Javma-journal of The American Veterinary Medical Association最新文献_第10页

Focus on brown dog tick-transmitted Rocky Mountain spotted fever in dogs and people: shared threats and solutions. 重点关注犬和人之间的棕色狗蜱传播的落基山斑疹热：共同的威胁和解决方案。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-29 Print Date: 2025-03-01 DOI: 10.2460/javma.24.11.0756

Janet Foley, Laura Backus, Andrés M López-Pérez

{"title":"Focus on brown dog tick-transmitted Rocky Mountain spotted fever in dogs and people: shared threats and solutions.","authors":"Janet Foley, Laura Backus, Andrés M López-Pérez","doi":"10.2460/javma.24.11.0756","DOIUrl":"10.2460/javma.24.11.0756","url":null,"abstract":"Rocky Mountain spotted fever (RMSF) kills people and dogs in rural communities throughout the Americas and in urban epidemics in Brazil and Mexico. The companion Currents in One Health by Foley et al, AJVR , March 2025, addresses the urban ecology of this devastating disease across the Americas. Cases acquired from Dermacentor spp ticks are sylvatic and sporadic, in contrast with peridomestic cases from Rhipicephalus sanguineus sensu lato, which relies on dogs as hosts. Since the early 2000s, RMSF reemerged in northern Mexico with at least 9,152 human cases and case mortality up to 50%. These cases tend to occur where people are impoverished and have marginal access to medical care. Data on RMSF in dogs are sparse, although dogs are sentinels for human risk. The presence of roaming dogs in neighborhoods is associated with human cases, canine seroprevalence, and tick abundance. Dogs and people share hematological and clinical chemical findings and results of targeted diagnostic tests. Diagnosis requires PCR confirmation or rising convalescent titers, although seropositivity can be a cross-reaction with other rickettsial organisms. Suspect cases should be treated with doxycycline immediately. Coinfection with other R sanguineus -transmitted pathogens is common. Veterinarians in clinical practice can help families manage RMSF risk with client education and provide tick preventive medication, although the considerable cost is a barrier. Veterinarians can also advise how to manage tick infestations in a home, recognizing that eradicating R. sanguineus is very difficult. To reduce roaming and canine population sizes, veterinarians should promote canine spay, neuter, and restraint to the home.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"293-300"},"PeriodicalIF":1.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clitoral hypertrophy in a 2-year-old intact female French Bulldog. 一只两岁大的法国斗牛犬阴蒂肥大。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-24 Print Date: 2025-05-01 DOI: 10.2460/javma.24.11.0721

Lily R Lewis, Mary D Kerby, D Michael Tillson, Christopher Premanandan, Robyn R Wilborn

引用次数: 0

Treatment, prognosis, and outcome of dogs treated for rectal plasmacytoma: a multicentric retrospective study. 犬直肠浆细胞瘤的治疗、预后和结果：一项多中心回顾性研究。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-22 Print Date: 2025-04-01 DOI: 10.2460/javma.24.10.0666

Juan Carlos Jimeno Sandoval, Matteo Cantatore, Lee Meakin, Timothy Menghini, Laura Owen, Ivan Doran, Matthew Erskine, Matteo Rossanese

