Italian journal of anatomy and embryology最新文献_第2页

Case series of two different dose regimen Rituximab therapy for severe Pemphigus 两种不同剂量方案的利妥昔单抗治疗重度天疱疮的病例系列

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13919

Federica Giuliani, G. Gualdi, P. de Sanctis, P. Amerio

{"title":"Case series of two different dose regimen Rituximab therapy for severe Pemphigus","authors":"Federica Giuliani, G. Gualdi, P. de Sanctis, P. Amerio","doi":"10.36253/ijae-13919","DOIUrl":"https://doi.org/10.36253/ijae-13919","url":null,"abstract":"Rituximab is a monoclonal antibody approved for treatment of adults with severe and refractory pemphigus vulgaris. Concerns about side effects and high costs of conventional doses have rised the hypothesis that low-dose rituximab regimen may be cost-effective with a better safety profile. Here we report our experience of seven patients with extensive/recalcitrant pemphigus, who either were steroid dependent, had contraindications or refused conventional treatment. Two patients received conventional rituximab (1000 mg 2 weeks apart) while five received ultra low-dose rituximab (200 mg 2 weeks apart). At 3 months, the two patients treated with high Rituximab regimen showed respectively a complete remission off therapy (CROT) and a complete remission on minimal therapy (CRMT), while among the five patients treated with ultra low-doses, three achieved CROT, one achieved CRMT and one a partial remission off therapy (PROT). All patients treated with ultra low-dose rituximab achieved complete depletion of cd19+ and cd19/45+ B lymphocytes after three months and all patients except one male manteined the zeroing after 6 months. No serious side effect was documented with low dose regimen except for a case of diziness. Our data suggest that ultra low-dose rituximab can be effective even in patients with extensive/recalcitrant pemphigus, with a lower probability of side-effects respect to higher dose regimen and may act as a steroid sparing strategy.","PeriodicalId":14636,"journal":{"name":"Italian journal of anatomy and embryology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48097456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue on Innovative Technologies in Clinical Medicine & Dentistry (InTEchMed) 临床医学与牙科创新技术特刊（InTEchMed）

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-14165

O. Trubiani

{"title":"Special issue on Innovative Technologies in Clinical Medicine & Dentistry (InTEchMed)","authors":"O. Trubiani","doi":"10.36253/ijae-14165","DOIUrl":"https://doi.org/10.36253/ijae-14165","url":null,"abstract":"The PhD course in Innovative Technologies in Clinical Medicine & Dentistry (InTEchMed) of the University “G. d’Annunzio” of Chieti-Pescara, is a newly instituted course that brings together professors and researchers belonging to scientific-disciplinary sectors that are homogeneous and coherent with a scientific project that has as its objective “ the pursuit of multidisciplinarity research” by finalizing the research, in terms of content and applicability, as a priority to satisfying the growing demands for a medicine of excellence with particular reference to spheres of interest of great relevance and considerable impact social responsibility attributable to the areas of specialization identified by the National Research Plan. \u0000The PhD course in InTechMEd incorporates and processes technological and scientific innovations in the context of the skills that characterize it and, with a synergistic work, seeks to interface with the national and international scientific community with a constructive and innovative spirit. To this end, to promote the research activity of their PhD students, the First PhD InTechMEd Conference was organized, where the students presented the preliminary data of the research carried out and these oral presentations were collected to be published in the special issue of the Italian Journal of Anatomy and Embryology.","PeriodicalId":14636,"journal":{"name":"Italian journal of anatomy and embryology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44717205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Off-line or on-line? – near-peer assisted anatomy education in the time of Covid-19 pandemic – a single center randomized controlled study 离线还是在线?- Covid-19大流行时期的近同伴辅助解剖学教育-一项单中心随机对照研究

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13877

J. Domański, M. Wanat, J. Ciach, Angelika Osuch, B. Kurc-Darak, Sławomir Woźniak, Z. Domagała

{"title":"Off-line or on-line? – near-peer assisted anatomy education in the time of Covid-19 pandemic – a single center randomized controlled study","authors":"J. Domański, M. Wanat, J. Ciach, Angelika Osuch, B. Kurc-Darak, Sławomir Woźniak, Z. Domagała","doi":"10.36253/ijae-13877","DOIUrl":"https://doi.org/10.36253/ijae-13877","url":null,"abstract":"The COVID-19 pandemic significantly changed the way anatomy classes were carried out, depriving students of practical learning using real anatomical specimens. Once COVID restrictions were lifted and students returned to a normal class setting a randomized study was carried out to elevate effectiveness of practical anatomy didactics. The aim of this study was to evaluate the impact of an anatomy workshop based on demonstrating anatomical structures delivered in a face-to-face format, and to compare it with a standard course based on online learning. The randomization involved 350 students from whom 80 participants were drawn to form both a study and control group. The study consisted of three parts: exam 1, workshop, exam 2. The study group participated in all parts of the project, while the control group participated only in the exam. The workshop was held by near peer teachers (NPT). Statistical analysis showed that participation in the workshop had an effect on the passing score of exam 2 (p=0.039). It was also shown that the difference in scores was significantly higher (p=0.049) in the study group compared to the control group. The study proved that the workshops which were based on demonstrating anatomical structures by NPT significantly affected the scores obtained by trainees. In conclusion, the project confirmed the importance of student interaction with anatomical specimens and that online teaching is not a substitute for teaching in a dissecting room. Additionally, this study confirmed the high usefulness of NPT as a support for the didactic process conducted by experts. ","PeriodicalId":14636,"journal":{"name":"Italian journal of anatomy and embryology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41504983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of the Movat pentachrome stain technique in the microanatomical analysis of the human placenta 莫瓦特五铬染色技术在人体胎盘显微解剖分析中的应用

