Javma-journal of The American Veterinary Medical Association最新文献

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Unilateral scrotal enlargement in a 16-month-old black Angus bull. 一头 16 个月大的黑色安格斯公牛单侧阴囊肿大。
IF 1.6 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-14 Print Date: 2024-06-01 DOI: 10.2460/javma.24.01.0026
Dane Schwartz, Bryan M Weaver, Michela Ciccarelli, Kristen J Hill-Thimmesch
{"title":"Unilateral scrotal enlargement in a 16-month-old black Angus bull.","authors":"Dane Schwartz, Bryan M Weaver, Michela Ciccarelli, Kristen J Hill-Thimmesch","doi":"10.2460/javma.24.01.0026","DOIUrl":"10.2460/javma.24.01.0026","url":null,"abstract":"","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel presentation of a feline patient with visceral and cervical lymph node hemangiosarcoma. 一名猫科动物内脏和颈淋巴结血管肉瘤患者的新病例。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-08 Print Date: 2024-05-01 DOI: 10.2460/javma.24.01.0015
Alexandra Goddard, Kristine Walters, Katy Campbell
{"title":"Novel presentation of a feline patient with visceral and cervical lymph node hemangiosarcoma.","authors":"Alexandra Goddard, Kristine Walters, Katy Campbell","doi":"10.2460/javma.24.01.0015","DOIUrl":"10.2460/javma.24.01.0015","url":null,"abstract":"<p><strong>Objective: </strong>To report a novel presentation of feline hemangiosarcoma.</p><p><strong>Animals: </strong>A 14-year-old spayed female feline patient diagnosed with hemangiosarcoma of the spleen and a cervical lymph node.</p><p><strong>Clinical presentation, progression, and procedures: </strong>The patient presented to the emergency service following a 1-week history of lethargy and hiding. Abdominal ultrasound revealed splenomegaly with multiple nodules and peritoneal fluid that was consistent with hemorrhagic effusion.</p><p><strong>Treatment and outcome: </strong>The patient underwent a routine splenectomy and was started on doxorubicin. Histopathologic evaluation of the spleen confirmed visceral hemangiosarcoma. When the disease showed signs of progression, combination chemotherapy with cyclophosphamide and vincristine was initiated. Four months following presentation, a submandibular lymph node was removed and found to have metastatic hemangiosarcoma. From presentation to euthanasia, the patient survived 205 days.</p><p><strong>Clinical relevance: </strong>Hemangiosarcoma is a rare cancer in feline patients, with a lack of veterinary literature on its presentation and chemotherapy protocols. The subject of this case report had a novel presentation of hemangiosarcoma and responded favorably to a chemotherapy protocol not previously described for this disease.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel corporate-community partnership model provides safe housing for pets of domestic violence victims. 一种新颖的企业-社区合作模式为家庭暴力受害者的宠物提供了安全住所。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-08 Print Date: 2024-05-01 DOI: 10.2460/javma.23.12.0716
Hillary L Pearce, Becca Spielman, Cassie Weatherwax, Monique Pairis-Garcia
{"title":"A novel corporate-community partnership model provides safe housing for pets of domestic violence victims.","authors":"Hillary L Pearce, Becca Spielman, Cassie Weatherwax, Monique Pairis-Garcia","doi":"10.2460/javma.23.12.0716","DOIUrl":"10.2460/javma.23.12.0716","url":null,"abstract":"<p><strong>Objective: </strong>To document and evaluate a novel partnership model of a safekeeping program for pets owned by domestic violence victims between May 1, 2021, and June 1, 2023.</p><p><strong>Animals: </strong>19 animals referred to the program.</p><p><strong>Methods: </strong>Procedures for identification, intake, medical and behavioral needs, and shelter of pets belonging to domestic violence victims were established and cases reviewed over the program's initial 2 years.</p><p><strong>Results: </strong>13 dogs and 6 cats belonging to 13 owners were referred to the program. Seven dogs and 1 cat were placed into foster housing. Most pets were intact. One pet had medical concerns at intake (cardiac disease and seizures). Five pets were returned to their owners after an average stay of 5.3 weeks. Two pets were rehomed to new owners.