Iranian Journal of Public Health最新文献_第4页

The Relationship between the Permanent Trigeminal Artery and Cerebrovascular Disease: A Meta-Analysis. 永久性三叉神经动脉与脑血管疾病的关系：元分析。

IF 1.4 4区医学

Iranian Journal of Public Health Pub Date : 2024-05-01 DOI: 10.18502/ijph.v53i5.15579

Jingyan Zhang, Yan Wang, Yongliang Gai, Hanmei Cui, Bo Liu, Jie Li, Yuguang Wang, Juncheng Lv, Shaosen Chen

{"title":"The Relationship between the Permanent Trigeminal Artery and Cerebrovascular Disease: A Meta-Analysis.","authors":"Jingyan Zhang, Yan Wang, Yongliang Gai, Hanmei Cui, Bo Liu, Jie Li, Yuguang Wang, Juncheng Lv, Shaosen Chen","doi":"10.18502/ijph.v53i5.15579","DOIUrl":"10.18502/ijph.v53i5.15579","url":null,"abstract":"Background: We aimed to analyze the variability of the permanent trigeminal artery (PTA) and its relationship with cerebrovascular disease.Methods: To analyze the variability of the PTA and its relationship with cerebrovascular disease by using the terms \"primitive trigeminal artery\", \"persistent primitive trigeminal artery\", \" persistent trigeminal artery variant\", \"PPTA\", \"PTAV\", \"carotid- basilar anastomoses\", \"carotid-vertebrobasilar anastomoses\", \"persisting embryonic vessels\" were used as keywords, and the English-language literature related to PTA and cerebrovascular diseases published in PubMed, EMBAS, and Web of Science databases from 2000 to 2022 were searched by using \"subject terms + free words\". A meta-analysis of the collected data was performed using stata14.0 statistical software to assess the relationship between the immortal trigeminal artery and cerebrovascular-related diseases.Results: A total of 1908 relevant articles were initially retrieved for this study. Ten papers were initially screened according to the inclusion and exclusion criteria, while the literature was then read one by one to exclude duplicates, reviews, case reports, and conference abstracts, and six papers were finally included for meta-analysis. The six papers included in this paper were all cross-sectional studies with 39,355 subjects, of which 206 subjects had PTA, with a variation rate of approximately 0.52%, including 77 males and 129 females, 117 left-sided variants and 87 right-sided variants. In contrast, of the 206 subjects with a PTA, 52 had cerebrovascular disease, with an overall prevalence of approximately 25.24%.Conclusion: The PTA could influence the development of cerebrovascular disease.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"53 5","pages":"988-996"},"PeriodicalIF":1.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Mean Platelet Volume and Systemic Lupus Erythematosus: A Meta-Analysis. 平均血小板体积与系统性红斑狼疮的关系：一项 Meta 分析。

IF 1.4 4区医学

Iranian Journal of Public Health Pub Date : 2024-05-01 DOI: 10.18502/ijph.v53i5.15578

Young Ho Lee, Gwan Gyu Song

{"title":"Association between Mean Platelet Volume and Systemic Lupus Erythematosus: A Meta-Analysis.","authors":"Young Ho Lee, Gwan Gyu Song","doi":"10.18502/ijph.v53i5.15578","DOIUrl":"10.18502/ijph.v53i5.15578","url":null,"abstract":"Background: This meta-analysis aimed to investigate the association between mean platelet volume (MPV) and systemic lupus erythematosus (SLE) disease activity, and laboratory parameters including the SLE Disease Activity Index (SLEDAI), C3 levels, anti-double-stranded DNA (anti-dsDNA) antibodies, and erythrocyte sedimentation rate (ESR).Methods: The Medline, Embase, and Cochrane databases were searched comprehensively to identify relevant articles. Meta-Analyses were performed to assess differences in MPV between patients with SLE and control groups and between active and inactive SLE. A separate meta-analysis explored correlation coefficients between MPV and SLEDAI, C3, anti-dsDNA, and ESR.Results: Fourteen studies comprising 659 patients with SLE and 682 controls were included. No significant difference in MPV was found between patients with SLE and control groups (standardized mean difference [SMD]: 0.406; 95% confidence interval [CI]: -0.087 to 0.899; P = 0.107). When stratified by ethnicity, the Arab population displayed markedly elevated MPV levels within the SLE group (SMD: 1.032; 95% CI: 0.475-1.588; P <0.001), unlike their European and Asian counterparts. MPV levels were higher in the active disease group than in the inactive group, particularly among the Arab population (SMD: 2.100; 95% CI: 0.406-3.794; P = 0.015), while no significant difference was observed within the Asian population (SMD: -1.493; 95% CI = -4.465 to 1.479; P = 0.325). MPV did not correlate with SLEDAI (correlation coefficient: 0.252; 95% CI: -0.016 to 0.486; P = 0.065), ESR, C3, or anti-dsDNA.Conclusion: MPV levels were generally higher in patients with SLE among the Arab population. Moreover, MPV and disease activity were positively correlated within the Arab population, underscoring the potential of MPV as a disease activity indicator in specific ethnic groups.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"53 5","pages":"978-987"},"PeriodicalIF":1.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Relationship between Cadmium Exposure and the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis. 调查镉暴露与前列腺癌风险之间的关系：系统回顾与剂量反应荟萃分析》。

