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Race- and Neighborhood-Level Social Determinants of Health in Diagnosis and Treatment of Atrial Fibrillation. 房颤诊断和治疗中种族和社区水平的健康社会决定因素
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.40279
Kano Amagai, Alya Nadji, Melissa Berkowitz, Atheendar S Venkataramani, Erica L Dixon
{"title":"Race- and Neighborhood-Level Social Determinants of Health in Diagnosis and Treatment of Atrial Fibrillation.","authors":"Kano Amagai, Alya Nadji, Melissa Berkowitz, Atheendar S Venkataramani, Erica L Dixon","doi":"10.1001/jamanetworkopen.2026.40279","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2026.40279","url":null,"abstract":"<p><strong>Importance: </strong>Early diagnosis and treatment of atrial fibrillation (AF) is critical for preventing stroke, heart failure, and mortality. Understanding patterns in diagnosis and treatment of AF may improve detection and reduce disparities.</p><p><strong>Objective: </strong>To evaluate the interactions between race and ethnicity and neighborhood social determinants of health on AF diagnosis and treatment.</p><p><strong>Design, setting, and participants: </strong>Retrospective cohort study using administrative claims for greater Philadelphia, Pennsylvania, area residents aged 18 years or older from Independence Blue Cross from 2017 to 2021. Baseline characteristics were assessed in 2017, and participants were followed up from 2018 through 2021. Data were analyzed from October 2023 to July 2026.</p><p><strong>Exposures: </strong>Exposures included Non-Hispanic Black race and ethnicity, neighborhood-level social determinants of health as measured by the social barrier index (SBI), and the interaction between the two.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was AF diagnosis ascertained from International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnosis codes. The secondary outcome was anticoagulant prescription among individuals with AF diagnoses as ascertained from pharmacy claims.</p><p><strong>Results: </strong>Of the 504 876 patients included, the mean (SD) age was 48 (18) years; 267 596 (53.0%) were female; 67 362 (13.3%) non-Hispanic Black, and 437 514 (86.7%) were non-Hispanic White. A total of 27 249 patients (5.1%) were diagnosed with AF during the study period. Non-Hispanic Black patients were less likely to be diagnosed with AF compared with non-Hispanic White patients (odds ratio [OR], 0.91; 95% CI, 0.82-1.00). The relative difference increased with increased SBI (which denotes more vulnerable neighborhoods) as shown by a significant interaction between race and ethnicity and SBI (OR, 0.90; 95% CI, 0.86-0.95). Among those diagnosed with AF, 15 722 (58%) had an anticoagulant prescription. There was a significant interaction between race and ethnicity and SBI (OR, 1.10; 95% CI, 1.00-1.20), suggesting that filled prescription patterns differed by race and ethnicity with SBI. For Black individuals one unit increase in SBI was associated with decreased odds of AF diagnosis (OR, 0.94; 95% CI, 0.90-0.99). For White individuals one unit increase in SBI was associated with increased odds of AF diagnosis (OR, 1.05; 95% CI, 1.03-1.07).</p><p><strong>Conclusions and relevance: </strong>This cohort study of Medicare Advantage and commercially insured individuals found that AF diagnosis rates declined with worsening neighborhood-level disadvantage among non-Hispanic Black individuals but increased among non-Hispanic White individuals. Conditional on diagnoses, rates of prescription of anticoagulants were similar across race and ethnicity groups. Targeted interven","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2640279"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight Gain During Pregnancy and Severe Maternal Morbidity. 孕期体重增加和严重的孕产妇发病率。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.40027
Sahar Khademioore, Elizabeth K Darling, Rohan D'Souza, Giulia M Muraca, Yanfang Guo, Laura N Anderson
