无脊椎动物的促肾上腺皮质激素:一种适用于所有季节的分子

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2016-01-29 DOI:10.25431/1824-307X/ISJ.V13I1.28-33

D. Malagoli, E. Ottaviani

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引用次数: 2

摘要

在脊椎动物和无脊椎动物模型中，促肾上腺皮质激素(ACTH)属于黑素皮质素相关肽群，它们有一个共同的前体，促肾上腺皮质激素(POMC)。功能实验表明，在无脊椎动物中，ACTH在多种生物学功能中发挥重要作用。ACTH的作用在进化过程中比其氨基酸序列更保守，它能够直接或间接地与扰乱体内平衡的物质形成对比。在这里，我们回顾了强调ACTH和ACTH样分子参与无脊椎动物模型对免疫、环境和寄生挑战的反应的证据。

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ACTH in invertebrates: a molecule for all seasons

In vertebrate and invertebrate models, adrenocorticotropic hormone (ACTH) belongs to the melanocortin group of related peptides, which share a common precursor, pro-opiomelanocortin (POMC). Functional experiments indicate that in invertebrates, ACTH plays a major role in several biological functions. ACTH, whose effects have been conserved during evolution more than its amino acidic sequence, is, directly or indirectly, able to contrast agents that perturb a body’s homeostasis. Here we review evidence highlighting the involvement of ACTH and ACTH-like molecules in the response of invertebrate models versus immune, environmental and parasitic challenges.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.