IF 1.4 4区医学

Iranian Journal of Public Health Pub Date : 2024-03-01 DOI: 10.18502/ijph.v53i3.15136

Abdollah Mohammadian-Hafshejani, Parisa Farahmandian, Abdolmajid Fadaei, Ramezan Sadeghi

{"title":"Investigating the Relationship between Cadmium Exposure and the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis.","authors":"Abdollah Mohammadian-Hafshejani, Parisa Farahmandian, Abdolmajid Fadaei, Ramezan Sadeghi","doi":"10.18502/ijph.v53i3.15136","DOIUrl":"10.18502/ijph.v53i3.15136","url":null,"abstract":"Background: Cadmium, a toxic heavy metal, experienced a surge in production during the 20th century due to the rise of nickel-cadmium batteries, metal plating, and plastic stabilizers. Exposure to cadmium primarily occurs through the consumption of contaminated food, such as vegetables and grains, as well as drinking water or inhaling polluted air. The objective of this study was to investigate the relationship between cadmium exposure and the incidence of prostate cancer using a systematic review and meta-analysis approach.Methods: This research involved searching and retrieving observational and experimental studies conducted until May 2022 from various databases, including ISI Web of Science, Cochrane, Science Direct, Scopus, Pub-Med, and Google Scholar. Data analysis was performed using Stata 15 statistical software.Results: The initial search yielded 794 articles, which were subsequently reduced to 427 articles after eliminating duplicates. Following the application of inclusion and exclusion criteria, a total of 16 studies were included in the meta-analysis. The odds ratio of prostate cancer compared to the first quartile of exposure in the second quartile was 1.03 (0.95-1.12), in the third quartile it was 1.12 (0.99-1.26) and in the fourth quartile of exposure was equal to 1.16 (0.79-1.70). Regarding the investigation of the probability of the occurrence of publication bias, the results of Begg's and Egger's tests were not statistically significant.Conclusion: Although exposure to cadmium leads to an increase in the chance of prostate cancer, this chance increase was not statistically significant.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"53 3","pages":"553-567"},"PeriodicalIF":1.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Relationship between Birthweight and Breast Cancer from A Non-Linear and Mediation Perspective. 从非线性和中介的角度研究出生体重与乳腺癌之间的关系。

IF 1.4 4区医学

Iranian Journal of Public Health Pub Date : 2024-01-01 DOI: 10.18502/ijph.v53i1.14695

Meng Zhang, Jiahao Qiao, Ping Zeng, Zhuanzhuan Liu

{"title":"Investigating the Relationship between Birthweight and Breast Cancer from A Non-Linear and Mediation Perspective.","authors":"Meng Zhang, Jiahao Qiao, Ping Zeng, Zhuanzhuan Liu","doi":"10.18502/ijph.v53i1.14695","DOIUrl":"https://doi.org/10.18502/ijph.v53i1.14695","url":null,"abstract":"Background: Epidemiological studies have shown a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations emerged. We re-explored the association between them in the UK Biobank cohort.Methods: Relying on the UK Biobank cohort data of white British volunteers recruited between 2006 and 2010 (5,760 cases and 162,778 controls), we evaluated the causal mediation between birthweight and breast cancer, with age of menarche and age at menopause as two potential mediators under the traditional mediation analysis framework. The non-linear relationship between birthweight and breast cancer was also investigated by including the square of birthweight or discretized birthweight categories (<2.5, 2.5~4.0, or >4.0). Furthermore, we performed a stratification analysis in terms of the menopause status.Results: Birthweight can indirectly influence breast cancer risk in adulthood via the path of age of menarche or age at menopause, and found statistical evidence supporting the existence of suggestive non-linear association between birthweight and breast cancer (β=0.062 and P=0.004 for the square of birthweight) although failing to discover a linear relationship (P=0.230). We also demonstrated such non-linear association seemed more pronounced and robust for premenopausal women compared with postmenopausal ones (27.5% vs. 19.5% increase in breast cancer risk).Conclusion: This study provided an in-depth insight into the observed relationship between birthweight and breast cancer and revealed that non-linear impact and causal mediation commonly drive the connection between the two traits.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"53 1","pages":"187-197"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Textual Analysis of Tweets Associated with Domestic Violence 家庭暴力相关推文文本分析