{"title":"Weight Gain During Pregnancy and Severe Maternal Morbidity.","authors":"Sahar Khademioore, Elizabeth K Darling, Rohan D'Souza, Giulia M Muraca, Yanfang Guo, Laura N Anderson","doi":"10.1001/jamanetworkopen.2026.40027","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2026.40027","url":null,"abstract":"<p><strong>Importance: </strong>Severe maternal morbidity (SMM) carries serious consequences for pregnant individuals, yet the association between gestational weight gain (GWG) and SMM remains poorly understood.</p><p><strong>Objective: </strong>To examine the association between GWG and SMM across prepregnancy body mass index (BMI) categories.</p><p><strong>Design, setting, and participants: </strong>This retrospective cohort study used linked birth registry data from Better Outcomes Registry & Network Ontario and hospitalization data from the Canadian Institute for Health Information for singleton pregnancies with a hospital delivery at a gestational age of 20 weeks or greater in Ontario, Canada, from April 1, 2012, to March 31, 2022. Data were analyzed from May 1 to November 1, 2025.</p><p><strong>Exposures: </strong>Continuous GWG as mean weekly gain in the second and third trimesters and categorical GWG (inadequate, adequate, or excessive) according to the 2009 Institute of Medicine recommendations based on prepregnancy BMI.</p><p><strong>Main outcomes and measures: </strong>SMM, defined as a composite of 13 indicators per the Canadian Perinatal Surveillance System, occurring during delivery hospitalization.</p><p><strong>Results: </strong>Among 1 035 927 pregnancies, 192 731 (18.6%) had inadequate, 296 448 (28.6%) had adequate, and 546 748 (52.8%) had excessive GWG; 15 119 (14.59 per 1000 births) experienced SMM. Compared with adequate GWG, excessive GWG was associated with increased SMM across all BMI categories: underweight (adjusted rate ratio [ARR], 1.33 [95% CI, 1.15-1.53]), normal weight (ARR, 1.24 [95% CI, 1.17-1.31]), overweight (ARR, 1.16 [95% CI, 1.06-1.27]), obesity class I (ARR, 1.21 [95% CI, 1.08-1.35]), obesity class II (ARR, 1.28 [95% CI, 1.07-1.54]), and obesity class III (ARR, 1.24 [95% CI, 1.03-1.48]). Inadequate GWG was associated with increased SMM predominantly among individuals with normal weight (ARR, 1.13 [95% CI, 1.06-1.21]) and overweight (ARR, 1.19 [95% CI, 1.05-1.35]). GWG showed nonlinear associations with SMM across all BMI categories, with risk elevated at both low and high GWG in individuals with underweight, normal weight, and overweight, while in those with obesity classes I to III, risk was concentrated at high GWG values. Estimated SMM rates were lowest at 0.4 kg/wk GWG for underweight through overweight BMI categories and declined across obesity classes to 0.1 kg/wk GWG for the obesity class III category.</p><p><strong>Conclusions and relevance: </strong>In this cohort study of 1 035 927 pregnancies, GWG outside Institute of Medicine-recommended ranges was associated with increased SMM risk, with patterns varying by BMI category. These findings may complement existing evidence informing GWG guidance.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2640027"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telehealth vs In-Clinic Medication Abortion Provision. 远程医疗与诊所药物流产提供。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.40034
Anna E Fiastro, Erin K Thayer, Samantha N Fredman, Mary Stoa, Sara Manns, Sarah B Munro, Emmalie Griswold, Abigail Aiken, Rebecca Gomperts, Wendy V Norman, Emily M Godfrey
{"title":"Telehealth vs In-Clinic Medication Abortion Provision.","authors":"Anna E Fiastro, Erin K Thayer, Samantha N Fredman, Mary Stoa, Sara Manns, Sarah B Munro, Emmalie Griswold, Abigail Aiken, Rebecca Gomperts, Wendy V Norman, Emily M Godfrey","doi":"10.1001/jamanetworkopen.2026.40034","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2026.40034","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;In states that restrict abortion provision, residents rely on telehealth medication abortion (teleMAB) or travel out of state for in-clinic care; however, little is known about how patients using these modalities differ.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare characteristics of Kansas and Texas residents receiving teleMAB vs in-clinic medication abortion and to assess geographic and socioeconomic factors associated with modality of care.