JAMA otolaryngology-- head & neck surgery最新文献

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Application of a Pediatric Tracheostomy-Specific Risk Tier System Using Administrative Data. 使用管理数据的儿科气管切开术特定风险分级系统的应用。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-24 DOI: 10.1001/jamaoto.2026.2840
Romaine F Johnson, Isabella Zaniletti, Cynthia S Wang, Yann-Fuu Kou, Stephen R Chorney
{"title":"Application of a Pediatric Tracheostomy-Specific Risk Tier System Using Administrative Data.","authors":"Romaine F Johnson, Isabella Zaniletti, Cynthia S Wang, Yann-Fuu Kou, Stephen R Chorney","doi":"10.1001/jamaoto.2026.2840","DOIUrl":"10.1001/jamaoto.2026.2840","url":null,"abstract":"<p><strong>Importance: </strong>Children undergoing tracheostomy have heterogeneous clinical profiles, yet no scalable, tracheostomy-specific system exists to stratify risk using administrative data. General severity measures such as All Patient Refined Diagnosis Related Group (APR-DRG) provide limited case mix differentiation for this population.</p><p><strong>Objective: </strong>To evaluate whether a literature-derived, tracheostomy-specific risk-tier system improves stratification of pediatric index hospitalization outcomes compared with APR-DRG severity classification.</p><p><strong>Design, setting, and participants: </strong>In this retrospective cohort study using the Pediatric Health Information System database, participants were children younger than 18 years undergoing index tracheostomy placement at 44 tertiary children's hospitals from January 1, 2016, through December 31, 2024, in the US.</p><p><strong>Main outcomes and measures: </strong>The primary outcomes were prolonged length of stay (greater than 90 days) and in-hospital mortality. Risk stratification was assessed by separation of outcomes across proposed tiers (standard, moderate, or critical risk) and supported by discrimination metrics (C statistics).</p><p><strong>Results: </strong>Among 14 275 patients (6027 female [42.2%]; 8237 male [57.7%]; median [IQR] age, 0 [0-7] years), 3431 (24%) were in the critical-risk tier, 9363 (66%) in the moderate-risk tier, and 1481 (10%) in the standard-risk tier. The median (IQR) length of stay increased from 34 (16-69) days (standard-risk tier) to 105 (54-192) days (moderate-risk tier) to 173 (104-263) days (critical-risk tier). Mortality increased from 70 (4.7%) in the standard-risk tier to 710 (7.6%) in the moderate-risk tier to 554 (16.1%) in the critical-risk tier. The tier system C statistic was 0.665 (95% CI, 0.658-0.672) for prolonged hospitalization and 0.608 (95% CI, 0.594-0.622) for mortality, compared with 0.521 (95% CI, 0.519-0.524) and 0.509 (95% CI, 0.507-0.511) for APR-DRG. Intraclass correlation coefficients were 0.065 (95% CI, -0.214 to 0.335) for prolonged stay and 0.005 (95% CI, -0.001 to 0.011) for mortality. The intraclass coefficient is bounded at 0. The negative lower limit reflects the Wald approximation for a variance component estimated near zero, not a genuinely negative correlation, consistent with negligible between-hospital variance.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, a tracheostomy-specific risk-tier system using administrative data provides meaningful case mix stratification for pediatric tracheostomy hospitalizations and outperforms general severity classification. This approach may support risk-adjusted benchmarking and multicenter comparisons, though modest discrimination limits individual-level prognostic use and warrants further validation.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three Pillars of Effective Scientific Communication: Telling the Story. 有效科学传播的三大支柱:讲故事。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-17 DOI: 10.1001/jamaoto.2026.2891
Jay F Piccirillo, Randy Olson
{"title":"Three Pillars of Effective Scientific Communication: Telling the Story.","authors":"Jay F Piccirillo, Randy Olson","doi":"10.1001/jamaoto.2026.2891","DOIUrl":"https://doi.org/10.1001/jamaoto.2026.2891","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suzetrigine for Postoperative Pain in Head and Neck Free Flap or Transoral Robotic Surgery. 苏泽三嗪治疗头颈部游离皮瓣或经口机器人手术术后疼痛。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-17 DOI: 10.1001/jamaoto.2026.2673
