JAMA otolaryngology-- head & neck surgery最新文献

{"title":"EORTC Quality-of-Life Questionnaire Responsiveness in Surgical Patients With Head and Neck Cancer.","authors":"Michael P Wu, Samir C Seshadri, Sarah Whittaker, Nadine McCleary, Ravindra Uppaluri, Eleni Rettig, Donald Annino, Laura Goguen, Rosh K V Sethi","doi":"10.1001/jamaoto.2024.5260","DOIUrl":"10.1001/jamaoto.2024.5260","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"409-411"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of 8 Smoking Metrics for Modeling Survival in Head and Neck Squamous Cell Carcinoma.","authors":"Andrew C L Lam, Katrina Hueniken, Martha Pienkowski, John J W Lee, Mei Dong, Brenda Diergaarde, Andrew F Olshan, Paul Brennan, Shama Virani, Deborah Saunders, Stacey A Santi, Michael S C Conlon, Tim Waterboer, D Neil Hayes, Miranda Pring, Gary J Macfarlane, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Antonio Agudo, Laia Alemany, Wolfgang Ahrens, Claire M Healy, David I Conway, Mari Nygard, Cristina Canova, Anna Hornakova, Lorenzo Richiardi, Ariana Znaor, Rayjean J Hung, Wei Xu, Geoffrey Liu","doi":"10.1001/jamaoto.2024.5392","DOIUrl":"10.1001/jamaoto.2024.5392","url":null,"abstract":"<p><strong>Importance: </strong>Cigarette smoking is a strong risk factor for mortality in patients diagnosed with head and neck squamous cell carcinoma (HNSCC). However, little evidence supports which smoking metric best models the association between smoking and survival in HNSCC.</p><p><strong>Objective: </strong>To determine which smoking metric best models a linear association between smoking exposure and overall survival (OS) in patients with HNSCC.</p><p><strong>Design, setting, and participants: </strong>A retrospective multicenter cohort study of 6 clinical epidemiological studies was performed. Five were part of the Human Papillomavirus, Oral and Oropharyngeal Cancer Genomic Research (VOYAGER) consortium. Participants included patients 18 years and older with pathologically confirmed HNSCC. Data were collected from January 2002 to December 2019, and data were analyzed between January 2022 to November 2024.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was OS. The performance of 8 smoking metrics, including pack-years, duration, and log cig-years (calculated as log10[cigarettes smoked per day + 1] × number of years smoked) for modeling OS were compared. Metric performance was measured by the strength of association in Cox proportional hazard models, linearity based on P for linear trend, Akaike information criterion (AIC; lower value indicates better model fit), and visual assessment of spline curves. Secondary outcomes included modeling OS in clinicodemographic subgroups and HNSCC anatomic subsites. Exploratory outcomes included cancer-specific survival and noncancer survival.</p><p><strong>Results: </strong>In total, 8875 patients with HNSCC (2114 [24%] female; median [IQR] age, 61 [54-69] years) were included. Of 8 smoking metrics evaluated, smoking duration (adjusted hazard ratio [aHR], 1.11 [95% CI, 1.03-1.19]) and log cig-years (aHR, 1.11 [95% CI, 1.04-1.18]) had the highest aHRs; both had a statistically significant linear association with OS. Log cig-years had the lowest AIC linear value and the most visually linear spline curve when modeling OS. Duration and log cig-years outperformed pack-years for modeling OS regardless of age, smoking status, and cancer stage. Both performed well in lip and oral cavity, laryngeal (only duration was significant), and human papillomavirus-negative oropharyngeal subsites. In an exploratory analysis, duration had the highest aHR (1.15 [95% CI, 1.02-1.29]), and log cig-years had the lowest AIC linear value when modeling noncancer survival.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, smoking duration and log cig-years best modeled a linear relationship with OS for patients with HNSCC. Both metrics maintained robust performance within specific clinicodemographic subgroups and anatomic subsites. Although most HNSCC survival models control for smoking exposure using smoking status or pack-years, duration and log cig-years may be superior metrics to ","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"360-370"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns Regarding Mouth Closure and Airflow in Obstructive Sleep Apnea-Reply.","authors":"Daniel Vena, Hyung Chae Yang, Scott A Sands","doi":"10.1001/jamaoto.2024.5076","DOIUrl":"10.1001/jamaoto.2024.5076","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"415-416"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to Work Up to 5 Years After the End of Treatment Among Patients With Head and Neck Cancer.","authors":"Femke Jansen, Simone E J Eerenstein, Sara Arman, Birgit I Lissenberg-Witte, Jose A Hardillo, Robert P Takes, Ruud H Brakenhoff, Remco de Bree, Femke Lamers, Johannes A Langendijk, C René Leemans, Irma M Verdonck-de Leeuw","doi":"10.1001/jamaoto.2024.4991","DOIUrl":"10.1001/jamaoto.2024.4991","url":null,"abstract":"<p><strong>Importance: </strong>Adverse effects of cancer and its treatment may hamper return to work (RTW) among patients with head and neck cancer (HNC).