{"title":"Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis.","authors":"Yanpeng Wang, Yinzhen Zhang, Changwei Zhao, Wenjun Cai, Zhengyan Wang, Wenhai Zhao","doi":"10.18502/ijph.v52i10.13848","DOIUrl":"https://doi.org/10.18502/ijph.v52i10.13848","url":null,"abstract":"<p><strong>Background: </strong>Sedentary behavior and physical activity are still ambiguous in their effects on osteoarthritis. We aimed to evaluate the effects of physical activity and sedentary behavior on osteoarthritis to provide a reference for the prevention of osteoarthritis.</p><p><strong>Methods: </strong>This study was conducted in Changchun, China in 2022. We used two-sample Mendelian randomization with the SNP as an instrumental variable to investigate the effect of physical activity and sedentary behavior on osteoarthritis. In addition, a two-step Mendelian randomization method was used to test whether mediating factors (BMI, smoking, Apolipoprotein B) were involved in mediating the effects of exposure factors on osteoarthritis.</p><p><strong>Results: </strong>TV watching was causally related to knee osteoarthritis and spine osteoarthritis, and they were positively correlated (knee osteoarthritis: OR=1.162,95 %CI: 1.027-1.315, <i>P</i>=0.017; spine osteoarthritis: OR=1.208,95 %CI: 1.033-1.413, <i>P</i>=0.018). BMI played a mediating role in the process of TV watching with knee osteoarthritis and spine osteoarthritis. ((The proportion of BMI mediating effect: knee osteoarthritis: 47.1% (95% CI: 36.7%~63.2%); spine osteoarthritis: 29.5% (95% CI: 19.3%~40.8%)). The proportion of Smoking mediating effect in the process of TV watching with spine osteoarthritis was 16.1% (95% CI: 3.7% ~ 31.6%).</p><p><strong>Conclusion: </strong>TV watching is a potential risk factor for osteoarthritis and plays a role through modifiable factors such as BMI and smoking, therefore, interventions on these factors have the potential to reduce the burden of osteoarthritis caused by longer TV watching times.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"52 10","pages":"2099-2108"},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aziz Rezapour, Amin Adel, Ali Aboutorabi, Elahe Askarzade, Saeed Husseini Barghazan, Arefeh Pourtaleb, Seyed Saeed Tabatabaee
{"title":"Economic Burden of Vision Loss and Eye Disorders in Iran.","authors":"Aziz Rezapour, Amin Adel, Ali Aboutorabi, Elahe Askarzade, Saeed Husseini Barghazan, Arefeh Pourtaleb, Seyed Saeed Tabatabaee","doi":"10.18502/ijph.v52i10.13859","DOIUrl":"10.18502/ijph.v52i10.13859","url":null,"abstract":"<p><strong>Background: </strong>Globally, population growth and ageing are expected to increase the risk of vision impairment for more people. Eye disorders impose heavy social and economic burdens on communities through increased poverty, reduced quality of life, and decreased employment. We aimed to calculate the economic burden of eye diseases in Iran.</p><p><strong>Methods: </strong>Prevalence-based and top-down cost estimation methods were used with a sociological approach. Data were collected from the Northeastern Ophthalmology Center Institute for Health Assessment, and Evaluation, besides the 2017 census. Eye diseases were classified according to the ICD10. Data were analyzed using Excel 2016 software.</p><p><strong>Results: </strong>Survey data were collected from 19,113 patients with vision loss and eye disorders. The average cost of vision loss/eye disorders was estimated to be $250.3. The findings indicated that the economic burden of visual diseases was $2,844 million a year, with direct medical costs comprising 87% (66% of inpatient and 21% of outpatient) and direct non-medical and indirect costs estimated at 6% and 7%, respectively. Furthermore, 72.8% of direct medical costs was paid by insurance companies, 20.6% by patients, and 6.6% by the government.</p><p><strong>Conclusion: </strong>Eye diseases and vision loss in Iran, as in other countries, are costly for the health system and society. Instituting effective policies and measures to address this rising burden should be a national priority. Another suggestion in this area would be to focus on preventive care and policies such as health education, highlighting the role of reorientation of health services and advocacy (for policies that promote eye health), where relevant.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"52 10","pages":"2207-2215"},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of Family with Sequence Similarity 110 Member C (FAM110C) as a Candidate Diagnostic and Prognostic Biomarker for Glioma.","authors":"Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang","doi":"10.18502/ijph.v52i10.13850","DOIUrl":"https://doi.org/10.18502/ijph.v52i10.13850","url":null,"abstract":"<p><strong>Background: </strong>Gliomas are the most frequent and dangerous primary cerebral tumors. Therefore, there is a need to develop molecular targets for the diagnosis and treatment for glioma.