JAMA Network Open最新文献

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Support for Alcohol Control Policies Among US Alcohol Consumers. 美国酒精消费者对酒精控制政策的支持。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.35337
Anna H Grummon, Carolyn Chelius, Cristina J Y Lee, Aline D'Angelo Campos, Noel T Brewer, Allison J Lazard, Callie Whitesell, Thomas K Greenfield, Marissa G Hall
{"title":"Support for Alcohol Control Policies Among US Alcohol Consumers.","authors":"Anna H Grummon, Carolyn Chelius, Cristina J Y Lee, Aline D'Angelo Campos, Noel T Brewer, Allison J Lazard, Callie Whitesell, Thomas K Greenfield, Marissa G Hall","doi":"10.1001/jamanetworkopen.2025.35337","DOIUrl":"10.1001/jamanetworkopen.2025.35337","url":null,"abstract":"<p><strong>Importance: </strong>Alcohol control policies are associated with lower alcohol-related disability and death. Policymakers are more likely to adopt policies with higher public support, but it remains unknown which alcohol control policies currently garner the most public support in the US.</p><p><strong>Objective: </strong>To determine the extent to which US adults who consume alcohol support alcohol control policies and whether support differs by behavioral and demographic characteristics.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional, online survey study of a nationally representative sample of US adults was conducted from September to October 2024. Adults aged 21 years or older who reported drinking at least 1 alcoholic beverage per week during the past 4 weeks were eligible.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was support for alcohol control policies (eg, requiring cancer warnings on alcohol containers or increasing alcohol taxes) measured on a 1 (strongly oppose) to 5 (strongly support) response scale. Associations of behavioral and demographic characteristics with policy support were estimated using average differential effects (ADEs; ie, differences in estimated mean overall support between groups on the 1-5 scale) were calculated.</p><p><strong>Results: </strong>A total of 1036 participants completed the survey (524 men [weighted percentage, 52%]; mean [SD] age, 49.4 [16.5] years; 138 [weighted percentage, 12%) Hispanic, Latino, or Spanish; 115 [weighted percentage, 11%] Black or African American; 681 [weighted percentage, 65%] White). Approximately one-half supported policies requiring alcohol containers to display cancer warnings (49%; 95% CI, 45% to 53%), drinks per container information (51%; 95% CI, 47% to 55%), and calorie content information (56%; 95% CI, 52%-60%). Likewise, 52% (95% CI, 48% to 56%) supported prohibiting alcohol advertisements on television when children are likely to be watching. Few participants (8% [95% CI, 6% to 11%] to 19% [95% CI, 16% to 23%]) opposed these policies. By contrast, fewer participants supported than opposed policies to lower the blood alcohol content limit for driving, prohibit alcohol sales late at night, and increase taxes on alcohol (range supporting: 16% [95% CI, 13% to 19%] to 25% [95% CI, 22% to 29%]); support was lowest for policies to reduce the number of outlets licensed to sell alcohol (10% [95% CI, 8% to 13%]). Across policies, support was greater among adults who reported drinking less often (ADE = -0.12; 95% CI, -0.23 to -0.02); not binge drinking (ADE = -0.15; 95% CI, -0.26 to -0.04); or reading the current alcohol health warning in the last 30 days (ADE = 0.14; 95% CI, 0.01 to 0.28); and among those who were women (ADE = 0.22; 95% CI, 0.11-0.32); Hispanic, Latino, or Spanish (ADE = 0.16; 95% CI, 0.001-0.33); Democrats (ADE = 0.14; 95% CI, 0.01-0.27); or political independents (ADE = 0.16; 95% CI, 0.02 t","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2535337"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARP Inhibitors in Metastatic Castrate-Resistant Prostate Cancer. PARP抑制剂在转移性去势抵抗性前列腺癌中的作用
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34973
Charles L Bennett, June M McKoy
{"title":"PARP Inhibitors in Metastatic Castrate-Resistant Prostate Cancer.","authors":"Charles L Bennett, June M McKoy","doi":"10.1001/jamanetworkopen.2025.34973","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.34973","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534973"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Ambient AI Scribe Revolution-Early Gains and Open Questions. 环境人工智能书写革命——早期收获和开放问题。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34982
Kaustav P Shah, Kevin B Johnson
{"title":"The Ambient AI Scribe Revolution-Early Gains and Open Questions.","authors":"Kaustav P Shah, Kevin B Johnson","doi":"10.1001/jamanetworkopen.2025.34982","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.34982","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534982"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicare Savings Program Take-Up Estimates and Profile of Enrolled and Unenrolled Individuals. 医疗保险储蓄计划的估算和登记和未登记个人的概况。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.35408
Sarah Kotb, Amanda Su, Anna D Sinaiko