</p><p><strong>Objectives: </strong>To investigate RTW among patients with HNC from end of treatment to 5 years after treatment and associations of RTW with sociodemographic, clinical, work-related, personal, lifestyle, physical, and psychological factors and cancer-related symptoms.</p><p><strong>Design, setting and participants: </strong>This prospective, longitudinal, multicenter cohort study of patients with HNC used data from the Netherlands Quality of Life and Biomedical cohort. This study focused on patients younger than 65 years (with a subanalysis of patients younger than 60 years) from time of cancer diagnosis (March 2014 to June 2018) to 5 years after end of treatment (January 2019 to July 2023). Data analysis occurred from April 2023 to August 2024.</p><p><strong>Exposure: </strong>Standard clinical care.</p><p><strong>Main outcomes and measures: </strong>Work status was measured at 3 and 6 months, and 1, 2, 3, 4, and 5 years after treatment using an adjusted version of the Productivity Cost Questionnaire. Cox regression analyses were performed to investigate factors (baseline, 3 months, and 6 months) associated with time to RTW.</p><p><strong>Results: </strong>A total of 184 patients with HNC younger than 65 years (mean [SD] age, 55.4 [7.0] years; 146 men [79%]) were included and 77 (42%) had oropharyngeal cancer. RTW increased from 26% (42 of 160 individuals) at 3 months to 65% (89 of 137 individuals) at 1 year, after which it reduced to 52% (51 of 98 individuals) at 5 years. At 5 years after treatment, an additional 28 of 98 participants (29%) were retired. Minor surgery (vs major surgery) was associated with faster RTW from end of treatment onwards (hazard ratio [HR], 2.73; 95% CI, 1.17-6.37). Older age (HR, 0.97; 95% CI, 0.94-0.999) and more fatigue at 3 months (HR, 0.99; 95% CI, 0.98-0.995) were associated with slower RTW from 3 months onwards. Older age was also associated with slower RTW from 6 months onwards (HR, 0.96; 95% CI, 0.93-0.998). Among the 127 patients with HNC younger than 60 years, RTW was 72% (47 individuals) at 5 years after treatment. Advanced tumor stage (HR, 0.59; 95% CI, 0.39-0.90) and more fatigue (HR, 0.99; 95% CI, 0.98-0.999) were associated with slower RTW in this group.</p><p><strong>Conclusion and relevance: </strong>This cohort study found that the majority of patients with HNC in the Netherlands returned to work within 1 year and that certain sociodemographic and clinical factors and cancer-related symptoms were associated with time to RTW. These results may inform patients with HNC and provide insight into potential targets, such as fatigue, to improve RTW.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"297-310"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of Bleeding From Pterygopalatal Injection: A Systematic Review and Meta-Analysis.","authors":"Sung Ryul Shim, Jieun Shin, Cheol Mog Hwang, Yong Kyun Kim, Jong Bum Park, Jong-Yeup Kim","doi":"10.1001/jamaoto.2024.5047","DOIUrl":"10.1001/jamaoto.2024.5047","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Endoscopic sinus surgery (ESS) is a minimally invasive surgical method that is widely used in the treatment of various sinonasal conditions, including chronic sinusitis, nasal polyps, and fungal sinusitis. However, intraoperative bleeding remains a significant challenge.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effects of pterygopalatal injections with lidocaine and adrenaline during sinus surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data sources: &lt;/strong&gt;PubMed/MEDLINE, the Cochrane Library, and EMBASE were systematically searched from database inception through July 31, 2024. Two authors also manually and independently searched all relevant studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study selection: &lt;/strong&gt;Randomized clinical trials with (1) patients diagnosed with sinusitis; (2) interventions that included pterygopalatal injections with lidocaine and adrenaline; (3) comparisons that were specified as normal saline or no injection; and (4) outcomes that used subjective scores (Boezaart surgical field grading [BSFG]) and objective markers (amount of bleeding, duration of surgery, and mean arterial pressure [MAP]).