</p><p><strong>Methods: </strong>In September 2020, we retrieved the expression matrix of glioblastoma (GBM) sufferers and pertinent clinical data from the TCGA (The Cancer Genome Atlas) database. Prognostic differences between various families with sequence similarity 110 member C (FAM110C) expression groups were assessed by Kaplan-Meier with log-rank test. The R platform get used to assess the accuracy of FAM110C delivery in predicting the prognosis of PDAC using a time-dependent receptor operating characteristic (ROC) curve. The delivery level of FAM110C was determined by qRT-PCR and western blot. Gene set enrichment investigated possible mechanisms between different FAM110C expression groups in GBM (GSEA). The impact of FAM110C on glioma cell movement was discovered using migration test. The drug's gene-targeting impact was validated by the CCK8 test.</p><p><strong>Results: </strong>A total of 173 GBM samples were obtained from the TCGA database, with 148 including information on IDH1 mutations and 151 containing information on overall survival. The mRNA expression level of FAM110C was greater in wild-type GBM, according to qRT-PCR data. The connection between FAM110C expression and Hallmark, GO, and KEGG pathway gene sets was investigated using GSEA software. We used migration test to assess the impact of FAM110C on glioma motility in order to confirm the findings of the GSEA analysis.</p><p><strong>Conclusion: </strong>FAM110C might get used as a possible diagnostic and prognostic biomarker for wild-type GBM, and its inhibition could be used to prevention and treatment wild-type GBM.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"52 10","pages":"2117-2127"},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of Alzheimer's in People with Coronavirus Using Machine Learning.","authors":"Shahriar Mohammadi, Soraya Zarei, Hossain Jabbari","doi":"10.18502/ijph.v52i10.13856","DOIUrl":"https://doi.org/10.18502/ijph.v52i10.13856","url":null,"abstract":"<p><strong>Background: </strong>One of the negative effects of the COVID-19 illness, which has affected people all across the world, is Alzheimer's disease. Oblivion after COVID-19 has created a variety of issues for many people. Predicting this issue in COVID-19 patients can considerably lessen the severity of the problem.</p><p><strong>Methods: </strong>Alzheimer's disease was predicted in Iranian persons with COVID-19 in using three algorithms: Nave Bayes, Random Forest, and KNN. Data collected by private questioner from hospitals of Tehran Province, Iran, during Oct 2020 to Sep 2021. For ML models, performance is quantified using measures such as Precision, Recall, Accuracy, and F1-score.</p><p><strong>Results: </strong>The Nave Bayes, Random Forest algorithm has a prediction accuracy of higher than 80%. The predicted accuracy of the random forest algorithm was higher than the other two algorithms.</p><p><strong>Conclusion: </strong>The Random Forest algorithm outperformed the other two algorithms in predicting Alzheimer's disease in persons using COVID-19. The findings of this study could help persons with COVID-19 avoid Alzheimer's problems.</p>","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"52 10","pages":"2179-2185"},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10612562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71412261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Functional Exercise Program on Improving Gluteus Medius Muscle Strength in Postmenopausal Women","authors":"Kyoung Soo Suh, Woo Yeul Baek","doi":"10.18502/ijph.v52i9.13583","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13583","url":null,"abstract":"The Article Abstract is not available.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mortality Rate and Years of Life Lost Due to Road Traffic Accidents in Fars Province, 2004-2019","authors":"Habibollah Azarbakhsh, Fatemeh Rezaei, Seyed Sina Dehghani, Jafar Hassanzadeh, Seyed Parsa Dehghani, Alireza Mirahmadizadeh","doi":"10.18502/ijph.v52i9.13581","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13581","url":null,"abstract":"Background: Traffic accidents are one of the most critical health problems and the ninth leading cause of death globally. We aimed to determine the Mortality rate and the number of Years of Life Lost (YLL) due to road traffic accidents.