Daniel E Bestourous, Silvia Soule, Jacob Beiriger, Brayden Seliger, Austin Tautfest, Larkin Harris, Rich Bavier, Sarah Drejet, Richard B Cannon, Marcus M Monroe, Luke O Buchmann, Jason P Hunt, Hilary C McCrary
{"title":"Suzetrigine for Postoperative Pain in Head and Neck Free Flap or Transoral Robotic Surgery.","authors":"Daniel E Bestourous, Silvia Soule, Jacob Beiriger, Brayden Seliger, Austin Tautfest, Larkin Harris, Rich Bavier, Sarah Drejet, Richard B Cannon, Marcus M Monroe, Luke O Buchmann, Jason P Hunt, Hilary C McCrary","doi":"10.1001/jamaoto.2026.2673","DOIUrl":"10.1001/jamaoto.2026.2673","url":null,"abstract":"<p><strong>Importance: </strong>Postoperative pain after head and neck surgery frequently necessitates opioid analgesia despite multimodal pain regimens. Suzetrigine, a selective NaV1.8 inhibitor that was recently approved in the US for acute postoperative pain, may reduce postoperative opioid requirements. However, the current surgical literature regarding suzetrigine use after head and neck surgery is limited.</p><p><strong>Objective: </strong>To evaluate the association of adjunctive suzetrigine use with postoperative opioid consumption after head and neck free flap reconstruction and transoral robotic surgery.</p><p><strong>Design, setting, and participants: </strong>This was a retrospective cohort study conducted at a single tertiary academic referral center of adult patients undergoing head and neck free flap reconstruction or transoral robotic surgery from January 1 to December 31, 2025. Patients with chronic high-dose opioid use, chronic pain disorders, liver dysfunction, or unavailable opioid data were excluded.</p><p><strong>Exposure: </strong>Protocolized multimodal analgesic regimen with or without adjunctive suzetrigine.</p><p><strong>Main outcomes and measures: </strong>Total inpatient morphine milligram equivalents (MMEs) consumed and MME consumption per hospital day. Secondary outcomes included hospital length of stay, 30-day readmissions, emergency department visits, oral intake consumption, postoperative pain scores, and medication-related adverse events.</p><p><strong>Results: </strong>Of 146 patients (mean [SD] age, 62.8 [13.9] years; 48 female [32.9%] and 98 male [67.1%]) included in the analysis, 41 (28.1%) received suzetrigine plus multimodal analgesia and 105 (71.9%) received standard multimodal analgesia; 114 (78.1%) underwent free flap reconstruction and 32 (21.9%) underwent transoral robotic surgery. Median inpatient opioid use was lower among patients in the free flap group receiving suzetrigine compared with those in the control (109.0 vs 142.1 MMEs; median difference, -50.0; 95% CI, -119.0 to -5.1). Among patients undergoing transoral robotic surgery, suzetrigine was associated with lower inpatient opioid use (29.0 vs 108.9 MMEs; median difference, -56.0; 95% CI, -110.0 to -5.5). Suzetrigine remained independently associated with lower opioid use after multivariable adjustment (adjusted median difference, -76.4 MMEs; 95% CI, -138.8 to -13.9). Postoperative pain scores were similar between groups. No medication-related adverse events were identified.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, adjunctive suzetrigine use was associated with lower postoperative opioid requirements after head and neck free flap reconstruction and transoral robotic surgery. Given the retrospective, nonrandomized design, these findings should be interpreted as associations warranting prospective confirmation.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Error in First Authorship. 第一作者错误。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-17 DOI: 10.1001/jamaoto.2026.3031
{"title":"Error in First Authorship.","authors":"","doi":"10.1001/jamaoto.2026.3031","DOIUrl":"10.1001/jamaoto.2026.3031","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suzetrigine in Head and Neck Surgery: A New Frontier in Opioid Stewardship. 苏泽三嗪在头颈部手术中的应用:阿片类药物管理的新领域。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-17 DOI: 10.1001/jamaoto.2026.2664