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This retrospective cross-sectional analysis used electronic medical record data for patients residing in Kansas or Texas who received medication abortion care from a teleMAB service or from an abortion facility in Kansas from February 1 to June 30, 2024. Patients younger than 18 years were excluded because only the telehealth site served this age group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;Patient sociodemographic characteristics (age, race and ethnicity, and number of children), gestational age, and county-level distance to the nearest abortion facility, social vulnerability, and rural-urban designation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The main outcome was receipt of teleMAB vs in-clinic care. Differences between patients who received teleMAB vs in-clinic care were assessed using χ2 and t tests for bivariate variables and multivariable logistic regression for adjusted comparisons.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The teleMAB service served 12 823 patients (Texas: n = 12 552; Kansas: n = 271); the clinic served 725 patients (Texas: n = 587; Kansas: n = 138). Mean (SD) age was 26 (6) years for Kansas residents and 27 (6) years for Texas residents. In both states, more telehealth patients self-identified as Hispanic, Latino, Latina, or Latine (Texas: 3739 of 12 552 [32%]; Kansas: 48 of 271 [18%]) than in-clinic patients (Texas: 14 of 587 [3%]; Kansas: 8 of 138 [7%]) (P &lt; .001). This difference remained among Texas residents after adjustment. In both states, compared with in-clinic patients, telehealth patients were more likely to be at less than 6 weeks' gestation (Texas: 7648 of 12 552 [61%] vs 155 of 587 [27%]; Kansas: 159 of 271 [59%] vs 45 of 138 [33%]; P &lt; .001) and to have no children (Texas: 5545 of 12 552 [44%] vs 42 of 587 [7%]; Kansas: 137 of 271 [51%] vs 5 of 138 [4%]; P &lt; .001). In Texas, patients who lived farthest from in-clinic care were more likely to receive telehealth than those who lived shorter distances (average marginal effect, 0.003; 95% CI, 0.002-0.004).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;In this cross-sectional study of patients who used medication abortion, teleMAB patients more often had no children, were living farther from an abortion facility, and represented populations facing structural racism and long-documented barriers to abortion care compared with in-clinic patients, particularly in abortion-restrictive states. A higher number of patients at lower gestatio","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2640034"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Court-Documented Adverse Financial Events Before Cancer Diagnosis and Mortality Risk. 法院记录的癌症诊断前的不良财务事件和死亡风险。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.37677
K Robin Yabroff, Anne-Michelle Noone, Angela Mariotto, Veena Shankaran, Kevin C Ward, Stephen M Schwartz, Xiao-Cheng Wu, Joan L Warren
{"title":"Court-Documented Adverse Financial Events Before Cancer Diagnosis and Mortality Risk.","authors":"K Robin Yabroff, Anne-Michelle Noone, Angela Mariotto, Veena Shankaran, Kevin C Ward, Stephen M Schwartz, Xiao-Cheng Wu, Joan L Warren","doi":"10.1001/jamanetworkopen.2026.37677","DOIUrl":"10.1001/jamanetworkopen.2026.37677","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2637677"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Error in the Figure Title. 图标题错误。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.42564
{"title":"Error in the Figure Title.","authors":"","doi":"10.1001/jamanetworkopen.2026.42564","DOIUrl":"10.1001/jamanetworkopen.2026.42564","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2642564"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Acting Lenacapavir and Cabotegravir and Viral Suppression Among People With HIV. 长效Lenacapavir和Cabotegravir对HIV病毒的抑制作用。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.38182
Nathanael L Gistand, Ishaan C Mishra, Kyle Hunter, Megan J Heise, Chesa Cox, Janet Grochowski, Francis Mayorga-Munoz, Jon Oskarsson, Mary Shiels, Matthew A Spinelli, Monica Gandhi
{"title":"Long-Acting Lenacapavir and Cabotegravir and Viral Suppression Among People With HIV.","authors":"Nathanael L Gistand, Ishaan C Mishra, Kyle Hunter, Megan J Heise, Chesa Cox, Janet Grochowski, Francis Mayorga-Munoz, Jon Oskarsson, Mary Shiels, Matthew A Spinelli, Monica Gandhi","doi":"10.1001/jamanetworkopen.2026.38182","DOIUrl":"10.1001/jamanetworkopen.2026.38182","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2638182"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital and Coaching Interventions for Uptake of Cancer Genetic Testing: The MiGHT Randomized Clinical Trial. 数字和指导干预对癌症基因检测的吸收:可能随机临床试验。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.38274
