JAMA otolaryngology-- head & neck surgery最新文献

{"title":"Woman Presenting With Calvarial Mass.","authors":"Carine Tamamian, Jingjing Hu, Theresa Guo","doi":"10.1001/jamaoto.2025.3474","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3474","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are We Training Too Many Head and Neck Fellows?","authors":"William Bill M Lydiatt","doi":"10.1001/jamaoto.2025.3471","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3471","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient With a Cough and Calcified Cervical Lymphadenopathy.","authors":"Wassim Najjar, Stanley M Chen Cardenas, Leila J Mady","doi":"10.1001/jamaoto.2025.3545","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3545","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Nicotine Patches-Concerns for Otolaryngologists.","authors":"Sophia Chen, Matthew Ern Lin, Tom Maxim, Maie A St John","doi":"10.1001/jamaoto.2025.3566","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3566","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomic Selection of Cancer-Testis Antigens as Precision Immuno-oncologic Targets in Head and Neck Cancer.","authors":"Abdullah A Memon, Musaddiq J Awan, Oscar Villarreal Espinosa, Rachel Kuehn, Anne Frei, Jamie Foeckler, Jennifer Bruening, Kenneth Akakpo, Becky Massey, Michael Stadler, Stuart Wong, Heather A Himburg, Joseph Zenga","doi":"10.1001/jamaoto.2025.3563","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3563","url":null,"abstract":"<p><strong>Importance: </strong>Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignant neoplasm with an increasing need for precision therapeutics. Cancer-testis antigens (CTAs) represent promising targets given their aberrant tumor expression and otherwise localized expression to immune-privileged tissues with no (testis-restricted) or minimal (testis-selective) expression in other human body sites. Despite their potential, limited studies rigorously evaluate CTAs as therapeutic targets in HNSCC.</p><p><strong>Objective: </strong>To orthogonally validate and present specific CTAs as potential precision immuno-oncologic targets in both previously untreated (de novo) and recurrent HNSCC tumors.</p><p><strong>Design, setting, and participants: </strong>This was a cross-sectional study conducting multiomic analyses on a single academic tertiary care center's tumor registry from 2018 to 2023, with validation using publicly available transcriptomic datasets. A total of 33 tumor samples from patients with HNSCC, including both de novo and radiation-recurrent tumors, were analyzed. Data were analyzed from August to December 2024.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was the identification and rigorous validation of specific CTAs with tumor-specific expression in HNSCC.</p><p><strong>Results: </strong>This study analyzed 33 HNSCC institutional tumor specimens, including 25 de novo and 8 radiation-recurrent tumors. Of 33 included patients, 25 (76%) were male, 8 (24%) were female, and the median (range) age was 61 (29-87) years. Tumor subsites included the oral cavity (24 [73%]), larynx (7 [21%]), and oropharynx (2 [6%]). Tumors were primarily T4a (23 [70%]), with nodal involvement in 16 (48%). Initial analysis of bulk RNA-sequenced institutional data and single-cell RNA-sequenced external data identified several CTAs (DKKL1, SPANXB1, SPANXD, and ACTL8) upregulated in recurrent tumors. An expanded reanalysis revealed that CTAs were expressed across HNSCCs, including robust expression not only in radiation-recurrent disease but also in de novo tumors. Immunohistochemistry was performed on ACTL8 to confirm transcriptional level findings at the protein level, which showed moderate focal cytoplasmic staining in tumor tissue. To refine the tumor-specific CTA list, an exclusionary analysis using single-cell RNA-sequenced data from normal oral mucosa was conducted, removing any CTAs with any expression in normal tissue. This resulted in a final list of 23 testis-restricted and 44 testis-selective CTAs specific to HNSCC, of which 14 CTAs overlapped across all transcriptomic datasets. Finally, using CopyKAT, CTAs were specifically enriched in malignant epithelial populations compared with benign populations within the same patients with HNSCC.</p><p><strong>Conclusions and relevance: </strong>In this study, a set of 23 testis-restricted and 44 testis-selective CTAs were orthogonally validated in multiple tumor dat","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Sex and Chronic Rhinosinusitis Diagnosis and Biomarkers.","authors":"Richard G Chiu, Abraham Ahn, Kamal Eldeirawi, Anthony I Dick, Sharmilee M Nyenhuis, Thasarat Sutabutr Vajaranant, Rachel Caskey, Victoria S Lee","doi":"10.1001/jamaoto.2025.3734","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3734","url":null,"abstract":"<p><strong>Importance: </strong>The inflammation-modulating properties of sex hormones provide a pathophysiological basis for anticipating sex-based differences in chronic rhinosinusitis (CRS), but the role of biological sex has not been thoroughly studied.</p><p><strong>Objectives: </strong>To investigate sex differences in CRS diagnosis and biomarkers.