{"title":"Medicare Savings Program Take-Up Estimates and Profile of Enrolled and Unenrolled Individuals.","authors":"Sarah Kotb, Amanda Su, Anna D Sinaiko","doi":"10.1001/jamanetworkopen.2025.35408","DOIUrl":"10.1001/jamanetworkopen.2025.35408","url":null,"abstract":"<p><strong>Importance: </strong>Medicare enrollees with low income report challenges affording out-of-pocket costs for health care. Although the Medicare Savings Programs (MSPs) were established to provide financial support, recent patterns in program take-up are understudied.</p><p><strong>Objectives: </strong>To provide national and state-level estimates of take-up of the MSPs from 2018 to 2020 and describe the profile of enrolled and unenrolled individuals eligible for the MSPs.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional analysis used data from the Medicare Current Beneficiary Survey (MCBS), a nationally representative survey of community-dwelling Medicare beneficiaries. Respondents from 2018 to 2020 who completed the income and assets questionnaire, which allowed assessment of MSP eligibility, were analyzed. Data were analyzed in July 2024.</p><p><strong>Exposures: </strong>Eligibility for the MSPs.</p><p><strong>Main outcomes and measures: </strong>The take-up rate of the MSPs, defined as the proportion of eligible beneficiaries enrolled in the program. The MCBS survey weights were applied to create a subsample that was nationally representative of the community-dwelling Medicare population.</p><p><strong>Results: </strong>The primary sample included 26 240 respondent-year observations, representing 179 221 355 beneficiary-years (14.0% [95% CI, 13.4%-14.5%] of respondents were <65 years, 55.1% [95% CI, 54.1%-56.0%] were female, and 37.7% [95% CI, 36.0%-39.4%] had a high school education or lower). A total of 20.9% (95% CI, 19.8%-22.0%) of the primary sample was eligible for the MSPs. Of those eligible, 56.7% (95% CI, 54.5%-59.0%) were enrolled. Take-up rates varied widely across states, ranging from 41.5% (95% CI, 25.7%-57.3%) in Ohio to 72.9% (95% CI, 67.6%-78.2%) in California. Take-up among Medicare Advantage beneficiaries was higher than among those in traditional Medicare (61.3% vs 52.9%; difference, 8.4 percentage points [pp] [95% CI, 3.5-13.2 pp]). Compared with eligible beneficiaries who were not enrolled, enrolled individuals had greater economic insecurity, including being 30.0 pp (95% CI, 25.4-34.6 pp) more likely to report income below 100% of the federal poverty level and 16.4 pp (95% CI, 13.2-19.6 pp) more likely to report assets less than $3000.</p><p><strong>Conclusions and relevance: </strong>This cross-sectional study of Medicare beneficiaries suggests that MSP take-up remains incomplete and varied across states despite policy efforts. A policy to encourage participation in the MSPs among eligible populations that target less socially and financially vulnerable-although still with low income and eligible for the MSPs-individuals may be more likely to be associated with gains in the MSP take-up.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2535408"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excess Adiposity Without Obesity in a High-Risk Population. 高危人群中非肥胖的过度肥胖
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.35194
Alexandra B Palmer, Rashedeh Roshani, Joseph B McCormick, Susan P Fisher-Hoch, Jennifer E Below, Kari E North, Penny Gordon-Larsen
{"title":"Excess Adiposity Without Obesity in a High-Risk Population.","authors":"Alexandra B Palmer, Rashedeh Roshani, Joseph B McCormick, Susan P Fisher-Hoch, Jennifer E Below, Kari E North, Penny Gordon-Larsen","doi":"10.1001/jamanetworkopen.2025.35194","DOIUrl":"10.1001/jamanetworkopen.2025.35194","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2535194"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-Augmented Electron Microscopy for Glomerular Disease Diagnosis. ai增强电子显微镜在肾小球疾病诊断中的应用。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34997
Wisit Cheungpasitporn, Alton B Farris
{"title":"AI-Augmented Electron Microscopy for Glomerular Disease Diagnosis.","authors":"Wisit Cheungpasitporn, Alton B Farris","doi":"10.1001/jamanetworkopen.2025.34997","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.34997","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534997"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adolescents' Daily Race-Related Online Experiences and Mental Health Outcomes. 青少年日常与种族相关的在线体验和心理健康结果
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.36870
Brendesha M Tynes, Taylor McGee, Devin English
{"title":"Adolescents' Daily Race-Related Online Experiences and Mental Health Outcomes.","authors":"Brendesha M Tynes, Taylor McGee, Devin English","doi":"10.1001/jamanetworkopen.2025.36870","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.36870","url":null,"abstract":"<p><strong>Importance: </strong>Despite the rise in exposure to both positive and negative race-related experiences online, research on how these experiences are associated with mental health outcomes is limited.</p><p><strong>Objective: </strong>To examine the associations between negative online race-related experiences (online racial discrimination, traumatic events online, and algorithmic and filter bias), positive racial socialization messages, and mental health outcomes (depressive and anxiety symptoms).