JAMA otolaryngology-- head & neck surgery最新文献

{"title":"Genetic and Molecular Differences in Head and Neck Cancer Based on Smoking History.","authors":"Rong Jiang, May Z Gao, Meng Chen, Darien J Weatherspoon, Tammara L Watts, Nosayaba Osazuwa-Peters","doi":"10.1001/jamaoto.2024.5409","DOIUrl":"10.1001/jamaoto.2024.5409","url":null,"abstract":"<p><strong>Importance: </strong>Up to 80% of survivors of head and neck squamous cell carcinoma (HNSCC) currently or previously smoked. Thus, tobacco use is a major modifiable risk factor for HNSCC, even in the era of human papillomavirus (HPV)-associated disease. However, how smoking underlies chromosomal and epigenetic changes that are associated with HNSCC outcomes remains unclear.</p><p><strong>Objective: </strong>To characterize genetic and molecular differences and associated biological pathways in patients with HNSCC based on smoking history.</p><p><strong>Design, setting, and participants: </strong>This retrospective cohort study included patients with a confirmed diagnosis of HNSCC from the Cancer Genome Atlas via cBioPortal data independent of HPV status. Data were analyzed between April 2023 and May 2024.</p><p><strong>Main outcomes and measures: </strong>Smoking history was defined as individuals who smoked (currently or previously) compared with nonsmokers (never smoked). Genetic and molecular differences of interest were single nucleotide variation, copy number alteration, DNA methylation, and messenger RNA (mRNA) expression. Accounting for multiple testing, we reported the false discovery rate (FDR), with a statistically significant FDR of 0.05 or less. Potential functions and pathways were investigated using the Panther classification system, and the Fisher exact test was used for overrepresentation, using the Reactome pathway dataset as a guide. Associations between smoking-related genetic alterations and overall survival were analyzed using log-rank tests.</p><p><strong>Results: </strong>Of 511 participants, 135 (26.4%) were female, and the mean (SD) age was 60.8 (11.9) years. People who smoked (389 [76.1%]) demonstrated significantly enriched copy number alterations on 9 genes located on chromosome 11q13 compared with nonsmokers (122 [23.9%]; FDR, 0.044-0.046). Two genes, FADD and CTTN, were significantly highly methylated in nonsmokers. Also, PPFIA1, FGF19, CCND1 and LTO1 were highly expressed in mRNA in those who smoked, while FADD mRNA expression was negatively correlated with FADD DNA methylation in nonsmokers (Pearson r = -0.53; 95% CI, -0.59 to -0.49) and those who smoked (Pearson r = -0.57; 95% CI, -0.63 to -0.51). People who smoked with altered FADD had higher risk of dying than those with FADD unaltered (hazard ratio, 1.40; 95% CI, 1.004-1.96). Pathway analysis showed the significant genes were collectively associated with cellular processes and biological regulations, including olfactory signaling and the PI3K/AKT network.</p><p><strong>Conclusion and relevance: </strong>The results of this cohort study suggest that there may be patterned genetic and molecular differences in patients with HNSCC based on smoking history, especially genes located on chromosome 11q13. These genomic differences due to smoking make smoking a modifiable risk factor for HNSCC outcomes.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"379-388"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back to the Workforce-An Important Marker of Survivorship.","authors":"Mark Varvares, Regan Bergmark, Nosayaba Nosa Osazuwa-Peters","doi":"10.1001/jamaoto.2024.5016","DOIUrl":"10.1001/jamaoto.2024.5016","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"311-312"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating 100 Years of Publishing Research in Otolaryngology-Head and Neck Surgery.","authors":"Jay F Piccirillo","doi":"10.1001/jamaoto.2024.5192","DOIUrl":"10.1001/jamaoto.2024.5192","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"293-296"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Therapy for Hearing Loss-Will the Price Be Right?","authors":"Lauren E Miller, Oliver F Adunka, Vinay K Rathi","doi":"10.1001/jamaoto.2024.5189","DOIUrl":"10.1001/jamaoto.2024.5189","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"291-292"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Taste Loss From Early Adulthood to Mid to Late Adulthood and Mortality.","authors":"Ruixin Zhu, Ran Wang, Jingjing He, Liwei Zhang, Peng An, Keji Li, Fazheng Ren, Weili Xu, Jie Guo","doi":"10.1001/jamaoto.2024.5072","DOIUrl":"10.1001/jamaoto.2024.5072","url":null,"abstract":"<p><strong>Importance: </strong>Evidence on the associations of taste function changes from early adulthood to mid to late adulthood with all-cause mortality is limited.