{"title":"Treatment, prognosis, and outcome of dogs treated for rectal plasmacytoma: a multicentric retrospective study.","authors":"Juan Carlos Jimeno Sandoval, Matteo Cantatore, Lee Meakin, Timothy Menghini, Laura Owen, Ivan Doran, Matthew Erskine, Matteo Rossanese","doi":"10.2460/javma.24.10.0666","DOIUrl":"10.2460/javma.24.10.0666","url":null,"abstract":"Objective: The aim of this study was to report the outcome and prognosis of canine patients treated medically or surgically for rectal plasmacytomas and to identify factors associated with recurrence, mortality, or progression to multiple myeloma.Methods: The databases of 7 referral hospitals were reviewed. The Kaplan-Meier method and Cox proportional hazards analysis were used to determine the association of a range of variables with recurrence and progression-free interval for the surgically treated patients.Results: 20 dogs were included. Nineteen cases were treated surgically, and 1 case was treated conservatively (analgesia and monitoring). Metastatic lesions were detected in 2 of 20 dogs (10%). Four of 19 dogs (21%) treated surgically developed postoperative complications, 1 major (1 of 19 [5.2%]) and 3 minor (3 of 19 [15.8%]). Tumor recurrence was identified in 6 of 19 dogs (31.5%). The 1-, 2-, and 3-year survival rates were 95%, 72%, and 66%, respectively. None of the variables tested were associated with occurrence of complications. Increased distance from the anus, incomplete surgical margins, and decreasing surgeon experience were associated with an increased risk of recurrence. No progression to multiple myeloma was seen in any of the cases.Conclusions: Surgical treatment of rectal plasmacytomas is associated with a low major complication rate and long survival. Metastasis and recurrence rates are significantly higher than previously reported.Clinical relevance: Conservative surgery leads to long-term survival, but recurrence is common. Future studies should focus on the benefits of adjuvant treatments.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposed digits increase weight bearing and alter sub-bandage pressures in dogs with forelimb splints. 暴露的手指增加负重和改变绷带下压力的狗与前肢夹板。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-22 Print Date: 2025-05-01 DOI: 10.2460/javma.24.10.0684

Sarah J Stark, Y Lucia Meester, Richard Evans, Wanda Gordon-Evans

{"title":"Exposed digits increase weight bearing and alter sub-bandage pressures in dogs with forelimb splints.","authors":"Sarah J Stark, Y Lucia Meester, Richard Evans, Wanda Gordon-Evans","doi":"10.2460/javma.24.10.0684","DOIUrl":"10.2460/javma.24.10.0684","url":null,"abstract":"Objective: The goal of this study was to evaluate the difference in weight bearing in a toes-in splint versus a toes-out forelimb splint and to determine the difference in sub-bandage pressures between the groups. We hypothesized that (1) weight bearing would not be different between the 2 splints and that (2) sub-bandage pressures would be distributed higher on the distal digits in the toes-out splint and pressures would be more evenly distributed across the paw in the toes-in splint.Methods: In this controlled crossover trial, a random forelimb of 10 healthy dogs was bandaged with a splint that left the digits exposed and again with a splint that encompassed the digits. The ground reaction forces and the difference in sub-bandage pressures between 2 sensor sections were compared between the toes-in and toes-out bandages.Results: The mean (SD) of peak vertical force was 26.76% (11.86%) for the toes-in bandage and 49.85% (9.21%) for the toes-out bandage. The mean (SD) sub-bandage pressure differences between sections were -121.28 (138.28) mm Hg and 130.32 (116.40) for toes-in and toes-out bandages, respectively (P = .001). This remained significant even after weight bearing was removed as a factor (P < .001).Conclusions: Leaving the distal aspect of digits 3 and 4 exposed by a splint results in better weight bearing, but also creates a sub-bandage pressure increase on the toes relative to the rest of the paw.Clinical relevance: These results suggest that splint placement should be adjusted based on the needs of each patient.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"635-639"},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dehiscence rate and associated risk factors after gastrotomy for removal of foreign material in dogs and cats. 狗和猫胃切除术去除异物后的开裂率及相关危险因素。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-22 DOI: 10.2460/javma.24.08.0531