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13882

Z. Domagała, A. Pinkowska, A. Piotrowska, J. Domański, Victoria Tarkowski, Aleksandra Zimmer-Stelmach, Jakub Śliwa

{"title":"Utility of the Movat pentachrome stain technique in the microanatomical analysis of the human placenta","authors":"Z. Domagała, A. Pinkowska, A. Piotrowska, J. Domański, Victoria Tarkowski, Aleksandra Zimmer-Stelmach, Jakub Śliwa","doi":"10.36253/ijae-13882","DOIUrl":"https://doi.org/10.36253/ijae-13882","url":null,"abstract":"The efficacy and utility of pentachrome staining has been demonstrated in many studies on diverse human body tissues. Movat pentachrome technique is used for multicolor staining of tissue sections and vascular and stroma visualization. So far, the utility of this method for microanatomical evaluation of placental structures has not been demonstrated. The aim of this study is to evaluate the image of normal placenta and to develop some reference images for future evaluation of pathological tissues based on this technique. Material and method. The study was carried out on 21 paraffin slices taken from seven mature human placenta of single pregnant women without significant pathology and completed with a planned, elective Caesarean section. All paraffin slices were used for preparation of tissue microarrays and then performing a histochemical staining (HE and Movat). Results. On the basis of the collected material, microscopic analysis enabled the identification of normal placental villi - terminal villi,mature intermediate villi and stem villi. Moreover the maternal part of placenta was visualized. It is worth emphasizing that in each case not only the trophoblast but also the stroma structures were visualized. Conclusions. This study proved the effectiveness and usefulness of Movat imaging of placenta especially in visualization of the stroma.","PeriodicalId":14636,"journal":{"name":"Italian journal of anatomy and embryology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45502958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioarcheological and paleopathological study of a multiple deposition burial from S. Antine- Genoni (SU) – Sardegna - Italy 意大利萨丁那-安亭-热那亚（SU）多沉积埋藏的生物地质和古病理学研究

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13842

R. Serra, P. Melis, A. Montella, P. Bandiera

引用次数: 0

Genotype-phenotype correlation and adaptive proteome reorganization in Marinesco-Sjögren syndrome Marinesco-Sjögren综合征的基因型-表型相关性和适应性蛋白质组重组

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13802

A. Ruggieri, M. Sallese

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Prevalence and localization of Maxillary Sinus Septa: a mini review 上颌窦间隔的患病率和定位：一项小型综述

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13781

Manlio Santilli, B. Sinjari, O. Trubiani, G. D’Addazio, Imena Rexhepi, Giuseppe Tafuri, Eugenio Manciocchi, S. Caputi

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A prospective, blinded, randomized-controlled study on regressive bone modeling around dental implants with different machined coronal portion 一项前瞻性、盲法、随机对照研究:不同冠状部分牙种植体周围骨模型的退化

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13789

Stefano Oliva, A. Scarano, O. Trubiani, B. Sinjari, M. Piattelli

引用次数: 0

Autophagy inhibitors in the treatment of colorectal cancer: a brief review 自噬抑制剂在结直肠癌治疗中的应用综述

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-13788

M. Ceci, M. Iezzi, M. Trerotola

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The vascular structure of the urethra: a historical overview 尿道的血管结构:历史概述

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI: 10.36253/ijae-11104

G. Natale, E. Armocida

{"title":"The vascular structure of the urethra: a historical overview","authors":"G. Natale, E. Armocida","doi":"10.36253/ijae-11104","DOIUrl":"https://doi.org/10.36253/ijae-11104","url":null,"abstract":"Penile structure and function aroused interest since ancient times, when the erectile activity was mainly attributed to an accumulation of air by Greek and Roman physicians. In the Renaissance period Leonardo da Vinci was one of the first to recognize the right functional importance of the presence of blood in penile tissues. Since then, although with different techniques and interpretations, the morphological studies reported the description of blood vessels differently arranged in complicated networks. The discovery of blood circulation by William Harvey in his famous Exercitatio anatomica de motu cordis (1628) and the demonstration of capillaries by Marcello Malpighi stimulated a deeper research. In particular, the presence of a non vascular spongy tissue (cavernous bodies) with cellular texture (cellular theory) was postulated and interpreted as consisting of a loose and elastic spongy tissue arranged in several cells into which, during erection, blood is poured from the arteries, and from which it is afterwards removed by veins. In the beginning of the 19th century, when both vascular and cellular texture theories concerning the penile anatomy were still coexisting, a particular attention was paid to the urethral structure. Thanks to improved injection techniques, Paolo Mascagni and Alessandro Moreschi provided accurate works on this subject, demonstrating the vascular nature of the cavernous bodies. Finally, in 1899 Victor Vecki von Gyurkovechky confirmed the vascular theory, histologically demonstrated by the presence of endothelium.","PeriodicalId":14636,"journal":{"name":"Italian journal of anatomy and embryology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41691553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0