</p><p><strong>Objective: </strong>To investigate the associations between subjective perception of taste loss from early adulthood to mid to late adulthood and all-cause mortality.</p><p><strong>Design, setting, and participants: </strong>This population-based cohort study used data from the US National Health and Nutrition Examination Survey (2011-2014) and linked mortality information from the National Death Index (NDI) and included adults aged 40 years and older. Data analyses were conducted between May 6, 2024, and July 22, 2024.</p><p><strong>Exposures: </strong>Subjective decline in taste function and ability to detect basic tastes (ie, salt, sourness, sweetness, or bitterness) since the age of 25 years.</p><p><strong>Main outcomes and measures: </strong>All-cause mortality was ascertained via linkage to the NDI with follow-up until December 31, 2019.</p><p><strong>Results: </strong>Among 7340 participants (52.8% female), 662 (weighted, 8.9%) reported subjective perception of taste loss from early adulthood to mid to late adulthood. During a median (IQR) follow-up of 6.67 (5.67-7.83) years, 1011 deaths occurred. Subjective perception of taste loss was associated with a 47% higher risk of mortality (multiadjusted hazard ratio [HR], 1.47; 95% CI, 1.06-2.03). Specifically, self-reported loss in ability to taste salt (multivariable adjusted HR [aHR], 1.65; 95% CI, 1.21-2.26) and sourness (aHR, 1.69; 95% CI, 1.19-2.40) was associated with increased mortality. Self-reported decline in ability to taste bitterness was associated with increased mortality only in female participants (aHR, 1.63; 95% CI, 1.05-2.53), whereas decline in ability to taste sourness was associated with increased mortality only in male participants (aHR, 1.69; 95% CI, 1.03-2.75). Moreover, among all and female participants without perceived smell function loss, those with perceived taste function loss still had increased mortality (all participants: aHR, 1.64; 95% CI, 1.12-2.40; female participants: aHR, 1.71; 95% CI, 1.14-2.56; male participants: aHR, 1.44; 95% CI, 0.80-2.59).</p><p><strong>Conclusions and relevance: </strong>In this population-based cohort study, subjective perception of taste loss from early adulthood to mid to late adulthood, particularly perception of salt and sourness, was associated with increased all-cause mortality. The mortality risk associated with perceived taste loss could not be mitigated by undeteriorated smell function. These findings suggest that subjective perception of taste loss may serve as a simple and valuable indicator for screening high-risk populations in clinic and public health practice.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"335-343"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflection on Transoral Robotic Surgery vs Transoral Laser Microsurgery in HPV-Positive Oropharyngeal Squamous Cell Carcinoma-Reply.","authors":"James T O'Hara, Christopher N Hurt, Terry M Jones","doi":"10.1001/jamaoto.2024.5064","DOIUrl":"10.1001/jamaoto.2024.5064","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"413-414"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origin and In-Office Treatment of Retrograde Cricopharyngeus Dysfunction.","authors":"Marie Mailly, Robin Baudouin, Claire Thibault, Stephane Hans, Jerome R Lechien","doi":"10.1001/jamaoto.2024.5046","DOIUrl":"10.1001/jamaoto.2024.5046","url":null,"abstract":"<p><strong>Importance: </strong>Retrograde cricopharyngeus dysfunction (R-CPD) is an emerging disorder associated with disabling symptoms. The origin of R-CPD remains unknown.</p><p><strong>Objective: </strong>To investigate the development of symptoms, diagnosis approach, and therapeutic outcomes of R-CPD in patients treated with in-office botulinum toxin injection (BTI) into the cricopharyngeus.</p><p><strong>Design, setting, and participants: </strong>This was a case series including patients with R-CPD who were consecutively and prospectively recruited from April 2022 to May 2024 in an academic hospital. Semistructured interviews were conducted to collect and analyze data on each patient's clinical history, potential causes or factors associated with R-CPD development, diagnostic approaches, and symptom presentation.</p><p><strong>Intervention: </strong>Clinic-based (in-office) BTI into the cricopharyngeus.</p><p><strong>Outcomes and measures: </strong>Associations with laryngopharyngeal reflux disease, patients' Reflux Symptom Score-12 (RSS-12), and BTI effectiveness, revisions, and complications were evaluated.