Betsey Daly, John C Chandler

{"title":"Dehiscence rate and associated risk factors after gastrotomy for removal of foreign material in dogs and cats.","authors":"Betsey Daly, John C Chandler","doi":"10.2460/javma.24.08.0531","DOIUrl":"https://doi.org/10.2460/javma.24.08.0531","url":null,"abstract":"Objective: Identify rate and associated risk factors for dehiscence following gastrotomy for foreign material removal.Methods: Medical records from 2 private practice emergency and referral hospitals were reviewed, and history, laboratory values, intraoperative findings, and outcomes were collected on 271 dogs and 31 cats (n = 302).Results: Hospital A performed 222 procedures and Hospital B performed 80 procedures. Three cats (3 of 31 [10%]) and 20 dogs (20 of 271 [7%]) had intraoperative intestinal perforations. Two cats (2 of 31 [6.5%]) and 7 dogs (7 of 271 [2.6%]) were diagnosed with preoperative septic peritonitis. Concurrent surgical procedures in felines included enterotomy (3 of 31 [10%]), multiple enterotomies (3 of 31 [10%]), intestinal resection and anastomosis (IR&A; 2 of 31 [6%]), and other (1 of 31 [3%]). Concurrent surgical procedures in canines included enterotomy (55 of 271 [20%]), multiple enterotomies (11 of 271 [4%]), IR&A (24 of 271 [9%]), IR&A and enterotomy (1 of 271 [0.4%]), splenectomy (11 of 271 [4%]), and other (50 of 271 [18%]). There was no proven gastrotomy dehiscence. Two patients that did not have follow-up surgery or necropsy before euthanasia developed postoperative septic peritonitis, and gastrotomy dehiscence could not be ruled out as a differential diagnosis. Assuming neither patient, 1 patient, or both patients had gastrotomy dehiscence, the gastrotomy dehiscence rate was 0% to 0.66%. However, these patients also had an IR&A.Conclusions: Two cases were presumed to have gastrotomy dehiscence, as the authors would rather overestimate the dehiscence rate. However, it is more likely that the IR&A was the dehiscence site rather than the gastrotomy.Clinical relevance: Gastrotomy dehiscence rate is low in cats and dogs, and the dehiscence rate reported in this study may be an overestimation.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"1-8"},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of peri-incisional liposomal bupivacaine was not different than placebo regarding pain score or rescue analgesia in a randomized clinical trial of 83 dogs. 在83只狗的随机临床试验中，使用切周脂质体布比卡因与安慰剂在疼痛评分或救援镇痛方面没有区别。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-22 Print Date: 2025-04-01 DOI: 10.2460/javma.24.09.0589

Danielle L Hollenbeck, Joseph D Knue, Bradley T Simon, Nicholas D Jeffery, Kelley M Thieman Mankin, Vanna M Dickerson

{"title":"Use of peri-incisional liposomal bupivacaine was not different than placebo regarding pain score or rescue analgesia in a randomized clinical trial of 83 dogs.","authors":"Danielle L Hollenbeck, Joseph D Knue, Bradley T Simon, Nicholas D Jeffery, Kelley M Thieman Mankin, Vanna M Dickerson","doi":"10.2460/javma.24.09.0589","DOIUrl":"10.2460/javma.24.09.0589","url":null,"abstract":"Objective: To evaluate the impact of peri-incisional liposomal bupivacaine (LB) on postoperative pain scores, opioid use after soft tissue surgeries, and incidence of incision site complications in dogs.Methods: Client-owned dogs (n = 83) were enrolled in a randomized, blinded, placebo-controlled clinical study for dogs undergoing a variety of soft tissue surgical procedures between March 31, 2021, and August 18, 2022. After incision closure, an injection of a placebo (0.9% NaCl) or LB was administered into the peri-incisional subcutaneous tissues. Pain was assessed via the Glasgow Composite Measure Pain Scale (CMPS-SF) preoperatively, at extubation, and at 2, 4, 8, 12, 24, 30, 36, 48, 54, 60, and 72 hours postoperatively or until time of discharge. The need for rescue analgesia was assessed based on CMPS-SF guidelines. The effect of LB on pain scores was analyzed with mixed-model linear regression, and the χ2 test was used to examine effects on incision complications and need for rescue analgesia.Results: 83 dogs were enrolled. There was no significant difference in CMPS-SF scores between LB and placebo groups at any time period. Rescue analgesia was administered to 21 dogs in each group and was not significantly different. There was no significant difference in incision site complications. The incidence of surgical site infections was 6.0% for all procedures.Conclusions: Peri-incisional LB did not significantly decrease the use of rescue analgesia for postoperative soft tissue surgeries in a clinical setting with the use of multimodal analgesia. This is consistent with findings in human literature.Clinical relevance: Clinicians should not rely on LB used in the peri-incisional subcutaneous tissue to improve analgesia in patients undergoing soft tissue surgery.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"521-527"},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folded-flap palatoplasty is not superior to cut-and-sew staphylectomy for the treatment of brachycephalic obstructive airway syndrome in English Bulldogs. 折叠皮瓣腭成形术并不优于切口缝合葡萄切开术治疗英国斗牛犬短头性阻塞性气道综合征。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-22 Print Date: 2025-05-01 DOI: 10.2460/javma.24.10.0686