4区医学

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI: 10.18502/ijph.v52i11.14039

Stephanie Chua, Janice Allison Sabang, Keng Sheng Chew, Puteri Nor Ellyza Nohuddin

{"title":"Textual Analysis of Tweets Associated with Domestic Violence","authors":"Stephanie Chua, Janice Allison Sabang, Keng Sheng Chew, Puteri Nor Ellyza Nohuddin","doi":"10.18502/ijph.v52i11.14039","DOIUrl":"https://doi.org/10.18502/ijph.v52i11.14039","url":null,"abstract":"Background: Domestic violence is a global public health concern as stated by World Health Organization. We aimed to conduct a textual analysis of tweets associated with domestic violence through keyword identification, word trends and word collocations. The data was obtained from Twitter, focusing on publicly available tweets written in English. The objectives are to find out if the identified keywords, word trends and word collocations can help differentiate between domestic violence-related tweets and non-domestic violence-related tweets, as well as, to analyze the textual characteristics of domestic violence-related tweets and non-domestic violence-related tweets. Methods: Overall, 11,041 tweets were collected using a few keywords over a period of 15 days from 22 March 2021 to 5 April 2021. A text analysis approach was used to discover the most frequent keywords used, the word trends of those keywords and the word collocations of the keywords in differentiating between domestic violence-related or non-domestic violence-related tweets. Results: Domestic violence-related tweets and non-domestic violence-related tweets had differentiating characteristics, despite sharing several main keywords. In particular, keywords like “domestic”, “violence” and “suicide” featured prominently in domestic-violence related tweets but not in non-domestic violence-related tweets. Significant differences could also be seen in the frequency of keywords and the word trends in the collection of the tweets. Conclusion: These findings are significant in helping to automate the flagging of domestic-violence related tweets and alert the authorities so that they can take proactive steps such as assisting the victims in getting medical, police and legal help as needed.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"74 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laryngeal Cancer: Epidemiology, Etiology, and Prevention: A Narrative Review 喉癌:流行病学、病因学和预防:叙述性回顾

4区医学

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI: 10.18502/ijph.v52i11.14025

Nurbek Igissin, Vera Zatonskikh, Zhansaya Telmanova, Rais Tulebaev, Malcolm Moore

{"title":"Laryngeal Cancer: Epidemiology, Etiology, and Prevention: A Narrative Review","authors":"Nurbek Igissin, Vera Zatonskikh, Zhansaya Telmanova, Rais Tulebaev, Malcolm Moore","doi":"10.18502/ijph.v52i11.14025","DOIUrl":"https://doi.org/10.18502/ijph.v52i11.14025","url":null,"abstract":"Laryngeal cancer comprises 30%-40% of head and neck malignancies, and it is the most common malignancy in otolaryngology. The main risk factors for laryngeal cancer are tobacco use, excessive alcohol consumption, gastroesophageal reflex, Plummer-Vinson syndrome, exposure to heat, chemicals, and some viral infections. This literature review summarizes all known data over the past decade with an assessment of the main etiological factors related to cancer incidence, general measurement issues in the cancer epidemiology and the current state of science in relation to laryngeal cancer. The geographical distribution of laryngeal cancer also reveals some important aspects. Europe remains the most prevalent continent for this type of malignancy, whilst the epidemiologic burden in Africa remains low. Overall, there are clear differences in morbidity and mortality from laryngeal cancer between urban and rural areas, with gender inequalities. In some countries, the incidence rates are high in rural areas, and in some, such as in China, the urban population is more affected. High rates of laryngeal cancer are closely associated with both low average income and a high percentage of the population with lower-than-average education countries with higher Socio-demographic Index (SDI) have made greater improvements in the treatment of LC than countries with lower SDI. Epidemiological data on risk factors can provide valuable information for developing cancer prevention strategies.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"77 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135036733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis on the Relationships of Smartphone Addiction, Learning Engagement, Depression, and Anxiety: Evidence from China 智能手机成瘾、学习投入、抑郁和焦虑的关系分析:来自中国的证据