</p><p><strong>Clinical relevance: </strong>Veterinarians are likely to encounter pets affected by domestic violence and may be mandatory reporters in some states. This paper will aid veterinarians and community partners to understand the challenges and pet types they are likely to encounter and how best to assist.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and outcome of odontogenic abscesses in client-owned rabbits (Oryctolagus cuniculus): 72 cases (2011-2022). 客户饲养的兔子(Oryctolagus cuniculus)牙源性脓肿的诊断和结果:72 例(2011-2022 年)。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-08 Print Date: 2024-05-01 DOI: 10.2460/javma.23.12.0718
Ivana Levy, Christoph Mans
{"title":"Diagnosis and outcome of odontogenic abscesses in client-owned rabbits (Oryctolagus cuniculus): 72 cases (2011-2022).","authors":"Ivana Levy, Christoph Mans","doi":"10.2460/javma.23.12.0718","DOIUrl":"10.2460/javma.23.12.0718","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the epidemiologic features of rabbits with odontogenic abscesses.</p><p><strong>Animals: </strong>72 client-owned rabbits.</p><p><strong>Methods: </strong>The medical record database of a veterinary teaching hospital was searched to identify rabbits with odontogenic abscesses characterized by a palpable facial mass and confirmed via CT scan. Data reviewed included age, breed, presenting complaint, abscess location, bacterial culture results, treatment, and outcome.</p><p><strong>Results: </strong>Lop-eared rabbits were the most common breeds affected (20/72 [28%]), and mini lop rabbits were significantly overrepresented. The mandibular quadrants were more frequently affected (65/92 [71%]), and osteomyelitis was a common comorbidity on CT (53/72 [74%]). The most common aerobic and anaerobic isolates were Streptococcus spp (17/40 [43%]) and Fusobacterium spp (10/22 [45%]), respectively. Systemic antibiotic therapy alone was performed in 35 of 62 (56%) treated cases, with documented resolution in 25%. Abscess packing with antibiotic-soaked gauze in conjunction with systemic antibiotic therapy was performed in 20 of 62 (32%) treated cases. Resolution of the odontogenic abscesses with this treatment protocol was documented in 17 of 20 (85%) cases. The number of packing procedures used to obtain resolution of infection was 4 (IQR, 3 to 5).</p><p><strong>Clinical relevance: </strong>A combination of the abscess-packing technique, which avoids extensive surgery and extraction of the involved elodont teeth, with systemic antibiotic therapy can be an effective treatment option for rabbits with palpable odontogenic abscesses and can result in a high cure rate comparable to more invasive surgical treatments. Antibiotic treatment alone is not recommended, as it has a low chance of abscess resolution.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maxillary mass in a 1-year-old feline. 一只 1 岁猫科动物的上颌骨肿块。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-08 Print Date: 2024-05-01 DOI: 10.2460/javma.24.01.0031
Allison M Groff, Peter J Welsh, Colleen M Lynch, Ryan Oliveira, Boel Fransson
{"title":"Maxillary mass in a 1-year-old feline.","authors":"Allison M Groff, Peter J Welsh, Colleen M Lynch, Ryan Oliveira, Boel Fransson","doi":"10.2460/javma.24.01.0031","DOIUrl":"10.2460/javma.24.01.0031","url":null,"abstract":"","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of canine perineal hernia with a fascia lata graft is noninferior to the elevation of the internal obturator muscle: a prospective randomized trial of 66 dogs. 用筋膜移植治疗犬会阴部疝气的效果并不亚于抬高腹股沟内肌:对 66 只犬进行的前瞻性随机试验。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-07 Print Date: 2024-05-01 DOI: 10.2460/javma.23.11.0650
Tuuli M Åhlberg, Kati Salla, Outi M Laitinen-Vapaavuori, Sari H Mölsä
