JBMR Plus最新文献_第3页

Differential effects of romosozumab across central and peripheral skeletal sites: a prospective DXA and HR-pQCT study in high-risk postmenopausal osteoporosis. romosozumab在中枢性和外周性骨骼部位的差异效应：一项绝经后高危骨质疏松症的前瞻性DXA和HR-pQCT研究

IF 3

JBMR Plus Pub Date : 2026-05-17 eCollection Date: 2026-07-01 DOI: 10.1093/jbmrpl/ziag089

Ko Chiba, Naoko Uchida, Kayoko Ota, Mika Kono, Kounosuke Watanabe, Ryuji Niimi, Keisuke Tokunaga, Kazuteru Shiraishi, Makoto Osaki

{"title":"Differential effects of romosozumab across central and peripheral skeletal sites: a prospective DXA and HR-pQCT study in high-risk postmenopausal osteoporosis.","authors":"Ko Chiba, Naoko Uchida, Kayoko Ota, Mika Kono, Kounosuke Watanabe, Ryuji Niimi, Keisuke Tokunaga, Kazuteru Shiraishi, Makoto Osaki","doi":"10.1093/jbmrpl/ziag089","DOIUrl":"10.1093/jbmrpl/ziag089","url":null,"abstract":"Introduction: Romosozumab is known to markedly increase areal BMD (aBMD) at the LS and proximal femur assessed by DXA; however, its effects on peripheral volumetric BMD (vBMD) and bone microarchitecture measured by HR-pQCT remain incompletely characterized in postmenopausal women at very high fracture risk.Materials and methods: In this single-center, prospective longitudinal observational study, postmenopausal women with primary osteoporosis and a history of fragility fractures received romosozumab for 12 mo. DXA (LS, proximal femur, and radius) and HR-pQCT (distal radius and tibia) were performed at baseline and at 6 and 12 mo.Results: Twenty-five patients were enrolled; 22 completed 12 mo and were analyzed. LS (L1-L4) aBMD increased by 18.0% at 6 mo and 24.4% at 12 mo (both p < .001), whereas TH aBMD increased by 4.9% and 7.3%, respectively (p = .001 and p < .001). In contrast, radius aBMD did not change significantly at either the one-third distal or ultradistal sites. On HR-pQCT, cortical vBMD at distal radius decreased modestly (-1.0% at 6 mo, -1.2% at 12 mo, p = .001 and p = .002), while trabecular thickness increased at 12 mo (+2.0%, p = .001); no other parameters changed significantly at the distal radius. No significant changes in vBMD or bone microarchitecture were observed at the distal tibia.Discussion: These findings suggest that 12 mo of romosozumab treatment resulted in marked increases in central aBMD at the LS and proximal femur by DXA, while effects on peripheral aBMD, vBMD, and bone microarchitecture at the distal radius and tibia assessed by DXA and HR-pQCT were limited, suggesting site-specific skeletal responses.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 7","pages":"ziag089"},"PeriodicalIF":3.0,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional quantitative morphometric analysis (QMA) allows for reproducible and sensitive assessment of bone and joint in a preclinical mouse model of osteoarthritis. 三维定量形态计量学分析（QMA）允许在骨关节炎的临床前小鼠模型中对骨和关节进行可重复和敏感的评估。

IF 3

JBMR Plus Pub Date : 2026-05-13 eCollection Date: 2026-07-01 DOI: 10.1093/jbmrpl/ziag087