 Methods: In this retrospective cohort study, mortality rate and YLL due to road traffic accidents were examined in Fars province, central Iran during the years 2004-2019. Mortality statistics were collected through death registration of ministry of health and medical education for Fars Province. Age Standardized mortality Rate (ASR) was calculated and join point regression analysis carried out to examine the trend of YLL rate. Data were analyzed using Excel spreadsheet version 2016 and Join point Regression Program 4.9.0.0.
 Results: During the 16-year study period, 25,858 deaths due to road traffic accidents occurred in the province. 79.2% (20483 cases) were in men, and 33.7% (8703 cases) were aged 15-29 years. Total YLL during the 16-year study period were 458,975 (14.6 per 1000 people) in men, 117,999 (3.8 per 1000 people) in women. According to the join point regression, the 16- year trend of YLL rate due to premature mortality was decreasing: AAPC was -4.9% (95% CI: -8.8 to -0.9; P=0.018) for male, and -3.5% (95% CI: -6.3 to-0.5; P=0.011) for female.
 Conclusion: Considering that the number of deaths, mortality rate and YLL has decreased in Fars province during the 16 years under study. Therefore, because the mortality rate due to road traffic accidents in Iran is higher than the global average, the need for training programs for drivers, compliance with standards and retrofitting of vehicles, road safety, driving supervision and the use of seat belts are essential.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship of the Prenatal Distress with Health Literacy and Health Perception of Pregnant Women","authors":"Meltem Ugurlu, Arzu Kul Uctu","doi":"10.18502/ijph.v52i9.13573","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13573","url":null,"abstract":"Background: The effects of health-literacy and health-perception on prenatal distress levels of pregnant women were not investigated. We aimed to examine the relationship between pregnant women’s prenatal distress levels with their health-literacy and health-perception and affecting factors.
 Methods: This descriptive and correlational study was conducted with 223 pregnant women in Ankara, Turkey in 2021. Data were collected with a personal information form, Health Literacy Scale (HLS), Health Perception Scale (HPS), and Prenatal Distress Scale (PDS).
 Results: Participants’ mean score on the PDS was 11.39±6.17. Participants who had a high level of education (P=0.040), working (P=0.026), no history of miscarriage/abortion (P=0.040), and a bad relationship with their spouses (P<0.001) had significantly higher mean scores on the PDS. There was a significant negative correlation between total PDS and HLS scores (P<0.001) and a positive correlation between total PDS and HPS scores (P<0.001). Total HLS and HPS scores, spousal relationship status, education level, and employment had an effect on the mean PDS score and that the explanatory power of the model was found 21.5% (R2=0.215).
 Conclusion: Pregnant women had a moderate level of prenatal distress. While the prenatal distress levels of pregnant women with high health-literacy levels decreased, the levels of those who were employed, had a higher level of education, and had a bad relationship with their spouses increased. Awareness of the factors affecting pregnant women’s prenatal distress can guide the provision of adequate care and support interventions during pregnancy.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"402 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Neoadjuvant Chemoradiotherapy as a Predictor of Long-Term Survival in Patients with Locally Advanced Rectosigmoid Junction Cancer: An Analysis Based On SEER Database","authors":"Qi Shen, Dandan Liu, Shaojun Liu","doi":"10.18502/ijph.v52i9.13575","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13575","url":null,"abstract":"Background: Neoadjuvant chemoradiotherapy is recommended to locally advanced rectal cancer, especially for the lower and middle ones. However, the role of neoadjuvant chemoradiotherapy in rectosigmoid junction cancer remains undetermined. We investigated whether patients with a good response to neoadjuvant chemoradiotherapy will have a relatively better long-term survival compared with those with no response.