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data extraction and synthesis: &lt;/strong&gt;Data extraction was completed independently by 2 extractors and cross-checked for research integrity. The pairwise meta-analysis was performed to compare the treatment group with control used in ESS. Hedges g standardized mean differences (SMDs) and mean differences (MDs) were used for improvement in all outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;Efficacy outcomes included subjective scores, such as BSFG, as well as objective markers measuring amount of bleeding, duration of surgery, and MAP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A comprehensive literature search identified 322 patients from 7 studies. The studies were conducted in Australia, Canada, Egypt, India, and Iran. The mean age range was 30 to 48.8 years, and 36.7% to 66.7% of the study populations were male. In most studies, the observation time of BSFG was measured at 15-minute intervals and measured from a minimum of 15 minutes to a maximum of 150 minutes. The pooled SMD for BSFG between treatments vs the control group was -1.01 (95% CI, -1.72 to -0.30), indicating that pterygopalatal injection with lidocaine and adrenaline was associated with improvement in the surgical field condition. The pooled MD for MAP between treatments vs the control group was -0.49 mm Hg (95% CI, -0.91 to -0.07), indicating that pterygopalatal injection was associated with significantly reduced MAP. The pooled MD for amount of bleeding between treatments vs the control group was -9.47 mL (95% CI, -29.05 to 10.11), and the pooled MD for duration of surgery between treatments vs the control group was -4.28 minutes (95% CI, -12.85 to 4.29), indicating that that this technique was not significantly associated with amount of bleeding or duration of surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;The findings of this systemat","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"389-395"},"PeriodicalIF":6.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JAMA Otolaryngology-Head & Neck Surgery Peer Reviewers in 2024.","authors":"","doi":"10.1001/jamaoto.2025.0271","DOIUrl":"https://doi.org/10.1001/jamaoto.2025.0271","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"e250271"},"PeriodicalIF":6.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and Outcomes of Intraoperative Nerve Monitoring During Thyroidectomy.","authors":"Madison Hearn, Bin You, Leila J Mady, Kaitlyn M Frazier, Lilah Morris-Wiseman, Aarti Mathur","doi":"10.1001/jamaoto.2024.4452","DOIUrl":"10.1001/jamaoto.2024.4452","url":null,"abstract":"<p><strong>Importance: </strong>Intraoperative nerve monitoring (IONM) is not considered standard of care during thyroidectomy, and guidelines are vague about its use in the absence of strong evidence of superiority over visualization of the recurrent laryngeal nerve (RLN) alone.</p><p><strong>Objective: </strong>To characterize patterns of IONM use during thyroidectomy in the US and evaluate the association of IONM with postoperative outcomes.</p><p><strong>Design, setting, and participants: </strong>This cohort study used the National Surgical Quality Improvement Program (NSQIP) thyroidectomy data from January 1, 2016, to December 31, 2022. A nationally representative sample included adult patients without poorly differentiated thyroid cancer who underwent thyroidectomy at multiple centers. Data were collected from the time of surgery until 30 postoperative days through January 31, 2023.</p><p><strong>Exposure: </strong>IONM during thyroidectomy.</p><p><strong>Main outcomes and measures: </strong>Prevalence of IONM during thyroidectomy and postoperative outcomes including RLN injury, hypocalcemia, and neck hematoma.</p><p><strong>Results: </strong>A total of 44 265 patients undergoing thyroidectomy were included (77.2% female; mean [SD] age, 51.8 [15.2] years), with 30 633 (69.2%) using IONM. Common indications for surgery in the cohort were goiter (35.3%) and a single nodule or neoplasm (39.2%). The prevalence of IONM increased from 62.5% in 2016 to 75.9% in 2022. RLN injury occurred in 6.0% of cases. On propensity score-matched analyses, IONM was associated with decreased odds of RLN injury overall (adjusted odds ratio [AOR], 0.98; 95% CI, 0.97-0.99) and decreased odds among patients with differentiated thyroid cancer (AOR, 0.96; 95% CI, 0.94-0.99). IONM was not associated with postoperative hypocalcemia (AOR, 0.99; 95% CI, 0.99-1.00) or neck hematoma (AOR, 1.00; 95% CI, 0.99-1.00).</p><p><strong>Conclusions and relevance: </strong>This cohort study found that IONM during thyroidectomy has become routine, and use has increased over the last 7 years. IONM was associated with a slightly decreased odds of RLN injury, but no difference in hypocalcemia or neck hematoma. Although IONM use is widespread, further research is needed to identify patients who would benefit the most from this technology.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"236-242"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Third Proceedings of The North American Airway Collaborative (NoAAC): Consensus Statement on Trial Design for Airway Stenosis.","authors":"Ruth J Davis, Lee M Akst, Clint T Allen, Richard J Battafarano, Hayley L Born, Paul C Bryson, Matthew S Clary, Tyler Crosby, Vaninder K Dhillon, Greg Dion, Hannah Kavookjian, Kevin P Leahy, Ioan Lina, Natasha Mirza, Robert J Morrison, Kevin M Motz, Rebecca C Nelson, Diego Preciado, Kishore Sandu, Joseph R Spiegel, Jonathan Walsh, Alexander T Hillel, Alexander Gelbard","doi":"10.1001/jamaoto.2024.4963","DOIUrl":"10.1001/jamaoto.2024.4963","url":null,"abstract":"<p><strong>Importance: </strong>Airway stenosis is a rare but debilitating disorder that significantly degrades the quality of life in affected patients. Treatments are primarily surgical, and disease management lacks established medical therapies. The North American Airway Collaborative held its third symposium at The Johns Hopkins Hospital in Baltimore, Maryland, on April 15, 2024, focused on strategies to advance the care of these patients. The proceedings summarize the discussion of trial design in airway stenosis and the resulting North American Airway Collaborative consensus regarding clinical end points for rigorous study of novel therapies.