</p><p><strong>Design, setting, and participants: </strong>This survey study examined data from a nationally representative, intensive longitudinal 7-day daily dairy, collected as part of the National Survey of Critical Digital Literacy. Surveys were administered daily, with a 24-hour response window, in December 2020. Participants included Black or Black biracial or multiracial (parent-identified) adolescents. Participants were part of a larger nationally representative sample of 1138 adolescents, aged 11 to 19 years of various racial and ethnic backgrounds, recruited through Ipsos' KnowledgePanel. One eligible adolescent per household was randomly selected to participate. Analyses were conducted in August 2021 and revised in July 2025.</p><p><strong>Main outcomes and measures: </strong>To examine the daily associations between online race-related experiences and mental health outcomes, dynamic structural equation models were estimated for the longitudinal data.</p><p><strong>Results: </strong>Results were drawn from survey responses of 141 Black and Black biracial or multiracial adolescents (mean [SD] age, 14.74 [2.51] years; 80 [56.7%] female). Adolescents reported a total of 6 online race-related experiences per day, including 3.2 that are considered online racism and 2.8 that are positive. The study found experiences of online racial discrimination (γ = 0.12; 95% credible interval [CrI], 0.01-0.21), algorithmic bias (γ = 0.11; 95% CrI, 0.02-0.19), and traumatic events online (γ = 0.10; 95% CrI, 0.01-0.19) were positively associated with next day anxiety symptoms. Online racial discrimination (γ = 0.20; 95% CrI, 0.01-0.33]), traumatic events online (γ = 0.10; 95% CI, 0.04-0.15), and algorithmic bias (γ = 0.13; 95% CrI, 0.03-0.22) were positively associated with next-day depressive symptoms. Positive racial socialization experiences were not associated with mental health outcomes.</p><p><strong>Conclusions and relevance: </strong>In this survey study of online race-related experiences, Black adolescents, on average, reported experiencing 6 per day. Negative experiences were associated with poor mental health. Because young people can experience algorithms almost constantly, this study suggests more research is needed on related daily mental health outcomes.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2536870"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profiles in Nonverbal Learning Disability, Academic Skills, and Psychiatric Diagnoses in Children. 儿童非语言学习障碍、学术技能和精神诊断的概况。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.33848
Amy E Margolis, Jacob DeRosa, Minji Kang, Prudence W Fisher, Lauren Thomas, Caroline Southwick, Jessica Broitman, John M Davis, Aki Nikolaidis, Michael P Milham
{"title":"Profiles in Nonverbal Learning Disability, Academic Skills, and Psychiatric Diagnoses in Children.","authors":"Amy E Margolis, Jacob DeRosa, Minji Kang, Prudence W Fisher, Lauren Thomas, Caroline Southwick, Jessica Broitman, John M Davis, Aki Nikolaidis, Michael P Milham","doi":"10.1001/jamanetworkopen.2025.33848","DOIUrl":"10.1001/jamanetworkopen.2025.33848","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Nonverbal learning disability (NVLD) has been described since the 1960s, with varying subtypes proposed to address clinical heterogeneity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To identify profiles of NVLD to improve clinical practice and increase rigor in research by parsing clinical heterogeneity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This cross-sectional study used data from the Healthy Brain Network (HBN; release 8, years 2017 and 2021), a study of brain development and youth mental health that enrolls a community sample of New York, New York, children and adolescents (ages 5-21 years), to identify youths who met the research-defined criteria for NVLD. HBN recruits for desire to participate in research or perceived clinical concern, yielding a high proportion of youths with behavioral, learning, or emotional problems. An unsupervised clustering approach, Louvain community detection, was applied to the diagnostic parameters that defined NVLD. Profiles were described by patterns of strengths and weaknesses across diagnostic tests and by associations with clinical symptoms. Data were analyzed between April 22 and September 27, 2021.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;Perceived clinical concern.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The outcome of interest was NVLD profiles; hypotheses were generated prior to data analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 1640 children and adolescents with complete data in the HBN, 180 participants (110 [61%] male; 86 participants [48%] age 10-14 years; range, 6-17 years) met the research criteria for NVLD. Four profiles emerged: profile 1 (44 children) included deficits in both dimensions of visual-spatial processing (mean [SD] Wechsler Visual-Spatial Index [VSI], 96.11 [11.91]; Fluid Reasoning Index [FRI], 77.18 [7.94]), highest inattention (mean [SD], 1.23 [1.05]]; P = .001) and aggression scores (mean [SD], 65.03 [15.89]; P = .001), and lowest reading comprehension scores (mean [SD], 93.81 [10.31]; P = .001); profile 2 (37 children) included deficits in VSI (mean [SD], 78.27 [13.55]) but not FRI, the highest math scores (mean [SD], 101.16 [17.57]; P = .001) and rate of anxiety