Han Liu, Pholpat Durongbhan, Catherine E Davey, Kathryn S Stok

{"title":"Three-dimensional quantitative morphometric analysis (QMA) allows for reproducible and sensitive assessment of bone and joint in a preclinical mouse model of osteoarthritis.","authors":"Han Liu, Pholpat Durongbhan, Catherine E Davey, Kathryn S Stok","doi":"10.1093/jbmrpl/ziag087","DOIUrl":"10.1093/jbmrpl/ziag087","url":null,"abstract":"Evidence suggests that subchondral bone and whole joint structure features can be used as morphological markers associated with early-stage osteoarthritis (OA). A three-dimensional quantitative morphometric analysis (3D QMA) was previously established and demonstrated to reproducibly quantify subchondral bone and whole joint structure in small animal models. This work evaluates the reproducibility of this previously defined 3D QMA in a mouse model of OA and characterizes the osteoarthritic changes to subchondral bone and whole joint structure. Thirty-five male C57BL/10 mice aged 9 wk were recruited and divided evenly into 5 cross-sectional groups. Of these, 14 10-wk-old mice were assigned to disease groups and underwent intraarticular injection of collagenase (CIOA) on the right knee joint to induce OA in the right tibiofemoral joint, and isotonic saline injected into the left contralateral knee joint. Animals were sacrificed at 3 time points (0, 4, and 8 wk) and scanned ex vivo repeatedly for five times with micro-CT (microCT). 3D QMA was performed, including subchondral cortical and epiphyseal bone measures, osteophyte detection and tibiofemoral joint metrics. The scan-rescan reproducibility of 3D QMA was tested on repeated microCT scans. Excellent reproducibility was obtained for all 3D QMA parameters, with ICC ranging from 0.771 to 0.999. Pathological changes caused by CIOA were characterized by measures of bone morphometry, osteophyte presence, as well as whole joint structure. Mechanical malalignment of tibiofemoral joint was observed in osteoarthritic joints, along with larger joint space width, reduced bone volume fraction, trabecular thinning predominantly in the lateral compartment, and osteophyte formation on medial joint margins.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 7","pages":"ziag087"},"PeriodicalIF":3.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional profiling of otic capsule and femur in the oim mouse model of osteogenesis imperfecta. 成骨不全小鼠模型中耳囊和股骨的转录谱分析。

IF 3

JBMR Plus Pub Date : 2026-05-13 eCollection Date: 2026-07-01 DOI: 10.1093/jbmrpl/ziag088

Ugur M Ayturk, Miracle Rogers, Ketsia Seide, David Oliver, Yurii Chinenov, Ezgi Aydin, Erin M Carter, Cathleen L Raggio

{"title":"Transcriptional profiling of otic capsule and femur in the oim mouse model of osteogenesis imperfecta.","authors":"Ugur M Ayturk, Miracle Rogers, Ketsia Seide, David Oliver, Yurii Chinenov, Ezgi Aydin, Erin M Carter, Cathleen L Raggio","doi":"10.1093/jbmrpl/ziag088","DOIUrl":"10.1093/jbmrpl/ziag088","url":null,"abstract":"Hearing loss is a common and debilitating complication of the brittle bone disorder osteogenesis imperfecta (OI). Existing treatments that are designed to address age-related hearing loss in the broader population do not meet the needs of OI patients, who exhibit skeletal fragility and begin to lose their hearing when they are young-adults. The biologic mechanisms responsible for hearing loss in OI are unknown, hindering the development of preventative therapies. To identify potential mechanisms that drive this condition, we performed transcriptome profiling on femoral and otic capsule specimens obtained from the Col1a2oim mouse model at 12- and 25-wk of age. We found that the bulk transcriptomes of femora and otic capsules were markedly different, regardless of mouse genotype. Further, bone formation-associated transcripts were reduced at 25-wk, compared to 12-wk. Mice homozygous for the oim mutation exhibited increased abundance of transcripts associated with osteoblast activity and type I collagen production compared to WT mice in both femoral and otic capsule specimens. The most notable difference between oim and WT mouse otic capsules was the depletion of the transcripts that encode mucin and keratin, suggesting dysregulation of epithelial cells, which has been previously linked to hearing loss. Our data offer new insights into the mechanisms that disrupt the middle ear in OI. Analysis of epithelial cells obtained from OI patients and additional models of OI could suggest novel strategies to prevent and/or treat hearing loss.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 7","pages":"ziag088"},"PeriodicalIF":3.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concerns regarding the critical evaluation of 3D-Shaper. 关于3D-Shaper的关键评估的关注。

IF 3

JBMR Plus Pub Date : 2026-05-13 eCollection Date: 2026-06-01 DOI: 10.1093/jbmrpl/ziag046

Ludovic Humbert, Sam Wilson

引用次数: 0

Bone fragility in a post-intestinal transplant patient with mesenteric heterotopic ossification. 肠移植后肠系膜异位骨化患者的骨脆性。

IF 3

JBMR Plus Pub Date : 2026-05-12 eCollection Date: 2026-06-01 DOI: 10.1093/jbmrpl/ziag082