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional study used data from the All of Us Research Program, a large national dataset of US adults, collected from partner health care organizations including academic medical centers, Veterans Affairs facilities, and community health centers. From May 2018 to October 2023, a total of 393 596 participants with electronic health records were considered for inclusion; those with incomplete data were excluded. Data analysis was conducted from April to September 2025.</p><p><strong>Exposures: </strong>Participant sex was the primary exposure, and covariates included demographics, socioeconomic status, risk factors, and comorbidities.</p><p><strong>Main outcomes and measures: </strong>CRS diagnosis, stratified into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP), and CRS biomarkers.</p><p><strong>Results: </strong>The analysis included 258 245 participants, of whom 38.4% were male and 61.6% were female and most (57.3%) were 50 years or older. After controlling for covariates, female sex was associated with an increased odds of CRSsNP among those younger than 60 years (odds ratio [OR], 1.44; CI with Holm-Bonferroni correction [CIH-B], 1.35 to 1.54) and 60 years or older (OR, 1.32; CIH-B, 1.23 to 1.40), but a lower odds of CRSwNP (OR, 0.63; CIH-B, 0.52-0.76) compared to males. Compared to male participants, female participants had a lower concentration of serum eosinophils (β, -0.35; CIH-B, -0.44 to -0.25) and IgE (β, -99.73; CIH-B, -190.49 to -8.96) among participants with CRSsNP after controlling for covariates, as well as lower eosinophils among participants with CRSwNP (β, -0.41; CIH-B, -0.80 to -0.01). Analyzing CRS prevalence by age group revealed a downtrend among female participants 60 years or older, despite an upward trend at younger age groups, with regression analysis demonstrating a negative interaction effect between female sex and age 60 years or older with odds of CRSsNP (OR, 0.91; CIH-B, 0.84 to 0.99).</p><p><strong>Conclusions and relevance: </strong>This cross-sectional study found that female sex was associated with a higher odds of CRSsNP, but a lower odds of CRSwNP compared to males. Biomarker analysis indicated a possible female disposition for nontype 2 inflammation.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflux Medication and Supraglottoplasty in Infant Laryngomalacia-Reply.","authors":"Habib G Zalzal, George H Zalzal","doi":"10.1001/jamaoto.2025.3557","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3557","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midline Tongue Defect in a Pediatric Patient.","authors":"Katherine C Babin, Kaylee Zettler, Jeffrey Carron","doi":"10.1001/jamaoto.2025.3479","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3479","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimbursement for Thyroid Surgery and Potential Solutions.","authors":"Philip R Brauer, David Octeau, Benjamin Wajsberg, Eric D Lamarre, Jamie A Ku, Mario Skugor, Danielle M Bottalico, Natalie L Silver, Brandon L Prendes, Joseph Scharpf","doi":"10.1001/jamaoto.2025.3696","DOIUrl":"10.1001/jamaoto.2025.3696","url":null,"abstract":"<p><strong>Importance: </strong>In 2024, the US Senate Committee on Finance released a white paper outlining future reforms to the Medicare payment models.</p><p><strong>Objective: </strong>To characterize trends in Medicare reimbursement for thyroid surgery and to provide evidence for future discussions on payment reforms.</p><p><strong>Design and setting: </strong>This retrospective economic evaluation used data on reimbursement for thyroid surgeries from the Centers for Medicare & Medicaid Services' Physician Fee Schedule from 2000 to 2023. Data were analyzed from May to June 2024.</p><p><strong>Main outcomes and measures: </strong>The main outcomes were reimbursement rates for thyroid surgery and changes in reimbursement over time. Dollar amounts were adjusted to January 2023 US dollars. Annual reimbursement was averaged nationally, and compound annual growth rate and Pearson correlation coefficient were used to characterize trends.</p><p><strong>Results: </strong>Between 2000 and 2023, Medicare reimbursement for thyroid surgeries decreased 38.7%, from $1517.59 to $929.55, when adjusted for inflation. The reimbursement for total thyroidectomy demonstrated the greatest decline at 47.8%, from $1803.16 to $942.07. Thyroid lobectomy and completion thyroidectomy both had reduced reimbursements at 41.7% (from $1250.38 to $729.02) and 25.5% (from $1499.26 to $1117.54), respectively. The compound annual growth rate for thyroid surgeries as a whole was 0.4% when not adjusted for inflation and -2.1% when adjusted for inflation. There was 0% growth in work relative value units between 2012 and 2023 for all thyroid surgeries.</p><p><strong>Conclusions and relevance: </strong>This economic evaluation found an almost 40% decrease in the rate of reimbursement for thyroid surgery, with total thyroidectomy having the greatest decrease at 47.8%. These findings provide evidence that current trends are not sustainable. Thyroid surgeons should take a proactive approach to improving reimbursements before these changes impact patient access to thyroid surgery.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Ossification of the Chorda Tympani Nerve by Photon-Counting CT.","authors":"Maria-Pia Tuset, Gabriel Garcia, Mary Daval, Julien Savatovsky, Denis Ayache, Guillaume Poillon","doi":"10.1001/jamaoto.2025.3570","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.3570","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}