Aditi Mukkara, Neel R Sangal
{"title":"Suzetrigine in Head and Neck Surgery: A New Frontier in Opioid Stewardship.","authors":"Aditi Mukkara, Neel R Sangal","doi":"10.1001/jamaoto.2026.2664","DOIUrl":"https://doi.org/10.1001/jamaoto.2026.2664","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Newborn Hearing Screening in the Otoferlin Gene Therapy Era. Otoferlin基因治疗时代新生儿听力筛查。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-17 DOI: 10.1001/jamaoto.2026.2695
Dana S Guggenheim, Kathleen C Y Sie, Lawrence R Lustig, Justin S Golub
{"title":"Newborn Hearing Screening in the Otoferlin Gene Therapy Era.","authors":"Dana S Guggenheim, Kathleen C Y Sie, Lawrence R Lustig, Justin S Golub","doi":"10.1001/jamaoto.2026.2695","DOIUrl":"https://doi.org/10.1001/jamaoto.2026.2695","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incremental Prognostic Value of Electrodiagnostic Results Beyond House-Brackmann Grade in Bell Palsy. 超过House-Brackmann分级的电诊断结果对贝尔性麻痹的增量预测价值。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-10 DOI: 10.1001/jamaoto.2026.2645
Wonwoo Chang, Hyeonji Oh, Ah-Hyeon Kim, Sujin Jeong, Seongmin Choi, Myung Chul Yoo
{"title":"Incremental Prognostic Value of Electrodiagnostic Results Beyond House-Brackmann Grade in Bell Palsy.","authors":"Wonwoo Chang, Hyeonji Oh, Ah-Hyeon Kim, Sujin Jeong, Seongmin Choi, Myung Chul Yoo","doi":"10.1001/jamaoto.2026.2645","DOIUrl":"10.1001/jamaoto.2026.2645","url":null,"abstract":"<p><strong>Importance: </strong>Current guidelines recommend electrodiagnostic testing in Bell palsy primarily for patients with complete or near-complete facial paralysis (House-Brackmann [H-B] grade V-VI). It is unclear whether patients with moderate paralysis (H-B grade IV) would benefit from this testing.</p><p><strong>Objective: </strong>To quantify the incremental prognostic value of electrodiagnostic findings beyond initial H-B grade for 6-month recovery from Bell palsy, including in moderate paralysis.</p><p><strong>Design, setting, and participants: </strong>This single-center cohort study included adults with acute Bell palsy between January 2010 and December 2025 who underwent standardized 4-branch electroneuronography and needle electromyography approximately 14 days after onset. Patients with Ramsay Hunt syndrome, bilateral palsy, or incomplete corticosteroid treatment were excluded.</p><p><strong>Exposures: </strong>An electroneuronography degeneration index (ENoG DI) of 90% or greater in any facial muscle branch, complete denervation (no voluntary motor unit activity on needle electromyography), and co-occurrence in the same muscle.</p><p><strong>Main outcomes and measures: </strong>Incomplete recovery at 6 months was defined as final H-B grade II or higher. Adjusted odds ratios (AORs) were estimated using Firth penalized logistic regression, overall and stratified by initial H-B grade. Incremental prognostic value was assessed by change in area under the receiver operating characteristic curve (ΔAUROC).</p><p><strong>Results: </strong>Of 3506 patients (mean [SD] age, 50.8 [17.0] years; 1878 [53.6%] female), 1891 (53.9%) completed 6-month follow-up; 1040 (55.0%) had incomplete recovery. Overall, ENoG DI of 90% or greater in any branch (AOR, 4.96; 95% CI, 3.97-6.19) and complete denervation (AOR, 5.91; 95% CI, 4.06-8.60) were independently associated with incomplete recovery; in initial H-B grade IV, both remained associated (AOR, 3.19; 95% CI, 2.00-5.11 and AOR, 3.17; 95% CI, 1.03-9.78, respectively). Co-occurrence of both findings had the highest odds of incomplete recovery in all patients (AOR, 8.41; 95% CI, 5.46-12.95) and in patients with initial H-B grade IV (AOR, 3.10; 95% CI, 1.01-9.54). Adding ENoG DI findings to initial H-B grade improved model discrimination (AUROC, 0.78 [95% CI, 0.76-0.80] vs 0.72 [95% CI, 0.70-0.74]; ΔAUROC, 0.06; 95% CI, 0.04-0.07).</p><p><strong>Conclusions and relevance: </strong>In this cohort study, ENoG DI of 90% or greater and complete denervation were independently associated with incomplete recovery even in moderate paralysis. These findings suggest that electrodiagnostic results may refine prognostic assessment in selected patients with moderate paralysis and warrant prospective validation before broader clinical application.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Pesticide Exposure Events and Self-Reported and Measured Olfactory Dysfunction. 高农药暴露事件与自我报告和测量的嗅觉功能障碍。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-10 DOI: 10.1001/jamaoto.2026.2605
