Iranian Journal of Public Health最新文献_第10页

Licochalcone A Inhibits Proliferation and Metastasis of Colon Cancer by Regulating miR-1270/ADAM9/Akt/NF-κB axis 甘草查尔酮A通过调控miR-1270/ADAM9/Akt/NF-κB轴抑制结肠癌增殖和转移

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13578

Changhai Pan, Hongjin Chen, Bolin Yang

{"title":"Licochalcone A Inhibits Proliferation and Metastasis of Colon Cancer by Regulating miR-1270/ADAM9/Akt/NF-κB axis","authors":"Changhai Pan, Hongjin Chen, Bolin Yang","doi":"10.18502/ijph.v52i9.13578","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13578","url":null,"abstract":"Background: We aimed to explor the therapeutic effect and molecular mechanism of licochalcone A (LCA) on colon cancer. Methods: This study was carried out in 2020-2021 in Nanjing Tongren Hospital, China. Colon cancer HCT116 cells were treated with different concentrations of LCA. Cell counting kit-8, colony formation and flow cytometry assays were used to analyze cell viability, proliferation and apoptosis. Wound healing and transwell experiments were used to measure cell migration and invasion ability. The expression of ADAM9 and apoptosis-related proteins in different LCA treatment groups was detected by western blot. HCT116 cells were transfected with ADAM9 small interfering RNAs (siRNAs) or overexpression vectors. The database screened the upstream miRNA targeting ADAM9 and predicted the targeted binding site between miR-1270 and ADAM9, which was verified by a dual-luciferase reporter assay. Rescue experiments were performed to confirm the effects of the miR-1270/ADAM9 axis on cell proliferation and metastasis. Results: LCA decreased cell growth (P<0.05), migration (P<0.05), and invasion (P<0.05) of colon cancer cells and inhibited ADAM9 expression in a dose-dependent manner. LCA affected the functions of colon cancer cells by negatively regulating the expression of ADAM9. MiR-1270, increased by LCA, targeted and suppressed ADAM9 expression significantly (P<0.001). ADAM9 overexpression restrained miR-1270 mimic and LCA-induced changes in cell proliferation, migration, and invasion, and promoted apoptosis in HCT116 cells significantly (P<0.01). LCA and miR-1270 mimic inactivated the Akt/NF-κB pathway, while ADAM9 overexpression rescued it. Conclusion: LCA exhibited antitumor efficacy in HCT116 cells by inhibiting the Akt/NF-κB signaling pathway by regulating the miR-1270/ADAM9 axis.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Gastric Cancer is Highly Dependent on Type of First-Degree Family Member Affected by Cancer: Lessons from a High-Risk Population in Iran 胃癌的风险高度依赖于受癌症影响的一级家庭成员类型:来自伊朗高危人群的经验教训

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13582

Esmat Abdi, Saeid Latifi-Navid, Saber Zahri, Behdad Mostafaiy, Abbas Yazdanbod, Farhad Pourfarzi

{"title":"Risk of Gastric Cancer is Highly Dependent on Type of First-Degree Family Member Affected by Cancer: Lessons from a High-Risk Population in Iran","authors":"Esmat Abdi, Saeid Latifi-Navid, Saber Zahri, Behdad Mostafaiy, Abbas Yazdanbod, Farhad Pourfarzi","doi":"10.18502/ijph.v52i9.13582","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13582","url":null,"abstract":"Background: Family history of gastric cancer (GC) in first-degree relatives may increase the risk of GC. This study aimed to assess how family history of GC in first-degree relatives really affects the risk of GC in an extremely high-risk population. Methods: A large population-based case-control study was carried out on 1222 incident GC cases and 1235 controls in Ardabil Province-a high-risk area in North-West Iran-to assess the associations of GC family history in first-degree relatives with the risk of GC (2003-2017). Results: GC family history did not significantly associate with the risk of GC overall (ORadj=1.09, 95% CI: 0.80–1.47, P=0.589). It found no significant association of GC family history in a parent, and in a father, mother, and sister separately, with the risk of GC. However, GC risk was significantly associated with a history of GC in a sibling (ORadj=1.61, 95% CI: 1.11–2.35, P=0.013), especially brother (ORadj=2.24, 95% CI: 1.41–3.64, P=0.0008). The risk was greatly increased in subjects with two or more affected brothers (ORadj =5.56, 95% CI: 2.33–14.20, P=0.0002). Conclusion: We did not find a familial tendency to cardia GC and non-cardia GC as well as histopathologic features. Determining the type of first-degree relationships with GC may, therefore, be more important than assessing family history alone for predicting the risk of GC in this high-risk area.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Customized Communication Training on Nonviolent Communication, Nonverbal Communication, and Self-Acceptance: Evidence from Korean Nursing Students 定制化沟通训练对非暴力沟通、非语言沟通和自我接纳的影响:来自韩国护生的证据