4区医学

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI: 10.18502/ijph.v52i11.14033

Bingzhuan Peng

{"title":"Analysis on the Relationships of Smartphone Addiction, Learning Engagement, Depression, and Anxiety: Evidence from China","authors":"Bingzhuan Peng","doi":"10.18502/ijph.v52i11.14033","DOIUrl":"https://doi.org/10.18502/ijph.v52i11.14033","url":null,"abstract":"Background: With the popularization of the Internet and smartphones, smartphone addiction among college students is becoming increasingly common, causing the problems of their learning engagement, anxiety, and depression. The study aimed to analyze the relationships of smartphone addiction, learning engagement, anxiety and depression among Chinese college students. Method: Based on the Self-Determination Theory, in January 2023, 780 college students from 6 universities in Heilongjiang Province in China were selected as examples for the study. Internet Addiction Test, Utrecht Work Engagement Scale-Student, Chinese version of Beck Depression Inventory-II, and Spielberger Trait Anxiety Inventory were employed to measure smartphone use, learning engagement, depression, and anxiety among college students. Pearson correlation and multiple logistic regressions were also used. Results: Smartphone use was negatively correlated with learning engagement (r = -0.097, P < 0.001), whereas it was positively correlated with depression (r = 0.184) and anxiety (r = 0.18, P < 0.001). Significant differences were observed in learning engagement and depression and anxiety symptoms in different degrees of smartphone use. Taking severe smartphone addiction as a comparison standard, depression and anxiety symptoms had a significant influence on different levels of smartphone use, whereas learning engagement did not have a significant influence on different smartphone use levels. Conclusion: The intervention and prevention of college students’ smartphone addiction can improve their learning engagement, relieve their anxiety and depression, and enhance their mental health level.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"77 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135036726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and Prognostic Value of miR-93 in Prostate Cancer: A Meta-Analysis and Bioinformatics Analysis miR-93在前列腺癌中的诊断和预后价值:荟萃分析和生物信息学分析

4区医学

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI: 10.18502/ijph.v52i11.14026

Hassane Gazzaz, Maha El Habchi, Mohammed El Feniche, Yassine El Aatik, Abdelghani El Ouardi, Ahmed Ameur, Abdellah Dami

{"title":"Diagnostic and Prognostic Value of miR-93 in Prostate Cancer: A Meta-Analysis and Bioinformatics Analysis","authors":"Hassane Gazzaz, Maha El Habchi, Mohammed El Feniche, Yassine El Aatik, Abdelghani El Ouardi, Ahmed Ameur, Abdellah Dami","doi":"10.18502/ijph.v52i11.14026","DOIUrl":"https://doi.org/10.18502/ijph.v52i11.14026","url":null,"abstract":"Background: Accurate and non-invasive diagnostic and prognostic markers are necessary to improve patient outcomes. MicroRNAs have been proposed as relatively non-invasive and pertinent biomarkers. miR-93 has been studied for its potential as a diagnostic and prognostic marker in prostate cancer (PCa), but findings from individual studies are inconsistent. We conducted a meta-analysis of its overall differential expression in 13 PCa studies and a bioinformatics analysis to provide a comprehensive appraisal of its diagnostic and prognostic role. Methods: We searched all published papers on miR-93 expression in PCa up to Nov 30, 2022 using PubMed, Science Direct, Web of Science, Cochrane Central Register of Controlled Trials databases. We used RevMan software to Meta-analyze the included literature. A bioinformatics analysis of genes and pathways that might be target to the effect of the mature miR-93-5p was carried out. Results: The pooled standardized mean difference (SMD) of miR-93 expression in PCa, its area under the curve (AUC) and hazard ratio (HR) were 1.26, 95% CI [-0.34–2.86], 0.84, 95% CI [0.76 –0.93] and 1.67, 95% CI [0.98, 2.84] respectively. Bioinformatics analysis revealed that mature miR-93-5p may regulate genes such as SMAD1, SMAD7 and MAPK and the PI3K-Akt signaling pathways. Conclusion: miR-93 has significant diagnostic and prognostic value in PCa. These findings highlight the potential of miR-93 as a non-invasive biomarker for PCa and may contribute to earlier detection and prognostic assessment. The target genes and signaling pathways regulated by miR-93 may provide insights into the underlying molecular mechanisms of PCa.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"77 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135036729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Expression of High Mobility Group Box-1 (HMG1) in the Peripheral Blood and its Relation with Systemic Vasculitis Patients 高迁移率组盒-1 (HMG1)在外周血中的表达及其与全身性血管炎的关系