Husam Hamshary, Dania S Bacha, Leila Z Khan

{"title":"Bone fragility in a post-intestinal transplant patient with mesenteric heterotopic ossification.","authors":"Husam Hamshary, Dania S Bacha, Leila Z Khan","doi":"10.1093/jbmrpl/ziag082","DOIUrl":"10.1093/jbmrpl/ziag082","url":null,"abstract":"Heterotopic ossification (HO) is the aberrant formation of mature lamellar bone in extraskeletal tissues, most commonly following trauma or surgery. Mesenteric involvement is rare and often discovered incidentally. We report the case of a 44-yr-old man with mesenteric HO in the setting of multiple emergent abdominal surgeries after a motor vehicle accident. Histopathology confirmed bone with cartilage and BM within the mesentery. He subsequently required an isolated small-intestinal transplantation for short gut syndrome. Following transplantation, the patient developed multiple vertebral compression fractures in the setting of bone fragility due to chronic antirejection medications and high-dose steroid use. He received more than a decade of treatment with zoledronic acid, with stabilization of BMD and no additional fractures. He was later transitioned to denosumab. This case underscores the rarity of HO occurring in the mesentery and highlights the challenges of managing bone fragility in high-risk post-intestinal transplant patients. This case highlights the importance of monitoring and managing bone fragility in patients undergoing intestinal transplantation and long-term immunosuppressive therapy.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 6","pages":"ziag082"},"PeriodicalIF":3.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13215589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Midlife risk factors predict long-term hip fracture risk in women: a 35-yr follow-up. 中年风险因素预测女性髋部骨折的长期风险：一项35年的随访。

IF 3

JBMR Plus Pub Date : 2026-05-08 eCollection Date: 2026-06-01 DOI: 10.1093/jbmrpl/ziag083

Otto A Mustonen, Reijo Sund, Heikki Kröger, Joonas Sirola, Kenneth E S Poole, Toni Rikkonen

{"title":"Midlife risk factors predict long-term hip fracture risk in women: a 35-yr follow-up.","authors":"Otto A Mustonen, Reijo Sund, Heikki Kröger, Joonas Sirola, Kenneth E S Poole, Toni Rikkonen","doi":"10.1093/jbmrpl/ziag083","DOIUrl":"10.1093/jbmrpl/ziag083","url":null,"abstract":"Hip fractures in the aging population are a substantial burden for health care. This study investigates whether risk factors presented in midlife could predict long-term hip fracture risk in the coming decades. The study cohort consisted of 11 169 Finnish women who completed a health survey in 1994, establishing the baseline risk factors. These included all FRAX variables except FN BMD. The national registry data was used to identify hip fractures and deaths. The follow-up baseline was set at the age of 55 and was terminated by hip fracture, death, or the end of the follow-up period, whichever occurred first. The follow-up age ranged from 55 to 90 yr, with a mean follow-up time of 29.5 yr (range 0.1-35.0 yr). Long-term risk estimates were performed for each risk factor individually over a cumulative time of 1-yr intervals, using Cox proportional hazard regression models. In total, 801 hip fractures were observed during the 35 yr. Several midlife risk factors appear to sustain their relevance later in life, predicting long-term hip fracture risk in women. The significant risk factors included (hazard ratio minimum to maximum) previous fracture (HR 1.5-4.4), parental hip fracture (HR 1.3-2.8), regular smoking (HR 1.8-4.1), glucocorticoid use (HR 1.7-5.3), rheumatoid arthritis (HR 2.2-4.8), poor self-reported health (HR 1.0-4.3), and polypharmacy (HR 1.1-2.7). The findings suggest that several risk factors identified in midlife demonstrate persistent associations with the long-term risk of hip fractures. Early detection and prevention of these factors may help to reduce the risk in later life.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 6","pages":"ziag083"},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to concerns regarding the critical evaluation of 3D-Shaper. 对有关3D-Shaper关键评估的关注的回应。

IF 3

JBMR Plus Pub Date : 2026-05-07 eCollection Date: 2026-06-01 DOI: 10.1093/jbmrpl/ziag084

Tristan Whitmarsh

引用次数: 0

Opportunities for deep learning techniques to advance the histological analysis of preclinical models of osteoarthritis beyond ordinal rank systems. 深度学习技术促进骨关节炎临床前模型的组织学分析的机会。

IF 3

JBMR Plus Pub Date : 2026-05-07 eCollection Date: 2026-06-01 DOI: 10.1093/jbmrpl/ziag039

Jacob L Griffith, Yenisel Cruz-Almeida, Alejandro Almarza, Robert Caudle, Kyle D Allen

