.19054","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2519054"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgeons' Contributions to Antibiotic Stewardship and Resistance Prevention.","authors":"Gabriel Birgand, Nicolas Jacquet, Hubert Johanet, Niki Christou, Patrick Castel, Patrice Baillet, Céline Pulcini","doi":"10.1001/jamanetworkopen.2025.21165","DOIUrl":"10.1001/jamanetworkopen.2025.21165","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2521165"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation of an EHR-Based Model for Risk of Patient No-Show in Primary Care.","authors":"Afiba Manza-A Agovi, Mirsada Serdarevic, Aaron W Gehr, Caitlin T Thompson, Wentao Li, Jeff Claassen, Matthew Cvitanovich, Rohit P Ojha","doi":"10.1001/jamanetworkopen.2025.21637","DOIUrl":"10.1001/jamanetworkopen.2025.21637","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2521637"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency Department Visits for Cannabis Hyperemesis Syndrome Among Adolescents.","authors":"Michael S Toce, Michael C Monuteaux, Michael D Fishman, Joel D Hudgins","doi":"10.1001/jamanetworkopen.2025.20492","DOIUrl":"10.1001/jamanetworkopen.2025.20492","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2520492"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Morbidity With Expectant Management of Life-Limiting Fetal Conditions.","authors":"Anjali Nambiar, Elaine Larissa Duryea, Lisa Renee Thiele, Patricia Santiago-Munoz, David B Nelson, Catherine Y Spong, Courtney C Baker","doi":"10.1001/jamanetworkopen.2025.21883","DOIUrl":"10.1001/jamanetworkopen.2025.21883","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 7","pages":"e2521883"},"PeriodicalIF":10.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}