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13576

Heeyoung Jung, Yeon Hee Lee, Jung-Ha Park

{"title":"Effects of Customized Communication Training on Nonviolent Communication, Nonverbal Communication, and Self-Acceptance: Evidence from Korean Nursing Students","authors":"Heeyoung Jung, Yeon Hee Lee, Jung-Ha Park","doi":"10.18502/ijph.v52i9.13576","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13576","url":null,"abstract":"Background: We aimed to investigate the effects of a nonviolent and nonverbal communication and self-acceptance training program among Korean nursing students. Methods: We enrolled students in nursing departments at three universities in Busan Metropolitan City, South Korea. The students were randomly allocated to the experimental (n = 38) and control groups (n = 36); subsequently, they completed questionnaires before and after training. Data were collected on March 2023. The experimental group was enrolled in a program comprising 390 minutes of lecture, practice, role play, discussion, and reflection in 8-h daily sessions, with a total of eight sessions. The training sought to allow students to understand and practice nonviolent and nonverbal communication. Data were analyzed using descriptive statistics, chi-square tests, and a paired t-test. Results: Compared with the control group, the experimental group showed a significant post-intervention improvement in the nonviolent communication scores (t = -2.442, P= 0.020); however, there were no significant between-group differences in the post-intervention nonverbal communication or self-acceptance scores. Conclusion: Customized communication training programs are required to address communication competencies among medical personnel, including nursing students. Moreover, it is crucial to set standards for communication competency. Specifically, from a long-term perspective, a continuous educational strategy is required to effectively improve the communication capabilities of nursing students in Korea. It is possible to develop training programs that can systematically improve communication competency among nursing students.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Two Methods with Less Donor Site Complications of Epidermal Cellular Grafting in Cell Therapy of Vitiligo 两种供区并发症少的表皮细胞移植治疗白癜风的方法

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13586

Mohammad Ali Nilforoushzadeh, Ali Ataei, Sona Zare

引用次数: 0

Health Promotion Interventions on Helmet Use: A Systematic Review and Meta-Analysis of Pre-Test and Post-Test Studies 健康促进对头盔使用的干预:测试前和测试后研究的系统回顾和荟萃分析

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13569

Leila Jahangiry, Saber Eisazadeh, Roghayeh Khabiri, Homayoun Sadeghi-Bazargani, Fatemeh Bakhtari-Aghdam, Koen Ponnet

{"title":"Health Promotion Interventions on Helmet Use: A Systematic Review and Meta-Analysis of Pre-Test and Post-Test Studies","authors":"Leila Jahangiry, Saber Eisazadeh, Roghayeh Khabiri, Homayoun Sadeghi-Bazargani, Fatemeh Bakhtari-Aghdam, Koen Ponnet","doi":"10.18502/ijph.v52i9.13569","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13569","url":null,"abstract":"Background: We aimed to review the effectiveness of health promotion interventions in the use of helmet and to identify the types of effective health promotion strategies among the examined studies. Methods: A systematic search was performed on the PubMed, Scopus, Cochrane, and Embase databases up to 1 Aug 2022 to find the studies evaluated the effectiveness of health promotion interventions for helmet use among target population. In this systematic review and meta-analysis, interventions with pre- post-test design were included. The dependent variable of the study is the percentage of participants who responded positively toward helmet use in the baseline and after the interventions. Random-effects models were used to pool study results. Results: Overall, 1,675 articles were found in the initial search and entered into the Endnote software. Of these, 917 duplicate articles were removed, leaving 758 articles were screened based on title and abstract. Finally, 12 eligible articles were included in the review and five with pre and post-test design were included in the meta-analysis. The overall random-effects pooled estimation of persons wearing helmets before and after interventions was 70% (95%CI 21 –119; P<0.001), without a heterogeneity (I2 =0%; P=0.94), which means that the average percentage of changing to helmet use is 70%. Community-based education program was the most commonly applied for interventional studies. The next most commonly used approaches were campaign designing. Conclusion: Wearing helmet approximately increased 70% among participant. Health promotion strategies may target helmet-wearing behavior to reduce head injuries in motorcyclist road traffic accidents.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective Strategies for Physical Activity Adherence in Heart Failure Patients: An Umbrella Review 心力衰竭患者坚持体力活动的有效策略:综述

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13566

Hossein Karimi Moonaghi, Shahnaz Ahrari, Seyed Mousa Mahdizadeh, Alireza Heidari Bakavoli, Seyed Mohammad Riahi