disorder (odds ratio, 2.19; 95% CI, 1.31-3.66; P = .02), and the lowest rate of specific learning disorder (odds ratio, 0.20; 95% CI, 0.05-0.84; P = .01); profile 3 (35 children) included deficits in FRI (mean [SD], 88.6 [12.63]) and highest reading comprehension scores (mean [SD], 101.8 [14.12]; P &lt; .001); profile 4 had no deficits in VSI or FRI, lowest verbal intelligence (mean [SD], 87.12 [13.07]; P = .001), and no functional impairments. In profiles with visual-spatial deficits (profiles 1, 2, and 3), VSI and FRI scores were positively associated with scores on measures of functional impairment, eg, FRI and math in profile 2 (Pearson r = .33; P &lt; .001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;In this cross-sectional study of heterogeneity in NVLD, 3 profiles ","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2533848"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-Effectiveness of HPV Self-Testing Options for Cervical Cancer Screening. 宫颈癌筛查中HPV自检方案的成本效益。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.34960
Richard T Meenan, Catherine Lacey, Diana S M Buist, Jasmin A Tiro, John Lin, Melissa L Anderson, Beverly B Green, Rachel L Winer
{"title":"Cost-Effectiveness of HPV Self-Testing Options for Cervical Cancer Screening.","authors":"Richard T Meenan, Catherine Lacey, Diana S M Buist, Jasmin A Tiro, John Lin, Melissa L Anderson, Beverly B Green, Rachel L Winer","doi":"10.1001/jamanetworkopen.2025.34960","DOIUrl":"10.1001/jamanetworkopen.2025.34960","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Mailing human papillomavirus (HPV) self-sampling kits to underscreened individuals increases cervical cancer screening and can be cost-effective. However, cost-effectiveness has not been evaluated across other screening histories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To conduct an economic evaluation of mailed HPV self-sampling among members of a US health care system with adherent, overdue, or unknown screening histories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This economic evaluation was a cost-effectiveness analysis (CEA) and budget impact analysis (BIA) based on results of a randomized clinical trial (RCT) conducted between November 20, 2020, to July 29, 2022, in an integrated health care system in Washington State. Intervention delivery costs were calculated from Kaiser Permanente Washington and Medicare perspectives and used wellness-based or screening-only visit costs. Participants included female members aged 30 to 64 years identified through electronic medical records. Data were analyzed from August 1, 2022, to July 29, 2025.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention: &lt;/strong&gt;Members were randomized by screening history. Adherent participants were assigned to 4 groups: usual care (UC), patient reminders, clinician electronic health record [HER] alerts), education (UC and mailed educational materials), direct mail (UC, education, and mailed self-sampling kit), or opt-in (UC, education, and mailed invitation to request kit). Overdue participants were assigned to 3 groups: UC, education, or direct mail. Participants with unknown adherence were assigned to UC, education, or opt-in.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcome and measures: &lt;/strong&gt;Primary RCT outcome was screening completion 6 months postrandomization. CEA outcome was incremental cost-effectiveness ratio for screening completion. BIA outcome was annual program implementation cost over 4 years.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Analyses included 31 355 individuals (mean [SD] age, 45.9 [10.4] years). Among screening adherent members, direct mail dominated all other strategies (more effective and cost-saving). Among overdue members, direct mail was also more effective than UC and generated an additional completed screen at a cost ranging from -$19 (95% CI, -$21 to -$16) (cost saving) to $63 (95% CI, $39 to $87) depending on cost basis and visit type. Among unknown members, opt-in generally dominated UC (more effective and cost-saving). The BIA indicated that although the screening adherent subgroup had the largest year 1 program budget, its budget declined fastest and, by year 4, was lowest among the 3 subgroups. Conversely, the smallest annual budget decreases were among eligible individuals with unknown history.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;In this economic analysis of a randomized clinical trial, directly mailing HPV kits to individuals who were screening adherent and overdue for screening was economically dominant over other strategies. P","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2534960"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Error in Author Name in Byline and Supplement. 署名和副刊中作者姓名错误。
IF 9.7 1区 医学
JAMA Network Open Pub Date : 2025-10-01 DOI: 10.1001/jamanetworkopen.2025.40719
{"title":"Error in Author Name in Byline and Supplement.","authors":"","doi":"10.1001/jamanetworkopen.2025.40719","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.40719","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"8 10","pages":"e2540719"},"PeriodicalIF":9.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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