{"title":"Treatment of canine perineal hernia with a fascia lata graft is noninferior to the elevation of the internal obturator muscle: a prospective randomized trial of 66 dogs.","authors":"Tuuli M Åhlberg, Kati Salla, Outi M Laitinen-Vapaavuori, Sari H Mölsä","doi":"10.2460/javma.23.11.0650","DOIUrl":"10.2460/javma.23.11.0650","url":null,"abstract":"<p><strong>Objective: </strong>To compare the recurrence rate after herniorrhaphy of canine perineal hernia (PH) using elevation of the internal obturator muscle (EIOM) or fascia lata graft (FLG) and assess how clinical signs related to defecation evolve during 12 months postoperatively.</p><p><strong>Animals: </strong>66 client-owned male dogs undergoing PH surgery between March 1, 2017, and December 31, 2020.</p><p><strong>Methods: </strong>Dogs were randomized into 2 groups (EIOM = 36; FLG = 30) applying 2 stratification factors: preoperative bladder location and the defecation signs score (DSS). Follow-up visits were at 2 weeks and 3, 6, and 12 months postoperatively. The main outcome, the recurrence of PH was evaluated by rectal examination. We evaluated the noninferiority of FLG to EIOM from the difference in recurrence proportions between the techniques (95% CI), comparing the CI with a pre-defined noninferiority margin (15%). To evaluate defecation signs, the DSS was calculated from the owner questionnaire and assessed with a linear mixed model (P < .05 significant).</p><p><strong>Results: </strong>In 63 dogs attending the 12-month follow-up, the recurrence rate was 8.8% (3/34) in the EIOM and 10.3% (3/29) in the FLG group. The CI (-11.94% to 14.99%) was below the pre-defined margin, indicating the noninferiority of FLG. After surgery, the DSS decreased (P < .001), remaining low during the follow-up.</p><p><strong>Clinical relevance: </strong>FLG was non-inferior to EIOM when considering recurrence. The DSS decreased postoperatively and complications were uncommon. FLG is a useful alternative for the treatment of canine PH.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extreme erythrocytosis in a cat reverts after short-term treatment with hydroxyurea and the cat remains healthy for years. 使用羟基脲进行短期治疗后,猫咪的极度红细胞增多症会得到缓解,并在数年内保持健康。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-07 Print Date: 2024-05-01 DOI: 10.2460/javma.23.11.0659
Jessica Billström-Saxon, Urs Giger
{"title":"Extreme erythrocytosis in a cat reverts after short-term treatment with hydroxyurea and the cat remains healthy for years.","authors":"Jessica Billström-Saxon, Urs Giger","doi":"10.2460/javma.23.11.0659","DOIUrl":"10.2460/javma.23.11.0659","url":null,"abstract":"<p><strong>Objective: </strong>This case report describes a cat with severe erythrocytosis (Hct, 80%), which after initial treatment with hydroxyurea has gone into remission for over 3 years.</p><p><strong>Animal: </strong>A 1-year-old neutered male American Maine Coon crossbred cat.</p><p><strong>Clinical presentation, progression, and procedures: </strong>A 1-year-old neutered male American Maine Coon crossbred domestic cat was presented with acute neurologic signs, systolic heart murmur, and extreme erythrocytosis (Hct, 80%; normal interval, 30% to 48%). There were no clinical signs of dehydration, and several diagnostic tests for absolute erythrocytosis did not identify an underlying cause. A presumptive diagnosis of primary erythrocytosis (polycythemia vera [P vera], a myeloproliferative disease) was made.</p><p><strong>Treatment and outcome: </strong>Repeated phlebotomies were declined by the owner, and thus the cat was treated with oral hydroxyurea. The neurologic signs, heart murmur, and erythrocytosis resolved within 2 months (Hct, 41%). Treatment with hydroxyurea was continued for 2 years and then discontinued. The Hct remained in the normal range (between 37% and 44%) during a 3-year observation period.</p><p><strong>Clinical relevance: </strong>This case illustrates the challenges of determining a precise cause of erythrocytosis. The extreme erythrocytosis reverted after treatment with hydroxyurea and did not recur even after drug withdrawal, suggesting an undefined singular or multifactorial cause of the erythrocytosis rather than a primary absolute erythrocytosis, such as P vera. The reversibility of this cat's erythrocytosis suggested that in select cases the discontinuation of treatment is warranted.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTED: Sixteen years of canine hepatic copper concentrations within normal reference ranges in dogs fed a broad range of commercial diets. 十六年来,喂食各种商用日粮的犬肝铜浓度均在正常参考范围内。