{"title":"Effective Strategies for Physical Activity Adherence in Heart Failure Patients: An Umbrella Review","authors":"Hossein Karimi Moonaghi, Shahnaz Ahrari, Seyed Mousa Mahdizadeh, Alireza Heidari Bakavoli, Seyed Mohammad Riahi","doi":"10.18502/ijph.v52i9.13566","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13566","url":null,"abstract":"Background: Despite the importance of physical activity in heart failure treatment, physical activity adherence in heart failure patients is low. The purpose of this umbrella review was to obtain the best strategies for enhancing physical activity adherence among HF patients. Methods: Databases were investigated from 2010 to Jan 2022. The full text of the papers was investigated in terms of inclusion and exclusion criteria. Eventually, out of 74 relevant papers, 7-review study with 20977 patients were eligible and included in the study. Results: Five key effective approaches were identified in two subsets for enhancing physical activity adherence as follows: 1) exercise-based approaches including 1.1) Exergames, whereby the extent of adherence to exergames was between 84 and 98%. 1.2) Tele-rehabilitation with 70%-100% adherence the intervention groups 1.3) Tai chi and Qigong practices (TQPs), whereby the exercise adherence in TQP groups was 67-100%, 2. Theoretical-behavioral approaches 2.1) approaches based on behavioral and psychological theories, which were a combination of an exercise program alongside a behavior modification intervention, 2.2) Self-efficacy. Conclusion: Approaches that are based on exercise alongside behavioral and theoretical interventions could enhance physical activity adherence among HF patients. It is suggested to evaluate mix methods of exercise-based approaches and theoretical-behavioral approaches mentioned in this study in future clinical trial studies. Use of capacity of TR programs improve to physical activity adherence should receive more attention.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations of Regular Walking Exercise and Body Mass Index with Type 2 Diabetes Prevalence in Korean Adults during the COVID-19 Pandemic COVID-19大流行期间韩国成年人定期步行锻炼和体重指数与2型糖尿病患病率的相关性

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13584

Dong-Il Kim

引用次数: 0

Length of Hospital Stay and its Related Factors in Iran: A Systematic Review and Meta-Analysis 伊朗住院时间长短及其相关因素:系统回顾与meta分析

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13570

Mohammad Khammarnia, Fatemeh Bagherbarahouei, Alireza Ansari-Moghaddam

{"title":"Length of Hospital Stay and its Related Factors in Iran: A Systematic Review and Meta-Analysis","authors":"Mohammad Khammarnia, Fatemeh Bagherbarahouei, Alireza Ansari-Moghaddam","doi":"10.18502/ijph.v52i9.13570","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13570","url":null,"abstract":"Background: One of the effective indicators used to determine the efficiency and optimal use of hospital resources is the length of stay (LOS). Then, we aimed to determine LOS and its related factors in Iran. Methods: A systematic literature review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using the online databases; Medline, EMBASE, Scopus, PubMed, SID, MagIran, and Medlib from 1995 to 2022 using a combination of medical subject. STATA version 11 used for data analysis. Results: Overall, 75 (cross-sectional, cohort, and case-control) reports were identified. The average length of stay in Iranian hospitals was 6.7 (95% CI: 5.32 -7.74) d. There was a significant relationship between the length of stay in the hospital and different wards of hospital (P=0.001). The average of men’ LOS was longer than women were [6.9 (95% CI: 5.32 -7.74) vs. 3.9 (95% CI: 1.67-9.41)]. Moreover, the average LOS before and after the Health Transformation Plan (HTP) in Iran has changed, so that it has increased from 5.8 (95% CI: 4.39 -7.86) to 7.1 (95% CI: 5.59 -9.25) d after HTP (P=0.30). Conclusion: The average length of stay of patients in Iranian hospitals is more than the expected index of the Ministry of Health and Medical Education and is in the unfavorable range (> four days). Moreover, considering the direct effect of the type of departments on LOS; therefore, hospital managers should pay more attention to hospital processes using new process-oriented and customer-oriented management approaches.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Costs of Hypertension Treatment in Iran 伊朗高血压治疗的直接费用

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13579

Mahmoud Zamandi, Rajabali Daroudi, Ali Akbari Sari

{"title":"Direct Costs of Hypertension Treatment in Iran","authors":"Mahmoud Zamandi, Rajabali Daroudi, Ali Akbari Sari","doi":"10.18502/ijph.v52i9.13579","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13579","url":null,"abstract":"Background: Hypertension is a common public health problem with potentially serious consequences. We aimed to explore the direct costs of hypertension treatment in Iran. Methods: Literature review and STEPS survey were used to estimate the incidence and prevalence of hypertension for Iranian males and females and the proportion of its treatment coverage in 2020. A standard national protocol for hypertension treatment was used to estimate the required medical services including visits, medications, and lab tests. The cost of each service and the total cost of the disease were identified using the national reference costs. Results: About 23.39 million people suffer from moderate systolic blood pressure (BP of 120 to 139 mm/Hg) and a further 14.6 million people had severe BP (≥140 mm/Hg). Nearby 39.8% of these patients, receive BP treatment. The direct costs of hypertension treatment were 19,006.08 billion IR Rials (USD 87.54 million), of which 16.60% and 83.40% of the costs were related to new and prior cases, respectively. The costs of patient visits, medications, and lab tests were 56%, 35.51%, and 8.49% of the total costs, respectively. Conclusion: The prevalence and economic burden of hypertension are relatively high in Iran. Early detection and treatment of hypertension might have a significant effect on reducing its complications and costs.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resilience Effect and Association Analysis between Sleep Dura-tion and Body Mass Index 睡眠时间与体重指数的弹性效应及相关性分析

4区医学

Iranian Journal of Public Health Pub Date : 2023-09-09 DOI: 10.18502/ijph.v52i9.13585

Wi-Young So, Taikyeong Ted. Jeong

引用次数: 0