Shengfang Song, Brenda L Plassman, Yaqun Yuan, Zhehui Luo, Jayant M Pinto, Christine G Parks, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler, Honglei Chen
{"title":"High Pesticide Exposure Events and Self-Reported and Measured Olfactory Dysfunction.","authors":"Shengfang Song, Brenda L Plassman, Yaqun Yuan, Zhehui Luo, Jayant M Pinto, Christine G Parks, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler, Honglei Chen","doi":"10.1001/jamaoto.2026.2605","DOIUrl":"10.1001/jamaoto.2026.2605","url":null,"abstract":"<p><strong>Importance: </strong>Pesticide exposure may contribute to olfactory dysfunction in adults, but empirical evidence is limited.</p><p><strong>Objectives: </strong>To examine the association between high pesticide exposure events and olfactory dysfunction in farmers.</p><p><strong>Design, setting, and participants: </strong>This survey study used data from a subcohort of the Agricultural Health Study (AHS), the Pesticide and Sense of Smell (PASS) Study, conducted from January 2020 to October 2021. Participants included farmers from Iowa and North Carolina, were alive as of June 2019, and either reported olfactory dysfunction in the AHS phase 4 survey or were randomly sampled from those reporting normal olfaction. Statistical analysis was conducted from August 2023 to December 2025.</p><p><strong>Exposure: </strong>High pesticide exposure events self-reported in the PASS Study and the AHS phase 1 through 3 surveys.</p><p><strong>Main outcomes and measures: </strong>The main outcome was olfactory dysfunction first self-reported and then measured using the 12-item Brief Smell Identification Test (defined as a score ≤8). To extrapolate PASS Study findings to the target population, inverse probability weights were constructed to account for death and study nonparticipation.</p><p><strong>Results: </strong>This analysis included 2545 of 4629 farmers (55.0%) who completed the study activities, including a survey and a smell identification test (mean [SD] age, 70.3 [9.6] years; 2467 [96.9%] male). The weighted prevalence of self-reported olfactory dysfunction was 21.2% (95% CI, 18.1%-24.3%) among farmers with a history of HPEEs and 15.1% (95% CI, 12.9%-17.3%) among those without, corresponding to a relative risk (RR) of 1.30 (95% CI, 1.04-1.62). The exposure was not associated with olfactory dysfunction identified from the smell test (RR, 0.97; 95% CI, 0.83-1.15) or with the farmers' perceived testing experience, including reporting substantial difficulty in identifying odorants (RR, 0.94; 95% CI, 0.78-1.13) and reporting the odorants as weak (RR, 1.01; 95% CI, 0.78-1.30). Results were similar when using exposure data from previous AHS surveys.</p><p><strong>Conclusions and relevance: </strong>This survey study found that HPEEs were associated with subjective reports of olfactory loss among farmers but not with their measured smell identification. These findings underscore the importance of incorporating both objective and subjective measures of olfaction in epidemiologic research.</p>","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compartment-Specific Recurrence in Medullary Thyroid Cancer. 甲状腺髓样癌的室特异性复发。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-03 DOI: 10.1001/jamaoto.2026.2597
Young-Ji Seo, Kelsey N Larios, Yifan V Mao, Yehia K Elkersh, Bryce England, Elena G Hughes, Alexandra N Lim, Jiyoon Kim, Masha J Livhits, Michael W Yeh, Trevor E Angell, Q Lina Hu-Bianco, Denise Lee, James X Wu