</p><p><strong>Observations: </strong>The lectures and panels centered on the translation of a growing body of preclinical data into therapeutic targets. Additionally, detailed discussion explored design of clinical trials to evaluate safety and efficacy of novel therapeutics. The need for a consensus regarding clinically meaningful end points in airway stenosis was identified to facilitate the comparison of outcomes across institutions and future multi-institutional trials.</p><p><strong>Conclusions and relevance: </strong>The group achieved consensus regarding change in peak expiratory flow as the primary clinical end point in airway stenosis. Additional clinical measures, such as disease recurrence (identified as time to recurrent intervention), anatomical characterization of subglottic scar via axial computed tomography imaging, and patient-reported outcome measures (Clinical COPD Questionnaire [CCQ], Voice Handicap Index-10 [VHI-10], Eating Assessment Tool-10 [EAT-10], and 12-Item Short-Form Health Survey, version 2 [SF-12]) were identified as essential secondary outcomes.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"263-267"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant GLP-1 Receptor Agonists in Sleep Surgery.","authors":"Ryan Chin Taw Cheong, Kenny Peter Pang","doi":"10.1001/jamaoto.2024.4593","DOIUrl":"10.1001/jamaoto.2024.4593","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"186-188"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residential Differences and Depression Among Older Adults With Dual Sensory Loss.","authors":"Ethan B Wang, Emmanuel E Garcia Morales, Alden L Gross, Frank R Lin, Nicholas S Reed, Jennifer A Deal","doi":"10.1001/jamaoto.2024.4488","DOIUrl":"10.1001/jamaoto.2024.4488","url":null,"abstract":"<p><strong>Importance: </strong>Investigating rural-urban and regional differences in the association between dual sensory loss (concurrent hearing and vision loss) and depression may highlight gaps in sensory loss research and health care services, and by socioeconomic status. Whether urbanicity and region may modify associations between sensory loss and depression is unknown.</p><p><strong>Objective: </strong>To describe the rural-urban and regional differences in the association of dual sensory loss with depression among older adults.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional study used data from wave 1 (April 2017-December 2019) of the population-based Longitudinal Aging Study in India (LASI). Participants were recruited from 35 states and union territories in India. LASI incorporated a multistage stratified area probability cluster sampling design to recruit participants 45 years and older and their spouses; 31 447 eligible participants 60 years of age or older were interviewed. Data analyses were conducted from May 17, 2022, to November 11, 2023.</p><p><strong>Exposures: </strong>Sensory loss (no sensory loss, hearing loss only, vision loss only, and dual sensory loss) was determined by respondents' self-reported perceived difficulty regarding hearing and vision function.</p><p><strong>Main outcomes and measures: </strong>The Composite International Diagnostic Interview (CIDI-SF) scale was used to identify major episodic depression. Logistic regression was used to estimate the odds ratios (ORs) and 95% CIs of depression comparing participants with vs without sensory loss, adjusting for demographic and clinical covariates. Rural-urban and regional differences were assessed by including interaction terms between these variables and sensory loss.</p><p><strong>Results: </strong>The study analysis included 27 927 participants (mean [SD] age, 68.0 [7.2] years; 14 477 [51%] females and 13 450 [49%] males). The fully adjusted models showed that the odds of depression with dual sensory loss (vs no loss) was higher in urban (OR, 3.16; 95% CI, 2.00-4.99) vs rural (OR, 1.73; 95% CI, 1.31-2.29) residents and among residents in the West (OR, 5.10; 95% CI, 1.74-14.97) vs North (OR, 1.38; 95% CI, 0.81-2.35) regions.</p><p><strong>Conclusions and relevance: </strong>These findings indicate that sensory loss is associated with depression in older adults, with differences by urbanicity and region. Adults with sensory loss across multiple systems may be an important group to target for intervention.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":"202-210"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}