{"title":"Opportunities for deep learning techniques to advance the histological analysis of preclinical models of osteoarthritis beyond ordinal rank systems.","authors":"Jacob L Griffith, Yenisel Cruz-Almeida, Alejandro Almarza, Robert Caudle, Kyle D Allen","doi":"10.1093/jbmrpl/ziag039","DOIUrl":"10.1093/jbmrpl/ziag039","url":null,"abstract":"Tools for assessing disease progression are needed to identify and confirm new mechanisms driving osteoarthritis (OA) progression and guide therapeutic development. This review focuses on the advantages and feasibility of leveraging deep learning techniques for quantitative analysis of rodent knee histology in preclinical OA models. Previous studies using radiographs and micro-CT have used deep-learning driven analysis, including convolutional neural networks (CNNs), to evaluate disease progression in OA patients and preclinical models. However, the use of these tools to analyze histology in rodent OA models is limited. The discrepancy between clinical and preclinical histological quantification partly relates to the size constraints of imaging, where the larger scale of clinical samples requires complex mapping and multiple samples to obtain a complete picture of the entire joint. Rodent OA samples provide a view of the entire joint on an individual slide and thereby enable the quantification of changes across the width of the joint. Here, we discuss approaches for using CNN-based pipelines to quantify and visualize joint remodeling in rodent OA models, complementing existing grading schemes and potentially providing insight into mechanisms driving joint pain and disability.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 6","pages":"ziag039"},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain and knee joint degeneration following anterior cruciate ligament injury in a mouse model of Alzheimer's disease. 阿尔茨海默病小鼠模型前交叉韧带损伤后的脑和膝关节变性。

IF 3

JBMR Plus Pub Date : 2026-05-07 eCollection Date: 2026-07-01 DOI: 10.1093/jbmrpl/ziag085

Wei Yao, Barton L Wise, Yu-Yang Lin, Ming Fan, Shanxiu Xu, I-Shin Ju, Jonathan I Berg, Jill L Silverman, Gabriela G Loots, Blaine A Christiansen

{"title":"Brain and knee joint degeneration following anterior cruciate ligament injury in a mouse model of Alzheimer's disease.","authors":"Wei Yao, Barton L Wise, Yu-Yang Lin, Ming Fan, Shanxiu Xu, I-Shin Ju, Jonathan I Berg, Jill L Silverman, Gabriela G Loots, Blaine A Christiansen","doi":"10.1093/jbmrpl/ziag085","DOIUrl":"10.1093/jbmrpl/ziag085","url":null,"abstract":"Alzheimer's disease (AD) and osteoarthritis (OA) are 2 of the most common health conditions affecting the elderly. Recent studies in mice and humans have described an association between OA and AD, with prevalent OA increasing the risk of developing AD-like cognitive declines. In this study, we investigated brain and knee joint degeneration and neurocognitive dysfunction in a mouse model of AD (APP/PS1 double transgenic mice) in the presence or absence of OA induced by non-invasive ACL rupture. We hypothesized that OA would be associated with increased beta amyloid (Aβ) and phosphorylated tau (pTau) in the injured joint and brain and would be associated with accelerated cognitive decline in APP/PS1-Tg mice. Non-invasive knee injury was performed at 7 mo of age in male and female APP/PS1-Tg mice and non-transgenic (WT) littermates. Neurocognitive tests, including open field, novel object recognition, and Morris water maze, were performed 6 wk post-injury. Knees were also assessed at 6 wk post-injury to quantify OA, and Aβ, Tau, and pTau levels in the brain and knee joints. We found that female APP/PS1-OA mice had significantly more osteophyte formation than WT-OA mice, and significantly greater Aβ and pTau levels in the brain and knee joints than in WT or APP/PS1-Sham mice. These results provide insights about the pathoetiology of AD and OA and suggest possible common mechanisms connecting OA-associated inflammation to cognitive function. Identifying novel mechanisms of crosstalk between these 2 conditions could improve clinical care and quality of life for at-risk patient populations.","PeriodicalId":14611,"journal":{"name":"JBMR Plus","volume":"10 7","pages":"ziag085"},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13232624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of romosozumab for osteoporosis in β-thalassemia major. romosozumab治疗重度β-地中海贫血患者骨质疏松症

IF 3

JBMR Plus Pub Date : 2026-05-07 eCollection Date: 2026-07-01 DOI: 10.1093/jbmrpl/ziag086

Chrislyn Ng, Navira Samad, Anne Trinh, Frances Milat, Phillip Wong

引用次数: 0