Janet A Grimes, Lisa R Reno, Mandy L Wallace, Brian J Sutherland, Rachel A Reed, Michael Perlini, Chad W Schmiedt

{"title":"Folded-flap palatoplasty is not superior to cut-and-sew staphylectomy for the treatment of brachycephalic obstructive airway syndrome in English Bulldogs.","authors":"Janet A Grimes, Lisa R Reno, Mandy L Wallace, Brian J Sutherland, Rachel A Reed, Michael Perlini, Chad W Schmiedt","doi":"10.2460/javma.24.10.0686","DOIUrl":"10.2460/javma.24.10.0686","url":null,"abstract":"Objective: To determine whether folded-flap palatoplasty (FFP) results in improved respiratory outcomes compared to standard staphylectomy (SS).Methods: English Bulldogs were randomized to receive FFP or SS in a parallel, equal-allocation, prospective study design at a single institution. Exercise-tolerance testing (ETT), arterial blood gas, head CT, and an owner survey were completed preoperatively and at recheck (approx 30 days postoperatively). Soft palate (SP) length and thickness and pharyngeal air volume were measured on blinded CT images. Linear mixed models and Mann-Whitney U tests were performed.Results: 16 dogs completed the study (FFP group, 8; SS group, 8) and 3 did not (excluded due to FFP dehiscence [2] and lack of recheck [1]). Median preoperative ETT grade was not different between groups (SS group, 1 [0 to 3]; FFP group, 1.5 [1 to 3]). Standard staphylectomy resulted in a greater reduction in SP length compared to FFP (P = .020; FFP, 5.79 ± 0.50 cm preoperatively, 4.86 ± 0.52 cm at recheck; SS, 6.13 ± 0.53 cm preoperatively, 4.57 ± 0.47 cm at recheck). No other variables differed between groups. At recheck, owners subjectively rated their dogs as improved (FFP group, 5; SS group, 8), unchanged (FFP group, 2), and not rated (FFP group, 1).Conclusions: Folded-flap palatoplasty did not improve SP thickness, pharyngeal air volume, ETT, arterial blood gas values, or owner survey variables more than SS in these English Bulldogs. Standard staphylectomy resulted in a greater reduction in SP length than FFP.Clinical relevance: Standard staphylectomy or FFP can be performed in English Bulldogs. Standard staphylectomy may be preferable due to dehiscence potential with FFP.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"612-618"},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical diagnosis and management of inflammatory bowel disease in a rabbit (Oryctolagus cuniculus). 兔炎症性肠病的临床诊断和治疗。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-22 Print Date: 2025-05-01 DOI: 10.2460/javma.24.11.0730

Katharine Hausmann Farris, Lorelei Clarke, Christoph Mans

引用次数: 0

Heparinized venous blood gas syringes are associated with a significant decrease in measured packed cell volume in dogs due to hemodilution. 由于血液稀释，肝素化静脉血气注射器与狗的测量堆积细胞体积显着减少有关。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-17 DOI: 10.2460/javma.24.11.0718