Sarah Austin, Emerson Delacroix, John D Rice, Erika Koeppe, Elizabeth Rizzo, Erika N Hanson, Liliana Arida-Moody, Shayna Weiner, Sarah T Hawley, Wendy R Uhlmann, J Scott Roberts, Versha Pleasant, Katrina R Ellis, Jennifer J Griggs, Ken Resnicow, Elena M Stoffel
{"title":"Digital and Coaching Interventions for Uptake of Cancer Genetic Testing: The MiGHT Randomized Clinical Trial.","authors":"Sarah Austin, Emerson Delacroix, John D Rice, Erika Koeppe, Elizabeth Rizzo, Erika N Hanson, Liliana Arida-Moody, Shayna Weiner, Sarah T Hawley, Wendy R Uhlmann, J Scott Roberts, Versha Pleasant, Katrina R Ellis, Jennifer J Griggs, Ken Resnicow, Elena M Stoffel","doi":"10.1001/jamanetworkopen.2026.38274","DOIUrl":"10.1001/jamanetworkopen.2026.38274","url":null,"abstract":"<p><strong>Importance: </strong>Germline genetic testing (GT) for hereditary cancer risk can inform cancer treatment, screening, and prevention, yet testing rates remain low. Alternative strategies are needed to improve facilitation of GT.</p><p><strong>Objective: </strong>To compare 2 patient-level interventions to increase uptake of hereditary cancer GT against usual care.</p><p><strong>Design, setting, and participants: </strong>The Michigan Genetic Hereditary Testing (MiGHT) randomized clinical trial analyzed self-reported GT outcome data from participants meeting clinical GT criteria between April 21, 2022, and November 21, 2025. Participants were adults (age ≥18 years) who met national criteria for genetic evaluation and had not previously completed germline GT recruited from oncology, primary care, and gastroenterology practices; research registries; and the general public in Michigan. Data were analyzed from April 30, 2025, to May 1, 2026.</p><p><strong>Interventions: </strong>Participants were randomized to either telephone-based health coaching, a self-directed digital intervention, or usual care. Both interventions incorporated genetics education and motivational interviewing concepts.</p><p><strong>Main outcomes and measures: </strong>GT uptake was assessed at 6- and 12-month time points. The primary outcome was completion of GT by 6 months. The effects of study group on GT uptake were evaluated using logistic regression, adjusting for cancer history, age, gender, and race.</p><p><strong>Results: </strong>A total of 793 participants (median [IQR] age, 64 [51-71] years; 458 [57.8%] female) were randomized to health coaching (261 participants), the digital intervention (265 participants), or usual care (267 participants). Overall, 31 participants (4.9%) reported completing GT by the 6-month time point, and 76 participants (9.6%) underwent GT across the 12-month study period. Compared with usual care, participants in the digital intervention group had higher odds of completing GT by 6 months (adjusted odds ratio [AOR], 3.88; 97.5% CI, 1.27-14.80), while those in the health coaching group had higher odds of completing GT by 12 months (AOR, 2.25; 97.5% CI, 1.11-4.77). Participants in the digital intervention group were more likely to express intention to test at 6 months (AOR, 2.36; 95% CI, 1.44-3.93), whereas those in the health coaching group had higher intention at both 6 (AOR, 2.99; 95% CI, 1.83-4.95) and 12 (AOR, 2.29; 95% CI 1.29-4.15) months compared with usual care.</p><p><strong>Conclusions and relevance: </strong>In this randomized clinical trial of GT interventions, GT uptake was higher among participants who received the digital or health coaching interventions compared with usual care, although overall testing rates were low. These results underscore the importance of content delivery, motivational messaging, and alternative GT care models.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID: NCT05162846.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2638274"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influenza Vaccination Preferences Among Adults Aged 60 Years and Older in Beijing, China. 中国北京60岁及以上成年人的流感疫苗接种偏好
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.38674
Mengmeng Jia, Yuxi Liu, Jiarui Zheng, Fenghua Su, Jitao Zhang, Mingyue Jiang, Tongsiman Wang, Xinqi Wang, Tao Wang, Wei Dai, Luzhao Feng
