ISJ-Invertebrate Survival Journal最新文献

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The immunosuppressive effects of continuous CpG ODNs stimulation in chinese mitten crab, Eriocheir sinensis 连续刺激CpG ODNs对中华绒螯蟹的免疫抑制作用
IF 0.7 4区 农林科学
ISJ-Invertebrate Survival Journal Pub Date : 2016-02-04 DOI: 10.25431/1824-307X/ISJ.V13I1.34-43
Depeng Zhao, L. Song, Rui-tian Liu, Zhongxiu Liang, L. Wang, Mingying Sun, B. Zhu
{"title":"The immunosuppressive effects of continuous CpG ODNs stimulation in chinese mitten crab, Eriocheir sinensis","authors":"Depeng Zhao, L. Song, Rui-tian Liu, Zhongxiu Liang, L. Wang, Mingying Sun, B. Zhu","doi":"10.25431/1824-307X/ISJ.V13I1.34-43","DOIUrl":"https://doi.org/10.25431/1824-307X/ISJ.V13I1.34-43","url":null,"abstract":"CpG oligodeoxynucleotides (CpG ODNs) have been widely used as a novel vaccine adjuvant inmammals due to its immune protection, long effectiveness and safety. In the present study, thelong-term immune effects as well as immunosuppression of CpG ODNs was evaluated by comparing the immune parameters of Chinese mitten crab, Eriocheir sinensis after continuous or interval feeding with CpG ODNs-supplement diet for 21 days (designated as CC and CI group, respectively). In the CI group, the mRNA transcripts of EsTolls (EsToll1 and EsToll2) and EsMyD88 (adaptor molecule) in hepatopancreas maintained at a significantly higher level (p < 0.05) compared with the CC group after 7 days and 14 days feeding, while there was no significant difference between them at the 21st day. Moreover, after a significant increase at 7th day, the expression level of EsLITAF mRNA [Lipopolysaccharide-induced tumor necrosis factor (TNF)-α] in CC group decreased at 14th-21st day, while that in CI group kept increasing at 14th day, followed by a decrease at 21st day. The TNF-α in plasma of CC group was abnormally increased at the 21st day (p < 0.05) in CC group compared with the significant raise at 7th-14th in CI group. Moreover, the phagocytic activity and reactive oxygens (ROS) level of hemocytes in continuous CpG ODNs feeding crabs were significantly lower than those in interval feeding crabs. These results indicated that long-term and continuous CpG ODNs stimulation could reduce the activation of pro-inflammatory cytokine production, hemocyte phagocytosis and ROS generation, displaying immunosuppressive effects on the immune system of crabs.","PeriodicalId":14623,"journal":{"name":"ISJ-Invertebrate Survival Journal","volume":"265 1","pages":"34-43"},"PeriodicalIF":0.7,"publicationDate":"2016-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87827018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
ACTH in invertebrates: a molecule for all seasons 无脊椎动物的促肾上腺皮质激素:一种适用于所有季节的分子
IF 0.7 4区 农林科学
ISJ-Invertebrate Survival Journal Pub Date : 2016-01-29 DOI: 10.25431/1824-307X/ISJ.V13I1.28-33
D. Malagoli, E. Ottaviani
{"title":"ACTH in invertebrates: a molecule for all seasons","authors":"D. Malagoli, E. Ottaviani","doi":"10.25431/1824-307X/ISJ.V13I1.28-33","DOIUrl":"https://doi.org/10.25431/1824-307X/ISJ.V13I1.28-33","url":null,"abstract":"In vertebrate and invertebrate models, adrenocorticotropic hormone (ACTH) belongs to the melanocortin group of related peptides, which share a common precursor, pro-opiomelanocortin (POMC). Functional experiments indicate that in invertebrates, ACTH plays a major role in several biological functions. ACTH, whose effects have been conserved during evolution more than its amino acidic sequence, is, directly or indirectly, able to contrast agents that perturb a body’s homeostasis. Here we review evidence highlighting the involvement of ACTH and ACTH-like molecules in the response of invertebrate models versus immune, environmental and parasitic challenges.","PeriodicalId":14623,"journal":{"name":"ISJ-Invertebrate Survival Journal","volume":"17 1","pages":"28-33"},"PeriodicalIF":0.7,"publicationDate":"2016-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81925945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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