{"title":"Compartment-Specific Recurrence in Medullary Thyroid Cancer.","authors":"Young-Ji Seo, Kelsey N Larios, Yifan V Mao, Yehia K Elkersh, Bryce England, Elena G Hughes, Alexandra N Lim, Jiyoon Kim, Masha J Livhits, Michael W Yeh, Trevor E Angell, Q Lina Hu-Bianco, Denise Lee, James X Wu","doi":"10.1001/jamaoto.2026.2597","DOIUrl":"10.1001/jamaoto.2026.2597","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Total thyroidectomy with bilateral central neck dissection is recommended for medullary thyroid carcinoma (MTC), even in patients without clinical nodal involvement. However, the role of contralateral prophylactic central neck dissection (pCND) remains debated, leading to variations in practice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the outcomes of nodal dissection in compartment-specific recurrence in patients undergoing surgical treatment for MTC, including a subgroup analysis of patients with preoperative clinically node-negative (cN0) disease stratified by whether they underwent contralateral pCND.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This was a multicenter retrospective cohort study of adult patients with MTC who underwent thyroidectomy between 1998 and 2021 in 4 academic referral centers. Data were analyzed from February to July 2026. Patients with missing operative data, including initial thyroidectomy information and central neck dissection laterality, were excluded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;Contralateral pCND at the time of initial surgical treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;Recurrence categorized as biochemical (calcitonin &gt;2 pg/mL without radiographic findings); ipsilateral central, ipsilateral lateral, contralateral central, and contralateral lateral neck; and distant metastatic. Effect size was reported as Rosenthal r (r) for continuous variables and as risk difference (RD) with 95% CIs for categorical variables. Multivariable Cox regression was used to evaluate risk factors for contralateral neck recurrence and overall recurrence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study in a total of 235 patients who underwent surgical treatment for MTC (132 [56%] female; median age, 56 years [IQR, 43-66 years]) found that, preoperatively, 105 patients (45%) had cN0 disease, of whom 58 (55%) underwent contralateral pCND. Genetic testing was performed in 127 (54%) patients, with a 25% rate of germline RET variant. Overall, 73 patients (31%) developed disease recurrence: 15% in the ipsilateral central, 15% ipsilateral lateral, 5% contralateral central, and 8% contralateral lateral neck; 11% distant metastatic; and 4% biochemical. Among patients with cN0 disease, differences in the rates of overall recurrence (22% vs 15%; RD, 0.07; 95% CI, -0.07 to 0.22) and contralateral central neck recurrence (5% vs 2%; RD, 0.03; 95% CI, -0.04 to 0.10) were small and imprecisely estimated between those who did and did not undergo contralateral pCND. On multivariable analysis adjusting for sex, tumor size, and nodal involvement, contralateral pCND was not associated with reduced overall recurrence (hazard ratio [HR], 0.59; 95% CI, 0.21-1.62) or contralateral neck recurrence (HR, 0.23; 95% CI, 0.02-3.08).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;This study found that, in MTC, the most frequent sites of recurrence were the ipsilateral central and lateral neck. Co","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Limits of Cost-of-Care Conversations-Managing Expectations. 了解医疗费用对话的局限性——管理期望。
IF 7 1区 医学
JAMA otolaryngology-- head & neck surgery Pub Date : 2026-09-03 DOI: 10.1001/jamaoto.2026.2564
Leila J Mady, Seema Kacker
{"title":"Understanding Limits of Cost-of-Care Conversations-Managing Expectations.","authors":"Leila J Mady, Seema Kacker","doi":"10.1001/jamaoto.2026.2564","DOIUrl":"https://doi.org/10.1001/jamaoto.2026.2564","url":null,"abstract":"","PeriodicalId":14632,"journal":{"name":"JAMA otolaryngology-- head & neck surgery","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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