{"title":"Influenza Vaccination Preferences Among Adults Aged 60 Years and Older in Beijing, China.","authors":"Mengmeng Jia, Yuxi Liu, Jiarui Zheng, Fenghua Su, Jitao Zhang, Mingyue Jiang, Tongsiman Wang, Xinqi Wang, Tao Wang, Wei Dai, Luzhao Feng","doi":"10.1001/jamanetworkopen.2026.38674","DOIUrl":"10.1001/jamanetworkopen.2026.38674","url":null,"abstract":"<p><strong>Importance: </strong>Influenza vaccination coverage among older adults remains suboptimal in China despite free vaccination policies in some regions. Understanding their preferences may inform strategies to improve uptake.</p><p><strong>Objective: </strong>To quantify preferences for influenza vaccination attributes and assess preference heterogeneity by prior influenza vaccination history.</p><p><strong>Design, setting, and participants: </strong>This community-based survey study was conducted at 2 districts in Beijing, China, where influenza vaccination is provided free of charge for adults aged 60 years or older. A convenience sample of adults aged 60 years or older was included from 6 Beijing subdistricts and participated in a discrete choice experiment conducted from August to September 2025.</p><p><strong>Main outcomes and measures: </strong>Stated choice among 2 hypothetical influenza vaccination profiles and an opt-out option. Attributes included vaccine effectiveness, risk of mild adverse effects, vaccination venue and operating hours, outreach method, information source, and message content. Conditional logit, mixed logit, scenario simulations, and vaccination-history interaction analyses were performed.</p><p><strong>Results: </strong>Among 514 participants included in the analyses, the median age was 71 years (IQR, 65-79 years), and 356 (69.3%) were women. Higher vaccine effectiveness was associated with greater vaccination preference (β = 2.12; 95% CI, 1.37 to 2.88), whereas higher perceived risk of mild adverse effects was associated with lower preference (β = -5.53; 95% CI, -7.83 to -3.22). Participants preferred community-based vaccination settings, telephone reminders (β = 1.06; 95% CI, 0.76 to 1.36), information from government or community organizations (β = 0.78; 95% CI, 0.54 to 1.02), and messages emphasizing protection of family members (β = 0.50; 95% CI, 0.26 to 0.74). Increasing vaccine effectiveness from 20% to 80% and reducing perceived risk of adverse effects from 20% to 5% were associated with 30.74- and 19.96-percentage-point (pp) increases in the model-estimated choice probability, respectively. Compared with participants with prior vaccination, never-vaccinated participants had a greater preference for opting out (difference in β = 1.07; 95% CI, 0.11 to 2.03), greater sensitivity to mild adverse effect risk (difference in β per 10-pp increase, -0.49; 95% CI, -0.93 to -0.05), and lower responsiveness to vaccine effectiveness (difference in β per 10-pp increase, -0.18; 95% CI, -0.31 to -0.04).</p><p><strong>Conclusions and relevance: </strong>In this discrete choice experiment of older adults in Beijing, influenza vaccination preferences were associated with vaccine profiles, trusted communication, and community-based service delivery. Prior vaccination history identified differences in benefit-risk weighting that may inform broad and targeted vaccination strategies.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2638674"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsy-Related Mortality Among Children and Adolescents. 儿童和青少年与癫痫有关的死亡率。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.38537
Naum Shaparin, Rafi Khandaker, Jan Schwarz, Ali Bordbar Jahantighi, Lorenz Droege, Tina Ramishvili, Constance Rippel, Steven C Lindo, Itay Tokatly Latzer, Jerry Chao, Ibraheem M Karaye
{"title":"Epilepsy-Related Mortality Among Children and Adolescents.","authors":"Naum Shaparin, Rafi Khandaker, Jan Schwarz, Ali Bordbar Jahantighi, Lorenz Droege, Tina Ramishvili, Constance Rippel, Steven C Lindo, Itay Tokatly Latzer, Jerry Chao, Ibraheem M Karaye","doi":"10.1001/jamanetworkopen.2026.38537","DOIUrl":"10.1001/jamanetworkopen.2026.38537","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 10","pages":"e2638537"},"PeriodicalIF":11.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep Duration and Daytime Sleepiness Among Adolescents. 青少年的睡眠时间和日间嗜睡。
IF 11.7 1区 医学
JAMA Network Open Pub Date : 2026-10-01 DOI: 10.1001/jamanetworkopen.2026.38588
Lu Dong, Wendy Troxel
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