</p><p><strong>Results: </strong>The case series comprised 106 patients with R-CPD treated with BTI (52 females [49.1%] and 54 males [51.9%]). Their mean (SD) age at symptom onset was 13.6 (7.7) years, and at diagnosis, 30.4 (6.4) years. Sixty-eight patients (64.2%) had potential congenital R-CPD, according to the parents' testimonies. A family history was reported in 18 of 62 cases (29.0%). In 105 cases (99.1%), patients made the diagnosis themselves despite medical consultations (n = 162), empirical treatments (n = 113), and additional examinations (n = 92). The cumulative success rate of BTI was 90.6% (96 of 106 patients). In 26 cases (24.5%), additional injections were administered to address the symptoms. Family history of R-CPD was a negative predictor of single-BTI success. Dysphagia was the primary adverse effect occurring after 89 of 126 BTIs (70.6%) and lasted a mean (SD) of 16.3 (12.0) days. In 10 cases, operating-room BTI was administered after primary in-office BTI.</p><p><strong>Conclusions and relevance: </strong>R-CPD is an emerging and poorly known disorder associated with high rates of ineffective consultations, additional examinations, and self-diagnosis by patients. In-office BTI was associated with a high rate of partial or total symptom relief and long-term effectiveness.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"396-400"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online Attention to Articles Published in Otolaryngology Journals.","authors":"Robert Stephen Hong, Caleb James Fan, Jacob Charles Lucas","doi":"10.1001/jamaoto.2024.5251","DOIUrl":"10.1001/jamaoto.2024.5251","url":null,"abstract":"<p><strong>Importance: </strong>The internet has changed the way that medical information by journals is disseminated, with a shift toward online distribution. Given this, it is important to include alternative metrics that measure online attention when determining the influence of otolaryngology journals.</p><p><strong>Objective: </strong>To describe a ranking system for otolaryngology journals that reflects the amount of publicity received online and to determine factors associated with these rankings.</p><p><strong>Design and setting: </strong>In this cross-sectional study, online attention was measured using Altmetric Attention Scores obtained for all 26 112 articles published by the 43 journals classified under the Journal Citation Reports category of otorhinolaryngology from 2018 to 2022. Data were analyzed from January to June 2023.</p><p><strong>Main outcomes and measures: </strong>Altmetric journal rankings were created from the top 500 articles with the highest Altmetric Attention Scores, using a rank sum weight-based method to assign credit for an article's attention online to its respective journal. The association of article content, study design and type, and social media presence on X (formerly Twitter) with ranking was examined. Comparisons between Altmetric journal rankings and bibliometric rankings (5-year Impact Factor) were also performed.</p><p><strong>Results: </strong>Of 43 otolaryngology journals, JAMA Otolaryngology-Head & Neck Surgery had the highest Altmetric journal ranking. Most articles in the Altmetric top 500 were nonoperative clinical studies (220 articles [43.5%]) or described the natural history of disease (176 articles [34.9%]) and involved otology/neurotology (158 articles [29.9%]) or rhinology/allergy (134 articles [25.4%]). The COVID-19 pandemic was a common topic (169 articles [33.5%]). The presence of an active X account for the entire 5-year period was associated with a higher Altmetric total rank sum score for journals (η2 = 0.07; 95% CI, 0.02-0.13 [moderate effect size]). There was a moderate statistically significant correlation between Altmetric journal rankings and 5-year Impact Factor rankings (r = 0.5; 95% CI, 0.2-0.7).</p><p><strong>Conclusions and relevance: </strong>This cross-sectional study demonstrates that metrics based on online attention provide an alternative way to assess the reach and influence of medical journals. Journals seeking to expand their influence online may benefit from a presence on social media.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"344-350"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflection on Transoral Robotic Surgery vs Transoral Laser Microsurgery in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.","authors":"Pitchaipillai Sankar Ganesh, Naji Naseef Pathoor, Rajesh Kanna Gopal","doi":"10.1001/jamaoto.2024.5061","DOIUrl":"10.1001/jamaoto.2024.5061","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"413"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sore Throat and Lymphadenopathy in an Older Man.","authors":"Emmanuel Ribereau-Gayon, François Durupt, Matthieu Godinot","doi":"10.1001/jamaoto.2024.5036","DOIUrl":"10.1001/jamaoto.2024.5036","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"405-406"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}