IF 1.6 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-07 DOI: 10.2460/javma.23.11.0621
Madison D Amundson, Laura A Motsinger, John Brejda, Leslie Hancock
{"title":"RETRACTED: Sixteen years of canine hepatic copper concentrations within normal reference ranges in dogs fed a broad range of commercial diets.","authors":"Madison D Amundson, Laura A Motsinger, John Brejda, Leslie Hancock","doi":"10.2460/javma.23.11.0621","DOIUrl":"10.2460/javma.23.11.0621","url":null,"abstract":"<p><strong>Objective: </strong>To examine the effects of age, sex, breed, liver histopathology, and year of death/sample collection on liver copper concentrations in dogs fed various commercial dog foods throughout their lives.</p><p><strong>Sample: </strong>During necropsy, 336 samples were collected between the years 2006 and 2022 from dogs that were fed a variety of commercial dog foods on the market. This study utilized all liver samples available and did not require specific criteria for sample selection.</p><p><strong>Methods: </strong>Liver samples (n = 336) were analyzed as dry weight for copper concentration by inductively coupled plasma-optical emission spectrometry. The potential effects of animal age and year of death/collection (scatterplots and linear regression), sex, liver histopathology (t test), and breed (ANOVA) on liver copper concentration were assessed.</p><p><strong>Results: </strong>Labrador Retrievers had lower liver copper concentrations than Beagles, but mixed breeds did not differ from Beagles or Labrador Retrievers. Analysis of year of death showed that liver copper concentrations decreased from 2006 through 2011, increased in 2012, decreased in 2013, and peaked in 2016, decreasing thereafter. Mean copper concentration of abnormal liver histopathology samples was lower than mean copper concentrations of normal liver histopathology samples. Age (12.9 ± 2.6 years) and sex had no effect on liver copper concentrations. Of note, some samples showed abnormal hepatic pathology.</p><p><strong>Clinical relevance: </strong>Liver copper concentrations varied significantly with breed and year of death; however, average liver copper concentrations of each year were within normal. However, this was a retrospective population study and diet histories of the dogs were unknown, requiring further investigation.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of remote assistance for point-of-care ultrasonography in a large animal hospital: a controlled randomized trial. 评估大型动物医院护理点超声波检查的远程协助:随机对照试验。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-07 Print Date: 2024-05-01 DOI: 10.2460/javma.23.09.0511
Laurence Leduc, Claire Underwood, Darko Stefanovski, Samuel Hurcombe, Cristobal Navas de Solis
{"title":"Evaluation of remote assistance for point-of-care ultrasonography in a large animal hospital: a controlled randomized trial.","authors":"Laurence Leduc, Claire Underwood, Darko Stefanovski, Samuel Hurcombe, Cristobal Navas de Solis","doi":"10.2460/javma.23.09.0511","DOIUrl":"10.2460/javma.23.09.0511","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether remote assistance is beneficial to the accuracy of point-of-care ultrasound (POCUS) examinations during equine emergency evaluations.</p><p><strong>Animals: </strong>Adult horses presenting to a tertiary care large animal emergency service for respiratory or gastrointestinal clinical signs.