 Methods: Overall, 1325 patients diagnosed with locally advanced rectosigmoid junction cancer from Surveillance, Epidemiology, and End-Results (SEER) cancer registry database (2004-2014, America) were selected. All of them had received neoadjuvant chemoradiotherapy and were evaluated by Collaborative Stage Data Collection System. We performed Kaplan–Meier univariate analysis and Cox regression multivariate analysis models to estimate the potential prognostic factors of long-term survival outcomes. Response to neoadjuvant chemoradiotherapy and histological type of tumor were the two prognostic factors.
 Results: The 5-year OS was 78.1% in responders, and 63.4% in nonresponders. In addition the 5-year DSS was 85.1% in responders, and 72.9% in nonresponders.
 Conclusion: Based on SEER database in locally advanced rectosigmoid junction cancer, patients with a good response to neoadjuvant chemoradiotherapy could have a benefit of long-term survival.","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abbas Homauni, Nader Markazi-Moghaddam, Ali Mosadeghkhah, Majid Noori, Kourosh Abbasiyan, Sanaz Zargar Balaye Jame
{"title":"Budgeting in Healthcare Systems and Organizations: A Systematic Review","authors":"Abbas Homauni, Nader Markazi-Moghaddam, Ali Mosadeghkhah, Majid Noori, Kourosh Abbasiyan, Sanaz Zargar Balaye Jame","doi":"10.18502/ijph.v52i9.13571","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13571","url":null,"abstract":"Background: Budgeting is the process resource allocation to produce the best output according to the revenue levels involved. Among the constraints that healthcare organizations, including hospitals, both in the public and private sectors, grapple with is budgetary constraints. Therefore, cost control and resource management should be considered in healthcare organizations under such circumstances.
 Methods: We aimed to identify methods of budgeting in healthcare systems and organizations as a systematic review. To extract and analyze the data, a form was designed by the researcher to define budgeting methods proposed in the literature and to identify their strengths, weaknesses, and dimensions. The search was conducted in Google Scholar, Web of science, Pub med and Scopus databases covering the period 1990-2022.
 Results: Overall, 33 articles were included in the study for extraction and final analysis. The study results were reported in four main themes: healthcare system budgeting, capital budgeting, global budgeting, and performance-based budgeting.
 Conclusion: Each budgeting approach has its own pros and cons and requires meeting certain requirements. These approaches are selected and implemented depending on each country's infrastructure and conditions as well as its organizations. These infrastructures need to be thoroughly examined before implementing any budgeting method, and then a budgeting method should be selected accordingly.
","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136191970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Quality Indicators in Home Health Services Delivery","authors":"Hatice Esen, Tugba Caliskan Sengoz","doi":"10.18502/ijph.v52i9.13577","DOIUrl":"https://doi.org/10.18502/ijph.v52i9.13577","url":null,"abstract":"Background: We aimed to evaluate the quality indicators monitored within the scope of quality standards health.
 Methods: In this descriptive study, patients who visited the home health services unit in 2021, were included. Patient age and diagnostic data were obtained from the Basic Health Statistics Module. Other information such as the number of patient visits and nutritional status were obtained from the indicator data collection form followed by the quality management unit of our hospital and from the home health services unit. We included the data of Antalya Training and Research Hospital. Microsoft Excel and SPSS 25.0 program were used in the analysis of the data, and the data obtained were shown as numbers and ratios (%).
 Results: When the quality indicators of home health services delivery were examined, the timely response rate of the application was 100%, the nutritional status of all patients was evaluated using the Nutritional Risk Score (NRS-2002) evaluation form at the first patient visit; the patients receiving health care from the home health unit of our hospital visited an average of three times in a year, and the health service from the home health unit was determined: the annual average rate of medical appointments kept with patients who receive medical care at the scheduled time is 83%.
 Conclusion: Quality indicators are being met well, and good-quality care services are being delivered in the home health service of the training and research hospitals.
","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}