伊朗非结核分枝杆菌抗生素耐药性趋势:系统回顾和荟萃分析

IF 1.4 4区医学 Q3 Medicine

Iranian Journal of Public Health Pub Date : 2023-11-12 DOI:10.18502/ijph.v52i11.14028

Hamid Heidari, Parisa Kalantari, Mohammad Sholeh, Sahel Hamze Pour, Atieh Darbandi, Abbas Maleki, Abbas Ghaysouri, Hossein Kazemian

{"title":"伊朗非结核分枝杆菌抗生素耐药性趋势:系统回顾和荟萃分析","authors":"Hamid Heidari, Parisa Kalantari, Mohammad Sholeh, Sahel Hamze Pour, Atieh Darbandi, Abbas Maleki, Abbas Ghaysouri, Hossein Kazemian","doi":"10.18502/ijph.v52i11.14028","DOIUrl":null,"url":null,"abstract":"Background: Non-tuberculous mycobacteria (NTM) infections have been continuously increasing as major concerns of public health in Iran. Because innate resistance of NTM species, the treatment of these infections is difficult task, but until now resistance pattern of NTM and suitable regimens are not determined. Methods: We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until Dec 2022). All statistical analyses were carried out using the statistical package R. Results: Eleven studies included in the analysis were performed in 6 provinces and investigated 1223 NTM clinical species. The majority of the studies originated in Tehran. Among the first-line anti-TB drugs, almost all NTM species were highly resistant to first-line anti-TB drugs. No significant difference in the isoniazid resistance rate was found in the slow or rapid-growing species and Runyon's classification of NTM isolates. A decreased in the prevalence of ciprofloxacin, clarithromycin, and moxifloxacin resistance were showed in during 2013-2022 years. Conclusion: Most investigated antibiotics have a minor effect on NTM species and a steady increase of resistance has been seen in last few years then, need more-effective alternative regimens is clear","PeriodicalId":14685,"journal":{"name":"Iranian Journal of Public Health","volume":"77 4","pages":"0"},"PeriodicalIF":1.4000,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Trends in the Antibiotic Resistance of Non-Tuberculous Mycobacteria in Iran: A Systematic Review and Meta-Analysis\",\"authors\":\"Hamid Heidari, Parisa Kalantari, Mohammad Sholeh, Sahel Hamze Pour, Atieh Darbandi, Abbas Maleki, Abbas Ghaysouri, Hossein Kazemian\",\"doi\":\"10.18502/ijph.v52i11.14028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Non-tuberculous mycobacteria (NTM) infections have been continuously increasing as major concerns of public health in Iran. Because innate resistance of NTM species, the treatment of these infections is difficult task, but until now resistance pattern of NTM and suitable regimens are not determined. Methods: We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until Dec 2022). All statistical analyses were carried out using the statistical package R. Results: Eleven studies included in the analysis were performed in 6 provinces and investigated 1223 NTM clinical species. The majority of the studies originated in Tehran. Among the first-line anti-TB drugs, almost all NTM species were highly resistant to first-line anti-TB drugs. No significant difference in the isoniazid resistance rate was found in the slow or rapid-growing species and Runyon's classification of NTM isolates. A decreased in the prevalence of ciprofloxacin, clarithromycin, and moxifloxacin resistance were showed in during 2013-2022 years. Conclusion: Most investigated antibiotics have a minor effect on NTM species and a steady increase of resistance has been seen in last few years then, need more-effective alternative regimens is clear\",\"PeriodicalId\":14685,\"journal\":{\"name\":\"Iranian Journal of Public Health\",\"volume\":\"77 4\",\"pages\":\"0\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Public Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/ijph.v52i11.14028\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Public Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijph.v52i11.14028","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

背景:非结核分枝杆菌(NTM)感染作为伊朗公共卫生的主要问题不断增加。由于NTM物种的先天耐药，治疗这些感染是一项艰巨的任务，但到目前为止，NTM的耐药模式和合适的治疗方案尚未确定。方法:系统检索PubMed、Scopus和Embase的相关研究(截止到2022年12月)。所有统计分析均使用统计软件包R. 结果:在6个省共开展11项研究，调查NTM临床种类1223种。大多数研究来自德黑兰。在一线抗结核药物中，几乎所有NTM菌株都对一线抗结核药物具有高度耐药性。慢速和快速生长菌株的异烟肼耐药率和Runyon分类无显著差异。2013-2022年，环丙沙星、克拉霉素和莫西沙星耐药率均呈下降趋势。结论:大多数研究的抗生素对NTM的影响较小，近年来耐药稳步增加，需要更有效的替代方案

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Trends in the Antibiotic Resistance of Non-Tuberculous Mycobacteria in Iran: A Systematic Review and Meta-Analysis

Background: Non-tuberculous mycobacteria (NTM) infections have been continuously increasing as major concerns of public health in Iran. Because innate resistance of NTM species, the treatment of these infections is difficult task, but until now resistance pattern of NTM and suitable regimens are not determined. Methods: We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until Dec 2022). All statistical analyses were carried out using the statistical package R. Results: Eleven studies included in the analysis were performed in 6 provinces and investigated 1223 NTM clinical species. The majority of the studies originated in Tehran. Among the first-line anti-TB drugs, almost all NTM species were highly resistant to first-line anti-TB drugs. No significant difference in the isoniazid resistance rate was found in the slow or rapid-growing species and Runyon's classification of NTM isolates. A decreased in the prevalence of ciprofloxacin, clarithromycin, and moxifloxacin resistance were showed in during 2013-2022 years. Conclusion: Most investigated antibiotics have a minor effect on NTM species and a steady increase of resistance has been seen in last few years then, need more-effective alternative regimens is clear

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Iranian Journal of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

7.10%

发文量

审稿时长

2 months

期刊介绍： Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.