</p><p><strong>Procedures: </strong>Prospective, randomized, controlled, clinical study. Cases were assigned to receive POCUS with remote assistance (\"POCUS-R\" group) or POCUS with no assistance (\"POCUS\" group). Accuracy of diagnosis, duration of sonograms and survival to discharge were the objective outcomes compared between groups. Perceptions about the use of teleultrasound were gathered using a survey.</p><p><strong>Results: </strong>29 cases were enrolled in the study over an 18-month period. Based on Cox regression estimates, sonogram duration was likely to be longer in the POCUS-R group (n = 13) relative to the POCUS group (16) hazard ratio 0.43 (95% CI, 0.9 to 0.2; P = .03). Whether the final diagnosis was included in the differential diagnosis list, number of diagnoses in the differential list and survival were not different between groups. Educational benefits were the most frequently mentioned benefit by clinician users while logistical and technical problems related to the use of the equipment and inconvenience of enrollment in the study was the most common negative aspect.</p><p><strong>Clinical relevance: </strong>Teleultrasound was generally not well adopted by users likely due to inconvenience and time constraints. Further work is indicated to assess differences in clinical outcomes in a setting that would allow a larger sample size to increase statistical power.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intranasal and intravenous apomorphine outperform ropinirole ocular drops for induction of emesis in dogs within ten minutes: a randomized, controlled clinical trial. 在十分钟内诱导狗呕吐方面,鼻内和静脉注射阿朴吗啡的效果优于罗匹尼罗滴眼液:一项随机对照临床试验。
IF 1.9 2区 农林科学
Javma-journal of The American Veterinary Medical Association Pub Date : 2024-03-07 Print Date: 2024-05-01 DOI: 10.2460/javma.23.11.0628
Sabrina R Manley, Alexia N Berg, Elizabeth A Rozanski, Benjamin A Sweigart, Alex M Lynch
{"title":"Intranasal and intravenous apomorphine outperform ropinirole ocular drops for induction of emesis in dogs within ten minutes: a randomized, controlled clinical trial.","authors":"Sabrina R Manley, Alexia N Berg, Elizabeth A Rozanski, Benjamin A Sweigart, Alex M Lynch","doi":"10.2460/javma.23.11.0628","DOIUrl":"10.2460/javma.23.11.0628","url":null,"abstract":"<p><strong>Objective: </strong>The primary goal was to compare the efficacy of administration of apomorphine (APO) administered by intranasal (IN), transconjunctival (TC), SC and IV routes with ropinirole eye drops for induction of emesis in dogs with a secondary goal to evaluate the time of emesis as well as difficulty in administration.</p><p><strong>Animals: </strong>125 client-owned dogs.</p><p><strong>Methods: </strong>Dogs were randomly enrolled between October 1, 2021, and March 30, 2022, into groups of 25: IV APO, IN APO, TC APO, SC APO, and ropinirole eye drops. The IV, SC, and TC groups were dosed at 0.03 mg/kg, the IN group was dosed at 0.06 mg/kg, and the ropinirole group was dosed according to manufacturer guidelines. Data collected included success rate of emesis within 600 seconds, time to emesis, time to administer, and difficulty score. Results were compared to IV with P values and CIs being adjusted for multiple comparisons.</p><p><strong>Results: </strong>Emesis was successful within 600 seconds using IV APO in 22 of 25 dogs. By comparison, IN APO induced emesis in 18 of 25 dogs (P = .63). Ropinirole (14/25), SC APO (6/25), and TC APO (4/25) were significantly less successful (P = .047, P = < .001, and P < 0.001, respectively). When emesis was successful, it occurred most rapidly with TC APO, followed by IN APO and then ropinirole. It was most difficult to administer IV APO and TC APO.</p><p><strong>Clinical relevance: </strong>Similar to IV APO, IN APO was a rapid, easy, and effective method of inducing emesis in dogs and should be considered when IV administration is not possible. Ropinirole was easy to administer but successfully induced emesis less reliably within a 10-minute timeframe. APO administered TC using the commercially compounded injectable formulation was ineffective.</p>","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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