4区医学

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI: 10.18502/ijph.v52i11.14038

Ying Qin, Xin Li, Lidong Shi, Yangyang Liu, Zhihui Wang, Yue Guan

{"title":"The Expression of High Mobility Group Box-1 (HMG1) in the Peripheral Blood and its Relation with Systemic Vasculitis Patients","authors":"Ying Qin, Xin Li, Lidong Shi, Yangyang Liu, Zhihui Wang, Yue Guan","doi":"10.18502/ijph.v52i11.14038","DOIUrl":"https://doi.org/10.18502/ijph.v52i11.14038","url":null,"abstract":"Background: We aimed to explore the expression of high mobility group box-1 (HMG1) in the peripheral blood of systemic vasculitis (SV) patients. Methods: The peripheral blood were collected from 35 healthy controls and 35 SV patients, and the expressions of HMGB1 and pyroptosis-related markers in the samples were detected by ELISA. They were admitted to the Department of Rheumatology and Immunology of the Third Affiliated Hospital of Qiqihar Medical University, China in 2022. The severity of diseases was graded according to the diagnosis and treatment norms of SV. The correlation between HMGB1 expression level and disease-related indicators and grades were explored through Pearson correlation analysis. The specific mechanism of HMGB1 mediating the occurrence and development of diseases through the regulation of endothelial pyroptosis was clarified. Results: HMGB1 expression significantly increased in the peripheral blood of SV patients compared with healthy controls (P<0.0001). Pearson correlation analysis indicated that HMGB1 expression level in serum gradually increased with the aggravation in SV patients. The expression levels of ASC (P<0.0001), IL-1β (P=0.004) and IL-18 (P<0.0001) in peripheral blood of SV patients were significantly increased, which were significantly positively correlated with HMGB1 in peripheral blood (P<0.0001). Recombinant HMGB1 significantly promoted the expression of ASC, IL-1β and IL-18 in vascular endothelial cells. Recombinant HMGB1 stimulation significantly activated NLRP3 inflammasome, and the additional addition of NLRP3 inhibitor significantly inhibited HMGB1-mediated endothelial pyroptosis. Conclusion: HMGB1 expression was significantly high in the peripheral blood of SV patients, which was positively correlated with the severity of diseases. HMGB1 could mediate pyroptosis through activating TLR4/NF-κB/NLRP3 signaling pathway.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"77 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135036589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the Antibiotic Resistance of Non-Tuberculous Mycobacteria in Iran: A Systematic Review and Meta-Analysis 伊朗非结核分枝杆菌抗生素耐药性趋势:系统回顾和荟萃分析

4区医学

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI: 10.18502/ijph.v52i11.14028

Hamid Heidari, Parisa Kalantari, Mohammad Sholeh, Sahel Hamze Pour, Atieh Darbandi, Abbas Maleki, Abbas Ghaysouri, Hossein Kazemian

{"title":"Trends in the Antibiotic Resistance of Non-Tuberculous Mycobacteria in Iran: A Systematic Review and Meta-Analysis","authors":"Hamid Heidari, Parisa Kalantari, Mohammad Sholeh, Sahel Hamze Pour, Atieh Darbandi, Abbas Maleki, Abbas Ghaysouri, Hossein Kazemian","doi":"10.18502/ijph.v52i11.14028","DOIUrl":"https://doi.org/10.18502/ijph.v52i11.14028","url":null,"abstract":"Background: Non-tuberculous mycobacteria (NTM) infections have been continuously increasing as major concerns of public health in Iran. Because innate resistance of NTM species, the treatment of these infections is difficult task, but until now resistance pattern of NTM and suitable regimens are not determined. Methods: We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until Dec 2022). All statistical analyses were carried out using the statistical package R. Results: Eleven studies included in the analysis were performed in 6 provinces and investigated 1223 NTM clinical species. The majority of the studies originated in Tehran. Among the first-line anti-TB drugs, almost all NTM species were highly resistant to first-line anti-TB drugs. No significant difference in the isoniazid resistance rate was found in the slow or rapid-growing species and Runyon's classification of NTM isolates. A decreased in the prevalence of ciprofloxacin, clarithromycin, and moxifloxacin resistance were showed in during 2013-2022 years. Conclusion: Most investigated antibiotics have a minor effect on NTM species and a steady increase of resistance has been seen in last few years then, need more-effective alternative regimens is clear","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"77 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135036590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0