Coyne M Hopey, Dana Caldwell, Erin Binagia, Deborah A Keys, Tereza Stastny

{"title":"Heparinized venous blood gas syringes are associated with a significant decrease in measured packed cell volume in dogs due to hemodilution.","authors":"Coyne M Hopey, Dana Caldwell, Erin Binagia, Deborah A Keys, Tereza Stastny","doi":"10.2460/javma.24.11.0718","DOIUrl":"https://doi.org/10.2460/javma.24.11.0718","url":null,"abstract":"Objective: To assess the effect of hemodilution on PCV when commercial preheparinized venous blood gas (PH-VBG) syringes are used compared to directly filled Hct tubes, and to evaluate the impact of delayed centrifugation on PCV.Methods: A prospective study of 102 dogs presenting to a private emergency department between November 1, 2023, and February 29, 2024, with 306 corresponding blood samples. Samples were collected by direct venipuncture. Samples were analyzed with the use of 3 methods: directly filled microhematocrit tubes (direct), PH-VBG syringe (PH-VBG), and PH-VBG syringe with a 15-minute delay before centrifugation (delayed PH-VBG).Results: Mean PCV of the direct method was 43.9%, the PH-VBG method was 41.7% (range, 11.0% to 60.0%; SD, 9.8%), and the delayed PH-VBG method was 40.1% (range, 7.0% to 60.0%; SD, 11.2%). When the direct and PH-VBG methods were compared, the direct method was biased on average 2.2% higher than the PH-VBG method, with limits of agreement (LOAs) of -0.9 to 5.3. The direct method was biased on average 3.8% higher than the delayed PH-VBG method, with LOAs of -4.3 to 11.9. In anemic dogs (n = 14), the direct method was biased on average 6.1% higher than the delayed PH-VBG method, with LOAs of -0.05 to 12.2. In nonanemic dogs (n = 88), the direct method was biased on average 2.3% higher than the PH-VBG method, with LOAs of -0.9 to 5.4.Conclusions: Use of preheparinized syringes and delayed sample processing led to hemodilution and lower PCV values.Clinical relevance: Direct venipuncture and immediate sample processing are recommended to ensure accurate PCV results.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective analysis of hepatic copper concentrations in an internal feeding colony of dogs fed a broad range of foods. 肝铜浓度的回顾性分析，在一个内部喂养菌落的狗喂养了广泛的食物。

IF 1.6 2区农林科学

Javma-journal of The American Veterinary Medical Association Pub Date : 2025-01-15 Print Date: 2025-04-01 DOI: 10.2460/javma.24.09.0634

Madison D Amundson, Laura A Motsinger, John Brejda, Leslie Hancock

{"title":"Retrospective analysis of hepatic copper concentrations in an internal feeding colony of dogs fed a broad range of foods.","authors":"Madison D Amundson, Laura A Motsinger, John Brejda, Leslie Hancock","doi":"10.2460/javma.24.09.0634","DOIUrl":"10.2460/javma.24.09.0634","url":null,"abstract":"Objective: To examine the effects of age, sex, year of death/sample collection, and liver histopathology on liver copper concentrations in dogs fed a wide variety of commercial dog foods throughout their lives.Methods: This study utilized all bioarchived liver samples collected during necropsy at time of death from 2006 to 2022 from dogs housed in a closed feeding colony. Liver samples were analyzed on a dry matter basis for copper concentration by inductively coupled plasma-optical emission spectrometry and did not require specific criteria for selection. The effects of animal age, year of death/collection, sex, and liver histopathology on liver copper concentrations were assessed.Results: Liver samples were analyzed from 296 dogs. Age and sex had no effect on liver copper concentrations, which increased linearly over time by an average of 3.41 ppm per year but remained within the normal reference range. Quantile regression indicated that the lowest 5% and highest 5% of liver copper concentrations analyzed were not changing and only a slight increase (3.7 ppm per year) was observed in the lower 25th quantile. The mean copper concentration of abnormal liver histopathology samples was not different from the mean copper concentration of normal liver histopathology samples.Conclusions: Histopathologic findings or animal demographic did not impact liver copper concentrations over a 16-year period. Liver copper concentration increased linearly but remained within the normal reference range.Clinical relevance: Mean liver copper concentrations for each year remained within normal limits. Studies assessing the impact of specific nutrient profiles and sources in various populations are warranted.","PeriodicalId":14658,"journal":{"name":"Javma-journal of The American Veterinary Medical Association","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0